Clinical trials: sponsored by UMC Utrecht
Delirium
Methylphenidate, Rivastigmine or Haloperidol in Hypoactive Delirium in Intensive Care Patients
The purpose of this pilot-trial is the feasibility of a large randomized, placebo controlled, doubleblind clinical trial to investigate the use of methylphenidate, rivastigmine or haloperidol in hypoactive ICU-delirium.
- Trial name
- NCT00599287
- Testing
- Haloperidol, Methylphenidate, Rivastigmine
- Where
- Netherlands
- Volunteers
- 80 people
- Sponsor
- UMC Utrecht
Unspecified Adult Solid Tumor, Protocol Specific
A Study to Identify a Biomarker Predictive for Response on Everolimus in Solid Tumors (CPCT-03)
The investigators hypothesize that certain mutations in the individual cancer genomes will predict response to Everolimus therapy.
- Trial name
- CPCT-03 (NCT01566279)
- Testing
- Everolimus
- Where
- 3 sites in Netherlands
- Volunteers
- 73 people
- Sponsor
- UMC Utrecht
Cardiovascular Diseases, Hypercholesterolemia
The ZWOlle Transmural Integrated Care for CArdiovaScular Risk Management Study
Cardiovascular disease (CVD) contributes importantly to mortality and morbidity. Prevention of CVD by lifestyle change and medication is important and needs full attention.
- Conditions
- Cardiovascular Diseases, Hypercholesterolemia, Hypertension
- Trial name
- ZWOT-CASE (NCT03428061)
- Testing
- Integrated care for cardiovascular risk management
- Where
- Netherlands
- Volunteers
- 740 people
- Sponsor
- UMC Utrecht
Spinal Muscular Atrophy, SMA
SPACE Trial: Pyridostigmine vs Placebo in SMA Types 2, 3 and 4
A trial investigating the effects of pyridostigmine (mestinon) versus a placebo in a double-blind cross over trial in patients with hereditary proximal spinal muscular atrophy (SMA) types 2, 3 and 4.
- Conditions
- Spinal Muscular Atrophy, SMA, Kugelberg-Welander Disease
- Trial name
- SPACE (NCT02941328)
- Testing
- Pyridostigmine
- Where
- Netherlands
- Volunteers
- 39 people
- Sponsor
- UMC Utrecht
Edema, Lymphedema
Breast Edema Compression Vest
A common complication of breast conserving therapy is breast edema, which may lead to chronic pain, but also reduced quality of life (QoL) and poor cosmetic outcome.
- Conditions
- Edema, Lymphedema, Breast Neoplasm, Breast Cancer
- Trial name
- NCT02627976
- Testing
- Compression vest, Thuasne
- Volunteers
- 25 people
- Sponsor
- UMC Utrecht
Lower Respiratory Tract Infection, Unspecified Fever
Assess a Diagnostic Tool to Distinguish Between Bacterial and Viral Infection
In the past 70 years antibiotics have served as the first line of defense against infectious diseases. However, antibiotics are only effective against bacterial infections and are not the solution for infections caused by viruses…
- Trial name
- OPPORTUNITY (NCT01931254)
- Where
- 3 sites in Israel, Netherlands
- Volunteers
- 777 people
- Sponsor
- UMC Utrecht
Postoperative Myocardial Injury
Direct Evaluation of Postoperative Myocardial Injury Using Coronary Computed Tomography Angiography After Non-Cardiac Surgery
This is a prospective study in patients who undergo routine postoperative troponin assessment after major (semi-)elective noncardiac surgery.
- Trial name
- NCT02682966
- Testing
- Coronary Computed Tomography Angiography
- Volunteers
- 354 people
- Sponsor
- UMC Utrecht
Medial Compartment Osteoarthritis of the Knee
Effects of Osteotomies Around the Knee on Cartilage Glycosaminoglycan Content Using dGEMRIC Non-invasive Imaging
Medial compartment osteoarthritis of the knee is commonly treated by a surgical intervention called 'high tibial osteotomy' (VTO).
- Trial name
- NCT01269944
- Where
- Netherlands
- Volunteers
- 10 people
- Sponsor
- UMC Utrecht
Neurocognitive Decline, HIV Associated Neurocognitive Disorder
Effect of SwitChing AtriPla to Eviplera on Neurocognitive and Emotional Functioning
This study will evaluate the effects of switching Atripla to Eviplera on neurocognition measured by neuropsychological testing and functional MRI
- Trial name
- ESCAPE (NCT02308332)
- Testing
- Eviplera
- Where
- Netherlands
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- UMC Utrecht
Osteoporosis
Shock Wave Therapy for Osteoporosis
Rationale: Osteoporotic fractures are associated with high morbidity and mortality. This is why prevention of these fractures is important.
