Clinical trials: sponsored by Medical University Innsbruck
Non Small Cell Lung Cancer
Trial Exploring Combined Neoadjuvant Therapy With Pembrolizumab/Lenvatinib + Adjuvant Pembrolizumab in Pat. With NSCLC
The primary aim of this single arm, phase II study is to determine the efficacy of the combination therapy Pembrolizumab/Lenvatinib regarding the rate of major pathological response (MPR-Rate).
- Trial name
- INNWOP1 (NCT04875585)
- Testing
- neoadjuvant therapy with Pembrolizumab/Lenvatinib, Surgery, Adjuvant Treatment Phase
- Where
- Austria
- Volunteers
- 33 people
- Sponsor
- Medical University Innsbruck
Pancreatic Cancer, Circulating Tumor Cell
Liquid Biopsy (ctDNA) Guided Treatment in Localized Pancreatic Cancer: Neoadjuvant CTX vs. Upfront Surgery
This study evaluates the clinical prognostic impact (on DFS and OS) of liquid biopsy guided treatment vs. standard of care (physicians choice) in localized pancreatic cancer (CA 19-9 levels <500, no vessel contact and recommended…
- Conditions
- Pancreatic Cancer, Circulating Tumor Cell, Predictive Cancer Model
- Trial name
- LIQUIPANC (NCT06391892)
- Testing
- Neoadjuvant chemotherapy instead of upfront surgery, Upfront surgery
- Where
- Austria
- Volunteers
- 100 people
- Sponsor
- Elisabethinen Hospital
Mastectomy and Breast Reconstruction, Tissue Expander Based Breast Reconstruction
Comparison of Mastectomy Expander Trial
Expanders are used outside their intended use, due to two following facts: It is possible that expander implantation exceed the "approved" duration of 6 months (maximal 10 months).
- Conditions
- Mastectomy and Breast Reconstruction, Tissue Expander Based Breast Reconstruction, Adjuvant Radiotherapy, Long Term Outcome
- Trial name
- COMMET (NCT07434648)
- Testing
- intervention (unilateral/bilateral), scheduled for (NSME/SSME), indication (breast cancer diagnosis (malignancy) with neoadjuvant chemotherapy or DCIS diagnosis without neoadjuvant chemotherapy
- Where
- Austria
- Volunteers
- 80 people
- Sponsor
- Medical University Innsbruck
Postoperative Pulmonary Complications (PPCs), Feasibility Studies
PROtective Ventilation With FLOW-Controlled Ventilation
The investigators want to investigate in patients undergoing robot-assisted laparoscopic surgery (a minimally invasive procedure) how applicable flow-controlled ventilation is, and whether it might also be safer than the current…
- Conditions
- Postoperative Pulmonary Complications (PPCs), Feasibility Studies, Pilot Study
- Trial name
- PROFLOW (NCT06703814)
- Testing
- Intraoperative flow-controlled ventilation strategy, Intraoperative pressure-controlled ventilation strategy
- Where
- 3 sites in Austria, Germany and 1 more
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Cantonal Hospital of St. Gallen
Abdominal Aortic Aneurysm
Cardiovascular Rehabilitation After Infrarenal Aortic Aneurysm Repair
Evidence about the benefit of cardiovascular rehabilitation (CR) after open or endovascular repair of an infrarenal aortic aneurysm is lacking.
- Trial name
- REHAB-AAA (NCT07690046)
- Testing
- Structured cardiovascular rehabilitation
- Where
- Austria
- Volunteers
- 40 people
- Sponsor
- Medical University Innsbruck
Sedation Complication, Sedation During GI Endoscopy
Safety of Sedation During Interventional Endoscopy
Sedation is routinely used during interventional endoscopic procedures to improve patient comfort and optimize procedural conditions.
- Trial name
- SCOPE-SAFE (NCT07872657)
- Testing
- Sedation during interventional endoscopy
- Where
- Austria
- Volunteers
- 500 people
- Sponsor
- Medical University Innsbruck
Thoracolumbar, Fractures in the Elderly
Monoaxial vs. Polyaxial Percutaneous Hybrid Stabilization
Vertebral body fractures in older adults mostly affect the thoracolumbar junction and are challenging to treat due to osteoporosis and other comorbidities.
