Clinical trials: sponsored by Alcon Research
Cataracts
Cataract Refractive Suite Study
The purpose of this study is to compare the refractive predictability (prediction error) between the Cataract Refractive Suite (CRS) and standard manual technique at one month post-operative
- Trial name
- NCT02974140
- Testing
- Cataract Refractive Suite (CRS), Standard manual technique
- Where
- 3 sites in United States
- Volunteers
- 39 people
- Sponsor
- Alcon, a Novartis Company
Vitreomacular Traction, Vitreomacular Adhesion
Ocriplasmin for Vitreomacular Traction/Symptomatic Vitreomacular Adhesion
The purpose of this study is to observe the anatomical and functional outcomes of ocriplasmin (JETREA™®) over a 6-month period.
- Trial name
- NCT02322229
- Testing
- Ocriplasmin 0.125 mg in a 0.1 mL volume
- Where
- Australia
- Volunteers
- 62 people
- Sponsor
- Alcon Research
Comparison of 3D Visualization and Microscope for VR Surgery
Comparision of Retinal Surgery by Three-dimensional Heads-up Display to the Standard Operating Microscope
Prospective, cross-sectional, observational study investigating a three dimensional heads up display for retinal surgery and comparing its outcomes and ease of use with the standard operative microscope.
- Trial name
- NCT03075852
- Testing
- Heads- Up Display Surgery
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- MidAtlantic Retina
Refractive Errors, Myopia
Clinical Assessment of a HYDRAGLYDE® Regimen
The purpose of this study is to evaluate worn AIR OPTIX® plus HYDRAGLYDE® (AOHG) lenses cleaned and disinfected with HYDRAGLYDE® containing lens solutions compared to each of the control habitual silicone hydrogel (SiHy) lenses…
- Conditions
- Refractive Errors, Myopia, Hypermetropia
- Trial name
- NCT03026257
- Testing
- Lotrafilcon B contact lenses with added wetting agent, Samfilcon A contact lenses, POLYQUAD/ALDOX-preserved contact lens solution with added wetting agent
- Where
- 8 sites in United States, Canada and 1 more
- Volunteers
- 323 people
- Sponsor
- Alcon, a Novartis Company
Otitis Media With Effusion in Children, Otitis Media Recurrent
Pediatric Pharmacokinetic (PK) Study of EXE844 Otic Suspension in Otitis Media at the Time of Tympanostomy Tube Insertion (OMTT)
The purpose of this study is to describe the pharmacokinetics (PK) of EXE844 Sterile Otic Suspension, 0.3% following a single bilateral ototopical dose in pediatric subjects, immediately after bilateral tympanostomy tube surgery.
- Trial name
- NCT02539654
- Testing
- EXE844 Sterile Otic Suspension, 0.3%, Tympanostomy Tube Insertion
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Alcon Research
Glaucoma
Alcon® Ex-PRESS® Glaucoma Filtration Device in Japanese Patients
The purpose of this study is to assess the efficacy and safety of the Alcon Ex-PRESS® Glaucoma Filtration Device (Ex-PRESS) in Japanese subjects with normal tension glaucoma.
- Trial name
- NCT02246777
- Testing
- Ex-PRESS® Glaucoma Filtration Device, Model P50PL
- Where
- Japan
- Volunteers
- 32 people
- Sponsor
- Alcon Research
Presbyopia
OPTI-FREE® PureMoist® for Presbyopic Contact Lens Wearers
The purpose of this study is to evaluate OPTI-FREE® PureMoist® (OFPM) compared to non-HYDRAGLYDE® multi-purpose contact lens solutions in presbyopes currently wearing soft contact lenses and experiencing symptoms of dryness.
- Trial name
- NCT02965820
- Testing
- Opti-Free® PureMoist® contact lens solution, Habitual Multi-Purpose Contact Lens Solution, Habitual Contact Lenses
- Volunteers
- 122 people
- Sponsor
- Alcon, a Novartis Company
Presbyopia
CLEAR CARE® PLUS for Presbyopic Contact Lens Wearers
The purpose of this study is to evaluate CLEAR CARE® PLUS (CCP) compared to non-HYDRAGLYDE® multi-purpose contact lens solutions in presbyopes currently wearing soft contact lenses and experiencing symptoms of dryness.
- Trial name
- NCT02965833
- Testing
- 3% hydrogen peroxide solution with HydraGlyde® Moisture Matrix, Habitual Multi-Purpose Contact Lens Solution, Habitual Contact Lenses
- Volunteers
- 126 people
- Sponsor
- Alcon, a Novartis Company
Glaucoma
Will the Use of Triesence During Glaucoma Surgery Provide Lower Eye Pressure and Improve the Results of the Surgery?
The investigators hypothesize that intracameral Triesence during glaucoma surgery will provide lower intraocular pressure through better control of ocular inflammation, thus leading to a more successful filtering procedure.
