Clinical trials: sponsored by University Hospital, Rouen
Active Non-anterior Non-infectious Uveitis
Efficacy and Tolerance of Baricitinib, a JAK Inhibitor, in the Treatment of Refractory Non-infectious Non-anterior Uveitis
The aim of the study is to evaluate the efficacy of Baricitinib, a JAK1 and 2 inhibitor, in the management of non-infectious non-anterior uveitis refractory to at least one line of biotherapy (anti-TNF alpha, tocilizumab) after 6…
- Trial name
- JAKUVEITE (NCT05651880)
- Testing
- Baricitinib 4 MG
- Where
- France
- Volunteers
- 33 people
- Sponsor
- University Hospital, Rouen
Anorexia Nervosa
Effects of Adapated Physical Activity Program on Kynurenin Metabolism During Refeeding in Anorexia Nervosa : APANOR Study
Physical hyperactivity is often associated to anorexia nervosa (AN). Data suggest common central pathways between hyperactivity and anorexia. Maintaining adapted physical activity (APA) during refeeding in AN is controversial.
- Trial name
- APANOR (NCT04817436)
- Testing
- physical activity program (APA)
- Where
- France
- Volunteers
- 9 people
- Sponsor
- University Hospital, Rouen
Total Hip Arthroplasty, Drain Insertion Site
Drains Ablation Post Total Hip Arthroplasty : Search for the Least Painful Technique
Comparison of ablation technique of drains
- Trial name
- TADDA (NCT03789266)
- Testing
- drain ablation
- Where
- France
- Volunteers
- 87 people
- Sponsor
- University Hospital, Rouen
Gout
Immediate Prescription of a Hypouricemic Treatment, Febuxostat, Compared to Its Delayed Administration
Gout, the most common inflammatory rheumatism in France, is a complication of chronic hyperuricemia (> 360umol / l). The resulting urate crystals are deposited in many tissues, especially the skeletal or kidneys.
- Trial name
- FEFACRIGOU (NCT05109936)
- Testing
- Adenuric
- Where
- 6 sites in France
- Volunteers
- 128 people
- Sponsor
- University Hospital, Rouen
Women With Stress Urinary Incontinence
Effectiveness of a Hip Abductor Training in Women With Stress Urinary Incontinence
Urinary incontinence (UI) is estimated to affect 25% à 45 % women all over the world. UI is associated with a poor Quality of life, with a strong level of certainty.
- Trial name
- PROTOGLUT (NCT05635175)
- Testing
- hip abductors physiotherapy self training, Standard pelvic floor muscle training, Standard pelvic floor muscle training self training
- Where
- 3 sites in France
- Volunteers
- 78 people
- Sponsor
- University Hospital, Rouen
Hysterotomy; Affecting Fetus
Effect of Preventive Analgesia by Injection of a Local Anesthetic Before Vaginal Incision for Hysterectomy by vNOTES Approach
The research procedure is the injection of 20 mL of Ropivacaine solution (vs. saline) to create a paracervical block at the beginning of surgery, while the patient is already under general anesthesia.
- Trial name
- ANOTES (NCT05969457)
- Testing
- Naropeine, questionnaires
- Where
- 2 sites in France
- Volunteers
- 108 people
- Sponsor
- University Hospital, Rouen
Peritonitis
Role of Protective Stoma After Primary Anastomosis for Generalized Peritonitis Due to Perforated Diverticulitis
This study is designed to be a multicentre, prospective, comparative, randomised trial, evaluating the efficacy of two surgical strategies for the treatment of generalised peritonitis due to perforated diverticulitis.
- Trial name
- DIVERTI2 (NCT04604730)
- Testing
- Primary anastomosis without protective stoma, Anastomosis with protective stoma
- Where
- 20 sites in France
- Volunteers
- 204 people
- Sponsor
- University Hospital, Rouen
Bronchial Endoscopy
Interest of in Situ Terlipressin Administration Before the Realisation of Bronchial Biopsy
The diagnostic yield of flexible bronchoscopy for the diagnosis of lung cancer depends on the location and the histological type of the lesion, as well as on the number of biopsy samples performed.
- Trial name
- TERLAB (NCT02970175)
- Testing
- Terlipressin administration, bronchoscopy under local anesthesia, Biopsy sampling
- Where
- France
- Volunteers
- 130 people
- Sponsor
- University Hospital, Rouen
Autism Spectrum Disorder, Schizophrenia Disorder
Understanding and Treating Severe and Resistant Pathological Aggression: Using Deep Brain Stimulation to Treat Resistant Aggression
Physical aggression can be defined as the use of force with the intention of causing physical injury, psychological damage or death. Pathological aggression may be associated with various psychiatric disorders.
