Clinical trials: sponsored by Poitiers University Hospital
Intermittent Hypoxia, Respiratory Endurance
Effect of Intermittent Hypoxia on Ventilatory Endurance in Healthy Volunteers
Sleep apnoea syndrome is a common disorder responsible for poor sleep quality and repeated oxygen depletion in the blood. Patients suffering from this disease experience a reduction in their endurance, i.e.
- Trial name
- ENDUR-HYPOX (NCT06714435)
- Testing
- Intermittent hypoxia, Normoxia
- Where
- France
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Poitiers University Hospital
Burn-Out
Reducing Burnout in Healthcare Workers Through Yoga and Square Breathing Practices
The mental health of healthcare workers, burnout, and the resulting suicides are now described as a real "public health crisis." Emergency departments are not spared by this phenomenon; in fact, up to 71% of emergency physicians…
- Trial name
- RESPYR (NCT07166510)
- Testing
- Yoga and meditation
- Where
- 2 sites in France
- Volunteers
- 75 people
- Sponsor
- Poitiers University Hospital
Alzheimer's Disease
Pathological and Non-pathological Aging, Physical Activity, Genotype and Cognition
Alzheimer's disease (AD) is an irreversible, progressive brain disease. It is the most common form of dementia and the major cause of functional dependence in the elderly.
- Trial name
- VIAGECO (NCT02520232)
- Testing
- Combination of aerobic and strength exercises, Stretching and balance exercise program
- Where
- 2 sites in France
- Volunteers
- 139 people, healthy volunteers welcome
- Sponsor
- University Hospital, Bordeaux
Vaccine, Streptococcus Pneumoniae
Clinical Trial Assessing the Immunogenicity of an Anti-pneumococcal Vaccination Strategy (PCV13+PPV23 Versus PREVENAR20) in Adult Patients Treated for a Lymphoma
The French Public Health Council recommended pneumococcal vaccination combined strategy for all immunocompromised patients in 2012.
- Conditions
- Vaccine, Streptococcus Pneumoniae, Lymphoma, Non-Hodgkin
- Trial name
- HEMATOVAC (NCT04460235)
- Testing
- Prevenar 13 + Pneumovax 23, PREVENAR20
- Where
- 7 sites in France
- Volunteers
- 160 people
- Sponsor
- Poitiers University Hospital
Ventricular Arrhythmia, Acute Myocardial Infarction (AMI)
Ventricular Arrhythmias in Acute Myocardial Infarction
Ventricular arrhythmias are a serious complication of myocardial infarction. The aim of this study is to provide reliable data on the management and mortality associated with ventricular arrhythmia in the setting of acute…
- Trial name
- ADVERSE-MI (NCT07517523)
- Where
- 8 sites in France
- Volunteers
- 500 people
- Sponsor
- Poitiers University Hospital
Post Extubation Respiratory Failure
Non-Invasive Ventilation Versus High-flow Nasal Oxygen in Intensive Care Units
In intensive care units (ICUs), around 20% of patients experience respiratory failure after planned extubation. Nearly 40-50% of them eventually require reintubation with subsequently high mortality rates reaching 30-40%.
- Trial name
- VENTILO (NCT05686850)
- Testing
- High-Flow Oxygen, Non invasive ventilation
- Where
- 47 sites in Belgium, France and 3 more
- Volunteers
- 670 people
- Sponsor
- Poitiers University Hospital
Pregnancy, Pregnancy - Prenatal Testing
Effect of Isometric Handgrip Exercise on Blood Pressure in Pregnant Women
Hypertension during pregnancy is a major public health concern, increasing the risk of cardiovascular complications for both the mother and the fetus.
- Conditions
- Pregnancy, Pregnancy - Prenatal Testing, Hypertension (HTN)
- Trial name
- GRIP4HEALTH (NCT07607795)
- Testing
- Isometric Handgrip Exercise, Control Rest
- Where
- France
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Poitiers
Post-Concussion Syndrome
Interest of the 7 Tesla MRI in the Diagnosis of Post-concussion Syndromes Among Patients With Mild Traumatic Brain Injury
We aimed to conduct a prospective longitudinal interventionnal monocentric study to assess the ability of seven tesla MRI to detect diffuses axonal lesions in patients presenting a post concussional syndrom (PCS) at seven days…
- Trial name
- SPIN (NCT04982562)
- Testing
- 7T MRI
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Poitiers University Hospital
Systemic Sclerosis
Systemic Sclerosis and Innate T Cells
Innate T cells (ITC) are decreased in systemic sclerosis (SS) and an early lymphocyte innateness has been reported. In the other part, ITC are implicated on inflammatory process, including the IL-33/ST2 axis, which is also…
- Trial name
- NCT04995588
- Testing
- Blood test
- Where
- France
- Volunteers
- 235 people, healthy volunteers welcome
- Sponsor
- Poitiers University Hospital
Oxygen, Respiratory Insufficiency
INSPIRatory Efforts Estimation Under High-flow Nasal Oxygen
High-flow nasal oxygen (HFNO) is recommended as first-line treatment to prevent intubation in acute hypoxemic respiratory failure and to prevent reintubation after extubation.
- Conditions
- Oxygen, Respiratory Insufficiency, Work of Breathing, Dyspnea
- Trial name
- INSPIRE-Pilot (NCT07228676)
- Testing
- Non-invasive estimation of inspiratory effort
- Where
- France
- Volunteers
- 20 people
- Sponsor
- Poitiers University Hospital
Vascular Access Complication, Device Related Infection
Novel Antimicrobial Dressing in Peripheral Intravenous Catheters (PIVCs)
The goal of this clinical trial is to compare a chlorhexidine impregnated dressing for peripheral intravenous catheters (PIVCs) to the standard dressing currently used in general medical and surgical inpatient wards.
