Clinical trials: sponsored by Georgetown University
Anxiety, Depression Disorder
Effects of Mindfulness and Self-regulation Training on Anxiety, Depression, PTSD, and Leadership
The goal of this study is to measure the effects of Mindfulness-based Mind Fitness Training (MMFT) on anxiety, depression, post-traumatic stress disorder, sleep quality, and leadership.
- Conditions
- Anxiety, Depression Disorder, PTSD - Post Traumatic Stress Disorder
- Trial name
- NCT07084233
- Testing
- Mindfulness based, trauma informed, self-regulation skills training
- Where
- Ukraine
- Volunteers
- 174 people, healthy volunteers welcome
- Sponsor
- Georgetown University
Cancer, Breast, Age-related Cognitive Decline
Older Breast Cancer Patients: Risk for Cognitive Decline
The goal of this study is to evaluate the impact of systemic therapy on cognition in older breast cancer patients, explore change in APE, LM and Cognition domains, measure associations between cognitive decline and QOL, and…
- Conditions
- Cancer, Breast, Age-related Cognitive Decline, Cognitive Decline
- Trial name
- TLC (NCT03451383)
- Where
- United States
- Volunteers
- 1,700 people, healthy volunteers welcome
- Sponsor
- Georgetown University
Parkinson's Disease
RESvEraTrol in Parkinson's Disease (RESET)
This is an exploratory phase 2a study to investigate two doses of resveratrol (JotrolTM) vs placebo in individuals diagnosed with Parkinson's Disease (PD).
- Trial name
- RESET (NCT07592767)
- Testing
- Trans-Resveratrol
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Georgetown University
Visual Field Defect, Stroke
Home-based Vision Rehabilitation Guided by Brain Imaging
The BRIGHT (Behavioral Rehabilitation Through Image-Guided Home-based Training) study aims to evaluate the effectiveness of image-guided, home-based perceptual training at improving visual performance in individuals with visual…
- Conditions
- Visual Field Defect, Stroke, Hemianopia Homonymous, Quadrantanopia
- Trial name
- BRIGHT (NCT07635329)
- Testing
- High-level perceptual learning-based training, Low-level perceptual learning-based training
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Georgetown University
Metastatic Pancreatic Ductal Adenocarcinoma
BXCL701 and Pembrolizumab in Patients With Metastatic Pancreatic Ductal Adenocarcinoma
Single-arm, open label study to determine the 18 week progression-free survival rate of the combination of BXCL701 and pembrolizumab in patients with pancreatic ductal adenocarcinoma in the second-line metastatic setting.
- Trial name
- EXPEL PANC (NCT05558982)
- Testing
- BXCL701, Pembrolizumab
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Georgetown University
Visual Field Defect, Stroke
Vision Improvement Through Behavioral Rehabilitation And Neuroplasticity Training
The VIBRANT (Vision Improvement through Behavioral Rehabilitation And Neuroplasticity Training) study is a prospective, double-blind, crossover design (within-subject) in participants with homonymous hemianopia-a type of visual…
- Conditions
- Visual Field Defect, Stroke, Hemianopia, Quadrantanopia
- Trial name
- VIBRANT (NCT07105358)
- Testing
- transcranial random noise stimulation (tRNS), Perceptual learning-based training
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Georgetown University
Thymoma, Thymic Carcinoma
A Phase II Trial of Sacituzumab Govitecan in Patients With Advanced Thymic Epithelial Tumors
The goal of this clinical trial is to study the effect of sacituzumab govitecan-hziy in adult patients with advanced thymoma and thymic carcinoma after progressing on at least one prior line of therapy.
- Trial name
- NCT06248515
- Testing
- Sacituzumab govitecan-hziy
- Where
- 4 sites in United States
- Volunteers
- 18 people
- Sponsor
- Georgetown University
Cervical Cancer, Metastatic Cervical Cancer
Pembrolizumab and Lenvatinib in Advanced Cervical Cancer
This is a phase II trial of combination therapy of pembrolizumab and lenvatinib in patients with locally advanced or metastatic cervical cancer that had failed first line of therapy.
- Trial name
- NCT04865887
- Testing
- Pembrolizumab, Lenvatinib
- Where
- 4 sites in United States
- Volunteers
- 35 people
- Sponsor
- Georgetown University
Breast Cancer
TALAVE: Induction Talazoparib Followed by Combination of Talazoparib and Avelumab in Advanced Breast Cancer
This is a multi-institutional pilot trial for patients with advanced breast cancer. The trial is designed to assess the safety and tolerability of induction talazoparib followed by combination of talazoparib and avelumab.
- Trial name
- NCT03964532
- Testing
- Talazoparib, Avelumab
- Where
- 2 sites in United States
- Volunteers
- 24 people
- Sponsor
- Georgetown University
Urethral Stricture, Male
Peri-operative Oral Pain Control Following Buccal Graft Urethroplasty
Patients undergoing buccal urethroplasty will often have significant post-operative oral pain from the graft site. Various graft harvest techniques and methods for post-harvest hemostasis including graft site closure have been…
- Trial name
- Buccal (NCT05300685)
- Testing
- Standard Buccal Harvest, Basic buccal procedure + Long acting local, Basic buccal procedure + Buccal block
- Where
- 2 sites in United States
- Volunteers
- 60 people
- Sponsor
- University of California, San Francisco
Non-squamous Non-small-cell Lung Cancer
Tiragolumab With Atezolizumab Plus Bevacizumab in Previously-Treated Advanced Non-squamous NSCLC
To evaluate the efficacy of tiragolumab with atezolizumab and bevacizumab in previously-treated advanced non-squamous NSCLC.
