Clinical trials: sponsored by Asan Medical Center
Cerebral Palsy
Feasibility of Vision-Language Models for Detecting Physical Assistance as an Observable Criterion Defining GMFCS Levels in Children Aged 2 to 6 Years With Cerebral Palsy
The GMFCS sorts children with cerebral palsy into five levels of gross motor function. What mainly separates one level from the next is two things an observer can see: whether another person has to physically help the child move…
- Trial name
- NCT07824531
- Testing
- Vision-language model assessment of movement video
- Where
- 2 sites in South Korea
- Volunteers
- 26 people
- Sponsor
- Samsung Medical Center
Mitral Valve Insufficiency
Clinical Outcomes of Edwards Lifesciences MITRIS RESLILA Mitral Valve in the Asian Population
The purpose of this study is to evaluate the early and mid-term safety and performance of the MITRIS RESILIA mitral valve in Asian patients in a real-world setting
- Trial name
- KOREA MITRIS (NCT06757049)
- Where
- South Korea
- Volunteers
- 200 people
- Sponsor
- Asan Medical Center
Esophageal Cancer
Circulating Tumor DNA MRD-Guided Adjuvant Therapy for Curatively Resected Locally Advanced Esophageal Squamous Cell Carcinoma
This study was a multicenter, randomized, phase 3 trial to determine whether adjuvant chemotherapy including tisleliizumab improves recurrence-free survival compared to follow-up alone without chemotherapy in patients with…
- Trial name
- MRD2START (NCT06914011)
- Testing
- Tislelizumab
- Volunteers
- 172 people
- Sponsor
- Asan Medical Center
Subjects With Resectable and Localized Gastric Cancer, Subjects With Resectable Esophageal Cancer or Liver Cancer
Phase II Study of Neoadjuvant Immune Checkpoint Inhibitor in Patients With Resectable Gastrointestinal Cancers
This is a phase II, open-label, prospective single-centered study. Subjects who meet the inclusion/exclusion criteria will be allocated to appropriate cohorts: 1) gastric cancer, 2) esophageal cancer and 3) hepatocellular…
- Conditions
- Subjects With Resectable and Localized Gastric Cancer, Subjects With Resectable Esophageal Cancer or Liver Cancer, Subjects With Resectable Liver Cancer
- Trial name
- NeoChance (NCT04196465)
- Testing
- IMC-001
- Where
- South Korea
- Volunteers
- 48 people
- Sponsor
- Asan Medical Center
Severe Pneumonia
Detection and Characterization of Lower Respiratory Infections in Critically Ill Patients
This study is a prospective observation study for lower respiratory tract infections in medical intensive care unit. Microbiologic and clinical characteristics and outcomes of patients with severe pneumonia in medical intensive…
- Trial name
- NCT01068990
- Where
- South Korea
- Volunteers
- 300 people
- Sponsor
- Asan Medical Center
Heart Diseases, Vascular Diseases
Goal-directed vs. Empirical Tranexamic Acid Administrationin Cardiovascular Surgery
The present study is a multi-center randomized prospective placebo-controlled non-inferiority trial. The study's primary objective is to compare the amounts of postoperative bleeding using two different TXA administration…
- Conditions
- Heart Diseases, Vascular Diseases, Transfusion Related Complication, Coagulation Disorder, Blood
- Trial name
- NCT05806346
- Testing
- TXA administration
- Where
- 3 sites in South Korea
- Volunteers
- 764 people
- Sponsor
- Konkuk University Medical Center
ICU-acquired Weakness
Evidence-based, Customized, Motion-recognition Rehabilitation System Development for Bed-ridden Patients - Validation of Effectiveness: Rehabit: Swim
This pilot study aims to evaluate the efficacy, safety, feasibility, and user satisfaction of "Rehabit: swim," a customized, evidence-based, motion-recognition-based rehabilitation exergame designed for hospitalized patients with…
