Clinical trials: sponsored by University of Aarhus
Bleeding, Hip Fracture
How Bleeding Affects Delirium in Older Patients With Hip Fractures: The IMPROVE-HIP Study
The goal of this clinical trial is to investigate whether early detection of bleeding and prompt blood transfusions can help prevent delirium in patients aged 75 and older who are admitted to the hospital with hip fractures.
- Conditions
- Bleeding, Hip Fracture, Delirium - Postoperative
- Trial name
- NCT06938789
- Testing
- Blood Transfusion, Standard care
- Where
- 2 sites in Denmark
- Volunteers
- 198 people
- Sponsor
- University of Aarhus
Migraine, Migraine With or Without Aura
New Methods for Evaluating Preventive Migraine Treatment
The study aims to test interactions between drug and placebo-responses in acute migraine treatment and to assess variation in adverse events according to treatment information provided.
- Conditions
- Migraine, Migraine With or Without Aura, Headache Disorders, Chronic Migraine, Headache
- Trial name
- NCT07071506
- Testing
- Active drug for chronic migraine treatment.
- Where
- 2 sites in Denmark
- Volunteers
- 60 people
- Sponsor
- University of Aarhus
Hip Dysplasia
Exercise and Patient Education Compared With Usual Care in Patients With Hip Dysplasia
This effectiveness trial will investigate if patients with hip dysplasia randomised to exercise and patient education have a different mean change in self-reported pain measured by the Copenhagen Hip and Groin Outcome Score…
- Trial name
- MovetheHip (NCT04795843)
- Testing
- Exercise and patient education, Usual Care
- Where
- 2 sites in Denmark
- Volunteers
- 200 people
- Sponsor
- University of Aarhus
Postmenopausal Bleeding
Evaluation of DNA Methylation Markers for Endometrial Cancer Risk-stratification Using Patient-collected Urine and Vaginal Samples and Clinician-collected Cervical Samples From Women With Postmenopausal Bleeding
The goal of this observational study is to investigate the clinical utility of DNA-methylation testing in urine and vaginal samples collected by patients and cervical samples collected by clinicians, to determine the risk of…
- Trial name
- NCT07400835
- Testing
- DNA-methylation testing in patient-collected urine and vaginal samples and clinician-collected cervical samples
- Where
- 3 sites in Denmark
- Volunteers
- 600 people
- Sponsor
- University of Aarhus
Diverticulitis Colon, Quality of Life
Quality of Life and Surgery in Diverticular Disease
Diverticular disease is one of the most common diseases of the gastrointestinal tract in industrial countries. Prevalence and admission rate due to diverticular disease increases.
- Conditions
- Diverticulitis Colon, Quality of Life, Diverticular Disease of Left Side of Colon
- Trial name
- NCT05393609
- Testing
- Sigmoidectomy, Conservative
- Where
- Denmark
- Volunteers
- 250 people
- Sponsor
- University of Aarhus
HIV-1 Infection
Pomalidomide as an Immune-enhancing Agent for the Control of HIV
This study is designed to evaluate the safety and efficacy of pomalidomide in HIV-1-infected individuals on ART and to determine the impact of pomalidomide on virological control in people living with HIV during an analytical…
- Trial name
- PEACH (NCT06660498)
- Testing
- Pomalidomide 2 mg, Aspirin 75 mg
- Where
- 2 sites in Australia, Denmark
- Volunteers
- 32 people
- Sponsor
- University of Aarhus
Mental Health Impairment, Diabetes Type 2
Problem-Solving Therapy for Patients With Chronic Disease and Poor Mental Well-being in General Practice
In Denmark the vast majority of patients with chronic ischemic heart disease and/or type 2 diabetes are managed in general practice. 20% of the patients suffer from poor mental health.
- Conditions
- Mental Health Impairment, Diabetes Type 2, Ischemic Heart Disease
- Trial name
- NCT05611112
- Testing
- Problem Solving Therapy
- Where
- Denmark
- Volunteers
- 147 people
- Sponsor
- University of Aarhus
Osteopenia
Optimal Meals to Reduce Bone Resorption in Women With Osteopenia
The goal of this clinical trial is to investigate whether different types of small meals can help reduce bone loss in postmenopausal women with osteopenia, a condition where bone density is lower than normal and may lead to…
- Trial name
- NCT07056322
- Testing
- 200 ml dairy, 100 ml milk, 100 g banana
- Where
- Denmark
- Volunteers
- 13 people
- Sponsor
- University of Aarhus
Arthritis, Rheumatoid
Bone Erosions in Rheumatoid Arthritis - Characterization Evaluated by Imaging and Histology
The aim of this study is to describe macro- and micro anatomical structures, including investigating vessels running in osseous pores in finger joints from participants with rheumatoid arthritis (RA) using histology and different…
- Trial name
- BERA (NCT04645381)
- Where
- 2 sites in Denmark
- Volunteers
- 9 people
- Sponsor
- University of Aarhus
Colorectal Cancer, Quality of Life
RESPONSE: Colorectal Cancer Survivors' Follow-up Care - Now Digital and Need-based
Over the last decades, the 3-year recurrence rates for patients with stage I and II colorectal cancer have decreased to just 5% and 12%.
