Clinical trials: sponsored by University Hospital, Limoges
Nervous System Diseases
Effects of the COTID (Community Occupational Therapist in Dementia) Program and Usual Occupational Therapy Care on Recurrence of Falls at 12 Months in Elderly People With Neurocognitive Disorders Who Had Been Hospitalized for Falls, After Their Return Home
This project will enable optimization of specific carried out by occupationist for older adults discharged from hospital for falls: on the environmental dimension at the participant's home on the involvement of the caregiver…
- Trial name
- ErgoFalls (NCT06237218)
- Testing
- COTID program
- Where
- France
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- University Hospital, Limoges
Kidney Disease
Identification and Characterisation of IgA With Nephritogenic Potential in IgA Deposition Nephropathies (Rep-IgAN)
IgA nephropathy (IgA Nephropathy), or Berger's disease, is the most common form of primary glomerulonephritis. It is a major cause of end-stage renal failure, often leading to dialysis or kidney transplantation.
- Trial name
- Rep-IgAN (NCT07295808)
- Testing
- Blood sample
- Where
- France
- Volunteers
- 150 people
- Sponsor
- University Hospital, Limoges
Hematopoietic Stem Cell Transplantation, Cytomegalovirus Infections
AntiCMV molécules Monitoring in Real-life in Stem Cell Recipients
Cytomegalovirus (CMV) is a ubiquitous herpesvirus that represent a major cause of morbidity in haematopoietic stem cell transplants (HSCT) recipients, mostly through reactivation of the recipient's virus.
- Conditions
- Hematopoietic Stem Cell Transplantation, Cytomegalovirus Infections, Antivirals, Antiviral Drug Resistance
- Trial name
- NAViRe (NCT04690933)
- Testing
- Real-life observatory of efficacy and resistance to anti CMV molecules in stem cell recipients
- Where
- 16 sites in France
- Volunteers
- 400 people
- Sponsor
- University Hospital, Limoges
Urinary Tract Infections in Children
INterest of the Negative Predictive Value of Integrons in Choosing a Narrow-spectrum Empirical anTibiotic Treatment vs Usual Empirical Antibiotic Treatment for Urinary Tract infectionS in the PEDiatric Emergency Department
INVICTUS PED primary objective is to show the non-inferiority of an empirical antibiotic therapeutic management guided by the early detection of integrons in the urine, compared to a usual empirical antibiotic treatment, for the…
- Trial name
- INVICTUS PED (NCT05066854)
- Testing
- integron research, usual practice
- Where
- 4 sites in France
- Volunteers
- 36 people
- Sponsor
- University Hospital, Limoges
Sepsis, Echocardiography
Emergency Echocardiography in Sepsis
Acute circulatory failure that combines hypovolemia, vasoplegia and cardiac dysfunction plays a major role in the development of sepsis-related organ dysfunction. Pathophysiological mechanisms are multiple and complex.
- Conditions
- Sepsis, Echocardiography, Organ Dysfunction Syndrome Sepsis, Emergencies
- Trial name
- GENESIS (NCT04580888)
- Testing
- early transthoracic echocardiography, standards of care
- Where
- 10 sites in France
- Volunteers
- 312 people
- Sponsor
- University Hospital, Limoges
Allograft
PK Assessment of Tacrolimus Exposure Before and After a Switch From Twice Daily Immediate-release (Prograf®) to Once-daily Prolonged Release Tacrolimus (Envarsus®)
Tools have been developed in our unit to calculate the inter-dose AUC (Area Under Curve) of immunosuppressive drugs (ISD) based on a limited number of blood concentrations (i.e., blood samples) using Bayesian methods.
- Trial name
- ENVARSWITCH (NCT02882828)
- Testing
- switched from Prograf® to Envarsus®
- Where
- 9 sites in France
- Volunteers
- 134 people
- Sponsor
- University Hospital, Limoges
High Risk of Preterm Delivery
Interest of Virtual Reality for the Management of Hospitalized Pregnant Patients at Risk of Preterm Delivery
Patients at high risk of preterm birth are hospitalized with an high stress for their child's future. In order to better prepare the patient to a possible preterm delivery we use to propose her a visit of the neonatology unit.
- Trial name
- OREV (NCT05547724)
- Testing
- Virtual reality
- Where
- France
- Volunteers
- 85 people
- Sponsor
- University Hospital, Limoges
Sepsis, Cardiomyopathies
Adjunctive DobutAmine in sePtic Cardiomyopathy With Tissue Hypoperfusion
Sepsis induces both a systolic and diastolic cardiac dysfunction. The prevalence of this septic cardiomyopathy ranges between 30 and 60% according to the timing of assessment and definition used.
- Conditions
- Sepsis, Cardiomyopathies, Hypoperfusion, Left Ventricular Systolic Dysfunction
- Trial name
- ADAPT (NCT04166331)
- Testing
- Dobutamine
- Where
- 21 sites in France
- Volunteers
- 136 people
- Sponsor
- University Hospital, Limoges
Invasive Candidiasis
Pharmacokinetics of Micafungin in Patients of Intensive Care Units
Invasive fungal infections (IFIs) are a frequent cause of morbidity and mortality in high-risk patients, such as immunocompromised patients.
- Trial name
- MI-K (NCT02164890)
- Testing
- micafungin
- Where
- France
- Volunteers
- 60 people
- Sponsor
- University Hospital, Limoges
Premature Birth
Parental Involvement in Enteral Nutrition in Neonatal Units
Hypothesis : Bolus feeding of the newborn with a syringe under parents' visual control increases parental presence when compared to enteral feeding with a syringe pump.