- Trial name
- NCT00853905
- Testing
- Triesence, balanced salt solution BSS
- Where
- United States
- Volunteers
- 77 people
- Sponsor
- Wills Eye
Cataract, Presbyopia
Retrospective / Prospective Clinical Study of AcrySof® IQ ReSTOR® +2.5 D Multifocal Toric Intraocular Lenses
The purpose of this study is to characterize the safety and effectiveness of the ACRYSOF IQ ReSTOR +2.5 diopter (D) Multifocal Toric Intraocular Lens (IOL) in subjects at least 3 months and no more than 14 months after IOL…
- Conditions
- Cataract, Presbyopia, Corneal Astigmatism
- Trial name
- NCT02176343
- Testing
- AcrySof® IQ ReSTOR® +2.5 D Multifocal Toric IOL
- Volunteers
- 37 people
- Sponsor
- Alcon Research
Cataract
Pilot Study of AcrySof® IQ ReSTOR® +3.0 D Multifocal Toric Intraocular Lens (IOL)
The purpose of this study is to describe visual outcomes, in particular spherical equivalent by manifest refraction and visual acuity across a range of distances, 6 months post implantation of the AcrySof® IQ ReSTOR® +3.0 D…
- Trial name
- NCT01200511
- Testing
- AcrySof® IQ ReSTOR® +3.0 D Multifocal Toric IOL
- Volunteers
- 49 people
- Sponsor
- Alcon Research
Neovascular Age-Related Macular Degeneration
Safety and Pharmacokinetics of RTH258 in Subjects With Age-Related Macular Degeneration
The purpose of this study is to assess the systemic pharmacokinetics (PK) and safety of 2 different doses of brolucizumab (3 milligrams (mg)/50 microliters (μL) and 6 mg/50 μL) when administered at 4-week intervals for a total of…
- Trial name
- NCT02507388
- Testing
- Brolucizumab 3 mg/50 μL, Brolucizumab 6 mg/50 μL
- Volunteers
- 51 people
- Sponsor
- Alcon Research
Intumescent Cataract
Femtosecond Laser Assisted Cataract Surgery in Intumescent Cataracts
The purpose of the study is to compare femtosecond laser-assisted capsulotomy to manual capsulorhexis in patients with intumescent cataracts. An intumescent cataract is defined as a cataract with a pressurized capsular bag.
- Trial name
- NCT02403206
- Testing
- Femtosecond laser, Continuous Curvilinear Capsulorhexis (CCC)
- Volunteers
- 406 people
- Sponsor
- Alcon, a Novartis Company
Myopia, Hyperopia
Accuracy of LASIK Flaps Created With the LenSx® Femtosecond Laser - A Pilot Study
The purpose of this study is to evaluate the thickness accuracy of Laser-assisted in situ keratomileusis (LASIK) flaps created with the LenSx® Laser.
- Trial name
- NCT02575911
- Testing
- Femtosecond Laser System, LASIK surgery
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- Alcon Research
Cataract
Investigation of AcrySof® IQ PanOptix™ Presbyopia-Correcting Intraocular Lens (IOL) Model TFNT00
The purpose of this study is to investigate visual outcomes and assess safety at 12 months (330-420 days) post bilateral implantation of the AcrySof® IQ PanOptix™ Presbyopia-Correcting IOL.
- Trial name
- NCT02529488
- Testing
- AcrySof® IQ PanOptix™ Presbyopia-Correcting IOL
- Volunteers
- 167 people
- Sponsor
- Alcon Research
Dry Eye
Evaluation of Clinical Outcomes After the Use of SYSTANE® HYDRATION
The purpose of this study is to compare SYSTANE® HYDRATION to Hyabak 0.15% based on total ocular surface staining scores (TOSS) at Day 42.
- Trial name
- NCT02470429
- Testing
- SYSTANE HYDRATION lubricant eye drops, Hyabak 0.15% eye drops, 0.9% saline eye drops
- Volunteers
- 114 people
- Sponsor
- Alcon Research
Cataracts
AcrySof® IQ ReSTOR® +3.0 D Multifocal Toric Intraocular Lens (IOL) Clinical Study in Japan
The purpose of this study is to evaluate safety and effectiveness of AcrySof® IQ ReSTOR® +3.0 D Multifocal Toric IOL Models SND1T3, SND1T4, SND1T5, and SND1T6 when implanted to replace the natural lens in Japanese cataract…
- Trial name
- NCT01323777
- Testing
- AcrySof® IQ ReSTOR® +3.0 D Multifocal Toric IOL
- Where
- 2 sites in Japan
- Volunteers
- 65 people
- Sponsor
- Alcon Research
Refractive Error
Clinical Evaluation of DAILIES TOTAL 1® Performance in a Japanese Population
The purpose of this study is to compare DAILIES TOTAL1® (DT1) to 1-DAY ACUVUE® TruEye® (TE) for Investigator-rated successful lens centration in Japanese population.
- Trial name
- NCT02710292
- Testing
- Delefilcon A contact lenses, Narafilcon A contact lenses
- Where
- Japan
- Volunteers
- 104 people
- Sponsor
- Alcon Research
Otitis Media With Effusion in Children, Otitis Media Recurrent
Safety and Efficacy of EXE844 Otic Suspension in Otitis Media at Time of Tympanostomy Tube Insertion (OMTT) - Study 2
The purpose of this study is to evaluate EXE844 plus tympanostomy tubes compared to tympanostomy tubes only based on sustained clinical cure at end-of-therapy (EOT).
- Trial name
- NCT02436304
- Testing
- EXE844 Sterile Otic Suspension, 0.3%, Tympanostomy Tube Insertion
- Volunteers
- 404 people
- Sponsor
- Alcon Research
Ocular Hypertension, Open-Angle Glaucoma
A Three Part Study of MGV354 in Ocular Hypertension or Glaucoma
The purpose of this study is to determine if the clinical profile of topical-ocular MGV354 merits further development for the indication of lowering intraocular pressure (IOP).
- Trial name
- NCT02743780
- Testing
- MGV354 ophthalmic suspension
- Volunteers
- 191 people, healthy volunteers welcome
- Sponsor
- Alcon Research