- Conditions
- Vascular Access Complication, Device Related Infection, Device Related Sepsis, Device Site Reactions
- Trial name
- ProP (NCT05741866)
- Testing
- Chlorhexidine gluconate impregnated bordered polyurethane dressing, Standard bordered polyurethane dressing
- Where
- 3 sites in Australia, France
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- The University of Queensland
Development of the Virtual Biopsy, Tumor Grade
Virtual Biopsy Development to Identify Patient's Glioma Grade at the CHU of Poitiers Using Magnetic Resonance Imaging
Glioma is a tumor of the central nervous system. These lesions are sorted with the WHO ranking regarding the tumoral oncotype. The tumoral MRI assessment is the first step before any medical decision.
- Conditions
- Development of the Virtual Biopsy, Tumor Grade, Artificial Intelligence Algorithms, Clinical
- Trial name
- MR3TGLIOBIOPSY (NCT04313140)
- Testing
- Diagnostic test
- Where
- France
- Volunteers
- 500 people
- Sponsor
- Poitiers University Hospital
Multiple Sclerosis, Magnetic Resonance Spectroscopy
MRI Biomarkers Predictive of Disability Progression in Patients With Multiple Sclerosis
The transition from relapsing-remitting multiple sclerosis to secondarily progressive multiple sclerosis (SPMS) is difficult to identify.
- Trial name
- NCT05491031
- Testing
- magnetic resonance spectroscopy
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Poitiers University Hospital
Multiple Myeloma, Myeloma Multiple
Multicenter Phase 2 Study of Subcutaneous Isatuximab Plus Bortezomib, Lenalidomide and Dexamethasone in the Treatment of Newly Diagnosed Transplant Ineligible Multiple Myeloma
Isatuximab was developed on a sub-cutaneous (SC) administration format. SC administration is expected to be more convenient for the patient, with a much shorter duration of administration compared to the currently approved IV…
- Conditions
- Multiple Myeloma, Myeloma Multiple, Myeloma
- Trial name
- NCT05889221
- Testing
- Drug and medical device
- Where
- France
- Volunteers
- 74 people
- Sponsor
- Poitiers University Hospital
Tyrosine Kinase Inhibitors, Chronic Myeloid Leukemia
Discontinuation of TyrosIne Kinase Inhibitors (TKI) in Chronic Myeloid Leukemia (CML) and Impact on the Immune System
Tyrosine kinase inhibitors (TKI) have revolutionized the management and prognosis of chronic myeloid leukemia (CML). Daily treatment with TKI, which is necessary due to lack of cure, is frequently associated with moderate…
- Trial name
- NCT05753384
- Testing
- treatment of TKI in CML
- Where
- 20 sites in France
- Volunteers
- 170 people, healthy volunteers welcome
- Sponsor
- Poitiers University Hospital
Myocarditis Acute, Ventricular Arrhythmia
Arrhythmic Risk in Myocarditis Outcome Research
The goal of this observational, retrospective, multicenter study is to characterize the arrhythmic burden and identify predictive factors for ventricular arrhythmias (VAs) in adult patients hospitalized for acute myocarditis…
- Trial name
- ARMOR (NCT07501481)
- Testing
- Treatment of acute myocarditis
- Volunteers
- 1,500 people
- Sponsor
- AZ Sint-Jan AV
Elderly, Emergency Departments
Prognostic Factors of Hospitalization for Patients Aged 75 and Over in Emergency Department in France - Monocentric Retrospective Cohort Study
A geriatric patient is defined as a patient aged 75 and over who meets certain medical or social vulnerability criteria and is characterised by coexisting physical and/or psychological dependence.
- Conditions
- Elderly, Emergency Departments, Prognostic Factors, Hospitalizations
- Trial name
- PROFACTHOS (NCT07475442)
- Where
- France
- Volunteers
- 967 people
- Sponsor
- Poitiers University Hospital
Myeloproliferative Neoplasm
Identification of Factors Associated With Treatment Response in Patients With Polycythemia Vera, Essential Thrombocythemia, and Pre-myelofibrosis.
First-line treatment for patients with polycythemia vera, essential thrombocythemia, and pre-myelofibrosis is based on hydroxyurea or pegylated interferon.
- Trial name
- BioPredictor (NCT05440838)
- Testing
- Next-generation sequencing
- Where
- 6 sites in France
- Volunteers
- 120 people
- Sponsor
- University Hospital, Angers
Hereditary Hemorrhagic Telangiectasia (HHT), Pulmonary Hypertension
Efficacy and Tolerance of Treatment With Bevacizumab for Severe Liver Involvement With High Cardiac Output in Hereditary Hemorrhagic Telangiectasia Within the French Hereditary Hemorrhagic Telangiectasia Network
High cardiac output secondary to hepatic arteriovenous malformations may be isolated or associated with left heart failure with post-capillary pulmonary hypertension.
- Conditions
- Hereditary Hemorrhagic Telangiectasia (HHT), Pulmonary Hypertension, Bevacizumab
- Trial name
- BevaHHearT (NCT07445347)
- Testing
- Bevacizumab
- Where
- France
- Volunteers
- 111 people
- Sponsor
- Poitiers University Hospital
Failed Back Surgery Syndrome, Chronic Pain
Study on Failed Back Surgery Syndrome Pathway Optimization: A Focus on Patient Identification, Chronicization Factors and Outcome Predictors
This pilot study is part of a global project that aims to better define and understand features of FBSS/POPS "post-operative persistent syndrome patients (shortened as "FBSS" in the following project).
- Trial name
- PREDIBACK (NCT02964130)
- Testing
- No name
- Where
- France
- Volunteers
- 200 people
- Sponsor
- Poitiers University Hospital