- Trial name
- NCT07896057
- Testing
- Rehabilitation
- Where
- South Korea
- Volunteers
- 20 people
- Sponsor
- Asan Medical Center
Coronary Artery Disease
The DECISION-CTO Extended 10 Y Follow-up
The goal of this study is to compare the 10-year clinical outcomes of an initial strategy of percutaneous coronary intervention (PCI) for chronic total occlusion (CTO-PCI) with an initial strategy of no CTO-PCI in patients with…
- Trial name
- DecisionCTO10Y (NCT06908499)
- Where
- 19 sites in India, Indonesia and 3 more
- Volunteers
- 804 people
- Sponsor
- Seung-Jung Park
Coronary Artery Disease
PREventive Invasive Strategy for Obstructive Coronary Artery Disease With Vulnerable Plaque Evaluated by CoroNary Computed Tomography Angiography-2
The PREVENT-2 trial is to determine whether an initial invasive strategy-consisting of early coronary angiography (CAG) with intent for preventive percutaneous coronary intervention (PCI) in addition to optimal medical therapy…
- Trial name
- PREVENT-2 (NCT07569692)
- Testing
- Initial Invasive Strategy, Initial Conservative Strategy
- Where
- South Korea
- Volunteers
- 2,500 people
- Sponsor
- Duk-Woo Park, MD
Preterm
Efficacy of a Video-based, Parent-centered Home Developmental Intervention for Infants at High Risk for Developmental Delay: a Multicenter Randomized Controlled Trial
The purpose of this study is to determine whether the Motor Composite Score on the Bayley-III (administered at 6 months of corrected age) shows significant improvement in an intervention group-receiving usual care combined with a…
- Trial name
- NCT07882199
- Testing
- Family-centered developmental training intervention
- Volunteers
- 170 people
- Sponsor
- Seoul National University Hospital
Coronary Vessels
Optical Coherence Tomography Versus Intravascular Ultrasound Guided Percutaneous Coronary Intervention
The primary aim of this study is to compare the clinical efficacy and safety of OCT-guided(optical coherence tomography (OCT)-guided) and IVUS-guided(Intravascular ultrasound (IVUS)-guided) strategies in patients undergoing…
- Trial name
- OCTIVUS (NCT03394079)
- Testing
- PCI
- Where
- 9 sites in South Korea
- Volunteers
- 2,008 people
- Sponsor
- Seung-Jung Park
Ischemic Stroke, Transient Ischemic Attack
Zastaprazan for the prEvention of Upper GI Bleeding in Ischemic Stroke
The goal of this clinical trial is to learn if zastaprazan can help prevent upper gastrointestinal bleeding in adults who have recently had a transient ischemic attack (TIA) or ischemic stroke and are taking antiplatelet or…
- Trial name
- NCT07730840
- Testing
- Zastaprazan
- Where
- 15 sites in South Korea
- Volunteers
- 984 people
- Sponsor
- Asan Medical Center
Metastatic Breast Cancer (HR+/ HER2-)
Predicting Endocrine Resistance Using Molecular Imaging and Liquid Biopsy in Metastatic Breast Cancer
This prospective observational study aims to evaluate the prognostic value of molecular imaging biomarkers derived from baseline [18F]FES and [18F]FDG PET/CT for progression-free survival in patients with estrogen receptor…
- Trial name
- NCT07867925
- Testing
- [18F] FES
- Where
- South Korea
- Volunteers
- 100 people
- Sponsor
- Asan Medical Center
Coronary Artery Disease
Noninferiority Trial Of Sirolimus With Ascorbic Acid Versus Everolimus in All-comers
The objective of this study is to demonstrate the primary hypothesis that, in patients with chronic and acute coronary syndromes requiring percutaneous coronary intervention (PCI), the novel sirolimus-ascorbic acid eluting stent…
- Trial name
