Clinical trials: sponsored by University of Pennsylvania
Pneumonia, Diabetes
Social Incentives to Increase Mobility
This study aims to assess the effectiveness of a social incentive-based gamification intervention to increase physical activity in the 3 months after hospital discharge.
- Conditions
- Pneumonia, Diabetes, Congestive Heart Failure, Chronic Obstructive Pulmonary Disease
- Trial name
- MOVE IT (NCT03321279)
- Testing
- Social Incentive
- Where
- United States
- Volunteers
- 233 people
- Sponsor
- University of Pennsylvania
Acute Tibial Fracture Requiring Intramedullary Nailing
T1Rho MRI Evaluation of Patellofemoral Changes After Tibial IM Nailing
This study will utilize T1-Rho MRI to evaluate the effect of intramedullary nailing on patellofemoral articular cartilage when the surgery is performed using the infrapatellar vs. the suprapatellar approach.
- Trial name
- NCT01879215
- Testing
- Intramedullary nailing of the tibia
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Pennsylvania
Time Restricted Feeding
Time Restricted Eating Pilot - Bariatrics
Bariatric surgery patients have a variable course of weight loss, maintenance and regain. Time restricted eating is an approach that may help individuals lose weight and improve metabolic functioning.
- Trial name
- NCT04006366
- Testing
- Time restricted feeding
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Healthy
Comparison of the Short-Term Effect of Dietary Carbohydrate Restriction Versus Exogenous Ketone Supplementation on Myocardial Glucose Suppression and Timing to Achieve a State of Ketosis Using FDG PET/CT Serial Imaging
The purpose of this study is to test different methods of preparation that can be used prior to a test called an FDG PET/CT scan. FDG PET/CT scans are routinely done for evaluation of heart inflammation.
- Trial name
- NCT04275453
- Testing
- FDG, Ketone Drink, Ketogenetic Diet
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Cocaine Dependence, Alcohol Dependence
HBPL Study of the Impact of the NK1 Antagonist Aprepitant
The proposed research will focus on investigating the determinants and consequences of CAD via measurement of physiological, behavioral and subjective effects of physiologic and psychologic stress cues in CAD volunteers in the…
- Trial name
- NCT01176591
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- University of Pennsylvania
Night Eating Syndrome
Brain Imaging and Treatment Studies of the Night Eating Syndrome
The purpose of this study is to determine the effectiveness of the anti-depressant Lexapro in the treatment of the Night Eating Syndrome.
- Trial name
- NES (NCT01401595)
- Testing
- escitalopram oxalate
- Where
- United States
- Volunteers
- 87 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Cocaine Dependence
Pilot Trial of Acamprosate for the Treatment of Cocaine Dependence
Trial to determine the safety, efficacy and tolerability of acamprosate for the treatment of cocaine dependence.
- Trial name
- CAMPRAL (NCT00385268)
- Testing
- acamprosate
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Pennsylvania
Purchasing Behaviors, Nutrition
Increasing Engagement With a Healthy Food Benefit
In collaboration with Vitality/Discovery in South Africa, an RCT amongst adult enrolled in the lowest tier of Vitality's HealthyFood benefit will be conducted.
- Trial name
- NCT02486588
- Testing
- Messaging, Financial incentives
- Volunteers
- 7,314 people
- Sponsor
- University of Pennsylvania
Interstitial Cystitis, Chronic Prostatitis
Trans-MAPP Symptom Patterns Study (SPS)
This study is the second phase of the MAPP Network and is designed to conduct a prospective, observational study of men and women with UCPPS, referred to as the Symptom Patterns Study (SPS), enriched with pre-defined subgroups…
- Trial name
- MAPP II SPS (NCT02514265)
- Where
- 6 sites in United States
- Volunteers
- 640 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Acute Lymphocytic Leukemia
Allo CART-19 Protocol
The primary objective is to determine the safety and survival of the redirected allogeneic T cells transduced with the anti-CD19 lentiviral vector (referred to as CART-19 cells).
- Trial name
- NCT01551043
- Testing
- CART-19
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- University of Pennsylvania
Dyslipidemia
Effects of Niacin On Fatty Acid Trapping
The purpose of this study is to understand whether a vitamin called NIcotinic ACid vitamIN (NIACIN for short, also known as vitamin B3) helps the body process dietary fat more efficiently.
