Clinical trials: sponsored by Canadian Cancer Trials Group
Breast Cancer
High Dose Chemotherapy Plus Peripheral Stem Cell Transplantation Compared With Standard Therapy in Treating Women With Metastatic or Recurrent Breast Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining chemotherapy with peripheral stem cell transplantation may allow the doctor to give higher doses of…
- Trial name
- NCT00003032
- Testing
- filgrastim, cisplatin, cyclophosphamide
- Where
- 25 sites in Canada
- Volunteers
- 224 people
- Sponsor
- NCIC Clinical Trials Group
Breast Cancer
Tamoxifen in Treating Women With High-Risk Breast Cancer
RATIONALE: Estrogen can stimulate the growth of breast cancer cells. Hormone therapy using tamoxifen may fight breast cancer by blocking the uptake of estrogen.
- Trial name
- NCT00002542
- Testing
- CMF regimen, cyclophosphamide, doxorubicin hydrochloride
- Where
- 48 sites in Canada
- Volunteers
- 672 people
- Sponsor
- NCIC Clinical Trials Group
Breast Cancer, Neutropenia
Docetaxel and Epirubicin With and Without G-CSF in Treating Women With Metastatic Breast Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Colony-stimulating factors such as G-CSF may increase the number of immune cells found in bone marrow or…
- Trial name
- NCT00002866
- Testing
- filgrastim, docetaxel, epirubicin hydrochloride
- Where
- 6 sites in Canada
- Volunteers
- 50 people
- Sponsor
- NCIC Clinical Trials Group
Breast Cancer
Tamoxifen With or Without Octreotide in Treating Postmenopausal Women With Stage I, Stage II, or Stage III Breast Cancer
RATIONALE: Estrogen can stimulate the growth of breast cancer cells. Hormone therapy using tamoxifen with or without octreotide may fight breast cancer by blocking the uptake of estrogen.
- Trial name
- NCT00002864
- Testing
- octreotide acetate, tamoxifen citrate
- Where
- 40 sites in United States, Canada
- Volunteers
- 667 people
- Sponsor
- NCIC Clinical Trials Group
Lymphoma
Radiation Therapy in Relapsed or Refractory Non-Hodgkin's Lymphoma Who Have Undergone Stem Cell Transplantation
RATIONALE: Radiation therapy uses high-energy x-rays to damage tumor cells. It is not yet known if giving radiation therapy after stem cell transplantation is more effective than stem cell transplantation alone in treating…
- Trial name
- NCT00031668
- Testing
- radiation therapy
- Where
- 9 sites in Canada
- Volunteers
- 6 people
- Sponsor
- NCIC Clinical Trials Group
Neoplasms
Beta-carotene and Alpha-tocopherol Chemoprevention of Second Primary Malignancies in Head and Neck Cancer Patients
Epidemiologic studies suggest that low dietary intakes and low plasma concentrations of antioxidant vitamins and minerals are associated with increased risks of cancer, especially for epidermoid tumors.
- Trial name
- NCT00169845
- Testing
- Alpha-Tocopherol and Beta-Carotene
- Where
- Canada
- Volunteers
- 540 people
- Sponsor
- Laval University
Carcinoma, Non-small-cell Lung
OSI-774 (Tarceva) in Treating Patients With Stage III or Stage IV Non-Small Cell Lung Cancer
The purpose of this study is to determine if OSI-774 will improve overall survival of patients with incurable stage IIIB/IV non-small cell lung cancer compared to standard of care.
- Trial name
- NCT00036647
- Testing
- Tarceva (erlotinib HCl, OSI-774 )
- Where
- 97 sites in United States, Argentina and 15 more
- Volunteers
- 731 people
- Sponsor
- OSI Pharmaceuticals
Pancreatic Cancer
OSI-774 (Tarceva) Plus Gemcitabine in Patients With Locally Advanced, Unresectable or Metastatic Pancreatic Cancer.
The purpose of this study is to determine if OSI-774 will improve overall survival when combined with a standard dose of the chemotherapy drug gemcitabine, to individuals with pancreatic cancer.
- Trial name
- NCT00040183
- Testing
- Tarceva (erlotinib HCl, OSI-774)
- Where
- 140 sites in United States, Argentina and 15 more
- Volunteers
- 569 people
- Sponsor
- OSI Pharmaceuticals
Anemia, Cervical Adenocarcinoma
Radiation Therapy and Cisplatin With or Without Epoetin Alfa in Treating Patients With Cervical Cancer and Anemia
Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Radiation therapy uses high-energy x-rays to damage tumor cells.