- NOVA (NCT07566091)
- Testing
- Sirolimus-Ascorbic Acid Eluting Stent, Everolimus-Eluting Stent
- Where
- South Korea
- Volunteers
- 2,034 people
- Sponsor
- Jung-min Ahn
Suicidal Ideation and Behavior, Mood Disorders
Videoconference-Based Brief Cognitive Behavioral Therapy for Patients With Mood Disorders at High Risk for Suicide
This study aims to investigate inflammatory biomarkers associated with suicide risk and to evaluate the efficacy of videoconference-based brief cognitive-behavioral therapy (V-BCBT) in patients with mood disorders at high risk…
- Conditions
- Suicidal Ideation and Behavior, Mood Disorders, Suicide Attempt, Cognitive Behavior Therapy
- Trial name
- V-BCBT-BIO (NCT07857291)
- Testing
- Videoconference-Based Brief Cognitive Behavioral Therapy, Treatment as Usual (TAU)
- Where
- South Korea
- Volunteers
- 320 people, healthy volunteers welcome
- Sponsor
- Hyung Keun Park
Diabetes Mellitus Type 2, Breast Neoplasms
AI-Based Phenome Data Analysis for Predicting the Onset of Major Diseases
This study aims to develop and validate an artificial intelligence (AI)-based predictive model to estimate the risk of incident onset of five major diseases or conditions: cardiovascular disease, type 2 diabetes mellitus, breast…
- Conditions
- Diabetes Mellitus Type 2, Breast Neoplasms, Low Back Pain, Osteoarthritis
- Trial name
- NCT07595718
- Where
- South Korea
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Jae Yong Jeon, MD
Suicidal Ideation and Behaviors, Suicide Attempt
Enhanced Brief CBT for Suicidal Inpatients With Mood Disorders
The goal of this clinical trial is to evaluate whether enhanced brief cognitive behavioral therapy (E-BCBT) can help reduce suicidal thoughts and behaviors among psychiatric inpatients.
- Conditions
- Suicidal Ideation and Behaviors, Suicide Attempt, Cognitive Behavioral Therapy
- Trial name
- E-BCBT (NCT07072845)
- Testing
- Enhanced Brief Cognitive Behavioral Therapy (E-BCBT) for Suicidal Inpatients, Treatment as Usual (TAU)
- Where
- South Korea
- Volunteers
- 30 people
- Sponsor
- Hyung Keun Park
General Anesthesia Induction for Elective Surgery, Sono Guided Catheterization
Sonographic Safety Margins of Subclavian Vein: Effect of View and Arm Position
The purpose of this observational study is to evaluate and compare the anatomical safety margins of the subclavian vein using ultrasound.
- Trial name
- NCT07556770
- Testing
- Non-invasive sonographic observation
- Where
- South Korea
- Volunteers
- 55 people
- Sponsor
- Asan Medical Center
Coronary Artery Disease
OPTIMIZE-APT: Tailored Versus Conventional Antiplatelet Therapy After Intravascular Imaging-guided Drug-eluting Stent Implantation
Objectives: To assess the safety of tailored antiplatelet therapy (short DAPT followed by P2Y12 inhibitor alone strategy) in patients who received optimized DES implantation guided by intravascular imaging (IVUS or OCT)…
- Trial name
- OPTIMIZE-APT (NCT05418556)
- Testing
- aspirin
- Where
- 33 sites in South Korea
- Volunteers
- 3,944 people
- Sponsor
- Asan Medical Center
Pancreatic Neoplasms, Stomach Neoplasms
Robotic vs Laparoscopic and Open Surgery for Abdominopelvic Cancers
Robotic surgery has become an increasingly common option for treating cancers in the abdomen and pelvis. However, whether robotic surgery leads to better cancer-related outcomes than laparoscopic (keyhole) surgery or open surgery…
- Conditions
- Pancreatic Neoplasms, Stomach Neoplasms, Rectal Neoplasms, Uterine Cervical Neoplasms
- Trial name
- NCT07821775
- Testing
- No Intervention: Observational Cohort
- Where
- South Korea
- Volunteers
- 32,949 people
- Sponsor
- Asan Medical Center