Clinical trials: sponsored by University of Alberta
Sleep Apnea, Obstructive
Use of Passive Myofunctional Appliances for Snoring and Mild Obstructive Sleep Apnea
It is unknown whether passive myofunctional appliances can be used for the treatment of obstructive sleep apnea and snoring, nor how to select the appropriate size per individual patient.
- Trial name
- NCT05497180
- Testing
- passive myofunctional appliance, standard oral appliance
- Where
- Canada
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Alberta
Spinal Cord Injuries
Effects of 5HTP on the Injured Human Spinal Cord
This study will assess how the serotonin precursor, 5-HTP, alter nervous system excitability and motor function in individuals with spinal cord injuries of differing chronicity and severity.
- Trial name
- 5-HTP only (NCT04520178)
- Testing
- 5-Hydroxytryptophan 100 MG, 5-Hydroxytryptophan, Carbidopa
- Where
- 2 sites in United States, Canada
- Volunteers
- 6 people
- Sponsor
- University of Alberta
Pediatric Sleep Apnea, Obstructive Sleep Apnea
Photobiomodulation for Pediatric Hypertrophic Tonsils
Pediatric obstructive sleep apnea is a medical condition where a child has great difficulty with breathing, or stops breathing all together, while asleep.
- Conditions
- Pediatric Sleep Apnea, Obstructive Sleep Apnea, Tonsils Hypertrophy
- Trial name
- NCT05459935
- Testing
- PBM Tonsil Arm
- Where
- Canada
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- University of Alberta
Liver Transplant; Complications, Renal Insufficiency
Extended-Release Tacrolimus Following Liver Transplantation
Medications used after transplant to prevent rejection are associated with many side effects. Tacrolimus side effects include kidney dysfunction; tremor, headaches, difficulty sleeping, change in sensation (legs), seizure, or…
- Conditions
- Liver Transplant; Complications, Renal Insufficiency, Immunosuppressant Adverse Reaction, Metabolic Syndrome
- Trial name
- NCT05242315
- Testing
- Envarsus Oral Product, Prograf (SOC)
- Where
- Canada
- Volunteers
- 94 people
- Sponsor
- University of Alberta
Spinal Cord Injuries
Can Brief Exposure to Hyperoxia Improve Function After Chronic Spinal Cord Injury?
This proof-of-principle study will determine if breathing an increased concentration of oxygen above the concentration in normal room air results in changes in the sensory and motor function in people with subacute or chronic…
- Trial name
- NCT05467215
- Testing
- Pure oxygen (99%) from Praxair, Edmonton, DIN# 02014408
- Where
- Canada
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University of Alberta
Psychiatric Illness
Peer and Text Message Support to Reduce Readmission Rates for Patients Discharged From Acute Psychiatric Care
Avoidable hospital readmissions are a pressing problem for our healthcare system. They lead to substantial human suffering and higher financial costs.
- Trial name
- NCT05133726
- Testing
- Text4Support, Peer support
- Where
- 7 sites in Canada
- Volunteers
- 1,149 people
- Sponsor
- University of Alberta
Malnutrition, Surgery
Outpatient Preoperative Parenteral Nutrition in Malnourished Surgical Patients
Malnutrition is common in surgical patients. Many studies have shown a clear association between malnutrition and poor surgical outcomes.
- Trial name
- OPPortuNity (NCT03926949)
- Testing
- Parenteral Nutrition, Standard Nutrition Care
- Where
- 2 sites in Canada
- Volunteers
- 13 people
- Sponsor
- University of Alberta
Preterm Birth
Initial Oxygen Concentration at Birth in Late-Preterm Infants
This study is aims to examine the best amount of oxygen to give preterm babies (born between 32 and 35 weeks) right after birth.
- Trial name
- OXY-PREEM (NCT07315594)
- Testing
- 60% Oxygen Group - Infants will start in 60% oxygen, 30% Oxygen Group - Infants will start in 30% oxygen
- Where
- Canada
- Volunteers
- 1,520 people
- Sponsor
- University of Alberta
Knee Osteoarthritis, Hip Osteoarthritis
Adapting Rehabilitation Delivery for Maximum Impact at Home-2 (ReDI-2)
People who live in rural areas and have hip or knee arthritis can have difficulty receiving physical therapy (PT) close to home.
- Trial name
- ReDI-2 (NCT07055113)
- Testing
- Individual-based Virtual Physical Therapy Program, Group-based Virtual Physical Therapy Program
- Where
- Canada
- Volunteers
- 270 people
- Sponsor
- University of Alberta
Frailty
Perioperative Prehabilitation on Markers of Fitness and Frailty in Patients Undergoing Elective Surgery
A growing body of evidence suggests that patients who receive good perioperative care (i.e. care prior to surgery, during surgery, and after surgery) tend to have fewer complications, quicker recovery times, and shorter hospital…
- Trial name
- NCT05977556
- Testing
- Combined neuromuscular exercise training and 'sit less, move more' program
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- University of Alberta
Heart Failure
Heart Failure Efficacy and Research Trial (HEART) Platform
The Heart Failure Efficacy and Research Trial (HEART) Platform is a multicenter, randomized platform study designed to improve outcomes for patients with heart failure through the simultaneous and sequential evaluation of…
- Trial name
- HEART (NCT07428135)
- Testing
- Domain Intervention(s), Control / Standard of Care Comparator
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- University of Alberta
Myalgic Encephalomyelitis/Chronic Fatigue Syndrome
RCT of Mind-body in Long COVID and Myalgic Encephalomyelitis
We are studying the effect of a mind-body treatment for people with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) with or without Long COVID (LC).