- Trial name
- NCT04958811
- Testing
- Tiragolumab, Atezolizumab, Bevacizumab
- Where
- 2 sites in United States
- Volunteers
- 29 people
- Sponsor
- Georgetown University
Mild Cognitive Impairment, Chronic Kidney Diseases
Accelerated Age-related Cognitive Decline: Impact of Exercise on Executive Function and Neuroplasticity
The purpose of this study is to see if 6 months of home-based walking will improve memory, and brain structure and function, compared to health education in older adults that have chronic kidney disease and mild cognitive…
- Trial name
- EXEC (NCT05655325)
- Testing
- Home-based walking exercise, Attention control
- Where
- 2 sites in United States
- Volunteers
- 144 people
- Sponsor
- Columbia University
Chronic Kidney Diseases, Apolipoprotein L1
APOL1 Genetic Testing Program for Living Donors
Living donor (LD) kidney transplantation is the optimal treatment for patients with end-stage kidney disease (ESKD). However, LDs take on a higher risk of future ESKD themselves.
- Conditions
- Chronic Kidney Diseases, Apolipoprotein L1, Kidney Transplantation
- Trial name
- NCT04910867
- Testing
- Components of Genetic Counseling, APOL1 genetic testing, EHR integration
- Where
- 2 sites in United States
- Volunteers
- 280 people
- Sponsor
- Northwestern University
Breast Cancer
Improving Communication and Adherence in Black Breast Cancer Survivors (Sisters Informing Sisters)
The purpose of this study is to test an evidence-based intervention designed to increase adherence to systemic therapy in Black women compared to enhanced usual care.
- Trial name
- SIS (NCT05334732)
- Testing
- SIS TALK Back Intervention
- Where
- 3 sites in United States
- Volunteers
- 225 people
- Sponsor
- Virginia Commonwealth University
Prostate Cancer, Localized Prostate Carcinoma
MRI-based Focal Intraprostatic Simultaneous Integrated Boost (SIB) Intensification With De-escalated Adaptive-risk SBRT for Patients With Low to Intermediate Risk Prostate Cancer
The goal of this clinical trial is to determine the safety of stereotactic body radiation therapy (SBRT) microboost technique in patients with low to intermediate risk prostate cancer.
- Trial name
- MIDAS (NCT07644598)
- Testing
- Microboost SBRT, Whole gland de-escalation 30 Gy, Whole gland de-escalation 35 Gy
- Where
- United States
- Volunteers
- 58 people
- Sponsor
- Georgetown University
Mild Cognitive Impairment
Metformin in Alzheimer's Dementia Prevention
MAP will be a multi-center phase 2/3 1:1 randomized controlled trial (RCT) of long-acting metformin (reduced mass Glucophage XR) vs.
- Trial name
- MAP (NCT04098666)
- Testing
- extended release metformin
- Where
- 22 sites in United States
- Volunteers
- 326 people, healthy volunteers welcome
- Sponsor
- Columbia University
Melanoma (Skin), Skin Cancer
Rural Adult and Youth Sun Protection Study
The purpose of this study is to help prevent skin cancer by improving the use of sun protective behaviors among youths living in rural communities in Utah and West Virginia.
- Trial name
- RAYS (NCT06439979)
- Testing
- RAYS Intervention
- Where
- 2 sites in United States
- Volunteers
- 843 people, healthy volunteers welcome
- Sponsor
- University of Utah
Safety Issues, Pain
Role of a CCK Receptor Antagonist Proglumide in Management of Chronic Pancreatitis
Chronic pancreatitis is a rare but debilitating condition associated with chronic abdominal pain, diarrhea, diabetes, and an 8-fold increased risk for the development of pancreatic cancer.
- Conditions
- Safety Issues, Pain, Pancreas Fibrosis
- Trial name
- ProCP (NCT05551858)
- Testing
- Proglumide
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Georgetown University
HIV-1-infection, Metabolic Syndrome
Healthy Lifestyles: A Home Based Physical Activity Intervention in Persons Living With HIV
This study is being done to understand how a physical activity walking intervention affects metabolic parameters (i.e., blood sugar, cholesterol, certain body measurements) in people with and without HIV.
- Trial name
- NCT05896852
- Testing
- physical activity
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Georgetown University
Anxiety Disorders, Generalized Anxiety Disorder
Mindful Self-Compassion for Anxiety Disorders and Depression
The study will compare 8-week Mindful Self-Compassion training, compared to a control group that does not receive the intervention, on anxiety and depression symptom severity in patients with diagnosed anxiety disorders…
- Conditions
- Anxiety Disorders, Generalized Anxiety Disorder, Social Anxiety Disorder, Social Phobia
- Trial name
- NCT05671419
- Testing
- Mindful Self-Compassion
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Georgetown University