Clinical trials: sponsored by University Hospital Heidelberg
COVID-19
CoronaWatch - Early Detection of Cardiovascular Risks in COVID-19 Via SmartWatch
In December 2019, a new viral disease called COVID-19 emerged. It is caused by the new corona virus SARS-CoV-2. It was initially described in the chinese city of Wuhan.
- Trial name
- CoronaWatch (NCT04376853)
- Testing
- Apple Watch Series 5
- Where
- Germany
- Volunteers
- 50 people
- Sponsor
- University Hospital Heidelberg
Acute Myeloid Leukemia
Daunorubicin or Idarubicin With Cytarabine Plus Quizartinib vs Physician's Choice in Newly Diagnosed FLT3-ITD+ AML
The orally administered second-generation bis-aryl urea tyrosine kinase inhibitor quizartinib is very specific for FLT3, has a high capacity for sustained FLT3-inhibition and an acceptable toxicity profile.
- Trial name
- Q-SOC (NCT04676243)
- Testing
- Quizartinib, Treatment according to Physician's Choice, Standard of Care Chemotherapy
- Sponsor
- University Hospital Heidelberg
Non-small Cell Lung Cancer
Immune Boost In Non-Small Cell Lung Cancer
Insufficient migration and activation of tumour specific effector T cells seems to be the one important reason for inadequate host anti-tumour immune response. Ionizing radiation can induce a variety of immune responses.
- Trial name
- RadImmune (NCT02319408)
- Testing
- Preoperative radiation
- Where
- 2 sites in Germany
- Volunteers
- 36 people
- Sponsor
- University Hospital Heidelberg
Sepsis, Septic Shock
Next-Generation Sequencing Diagnostics of Bacteremia in Sepsis
Sepsis remains a major challenge, even in modern intensive care medicine. The identification of the causative pathogen is crucial for an early optimization of the antimicrobial treatment regime in patients with sepsis.
- Trial name
- NextGeneSiS (NCT03356249)
- Testing
- Next-Generation Sequencing
- Where
- 21 sites in Germany
- Volunteers
- 500 people
- Sponsor
- University Hospital Heidelberg
Psychosomatic Medicine
Evaluation of the "Platform Model" for Staffing in Psychiatric and Psychosomatic Clinics
This study aims to evaluate the so-called platform model and its suitability to determine staffing in hospitals for psychosomatic medicine and psychotherapy.
- Trial name
- EPPIK (NCT05240105)
- Testing
- no intervention, purely observational
- Where
- Germany
- Volunteers
- 5,961 people
- Sponsor
- University Hospital Heidelberg
Solid Tumor, Adult
Systematic Evaluation of Human Explant Model Systems Engineering
All current forms of therapy for tumor patients are essentially based on clinical, genomic or histopathological criteria for the choice of therapy.
- Trial name
- SEEDLING (NCT04671654)
- Where
- Germany
- Volunteers
- 100 people
- Sponsor
- University Hospital Heidelberg
Psychotherapy, Attachment
Attachment, Patient Self-disclosure and Psychotherapy Outcome
This study investigates whether within- and between-patient effects of attachment moderate the association between self-disclosure and psychotherapy outcome.
- Conditions
- Psychotherapy, Attachment, Self Disclosure, Treatment Outcome
- Trial name
- NCT05151354
- Testing
- Psychotherapy
- Volunteers
- 1,500 people
- Sponsor
- University Hospital Heidelberg
Self-Criticism, Psychological Distress
Interplay of Self-Criticism and Symptom Severity Over the Course of In-patient Psychotherapeutic Treatment
The purpose of this study is to assess the interplay between self-criticism and symptom severity in patients undergoing psychotherapeutic treatment.
- Conditions
- Self-Criticism, Psychological Distress, In-Patient Treatment
- Trial name
- InSeCur (NCT05120453)
- Volunteers
- 2,778 people
- Sponsor
- University Hospital Heidelberg
Head and Neck Cancer, Anogenital Cancer
Decitabine Treatment in HPV-Induced Anogenital and Head and Neck Cancer Patients After Radiotherapy or as Novel Late Salvage
Open-label, single-center phase I study to evaluate first signs of efficacy and to confirm the safety and tolerability of a decitabine safe-dose treatment in two strata of patients with HPV induced anogenital and head and neck…
- Trial name
- DERANO (NCT04252248)
- Testing
- Dacogen
- Where
- Germany
- Volunteers
- 3 people
- Sponsor
- University Hospital Heidelberg
Skull Base Meningioma
Comparison of Proton and Carbon Ion Radiotherapy With Advanced Photon Radiotherapy in Skull Base Meningiomas: The PINOCCHIO Trial.
In PINOCCHIO-Triayl, carbon ion radiotherapy is compared to proton and advanced photon radiotherapy in patients with skull base meningiomas.
- Trial name
- PINOCCHIO (NCT01795300)
- Testing
- Carbon Ion Radiotherapy, Proton Therapy, Hypofractionated Photon Radiotherapy
- Where
- Germany
- Sponsor
- University Hospital Heidelberg
Cancer, Hematological
Pre-Exercise for Allogeneic Stem Cell Transplant Patients
The PRESENT-P study is a one-arm exercise intervention study for hematological cancer patients prior allogeneic stem cell transplantation (allo-HCT).