- Trial name
- STAR (NCT07315685)
- Testing
- neurostimulator
- Where
- 2 sites in France
- Volunteers
- 6 people
- Sponsor
- University Hospital, Rouen
Non-cancerous Pain, Opioid Use
Usual Care Intervention Research Evaluating the Impact of a Personalized Pharmaceutical Plan on the Duration of Opioid Treatment in Non-cancerous Pain
Many treatments with WHO grade III opioids are being introduced in the rheumatology department for non-cancerous pain. The duration of this treatment prescribed at discharge is often uncontrolled and sometimes leads to…
- Trial name
- PPP-Care (NCT05196386)
- Testing
- Admission conciliation interview, Discharge conciliation interview, Targeted pharmaceutical interview
- Where
- France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Rouen
Osteoporosis
Study of a Bone Assessment Technique, Bone Mineral Analyser, Concerning the Prediction of Improvement in Bone Status After an Infusion of Zoledronic Acid in Osteoporotic Women
Collection of epidemiological data Biological assessment as part of routine care. Measurement of the Hurst coefficient at D0 Measurement of bone density and TBS on D0 Zoledronic acid infusion the month following inclusion phone…
- Trial name
- TEOBASO (NCT04253340)
- Testing
- Bone mineral analyser
- Sponsor
- University Hospital, Rouen
Patients Scheduled for Cerebral Arteriography for Diagnostic or Therapeutic Purposes
Evaluation of the Influence of Aromatherapy and Music Therapy on Stress During the Management of Cerebral Arteriography
Cerebral arteriography is a reference examination in medical imaging. This examination is performed to allow the diagnosis and therapeutic management of patients with vascular pathologies.
- Trial name
- HERMES (NCT06425237)
- Testing
- music therapy, aromatherapy
- Where
- France
- Volunteers
- 224 people
- Sponsor
- University Hospital, Rouen
Critically Ill, Extubation
Does Tracheal Suction During Extubation in Intensive Care Unit Decrease Functional Residual Capacity
Little is known about the procedure of extubation of patients admitted in Intensive Care Units (ICU). In particular, effects of tracheal suction during extubation have never been evaluated.
- Conditions
- Critically Ill, Extubation, Intensive Care Unit
- Trial name
- NCT03681626
- Testing
- no tracheal suction, tracheal suction
- Where
- France
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University Hospital, Rouen
Kidney Transplantation, Primary Prevention
Renal Function Evaluation After Reduction of Cyclosporine A Dose in Renal Transplant Patients
The purpose of the study is to show the efficacy of reduction of cyclosporine A exposure measured by the area under the curve by Bayesian estimator on the primary prevention of degradation of the renal function in renal…
- Conditions
- Kidney Transplantation, Primary Prevention, Kidney Failure
- Trial name
- DICAM (NCT00213590)
- Testing
- cyclosporine A
- Where
- France
- Volunteers
- 208 people
- Sponsor
- University Hospital, Rouen
Functional Colonic Disease, Fecal Incontinence
Effect of Lumbo-sacral Magnetic Stimulation on Colonic Motility
The purpose of this study is to evaluate the effect of sacral nerve magnetic stimulation on the colonic motility in healthy subjects, in incontinent and constipated patients.
- Trial name
- NCT00213317
- Testing
- lombo-sacral magnetic stimulation
- Where
- France
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University Hospital, Rouen
Acute Respiratory Failure With Hypoxia
High-flow Oxygen Therapy vs Non-invasive Ventilation: Comparison of Alveolar Recruitment in Acute Respiratory Failure
This physiological study showed an increase in regional ventilation with NIV but no difference in alveolar recruitment as compared to HFNC in patients with hypoxemic ARF.
- Trial name
- IRAvista (NCT04664322)
- Testing
- non invasive ventilation and high flow nasal canulae oxygen therapy
- Where
- France
- Volunteers
- 16 people
- Sponsor
- University Hospital, Rouen
Severe Acute Cardiogenic Pulmonary Edema
CPAP Versus Bilevel Pressure Support Ventilation in Cardiogenic Pulmonary Edema
To evaluate whether bilevel positive airway pressure more rapidly improves ventilation than continuous positive airway pressure (CPAP) in patients with acute pulmonary edema.
- Trial name
- NCT00213681
- Testing
- Boussignac CPAP - bilevel ventilation support
- Where
- France
- Sponsor
- University Hospital, Rouen
Fecal Incontinence
Effect of Sacral Nerve Stimulation on Enteric Nervous System
Sacral nerve stimulation (SNS) is a new therapeutic option to treat fecal incontinence, although its mecanims of action remains poorly understood. The investigators hypothtized that SNS could act on enteric nervous system (ENS).
- Trial name
- ENS-3 (NCT01786304)
- Testing
- Sacral nerve stimulation
- Where
- 2 sites in France
- Volunteers
- 37 people
- Sponsor
- University Hospital, Rouen
Autism Spectrum Disorder
Diagnostic Performance of Exome Sequencing in Autism Spectrum Disorders
Evaluation of the diagnostic performance of exome sequencing in a prospective series of patients with autism spectrum disorders (ASD).
- Trial name
- REDIA (NCT04043351)
- Testing
- blood test
- Where
- France
- Volunteers
- 300 people
- Sponsor
- University Hospital, Rouen
Acute Renal Failure
A New Way to Detect Acute Kidney Injury
Acute renal failure after cardiac surgery is a common postoperative complication, affecting approximately 20% of patients. It is associated with an increase in short-term mortality and an increase in hospital stay; but is also…
- Trial name
- VEX-CARDS (NCT07198906)
- Testing
- Determination of VEXUS score and onset of chronic renal failure
- Where
- France
- Sponsor
- University Hospital, Rouen