- Trial name
- NCT07408726
- Testing
- Monoaxial instrumentation - the M.U.S.T. Monoaxial Pedicle Screw Cannulated (Medacta International SA, Switzerland), Polyaxial instrumentation - the M.U.S.T. LT Pedicle Screw System (Medacta International SA, Switzerland)
- Where
- Austria
- Volunteers
- 44 people
- Sponsor
- Medical University Innsbruck
Migraine, Headache Disorders
High-Intensity Interval Training and Progressive Muscle Relaxation as a Movement-Based Group Intervention for the Non-Pharmacological Prevention of Adolescent Migraine
Background: The prevalence of migraine during adolescence is 7.7%, affecting 9.7% of girls and 6.0% of boys. Despite its high prevalence, treatment options remain limited.
- Conditions
- Migraine, Headache Disorders, Pediatric Migraine
- Trial name
- MigraFit (NCT07850622)
- Testing
- Weekly group training
- Where
- Austria
- Volunteers
- 27 people
- Sponsor
- Medical University Innsbruck
Prehabilitation
High Intensity PreHab Before Major Abdominal Surgery
The risk for major cardiac cardiovascular events (MACE) within the first 30 day after surgery is nit only associated to the patient relate risk factors but also to the kind of surgery.
- Trial name
- NCT05355909
- Testing
- Individualized high intensity preoperative fitness training
- Where
- Austria
- Volunteers
- 60 people
- Sponsor
- Medical University Innsbruck
ST-elevation Myocardial Infarction (STEMI), Clonal Hematopoiesis of Indeterminate Potential (CHIP)
Clonal Hematopoiesis of Indeterminate Potential and Infarct Severity in ST-Elevation Myocardial Infarction
Clonal Hematopoiesis of Indeterminate Potential (CHIP) refers to the age-related expansion of hematopoietic stem cell clones carrying somatic mutations in leukemia-associated driver genes (e.g., DNMT3A, TET2, ASXL1) in the…
- Trial name
- CHIP in STEMI (NCT07615023)
- Testing
- Clonal hematopoiesis assessment and cardiac magnetic resonance imaging
- Where
- Austria
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- Medical University Innsbruck
Alcohol-Associated Hepatitis
Effect of Alpha-1 Antitrypsin Supplementation on Alcohol-Associated Hepatitis
The trial is designed as a prospective, single center, open label, randomized controlled pilot study evaluating the effect of A1AT (Alpha 1 Antitrypsin) on inflammation in patients with severe AAH (alcohol-associated hepatitis).
- Trial name
- EARTH (NCT06582329)
- Testing
- Alfa1 Antitrypsin
- Where
- Austria
- Volunteers
- 16 people
- Sponsor
- Medical University Innsbruck
Aortic Stenosis, Heart Failure
High-Sensitivity Troponin T Plasma Levels in Patients With Aortic Stenosis (Tyrolean Aortic Stenosis Study-2)
TASS-2 (Tyrolean Aortic Stenosis Study-2) aims to characterize the clinical value of minimally elevated troponin T plasma levels both in patients with asymptomatic and symtomatic aortic stenosis.
- Conditions
- Aortic Stenosis, Heart Failure, Syncope, Angina Pectoris
- Trial name
- TASS-2 (NCT02448485)
- Testing
- Aortic Valve Intervention (surgical or transcatheter)
- Where
- Austria
- Volunteers
- 10,000 people
- Sponsor
- Medical University Innsbruck
COVID-19, SARS-CoV 2
Conjunctival Swab vs Nasopharyngeal Swab in Patients With COVID-19
The aim of this possible study is to identify if SARS-CoV-2 can be found in the tear film and conjunctiva of a patient with COVID-19.