- Trial name
- NOFAT (NCT01984073)
- Testing
- ER Niacin Oral Fat Challenge, IR Niacin Oral Fat Challenge
- Where
- 2 sites in United States
- Volunteers
- 26 people
- Sponsor
- University of Pennsylvania
Stroke, Aphasia
TMS as a Biological Marker of Neuroplasticity
TMS is a non-invasive brain stimulation technique, which can be used to change the activity of a person's brain cells without needles or surgery.
- Trial name
- NCT02867670
- Testing
- Transcranial Magnetic Stimulation
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- University of Pennsylvania
Healthy
Enduring Exercise Habits
The objective of this study is to test whether the interventions offering short-term incentives (points redeemable for prizes), specific cued plans, and science-backed tips can help with creating enduring exercise habits.
- Trial name
- NCT03634423
- Testing
- Sweet Spot: Flexible high incentive condition, Sweet Spot: Flexible low incentive condition, Sweet Spot: Rigid high incentive condition
- Where
- United States
- Volunteers
- 32,000 people
- Sponsor
- University of Pennsylvania
Well-Being, Depression
Single-Session Computerized Mental Health Intervention for Rural Indian Adolescents
The overall aim of this project is to understand if single-session interventions are acceptable, culturally appropriate, and effective for Indian adolescents attending a rural, low-resource government school.
- Conditions
- Well-Being, Depression, Anxiety
- Trial name
- NCT04020549
- Testing
- Growth, Gratitude, & Positive Activities, Study Skills Control
- Where
- India
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Well-being, Depression
Computerized Single-Session Interventions for Indian Adolescents
The overall aim of this project is to understand if single-session interventions are acceptable, culturally appropriate, and effective for Indian adolescents.
- Conditions
- Well-being, Depression, Anxiety
- Trial name
- NCT03982563
- Testing
- Growth Mindset, Gratitude, Behavioral Activation
- Where
- 4 sites in India
- Volunteers
- 958 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Patient Handoff, Healthcare Team
Handoffs and Transitions in Critical Care
The HATRICC study will use mixed methods to implement a standardized process for operating room to intensive care unit handoffs that is accepted and sustainably used by perioperative clinicians.
- Conditions
- Patient Handoff, Healthcare Team, Communication, Patient Safety
- Trial name
- HATRICC (NCT02267174)
- Testing
- Standardized handoff
- Where
- 2 sites in United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Aortic Valve Stenosis
Targeting Pulsatile Load to Increase Exercise Capacity and Quality of Life After Aortic Valve Replacement for Severe Aortic Stenosis (PULSE AS)
The current trial is designed to assess the safety and efficacy of sustained oral administration of inorganic nitrate in patients with severe aortic stenosis and to assess the mechanisms by which inorganic nitrate enhances oxygen…
- Trial name
- PULSE-AS (NCT03483051)
- Testing
- Potassium Nitrate, Potassium Chloride
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- University of Pennsylvania
Lower Limb Amputation Above Knee (Injury), Lower Limb Amputation Below Knee (Injury)
Virtual Reality Treatment for Phantom Limb Pain
Patients with limb amputations experience the sensation of the missing extremity, which is sometimes coupled with a persistent and debilitating pain in the missing limb, a condition known as phantom limb pain (PLP).
- Conditions
- Lower Limb Amputation Above Knee (Injury), Lower Limb Amputation Below Knee (Injury), Phantom Limb Pain
- Trial name
- NCT03338842
- Testing
- Distractor and Lower limb VR
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Healthy
Incentivizing Reflection and Output in Exercise
This study will test whether incentivizing post-workout activities (i.e., reflecting on workouts) is more effective than incentivizing actual workouts.
- Trial name
- NCT03742778
- Testing
- Incentivizing reflection, Incentivizing exercise
- Where
- United States
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Healthy
Enduring Exercise Habits: Trending Norms
Learning that most people engage in an activity can be a powerful motivator to adoption. But are there instances in which people can similarly find motivation from learning that only a minority of others engage in a behavior?…
- Trial name
- NCT03627871
- Testing
- Majority Norm, Trending Minority Norm, Minority Norm
- Where
- United States
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
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