Clinical trials: sponsored by University Hospital, Rouen
Rectal Cancer
Interest of Early Erectile Rehabilitation With Sildenafil After Radiotherapy and Proctectomy for Rectal Cancer
This study aims to evaluate the efficacy of erectile rehabilitation with Sildenafil, in men treated with neoadjuvant proctectomy and radiotherapy for rectal cancer, in preventing long-term erectile dysfunction at 12 months…
- Trial name
- RECTIL (NCT06123156)
- Testing
- Sildenafil
- Where
- 14 sites in France
- Volunteers
- 188 people
- Sponsor
- University Hospital, Rouen
Medical Care
Performance of the Gynaecological Examination in the Lateral Decubitus Position
The gynaecological examination consists of a breast examination, abdominal examination, inspection of the vulva, vaginal touch and pelvic examination with a speculum.
- Trial name
- EXADELA (NCT05880290)
- Testing
- gynaecological examination in lateral decubitus
- Where
- 21 sites in France
- Volunteers
- 547 people, healthy volunteers welcome
- Sponsor
- University Hospital, Rouen
Apnea, Obstructive
EFFECT OF A SUBSTANCE P ANTAGONIST ON THE SECRETION OF ALDOSTERONE IN PATIENTS WITH OBSTRUCTIVE SLEEP APNEA SYNDROME AND ARTERIAL HYPERTENSION
Obstructive sleep apnea syndrome (OSAS) is associated with hyperaldosteronism with elevated plasma aldosterone/renin ratio, the physiopathological mechanism of which remains uncertain.
- Trial name
- APHOS3 (NCT06462287)
- Testing
- Aprepitant 125 and 80Mg Oral Capsule
- Where
- France
- Volunteers
- 24 people
- Sponsor
- University Hospital, Rouen
Analgesia, Emergencies
Nebulized Fentanyl in Healthy Volunteers
Pain constitutes the predominant motive prompting individuals to seek emergency medical attention, accounting for 80% of admissions to emergency departments.
- Trial name
- AEROfen (NCT06281951)
- Testing
- Fentanyl - Inhalation by facial nebulization, Fentanyl - Nebulisation
- Where
- France
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University Hospital, Rouen
Healthy
Balance Control During Gait
Gait and balance disorders are important public health problem necessitating studies to try to prevent falls. Many studies have dealt with spatiotemporal gait parameters or balance during quiet standing (posturography).
- Trial name
- FREINAGE3D (NCT02231827)
- Testing
- Gait analysis
- Where
- France
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University Hospital, Rouen
Voluntary
Effectiveness of Neurodynamic Sliding Mobilisation in the "Slump" Position in Relation to the Perceptible Pain Threshold in Asymptomatic People
According to the French National Health Agency, the use of manual therapy techniques is "possible" [grade B] as part of a multimodal combination of treatments for low back pain.
- Trial name
- SPEAKER 2 (NCT06357715)
- Testing
- "slump"position, no" slump" position
- Where
- France
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- University Hospital, Rouen
Breast Cancer, Ovarian Cancer
Targeted Next-generation Sequencing Panel for Identification of Germline Mutations in Early Onset Cancers With Sporadic or Hereditary Presentation
Despite relevant clinical and/or familial presentations suggesting a hereditary predisposition (early-onset, multiple primary tumors, familial aggregation), targeted genomic analysis based on the phenotype are often non…
- Conditions
- Breast Cancer, Ovarian Cancer, Colorectal Cancer, Pediatric Cancers
- Trial name
- PANEL (NCT02664389)
- Testing
- Genetic analysis
- Where
- France
- Volunteers
- 289 people
- Sponsor
- University Hospital, Rouen
Rectal Cancer Patients
Evaluation of Gynecological and Sexual Sequelae
Rectal cancer accounts for approximately 40% of colorectal cancers. In France, there are 15,000 new cases per year, and the 5-year survival rate is 55% across all stages.
- Trial name
- GYNERECT (NCT07389863)
- Where
- France
- Volunteers
- 15 people
- Sponsor
- University Hospital, Rouen
Circulating Tumor Cells, Pancreatic Adenocarcinoma
Detection of Circulating Tumor Cells for the Diagnostic of Pancreatic Adenocarcinoma.
Histological proof is a crucial and necessary step for appropriate care in oncology. In the case of pancreatic cancer, histological proof from pathological analysis of the surgical specimen is very rare due to the limited number…
- Conditions
- Circulating Tumor Cells, Pancreatic Adenocarcinoma, Circulating Tumor DNA (KRAS), CA 19.9
- Trial name
- CTC-Pancreas (NCT02072616)
- Testing
- Pancreatic adenocarcinoma diagnosis
- Where
- France
- Volunteers
- 101 people
- Sponsor
- University Hospital, Rouen
Infant, Premature
Language and Motricity in Preterm School Age Children
A total of 40% of neurodevelopmental difficulties have been reported in very premature infants less than 32 weeks of age. The Epipage1 study reported a decreasing prevalence of cerebral palsy (9-6%) but a high prevalence of…
- Trial name
- LAMOPRESCO2 (NCT02811029)
- Testing
- measurement of phonology
- Where
- France
- Volunteers
- 108 people
- Sponsor
- University Hospital, Rouen
Thrombotic Thrombocytopenic Purpura (TTP)
Immunological Aspect of Thrombotic Thrombocytopenic Purpura (TTP)
The general objective of the proposed project is to characterise phenotypically and functionally ADAMTS13-specific memory B lymphocytes and autoreactive T lymphocytes, in particular follicular helper T lymphocytes, in the acute…
- Trial name
- Lympho-PTT (NCT06945861)
- Where
- France
- Volunteers
- 44 people
- Sponsor
- University Hospital, Rouen
Paediatric Surgery, Analgesics Prescriptions
Setting up a Website in Paediatric Surgery at the Rouen University Hospital for Parents and Children to Better Understand the Postoperative Prescription of Painkillers.
