Osteochondritis DissecansNCT02771496
Osteochondritis Dissecans of Knee Prospective Cohort
An observational study of Osteochondritis Dissecans, run by University of Pennsylvania at 1 site in United States.
Trial summary
The Cohort is a multi-site prospective data collection study that will enroll any patient with diagnosis of knee OCD (confirmed by a standard of care x-ray or MRI). Patients will be followed for up to the next 50 years of their lives to study courses of care, disease progression, treatment/surgical options/results… Read more about this study
- Who is it for?
- Any age
- Conditions the study is for
- Osteochondritis Dissecans
- How many people
- 3,000 participants
- Where
- 1 siteUnited States
- Study dates
- 1 May 2014to 1 Dec 2074
- Phase
- Observational
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages Any age
- All sexes
- No healthy volunteers
- Child, Adult, Older adult
Study population: Patients of all ages with osteochondritis dissecans (OCD) or focal articular cartilage defects confirmed via MRI or x-ray.
Who may be able to join
- Diagnosis of osteochondritis dissecans or focal articular cartilage defects as confirmed by x-ray or MRI
Who cannot join
- Non-confirmed diagnosis (i.e. patient does not yet have imaging confirmation)
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
United States1 site, 1 recruiting
- Recruiting
University of Pennsylvania
Philadelphia, Pennsylvania, 19104
Mounika Ponakala, BS, Mounika.Ponakala@Pennmedicine.upenn.edu
James L Carey, MD
About this study
Official title: ROCK Comprehensive Prospective Cohort for Osteochondritis Dissecans of the Knee
The Cohort is a multi-site prospective data collection study that will enroll any patient with diagnosis of knee OCD (confirmed by a standard of care x-ray or MRI). Patients will be followed for up to the next 50 years of their lives to study courses of care, disease progression, treatment/surgical options/results, and specific sports-related outcomes in athletic patients. Subjects will complete quality of life surveys as part of the Cohort. Course of care will not be affected.
Read the detailed description
Patients will be recruited and consented at the visit in which their eligibility is determined. Once a patient is eligible and provides informed consent, he or she will be in the study for up to 50 years, or until his or her OCD lesion is healed successfully.
At the initial visit, a subject will complete a basic medical history form, and three questionnaires: the IKDC Subjective questionnaire (ages over 18) or the PEDI-IKDC Subjective questionnaire (ages under 18); the KOOS questionnaire; and the Marx Activity Scale (adult) or Pedi-FABS Scale (pediatric). Patients will then continue with their normal course of care as determined by their surgeon and care team.
Mandatory surveys (same as above) will be collected from patients at 2 years, 5 years, 10 years, and 25 years. Patients who cannot return to clinic will have the option to complete the assessments and return in pre-stamped and addressed return envelopes provided by the clinical site the subject is a patient at. Any other follow-up visits between these time intervals will also be options for patients to complete these assessments, however patients will not complete them any closer than intervals 12 weeks apart in order to prevent redundancy.
Additionally, at the initial visit, the surgeon will complete a routine patient history and physical exam, which will be collected. Any surgical procedures or physical therapy a patient undergoes for treatment of his or her OCD lesion will also be documented and collected. At follow-up visits, surgeons will complete their own physical exam follow-up assessment forms, which will be collected.
- Conditions
- Osteochondritis Dissecans
- Being tested
- Other: observational only- no intervention
- Medical subject headings
- Osteochondritis Dissecans
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Other: observational only- no interventionOther
Other: observational only- no intervention
| Study group | Role | What they receive |
|---|---|---|
| Patients with OCD | Patients with diagnosis of OCD as confirmed by x-ray or MRI. Surveys collected from patients at 2 years, 5 years, 10 years, and 25 years. Receives: Other: Other: observational only- no intervention |
What is being measured
The primary outcome is the main question the study is designed to answer.
IKDC questionnaire
The primary outcome endpoint for this study is the patient's score on the IKDC Subjective questionnaire, or PEDI-IKDC Subjective questionnaire for patients under 18 years of age.
Measured: baseline up to 50 years
PEDI-IKDC questionnaire
The primary outcome endpoint for this study is the patient's score on the IKDC Subjective questionnaire, or PEDI-IKDC Subjective questionnaire for patients under 18 years of age.
Measured: baseline up to 50 years
Secondary outcomes (4)
KOOS Knee score
The Knee injury and Osteoarthritis Outcome Score (KOOS) evaluates short-term and long-term symptoms and function in subjects with knee injury and osteoarthritis.
Measured: baseline up to 50 years
Marx Activity Score questionnaire
Measure of physical activity at healthiest and most active state from time of taking to year prior.
Measured: baseline up to 50 years
Pedi-FABS Score
An eight-item scale that measures level of physical activity and fitness.
Measured: baseline up to 50 years
Radiographic Healing
Visualization of bone healing through x-ray images.
Measured: baseline up to 50 years
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted13 May 2016 (estimated)
- Study start1 May 2014
- Primary completion1 May 2074 (estimated)
- Study completion1 Dec 2074 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (1)Papers the sponsor has linked to this study.