- Trial name
- BOEST (NCT02630381)
- Testing
- Unfocused extracoporeal shock wave therapy
- Volunteers
- 12 people
- Sponsor
- UMC Utrecht
Cerebral Perfusion, Cerebral Oxygenation
Parameters of Cerebral Perfusion
The purpose of this study is to determine whether cerebral blood flow and cerebral tissue oxygenation is most dependent on cardiac output or on mean arterial pressure in patients undergoing cardiac surgery with the use of…
- Conditions
- Cerebral Perfusion, Cerebral Oxygenation, Cardiopulmonary Bypass
- Trial name
- NCT02806492
- Testing
- 50-100ug phenylephrine before CPB, 50-100ug phenylephrine during CPB, decreasing CPB flow
- Where
- Netherlands
- Volunteers
- 15 people
- Sponsor
- UMC Utrecht
Recurrent Miscarriages
Maternal Embryo Interaction in Recurrent Miscarriages
Background of the study: The etiology of recurrent miscarriage (RM, defined as three or more consecutive miscarriages without any proven maternal or fetal cause), remains undiagnosed in more than 50% of cases.
- Trial name
- MEER (NCT03156491)
- Where
- Netherlands
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- UMC Utrecht
FSH Assay
Spiking-and-Recovery Experiment DOREMI Study
The purpose of this study is to test the validity of our in-house chemiluminescence assay for measurement of folliclestimulating hormone (FSH) serum levels before and during exogenous recombinant FSH (rFSH) administration.
- Trial name
- NCT02622347
- Where
- Netherlands
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- UMC Utrecht
Esophageal Resection Candidates
Preoperative Inspiratory Muscle Training in Esophageal Resection
The PREPARE study is the first multicenter randomized controlled trial to evaluate the hypothesis that preoperative inspiratory muscle training leads to decreased pulmonary complications in patients undergoing esophageal…
- Trial name
- PREPARE (NCT01893008)
- Testing
- Inspiratory Muscle Training (IMT)
- Where
- 9 sites in Belgium, Finland and 2 more
- Volunteers
- 245 people
- Sponsor
- UMC Utrecht
Neoplasm Metastasis
Stereotactic Body Radiotherapy Followed by Surgical Stabilization for Patients With Unstable Spinal Metastases
The aim of this study is to assess the feasibility and safety of combining stereotactic body radiotherapy (SBRT) and pedicle screw fixation in a 48-hour window for the treatment of painful unstable metastases of the thoracic…
- Trial name
- BLEND (NCT02622841)
- Testing
- BLEND
- Where
- Netherlands
- Volunteers
- 13 people
- Sponsor
- UMC Utrecht
Breast Cancer Risk
The Effects of Equivalent Weight Loss With or Without Exercise Training on Breast Cancer Risk (SHAPE-2)
Physical inactivity and overweight are two accepted risk factors for breast cancer. However, because of their correlation it is not clear which is most relevant to risk.
- Trial name
- SHAPE-2 (NCT01511276)
- Testing
- Diet, Mainly exercise induced weight loss
- Where
- 2 sites in Netherlands
- Volunteers
- 243 people, healthy volunteers welcome
- Sponsor
- UMC Utrecht
Appetite Regulation
Brain Activity and Hormonal Changes During Food Administration
The amount and kind of food which is ingested influences the regulation of meal size. Neural signals from the gastrointestinal tract travel via the vagus nerve to the brainstem and thalamus, which projects to the rest of the…
- Trial name
- NCT01644539
- Testing
- Water with guar gum - Non Caloric, Chocolate milk - Oral Caloric, Chocolate milk - Intra Gastric Caloric
- Where
- Netherlands
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- UMC Utrecht
Delirium
Validation of a Delirium Monitor
Delirium is a common disorder in hospitalized patients, nevertheless it is poorly recognized by physicians and nurses, even when screening instruments are used.
- Trial name
- NCT02404181
- Where
- Netherlands
- Volunteers
- 159 people
- Sponsor
- UMC Utrecht
Coronary Artery Disease, Atherosclerosis
Drug-eluting Balloon in Acute Myocardial Infarction
The investigators hypothesize that patients with Acute ST Elevation Myocardial Infarction may benefit from primary angioplasty with use of a drug eluting balloon/bare metal stent combination without impairing the process of…
- Conditions
- Coronary Artery Disease, Atherosclerosis, Thrombosis, Acute Myocardial Infarction
- Trial name
- DEB-AMI (NCT00856765)
- Testing
- Drug eluting balloon, Bare metal stent, Drug eluting stent
- Where
- 2 sites in Italy, Netherlands
- Volunteers
- 150 people
- Sponsor
- UMC Utrecht
Uterine Fibroid
Targeted Vessel Ablation of Type 3 Uterine Fibroids With Magnetic Resonance Guided High Intensity Focused Ultrasound
So-called type 1 and 2 uterine fibroids are well treatable with Magnetic Resonance guided High Intensity Focused Ultrasound (MR-HIFU).
- Trial name
- NCT02633254
- Testing
- Magnetic Resonance guided High Intensity Focused Ultrasound
- Where
- Netherlands
- Volunteers
- 6 people
- Sponsor
- UMC Utrecht