Clinical trials: sponsored by Milton S. Hershey Medical Center
Solid Tumor, Central Nervous System Tumor
Safety and Dose Finding Study of Neratinib in Children and Young Adults With Cancer That Has Returned or Not Responded to Treatment
The purpose of this study is to test the safety of neratinib at different dose levels and to find out what effects, good and bad, it has on the patients and the cancer.
- Conditions
- Solid Tumor, Central Nervous System Tumor, Lymphoma, Leukemia
- Trial name
- NCT02932280
- Testing
- Neratinib
- Where
- 9 sites in United States, Canada
- Volunteers
- 14 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Central Line Complication, Central Line Infection
Study Dynamic Haptic Robotic Trainer (DHRT) and DHRT+ for Central Venous Catheterization Insertion Training for Residents
Human participants will include medical residents. Each year, the entering first-year medical residents at Milton S. Hershey Medical Center and Cedars-Sinai Medical Center will be taught to perform central venous catheterization…
- Trial name
- NCT04541446
- Testing
- Dynamic Haptic Robotic Trainer (DHRT), Advanced Dynamic Haptic Robotic Trainer (DHRT+)
- Where
- United States
- Volunteers
- 773 people
- Sponsor
- Milton S. Hershey Medical Center
Acute Myeloid Leukemia, in Relapse, Acute Myeloid Leukemia, Refractory
Study of C6 Ceramide NanoLiposome (CNL) in Patients With Relapsed/Refractory Acute Myeloid Leukemia
The study objective is to evaluate patient safety for patients with refractory and relapsed AML being treated with Ceramide NanoLiposome (CNL) .
- Conditions
- Acute Myeloid Leukemia, in Relapse, Acute Myeloid Leukemia, Refractory, Refractory/Relapse Acute Myeloid Leukemia
- Trial name
- KNAN2001 (NCT04716452)
- Testing
- Ceramide NanoLiposome (Ceraxa)
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Keystone Nano, Inc
Communication, Anxiety
AYA-PeerConnect: A Communication Coaching Intervention for Adolescent/Young Adult Cancer Survivors (AYACS)
This research is being done to test a communication coaching intervention pilot designed to improve communication quality between adolescent/young adult cancer survivors (AYACS) and their friends/peers.
- Conditions
- Communication, Anxiety, Depression, Social Isolation
- Trial name
- NCT07454460
- Testing
- Asynchronous coaching and artificial intelligence (AI) Yoodli coach sessions
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Milton S. Hershey Medical Center
Lumbar Spondylosis
Comparative Effectiveness of Two Different Approaches to Radiofrequency Ablation of Lumbar Medial Branch Nerves
The purpose of this voluntary research study is to determine whether the parasagittal approach to lumbar medial branch (LMB) nerve radio frequency ablation (RFA) will have greater efficacy than the traditional approach to lumbar…
- Trial name
- LMB-RFA (NCT06283628)
- Testing
- Radiofrequency ablation of lumbar medial branch nerves.
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Milton S. Hershey Medical Center
Diabetes Mellitus, Type 1
Closed Loop and Education for Hypoglycemia Awareness Restoration
The purpose of the CLEAR study is to determine the effect on counterregulatory responses (CRR) of intervening (by attempting to strictly avoid hypoglycemia) to improve awareness of hypoglycemic symptoms among adults with type 1…
- Trial name
- CLEAR (NCT06325202)
- Testing
- Omnipod 5 or Medtronic 780G, My HypoCOMPaSS Education, HARPdoc Education
- Where
- 8 sites in United States, Australia and 1 more
- Volunteers
- 324 people
- Sponsor
- Milton S. Hershey Medical Center
Sleep, Autism Spectrum Disorder
Transdiagnostic Sleep and Circadian Treatment for Autistic Adolescents
Sleep and circadian problems are associated with deleterious social, emotional, and cognitive outcomes, yet are modifiable. This prospective study will adapt and optimize an empirically supported behavioral intervention that…
- Conditions
- Sleep, Autism Spectrum Disorder, Transdiagnostic
- Trial name
- NCT07612111
- Testing
- Transdiagnostic Intervention for Sleep and Circadian Dysfunction
- Volunteers
- 12 people
- Sponsor
- Milton S. Hershey Medical Center
Polycystic Ovary Syndrome, Anovulation
Inositol Supplementation to Treat PCOS (INSUPP-PCOS)
To determine if Inositol, a dietary supplement, will improve ovarian and adrenal androgen excess in women with Polycystic Ovarian Syndrome(PCOS).
- Conditions
- Polycystic Ovary Syndrome, Anovulation, Hyperandrogenism, Insulin Resistance
- Trial name
- INSUPP-PCOS (NCT03864068)
- Testing
- Inositol
- Where
- 2 sites in United States
- Volunteers
- 154 people
- Sponsor
- Milton S. Hershey Medical Center
Prostate Cancer
Rectal Spacer for Prostate Cancer Radiation Image Guidance
The purpose of the study is to determine if a radiopaque hydrogel rectal spacer, SpaceOAR Vue®, can be used in place of fiducial markers when aligning patients for radiotherapy.
- Trial name
- NCT05650021
- Testing
- SpaceOAR Vue
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Milton S. Hershey Medical Center
Delirium in the Intensive Care Unit, Sleep Quality in Adult ICU Patients
Virtual Reality to Reduce Anxiety, Agitation and Delirium in Critically Ill Patients
This is a pilot feasibility study examining the use of immersive virtual reality (VR) in adult intensive care unit (ICU) patients.