Although outpatient surgery is increasing in France, particularly in paediatrics, compliance with analgesics prescriptions and pain management on return home remain poorly controlled parameters, although they are essential for…
- Trial name
- DOLIPAR (NCT04564248)
- Testing
- Website access
- Where
- France
- Volunteers
- 200 people
- Sponsor
- University Hospital, Rouen
Resectable Non-small Lung Cancer
Association Between Circulating Immune Cells and the Tumor Immune Contexture in Resectable Non-small Cell Lung Cancer
With the recent approval of Nivolumab for second-line treatment of stage IIIb/IV non-small cell lung cancer (NSCLC), immune checkpoint inhibitors are entering the standard of care for lung cancer.
- Trial name
- LYMPHOLUNG (NCT02551211)
- Testing
- blood drawn, surgical resection of cancer
- Where
- France
- Volunteers
- 22 people
- Sponsor
- University Hospital, Rouen
Inflammatory Bowel Disease
Inflammatory Bowel Disease : Could a Regular Physical Activity Reduce Patients Fatigue ?
The chronic fatigue is observed in approximately 40 % of the patients with a chronic quiet inflammatory bowel disease (IBD) and impacts the quality of life of the patients.
- Trial name
- MICI (NCT02861053)
- Testing
- regular and moderate physical activity, No regular and moderate physical activity more than usual
- Where
- France
- Volunteers
- 3 people
- Sponsor
- University Hospital, Rouen
ADHD
Impact of Ostracism on Prospective Memory in ADHD Children With or Without Emotional Dysregulation
Assess the effect of exposure to a situation of social exclusion or ostracism on the prospective memory of children with ADHD
- Trial name
- IOM-ADHD (NCT05520996)
- Testing
- Cyberball
- Where
- France
- Volunteers
- 24 people
- Sponsor
- University Hospital, Rouen
Fetal Cardiac Rhythm Abnormalities
Epidural Analgesia and Troubles of Fetal Cardiaq Rythm : Effect of the Systemic Transfer of Ropivacaine and Sufentanil
The aim of the investigators study is to demonstrate the association between fetal cardiac rhythm abnormalies after epidural analgesia and the maternal systemic transfer of ropivacaine and/or sufentanil.
- Trial name
- epidarc (NCT01686347)
- Testing
- ropivacaine
- Where
- France
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University Hospital, Rouen
Cardiac Resynchronization Therapy
Prospective Randomized Trial Comparing TRIPLE Site ventriculAr Stimulation Versus Conventional Pacing in CRT canDidates
Cardiac resynchronization therapy (CRT) is a recommended treatment for selected patients with symptomatic heart failure (HF). Although most treated patients show a benefit from CRT, a lack of response is observed for about 25-30%…
- Trial name
- TRIPLEAD (NCT02962791)
- Testing
- Cardiac resynchronization therapy implantation, Stimulation of 3 ventricular sites, Stimulation of 2 ventricular sites
- Where
- France
- Volunteers
- 36 people
- Sponsor
- University Hospital, Rouen
Hepatectomy
Efficacy of Local Anesthesic on Diaphragmatic Function After Upper Abdominal Surgery
Upper abdominal surgery is known to induce such pulmonary complications as pneumonia, atelectasis, pleural effusion. The post operative diaphragmatic dysfunction participates to these complications and lasts for 7 days after…
- Trial name
- CATPAR (NCT02353702)
- Testing
- Sniff test, Infusion of Ropivacaine during 48 hours, Continuous parietal infusion with parietal catheter
- Where
- France
- Volunteers
- 31 people
- Sponsor
- University Hospital, Rouen
Corona Virus Infection
Evaluation of Serological Techniques for Screening for COVID-19 Infection at the University Hospital of Rouen
At present, the offer of tests for the serological diagnosis of CoVID-19 (detection of IgG, IgM or IgA antibodies against CoV-2 SARS) is plethoric and is based on the use of a very large number of rapid diagnostic unit tests, a…
- Trial name
- SeroCOV (NCT04707833)
- Testing
- Serological testing for COVID-19 infection
- Where
- France
- Volunteers
- 101 people
- Sponsor
- University Hospital, Rouen
Kidney Transplant Recipients
Role of Epoxyeicosatrienoic Acids in Chronic Allograft Nephropathy - The TRANSPLANT-EETs Study
Endothelial lesions within the transplanted kidney are a major determinant of chronic allograft nephropathy. Epoxyeicosatrienoic acids (EETs) are endothelium-derived hyperpolarizing factors with anti-inflammatory…
- Trial name
- TRANSPLANTEETs (NCT02555566)
- Testing
- Blood sampling, flow-mediated distal stimulation of the forearm radial artery by cutaneous heating
- Where
- France
- Volunteers
- 80 people
- Sponsor
- University Hospital, Rouen