- Trial name
- PREMALIM (NCT05272956)
- Testing
- enteral feeding with pushed syringe by the parents
- Where
- 2 sites in France
- Volunteers
- 72 people
- Sponsor
- University Hospital, Limoges
Sepsis, Emergency Care
Hemodynamic Evaluation Using Microcirculation for Early Treatment of Septic Patients
Despite early treatment, the deterioration and mortality of sepsis patients remains high. A possible explanation could be persistent tissue hypoperfusion, or undetected in the early phase despite the normalization of…
- Conditions
- Sepsis, Emergency Care, Microcirculation
- Trial name
- HEMOCAP (NCT06910891)
- Testing
- measurement of the peripheral perfusion index and marbling assessment
- Where
- 6 sites in France
- Volunteers
- 556 people
- Sponsor
- University Hospital, Limoges
Sustained Immunosuppression
Prevention of Secondary Infections by Interferon Gamma in ICU-acquired Sustained Immune-suppression
The goal of this clinical trial is to demonstrate the benefit of a standardized immunotherapy (Interferon gamma) on the incidence of secondary infections. . It will also learn about the safety of Interferon-gamma.
- Trial name
- PLATINIUM (NCT06774235)
- Testing
- Interferon Gamma 1-b
- Where
- 23 sites in France
- Volunteers
- 326 people
- Sponsor
- University Hospital, Limoges
Cancer Colorectal, Polyps Colorectal
French Colorectal ESD Cohort in Experts Centers
Initially developed in Japan for the treatment of endemic superficial gastric cancers, endoscopic submucosal dissection (ESD) allows resection of pre-neoplastic and neoplastic lesions of the digestive tract into a single…
- Conditions
- Cancer Colorectal, Polyps Colorectal, Endoscopic Submucosal Resection
- Trial name
- FECCo (NCT04592003)
- Testing
- Endoscopic submucosal dissection
- Where
- 25 sites in France
- Volunteers
- 1,200 people
- Sponsor
- University Hospital, Limoges
Viral Hepatitis
Acceptability and Feasibility of Simultaneous Screening for Viral Hepatitis B, C and HIV Among Drug Users and Vulnerable Populations, in Non-conventional Structures "Outside the Walls" by Dual Screening Method RTDs and FibroScan®
The "Scanvir" concept aims to achieve barriers to HCV screening and treating of marginalized patients. The concept is applicable to other various populations and territories and should effectively improve HCV patient's health…
- Trial name
- SCANVIRE2 (NCT06904820)
- Where
- France
- Volunteers
- 2,300 people
- Sponsor
- University Hospital, Limoges
Ageing
Effects of an Exergame Focused on Cognitive-motor Interference on the Cognitive and Motor Capacities of Older Adults
Ageing is accompanied by a high risk of developing physical or cognitive impairments, as well as a decrease in abilities to perform two tasks simultaneously, contributing to loss of autonomy.
- Trial name
- INCOME (NCT04803799)
- Testing
- Training Programme
- Where
- 2 sites in France
- Volunteers
- 40 people
- Sponsor
- University Hospital, Limoges
Renal Transplant Recipient, Immunized Against the Cytomegalovirus
Assessing the Risk of CMV Infection of the Renal Transplant About R + by Cellular Immunity Analyzed by the QuantiFERON ®-CMV Test.
Cytomegalovirus (CMV) infection was observed in over 30% of organ recipients with high morbidity. Moreover, no prophylaxis, 75% R + D-transplanted, 55%, R + D + and D-25% R + develop CMV.
- Trial name
- QUANTIC-R+ (NCT02064699)
- Testing
- CMV Infection
- Where
- 12 sites in France
- Volunteers
- 75 people
- Sponsor
- University Hospital, Limoges
Peripheral Arterial Disease, Ankle Brachial Index, Doppler
Comparison of the Ankle-Brachial Index Measurement Using a Specific Oscillometric Device vs. the Doppler Method
Several methods are available to measure ankle brachial index (ABI) non-invasively. A recent scientific statement of the AHA considers the Doppler method as the reference.
- Trial name
- ABIOSCILLO (NCT03511612)
- Testing
- Measure ankle brachial index (ABI)
- Where
- France
- Volunteers
- 51 people
- Sponsor
- University Hospital, Limoges
Urinary Infection
Position of Children During Urine Collection: Evaluation Study
Urinary tract infection (UTI) is a frequently suspected cause of fever in young children, justifying urine cultures. Sampling procedures are decisive for the reliability of UTI diagnosis.
- Trial name
- PUCES (NCT01862822)
- Testing
- upright position
- Where
- France
- Volunteers
- 803 people
- Sponsor
- University Hospital, Limoges
Chronic Hepatitis C
Study of the Pharmacokinetic Action of Amantadine and Ribavirin in Chronic Hepatitis C. CINAM
Peg interferon and ribavirin currently represent the standard approved association for treating patients infected with hepatitis C virus (HCV) .
- Trial name
- CINAM (NCT00199719)
- Testing
- Ribavirine
- Where
- 2 sites in France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Limoges
Urinary Infection
The Painful Real-life Experience of the Child of Less Than Three Years During the Removal of the Collecting Bags in the Pediatric Urgency: What Strategy of Coverage?
Urinary infection is one of the most common bacterial infections in pediatrics and requires urine collections to be diagnosed. In France, among children under 3, urine samples are collected thanks to collecting bags.
- Trial name
- LINIPOCHE (NCT01659190)
- Testing
- Oiled-limestone liniment
- Where
- France
- Volunteers
- 136 people
- Sponsor
- University Hospital, Limoges