- Trial name
- NCT04444596
- Testing
- Conjunctival swab and nasopharyngeal swab
- Where
- Austria
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Medical University Innsbruck
ST Elevation Myocardial Infarction, C-Reactive Protein
CRP Apheresis in STEMI
Background: In patients with acute ST-elevation myocardial infarction (STEMI), the amount of infarcted myocardium (infarct size) is known to be a major predictor for adverse remodeling and recurrent adverse cardiovascular events.
- Conditions
- ST Elevation Myocardial Infarction, C-Reactive Protein, Apheresis, Myocardial Injury
- Trial name
- NCT04939805
- Testing
- Selective CRP apheresis using the PentraSorb®-CRP system
- Where
- 5 sites in Austria, Germany
- Volunteers
- 202 people
- Sponsor
- Medical University Innsbruck
Diabetes Mellitus, Obesity
Multinational Point Prevalence Study on the Management of Diabesity in Hospitals
Diabetes related to obesity ("diabesity") is becoming increasingly prevalent. Hospitalizations among people with diabetes are frequent and glycaemic control is often suboptimal during these stays.
- Trial name
- DiabesityDay (NCT06680674)
- Testing
- Routine care for people with diabetes, with or without obesity, in the hospital setting
- Where
- 8 sites in Austria, Czechia and 6 more
- Volunteers
- 207 people
- Sponsor
- Medical University of Vienna
Aortic Valve Stenosis and Insufficiency, Coronary Artery Disease(CAD)
Assessment of Coronary Artery Disease Before Transcatheter Aortic Valve Replacement: A Randomized, Multicenter, Non-Inferiority Trial
The goal of this clinical trial is to determine whether a non-invasive coronary assessment strategy using photon-counting detector computed tomography (PCD-CT) is non-inferior to invasive coronary angiography (ICA) for evaluating…
- Conditions
- Aortic Valve Stenosis and Insufficiency, Coronary Artery Disease(CAD), Transcatheter Aortic Valve Replacement (TAVR)
- Trial name
- TAVR-CT (NCT07107568)
- Testing
- Standard Invasive Coronary Angiography, PCD-CT-Guided Diagnostic Strategy
- Where
- 2 sites in Austria
- Volunteers
- 700 people
- Sponsor
- Medical University Innsbruck
Bipolar 1 Disorder, Control Subjects
Socio-cognitive and Biological Responses to Maltreatment
The study will investigate how a history of emotional childhood maltreatment (CM) is associated with different aspects of psychological (social behaviour, empathy) and biological (brain function and structure, inflammation)…
- Trial name
- NCT07101107
- Where
- Austria
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Medical University Innsbruck
Healthy Control Subjects, Schizophrenia Diagnosis
Understanding Lifespan Trajectories of Social Cognition, Brain Microstructure and Iron Dysregulation in Schizophrenia
This study aims to better understand how schizophrenia may affect social thinking, emotion regulation, brain function, and biological processes over time. Two groups will take part in the study: 1.
- Trial name
- NCT07856381
- Where
- Austria
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Medical University Innsbruck
COVID-19
α-synuclein Seeding Activity in the Olfactory Mucosa in COVID-19
Loss of the sense of smell is a characteristic feature of COVID-19 and likely related to viral invasion of the olfactory mucosa but is also a prodromal feature of PD.
- Trial name
- NCT05401773
- Testing
- Real-time Quaking-Induced Conversion (RT-QuIC)
- Where
- Austria
- Volunteers
- 188 people, healthy volunteers welcome
- Sponsor
- Medical University Innsbruck
Migraine, Headache Disorders
MIGRAFIT: Evaluating a Group Therapy Program Combining Physical Activity, Progressive Muscle Relaxation and Psychoeducation for Adolescents With Migraine
Background: Migraine is a headache disorder highly prevalent in children and adolescents. It significantly affects academic performance and quality of life.
- Conditions
- Migraine, Headache Disorders, Pediatric Migraine
- Trial name
- NCT07419607
- Testing
- Weekly group training
- Where
- Austria
- Volunteers
- 6 people
- Sponsor
- Medical University Innsbruck