- Trial name
- PRESENT-P (NCT03080792)
- Testing
- Experimental: moderate to high-intensity exercise
- Where
- 5 sites in Germany
- Volunteers
- 14 people
- Sponsor
- University Hospital Heidelberg
Paediatric Kidney or Liver Transplantation, Chronic Kidney Disease
Prevention of Human Papillomavirus (HPV) Infection in Paediatric Kidney and Liver Transplant Recipients and in Paediatric Patients With Advanced Chronic Kidney Disease
Due to their immunosuppressive therapy, solid-organ transplant (SOT) recipients bear a 10 to 100 times higher risk of human papillomavirus (HPV)-associated malignancies than healthy individuals.
- Trial name
- NCT03100682
- Where
- Germany
- Volunteers
- 140 people
- Sponsor
- University Hospital Heidelberg
Ischemic and Hemorrhagic Stroke, Subarachnoid Hemorrhage
Early Tracheostomy in Ventilated Stroke Patients 2
Patients with severe ischemic and hemorrhagic strokes, who require mechanical ventilation, have a particularly bad prognosis. If they require long-term ventilation, their orotracheal tube needs to be, like in any other intensive…
- Trial name
- SETPOINT2 (NCT02377167)
- Testing
- Tracheostomy
- Where
- Germany
- Volunteers
- 380 people
- Sponsor
- University Hospital Heidelberg
Major Surgery
Impact of an Anesthesia Care Handover-Checklist on Adverse Perioperative Outcome
The aim of the study is to collect information on feasibility and effect size of a confirmatory, prospective study with the question: Does a standardized checklist during intraoperative handover of anaesthesia care reduce the…
- Trial name
- AnCHor (NCT04582513)
- Testing
- AnCHor-Checklist implementation
- Where
- Germany
- Volunteers
- 300 people
- Sponsor
- University Hospital Heidelberg
Multiple Myeloma
Bendamustine, Prednisone and Velcade® for First-line Treatment of Patients With Symptomatic Multiple Myeloma
The purpose of this study is to improve efficacy of treatment for patients with newly diagnosed multiple myeloma who are not eligible for high-dose chemotherapy followed by autologous stem cell transplantation by Bendamustin…
- Trial name
- BPV (NCT02237261)
- Testing
- Bendamustine, Bortezomib, Prednisone
- Where
- 15 sites in Germany
- Volunteers
- 46 people
- Sponsor
- University Hospital Heidelberg
Liver Transplantation
Evaluation of the Impact of Tacrolimus-based Immunosuppression on Heidelberg Liver Transplant Cohort (HDTACRO): Study Protocol for an Investigator Initiated, Non-interventional Prospective Study
Modern immunosuppression is characterized by a combination of different immunosuppressants. As a result, the dose of the individual substances, and thus also their side effects can be reduced.
- Trial name
- NCT04444817
- Testing
- Tacrolimus
- Where
- Germany
- Volunteers
- 100 people
- Sponsor
- University Hospital Heidelberg
Cancer of Unknown Primary Site
Nivolumab/Ipilimumab in Second Line CUP-syndrome
To compare the efficacy of nivolumab plus ipilimumab in subjects with high vs. Intermediate/low TMB poor-prognosis CUP (non-specific subset) who are relapsed or refractory to platinum-based first-line chemotherapy.
- Trial name
- CheCUP (NCT04131621)
- Testing
- Nivolumab/Ipilimumab
- Where
- Germany
- Volunteers
- 194 people
- Sponsor
- University Hospital Heidelberg
Primary Glioblastoma
Carbon Ion Radiotherapy for Primary Glioblastoma
Treatment standard for patients with primary glioblastoma (GBM) is combined radiochemotherapy with temozolomide (TMZ). Radiation is delivered up to a total dose of 60 Gy using photons.
- Trial name
- CLEOPATRA (NCT01165671)
- Testing
- Carbon Ion Radiotherapy, Proton Radiotherapy
- Where
- Germany
- Volunteers
- 100 people
- Sponsor
- University Hospital Heidelberg
Retroperitoneal Soft Tissue Sarcoma
Trial of Neoadjuvant Intensity-Modulated Radiation Therapy Followed by Surgery and Intraoperative Radiation Therapy in Resectable Retroperitoneal Soft Tissue Sarcoma (RETRO-WTS)
Local control rates in patients with retroperitoneal soft tissue sarcoma (RSTS) remain disappointing even after gross total resection, mainly because wide margins are not achievable in the majority of patients.
- Trial name
- NCT01566123
- Testing
- Neoadjuvant intensity-modulated radiation therapy (IMRT), intraoperative radiation therapy (IORT)
- Where
- Germany
- Volunteers
- 37 people
- Sponsor
- University Hospital Heidelberg
Cancer
Individually Tailored Training Prescriptions in Cancer Patients: The TOP Study
The TOP Study is a two-stage study on individually tailored endurance and resistance training prescriptions for breast and prostate cancer patients after the end of primary therapy in order to optimize training effects.
- Trial name
- TOP (NCT02883699)
- Testing
- Standard endurance training, Polarized endurance training, Standard resistance training
- Where
- Germany
- Volunteers
- 132 people
- Sponsor
- University Hospital Heidelberg