- Conditions
- Delirium in the Intensive Care Unit, Sleep Quality in Adult ICU Patients, Agitation Associated With Critical Illness, Anxiety Acute
- Trial name
- NCT07649876
- Testing
- Virtual reality (VR) therapy
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Milton S. Hershey Medical Center
Endometriosis, Pain
Feasibility of a Mindfulness Intervention for Endometriosis Surgery
Endometriosis is a common cause of pelvic pain in women which has been historically under-studied and under-diagnosed. The goal of this research is to pilot-test the feasibility and acceptability of a manualized, single-session…
- Conditions
- Endometriosis, Pain, Mindfulness
- Trial name
- NCT06141720
- Testing
- pain education, mindfulness of pain introduction and intervention
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Milton S. Hershey Medical Center
Osteoarthritis of Shoulder
Evaluation of Structural and Functional Integrity of the Rotator Cuff After Total Shoulder Arthroplasty
The purpose of this study is to examine the rotator cuff muscles in your shoulder at one and two year post total shoulder replacement surgery.
- Trial name
- NCT03921944
- Testing
- CT scan of the shoulders
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Milton S. Hershey Medical Center
Tobacco Dependence
Use of Nicotine Pouches Among Daily Smokers
The purpose of this clinical trial is to understand the health effects of a new oral nicotine pouch, and also to understand if this product can help reduce traditional cigarette smoking. The main aims are: 1.
- Trial name
- NCT06043362
- Testing
- 0 mg nicotine pouch, 3 mg nicotine pouch, 6 mg nicotine pouch
- Where
- 2 sites in United States
- Volunteers
- 375 people, healthy volunteers welcome
- Sponsor
- Milton S. Hershey Medical Center
Anorexia Nervosa
Adapting Exposure for Adolescent AN
This pilot study is evaluating Exposure Therapy (Exp-AN) as a virtual treatment for adolescents (ages 14 - 17 years) with anorexia nervosa (AN) recruited from eating disorder clinic waitlists and clinician referrals at the Penn…
- Trial name
- NCT07188155
- Testing
- Exposure Therapy for Anorexia (Exp-AN)
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Milton S. Hershey Medical Center
Depression, Anxiety
Development of a College Student-Delivered Cognitive-Behavioral Therapy (CBT) Intervention for Rural High School Students
This research is being done to find out the effectiveness, feasibility, and acceptability of a college student-delivered cognitive-behavioral therapy (CBT) intervention in high schools in rural Schuylkill County, Pennsylvania to…
- Conditions
- Depression, Anxiety, Stress
- Trial name
- NCT07240792
- Testing
- Student Delivered Cognitive Behavioral Therapy Intervention
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Milton S. Hershey Medical Center
Advance Care Planning, American Indian or Alaska Native
Using a Conversation Game to Engage Native American Washoe Tribe Members in Advance Care Planning: Preparation for a Clinical Trial
The goal of this study is to learn if a culturally adapted version of the Hello game, an advance care planning (ACP) conversation tool, is feasible and acceptable for use with members of the Washoe Tribe.
- Conditions
- Advance Care Planning, American Indian or Alaska Native, Gamification
- Trial name
- NCT07439393
- Testing
- Aim 1: Talking Circles, Aim 2: Play Modified Hello Game
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- Milton S. Hershey Medical Center
Meningitis, Bacteremia
THiamine for Recovery In Vulnerable Early-life Infections
To determine if the addition of thiamine to standard-of-care treatment will improve neurodevelopmental outcomes for infants with meningitis or bacteremia
- Trial name
- THRIVE (NCT07868679)
- Testing
- thiamine hydrochloride 100 mg
- Where
- 2 sites in United States
- Volunteers
- 240 people
- Sponsor
- Milton S. Hershey Medical Center
Amyotrophic Lateral Sclerosis (ALS)
Do Video Recordings of Multidisciplinary Clinics Improve Quality of Life for People With ALS and Their Caregivers?
Amyotrophic lateral sclerosis (ALS) is a fatal, rare neurodegenerative disease affecting 30,000 people in the United States. The gold standard of care for people with ALS is multidisciplinary clinics (MDC).
- Trial name
- VITALS (NCT07454733)
- Testing
- Video recording, Notes Instruction
- Where
- 7 sites in United States
- Volunteers
- 800 people
- Sponsor
- Trustees of Dartmouth College
Neuroblastoma, Ewing Sarcoma
Silmitasertib (CX-4945) in Combination With Chemotherapy for Relapsed Refractory Solid Tumors
The purpose of this study is to evaluate the investigational drug, silmitasertib (a pill taken by mouth), in combination with FDA approved drugs for solid tumors.
- Conditions
- Neuroblastoma, Ewing Sarcoma, Osteosarcoma, Rhabdomyosarcoma
- Trial name
- NCT06541262
- Testing
- Silmitasertib, Irinotecan, Temozolomide
- Where
- 24 sites in United States, Canada
- Volunteers
- 104 people
- Sponsor
- Milton S. Hershey Medical Center
Endometriosis
The Impact of Yoga on Endometriosis-Related Pain
The central hypothesis of the investigators is that the practice of yoga will result in an improvement of endometriosis related pain symptoms for women with endometriosis.
- Trial name
- NCT06559852
- Testing
- Yoga
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Milton S. Hershey Medical Center