- Trial name
- MILES (NCT06933173)
- Testing
- Dynamic neural retraining system
- Where
- 2 sites in Canada
- Volunteers
- 200 people
- Sponsor
- University of Alberta
Heart Failure
Accelerating Access and Improving Imaging in Heart Failure Care (A2I2HF) Pilot Study
This is a prospective, multicenter, cluster randomised trial which will assess the feasibility and acceptability of AI-assisted point of care echocardiography on HF detection and downstream care processes for patients with…
- Trial name
- NCT07624565
- Testing
- AI-assisted point-of-care ultrasound (POCUS)
- Volunteers
- 84 people
- Sponsor
- University of Alberta
Noninvasive Ventilation, Child, Only
Custom Non-invasive Ventilation Masks in Children
One significant challenge to non-invasive ventilation (NIV) use in children is finding masks to fit a wide range of growing shapes and sizes.
- Conditions
- Noninvasive Ventilation, Child, Only, Adherence, Patient
- Trial name
- NCT05336136
- Testing
- Custom mask, Current commercial mask
- Where
- Canada
- Volunteers
- 16 people
- Sponsor
- University of Alberta
ACS (Acute Coronary Syndrome), Hyperlipidemia
Electronic Health Record Augmented LDL-Cholesterol Optimization and Control Via Active Lipid Engagement (EHR-LOCALE): A Quality Improvement Implementation Study
The purpose of this study is to determine whether a proactive, EHR-guided approach helps more individuals reach safe cholesterol levels, improves medication use, and reduces future heart attacks and strokes, compared to usual…
- Conditions
- ACS (Acute Coronary Syndrome), Hyperlipidemia, Dyslipidemia, Low-Density-Lipoprotein-cholesterol Level
- Trial name
- EHR-LOCALE (NCT07685639)
- Testing
- Pharmacist-led lipid optimization pathway
- Where
- 2 sites in Canada
- Volunteers
- 2,000 people
- Sponsor
- University of Alberta
Continuous Renal Replacement Therapy (CRRT), Acute Kidney Injury
Insights Into the Continuous Renal Replacement Therapy to Critical Ill Patients
This is a multinational, prospective, observational study designed to characterize patient demographics, prescription parameters, and process measures of continuous renal replacement therapy (CRRT) in intensive care units (ICUs)…
- Conditions
- Continuous Renal Replacement Therapy (CRRT), Acute Kidney Injury, Renal Dialysis, Critical Illness
- Trial name
- iCRRT (NCT07365111)
- Testing
- continuous renal replacement therapy
- Where
- Canada
- Volunteers
- 100,000 people
- Sponsor
- University of Alberta
Perinatal Stroke
Parent Therapist Partnership to Provide Early, Intensive Exercise in Perinatal Stroke
A prospective, single blind, parallel group, randomized control trial to determine if early, intensive lower extremity activity delivered by a physical therapist and a parent in partnership improves gross motor function more than…
- Trial name
- NCT03672864
- Testing
- Intensive exercise
- Where
- 3 sites in Canada
- Volunteers
- 18 people
- Sponsor
- University of Alberta
Prostate Cancer
Micro-UltraSound In Cancer - Active Surveillance
This study will compare the two imaging modalities (MRI and micro-ultrasound) during Active Surveillance of prostate cancer (PCa).
- Trial name
- MUSIC-AS (NCT05558241)
- Testing
- High-resolution micro-ultrasound
- Where
- 6 sites in United States, Canada and 2 more
- Volunteers
- 210 people
- Sponsor
- University of Alberta
Heart Failure, Cognitive Impairment
COgnitioN With VERiciGuat Evaluation in Heart Failure
CONVERGE-HF is a 4-center pilot phase IIb randomized control trial in ambulatory patients with chronic heart failure (≥ 6 months) and mild-to-moderate cognitive impairment.
- Trial name
- CONVERGE-HF (NCT06601465)
- Testing
- Vericiguat
- Where
- 4 sites in Canada
- Volunteers
- 120 people
- Sponsor
- University of Alberta
Dysphagia, Parkinson Disease (PD)
Exploring the Efficacy of the Effortful Swallow Maneuver for Improving Swallowing in People With PD
The goal of this clinical trial is to learn whether a 4-week effortful swallow exercise program helps adults with Parkinson disease who have swallowing problems.
- Trial name
- EFFORT-PD (NCT07773025)
- Testing
- Effortful swallow
- Volunteers
- 74 people
- Sponsor
- University of Alberta