- Conditions
- Anemia, Cervical Adenocarcinoma, Cervical Adenosquamous Carcinoma, Cervical Squamous Cell Carcinoma
- Trial name
- NCT00017004
- Testing
- External Beam Radiation Therapy, Cisplatin, Internal Radiation Therapy
- Where
- United States
- Volunteers
- 114 people
- Sponsor
- Gynecologic Oncology Group
Esophagus Cancer
Advanced Oesophageal Cancer Study to Compare Quality of Life and Palliation of Dysphagia.
To compare the treatment of gullet cancer with radiotherapy alone and assess the advantage and toxicity of adding chemotherapy. The hypothesis to be tested is as follows: That the addition of chemotherapy to a short course of…
- Trial name
- NCT00193882
- Testing
- Cisplatin, Radiotherapy, 5-Fluorouracil
- Where
- 25 sites in Australia, Canada and 2 more
- Volunteers
- 220 people
- Sponsor
- Trans Tasman Radiation Oncology Group
Kidney Cancer
Immediate Surgery or Surgery After Sunitinib Malate in Treating Patients With Metastatic Kidney Cancer
RATIONALE: Sunitinib malate may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth and by blocking blood flow to the tumor.
- Trial name
- SURTIME (NCT01099423)
- Testing
- timing of surgery, gene expression analysis, biologic sample preservation procedure
- Where
- 29 sites in Belgium, Canada and 3 more
- Volunteers
- 99 people
- Sponsor
- European Organisation for Research and Treatment of Cancer - EORTC
Endometrial Neoplasms
Studies of the Tumour Suppressor Gene PTEN - Endometrial Cancer
This project seeks to understand the role of the PTEN tumour suppressor gene in endometrial cancer (tumours of the uterine lining), the most common gynecologic cancer in the developed world.
- Trial name
- NCT02724501
- Testing
- questionnaire, Blood sample-DNA testing / Tumour-genetic markers
- Where
- Canada
- Volunteers
- 217 people
- Sponsor
- University Health Network, Toronto
Cognition, Fatigue
Cognitive Function and Fatigue in Colorectal Cancer (CRC) Patients After Chemotherapy
This is a prospective, longitudinal cohort study to evaluate fatigue and cognitive function in patients with colorectal cancer (CRC) treated with chemotherapy, and in patients with the same malignancy, that do not receive…
- Conditions
- Cognition, Fatigue, Colorectal Neoplasm
- Trial name
- NCT00188331
- Testing
- Neuropsychological Testing
- Where
- 2 sites in Australia, Canada
- Volunteers
- 441 people
- Sponsor
- University Health Network, Toronto
Recurrent and Metastatic Endometrial Cancer
A Study of Letrozole in the Treatment of Endometrial Cancer
Currently available treatments for endometrial cancer are associated with limited efficacy and significant toxicity. This study will assess the safety and efficacy of letrozole, an aromatase inhibitor, on endometrial cancer.
- Trial name
- NCT00333086
- Testing
- Letrozole
- Where
- Germany
- Volunteers
- 36 people
- Sponsor
- Novartis Pharmaceuticals
Prostate Cancer
A Randomized Trial of External Beam Radiotherapy Versus Cryoablation in Patients With Localized Prostate Cancer
A trial to determine if cryoablation is as effective as radiation in the treatment of men with localized prostate cancer.
- Trial name
- NCT00489060
- Testing
- Cryoablation and External Beam Radiation
- Where
- Canada
- Volunteers
- 244 people
- Sponsor
- University of Calgary
Breast Neoplasms
RCT of a Group Intervention for Women With a Family History of Breast Cancer
One in 10 Canadian women will be diagnosed with breast cancer (BC) and approximately 5% of all BC is believed to be hereditary. Women with a family history experience high levels of perceived risk for developing BC.
- Trial name
- NCT00150917
- Testing
- Supportive-Expressive Group Therapy
- Where
- Canada
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University Health Network, Toronto
Uterine Cancer, Cervical Cancer
Effectiveness of an Individualized Symptom Education Program (ISEP)
The purpose of this study is to examine whether an Individualized Symptom Education Program (ISEP) is helpful to women to manage their symptoms when they are receiving radiation therapy for gynecological cancer.
- Conditions
- Uterine Cancer, Cervical Cancer, Vaginal Cancer, Vulvar Cancer
- Trial name
- NCT00275353
- Testing
- Individualized Symptom Education
- Where
- Canada
- Volunteers
- 144 people
- Sponsor
- University of Toronto