- Conditions
- Colorectal Cancer, Quality of Life, Survivorship
- Trial name
- RESPONSE (NCT06614647)
- Testing
- Recurrence monitoring with circulating tumor DNA (ctDNA) as a high risk biomarker, Monitoring for late adverse effects with electronic patient reported outcome measures (ePROMs), Systematic treatment of organ-specific late effects and/or biopsychosocial late effects
- Where
- 9 sites in Denmark
- Volunteers
- 400 people
- Sponsor
- University of Aarhus
Focused Acceptance and Commitment Therapy (FACT), Wailist
Focused Acceptance and Commitment Therapy (FACT) for Stress, Anxiety, and Depression
This study is an interventional study examining the feasibility and acceptability of Focused Acceptance and Commitment Therapy (FACT) as a short-term intervention.
- Trial name
- NCT07341425
- Testing
- Focused Acceptance and Commitment Therapy
- Where
- Denmark
- Volunteers
- 60 people
- Sponsor
- University of Aarhus
NSTEMI - Non-ST Segment Elevation Myocardial Infarction (MI), Acute Myocardial Infarction (AMI)
Treatment With Aspirin Alone Versus Aspirin in Combination With Fondaparinux Before Early Coronary Assessment in Patients With Non-ST-Elevation Myocardial Infarction
The main goal of this study is to compare two treatments in patients with a specific type of heart attack called Non-ST-elevation Myocardial Infarction (NSTEMI).
- Trial name
- FOXY (NCT06710184)
- Testing
- Aspirin, Fondaparinux Sodium
- Where
- 10 sites in Denmark
- Volunteers
- 5,076 people
- Sponsor
- University of Aarhus
TMJ, Apical Periodontitis
Application of a Dental-dedicated MRI in the Diagnosis of Temporomandibular Joint Disorders, Tissue Alterations Related to Third Molars, Periapical and Periodontal Inflammatory Diseases, and Implant Treatment Planning
The aim of the present study is to show that the use of 0.55T MRI combined with a "dental" coil produces images of sufficient diagnostic value to assess areas of interest in dentistry, and to compare MR images to traditional…
- Conditions
- TMJ, Apical Periodontitis, Periodontal Inflammation, Retained Tooth
- Trial name
- NCT05439330
- Testing
- MRI of teeth and surrounding structures
- Where
- Denmark
- Volunteers
- 470 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Urea Cycle Disorder, Uremia
Dysregulated Urea-synthesis at Terminal Uremia
This project will examine the dysregulation of the urea cycle in patients with terminal uremia using a validated method named "Functional Hepatic Nitrogen Clearance"
- Trial name
- NCT05076318
- Testing
- Aminoacid, alanine-infusion
- Where
- Denmark
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Colorectal Cancer
IMPROVE: Circulating Tumor DNA Analysis to Optimize Treatment for Patients With Colorectal Cancer
The overall objective of these studies are to confirm that ctDNA detected in plasma after intended curative treatment for CRC can be applied in clinical practice as a marker of subclinical residual disease and risk of recurrence.
- Trial name
- NCT03637686
- Where
- 10 sites in Denmark
- Volunteers
- 3,182 people
- Sponsor
- University of Aarhus
Peripheral T-cell Lymphoma, NK/T-Cell Lymphoma
Circulating Tumor DNA in Peripheral T-cell Lymphomas
The aim of this study is to evaluate the feasibility of circulating tumor DNA (ctDNA) measurement in blood plasma for the applicability in prognostication, treatment evaluation and measurable residual disease (MRD) surveillance…
- Trial name
- CIRCULATE (NCT06362148)
- Testing
- Tumor- and plasma-informed, next-generation sequencing (NGS)-based patient-specific droplet digital (dd)PCR assay, 18F-fludeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT)
- Where
- Denmark
- Volunteers
- 50 people
- Sponsor
- University of Aarhus
Post-Traumatic Headache, Concussion, Mild
GAIN Symptoms: Post-traumatic Headache
The overall aim of the study is to advance the knowledge on the characterization and underlying pathophysiological mechanisms of persistent post-traumatic headache (PTH) with a direct impact on the ability to diagnose and manage…
- Conditions
- Post-Traumatic Headache, Concussion, Mild, MTBI - Mild Traumatic Brain Injury
- Trial name
- NCT05857761
- Testing
- Active repetitive transcranial magnetic stimulation (rTMS)
- Where
- Denmark
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Healthy
Recruiting Healthcare Workers on the International Labor Market: A Megastudy
Public health organizations in Denmark and most Organization for Economic Cooperation and Development (OECD) countries face an urgent demand for nursing staff.
- Trial name
- MORE (NCT06793592)
- Testing
- Behaviorally informed recruitment message, Simplified direct message with no employer value proposition, No message
- Where
- Denmark
- Volunteers
- 110,000 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Obesity, Insulin Resistance
Effects of Intermittent Fasting on Insulin Resistance, Cardiac Metabolism, and Cerebral Perfusion
The overall purpose of the study is to investigate whether three weeks of intermittent fasting (alternate-day fasting, (ADF)) result in a more pronounced "metabolic shift" towards the use of ketone bodies than three weeks of…
- Trial name
- NCT05181267
- Testing
- Intermittent fasting
- Where
- Denmark
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
AV Block
Danish Randomized Trial on Leadless vs Transvenous Pacing
The purpose of this study is to evaluate the quality of life, patient acceptance and exercise capacity with leadless compared to transvenous pacing in elderly patients with new-onset high-grade atrioventricular block.
- Trial name
- DANVERS (NCT05856799)
- Testing
- Leadless Micra AV Transcatheter Pacing System, Transvenous Azure XT DR dual chamber pacemaker
- Where
- 2 sites in Denmark
- Volunteers
- 80 people
- Sponsor
- University of Aarhus
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