- Other trials for Osteochondritis DissecansStudies of the same condition, open and under way.
- More trials run by University of PennsylvaniaThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Cohort
- Time perspective
- Prospective
- Enrolment
- 3,000 participants (estimated)
Sponsor and investigators
- Lead sponsor
- University of Pennsylvania
- Sponsor type
- University, hospital or other
- Collaborators
- Altona Children's Hospital, Boston Children's Hospital, Children's Hospital Medical Center, Cincinnati, Children's Health Andrews Institute for Orthopaedics & Sports Medicine, Children's Healthcare of Atlanta, Children's Hospital Colorado, Children's Hospital of Philadelphia, Children's Hospital and Health System Foundation, Wisconsin, Children's Mercy Hospital Kansas City, Connecticut Children's Medical Center, Hospital for Special Surgery, New York, Kaiser Permanente, Mayo Clinic, National University Hospital, Singapore, Rady Children's Hospital, San Diego, Stanford University, Tennessee Orthopedic Alliance, Texas Scottish Rite Hospital for Children, The Rocky Mountain Hospital for Children, The Hospital for Sick Children, Göteborg University, University of Minnesota/TRIA Orthopaedic Center, Washington University School of Medicine
- Responsible party
- Sponsor
- Investigators
- James L Carey, MD, Principal investigator, University of Pennsylvania
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT02771496
- Sponsor's protocol ID
- 820147
- Status last verified
- May 2026
- First submitted
- 10 May 2016
- Last updated
- 27 May 2026
- Results posted
- No
- Data monitoring committee
- No
- Individual data sharing
- Undecided
Publications
ROCK Group; Nissen CW, Albright JC, Anderson CN, Busch MT, Carey JL, Carlson C, Carsen S, Chambers HG, Crepeau A, Edmonds EW, Ellermann JM, Ellis HB Jr, Erickson JB, Fabricant PD, Godin J, Ganley TJ, Green DW, Grimm NL, Heyworth BE, Hui Hoi Po J, Kocher MS, Koehler R, Krych AJ, Latz KH, Loveland DM, Lyon RM, Meenen NM, Milewski MD, Myer GD, Nelson BJ, Nepple JJ, Nguyen JC, Pace JL, Paterno MV, Pennock AT, Perkins CA, Polousky JD, Riley P, Saluan P, Shea KG, Tompkins MA, Wall EJ, Weiss JM, Willimon SC, Wilson PL, Wright RW, Kostyun RO. The Efficacy of Bracing in Nonoperative Care of Medial Femoral Condyle Osteochondritis Dissecans: A Study From the Research in Osteochondritis Dissecans of the Knee (ROCK) Study Group. Am J Sports Med. 2026 May;54(6):1415-1422. doi: 10.1177/03635465261429407. Epub 2026 Apr 14.
PubMed 41981903
Study at a glance
From the registry record, last updated by the sponsor on 27 May 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- ROCK Comprehensive Prospective Cohort for Osteochondritis Dissecans of the Knee
- ClinicalTrials.gov ID
- NCT02771496
- Acronym / sponsor ID
- 820147
- Conditions
- Osteochondritis Dissecans
- Study type
- Observational
- Recruitment status
- Recruiting
- Enrolment
- 3,000 participants (estimated)
- Lead sponsor
- University of PennsylvaniaUniversity, hospital or other
- Collaborators
- Altona Children's Hospital, Boston Children's Hospital, Children's Hospital Medical Center, Cincinnati, Children's Health Andrews Institute for Orthopaedics & Sports Medicine, Children's Healthcare of Atlanta, Children's Hospital Colorado, Children's Hospital of Philadelphia, Children's Hospital and Health System Foundation, Wisconsin, Children's Mercy Hospital Kansas City, Connecticut Children's Medical Center, Hospital for Special Surgery, New York, Kaiser Permanente, Mayo Clinic, National University Hospital, Singapore, Rady Children's Hospital, San Diego, Stanford University, Tennessee Orthopedic Alliance, Texas Scottish Rite Hospital for Children, The Rocky Mountain Hospital for Children, The Hospital for Sick Children, Göteborg University, University of Minnesota/TRIA Orthopaedic Center, Washington University School of Medicine
- Study start
- 1 May 2014 (actual)
- Primary completion
- 1 May 2074 (estimated)
- Study completion
- 1 Dec 2074 (estimated)
- First posted
- 13 May 2016 (estimated)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The Cohort is a multi-site prospective data collection study that will enroll any patient with diagnosis of knee OCD (confirmed by a standard of care x-ray or MRI). Patients will be followed for up to the next 50 years of their lives to study courses of care, disease progression, treatment/surgical options/results, and specific sports-related outcomes in athletic patients. Subjects will complete quality of life surveys as part of the Cohort. Course of care will not be affected.
Detailed description
Patients will be recruited and consented at the visit in which their eligibility is determined. Once a patient is eligible and provides informed consent, he or she will be in the study for up to 50 years, or until his or her OCD lesion is healed successfully.
At the initial visit, a subject will complete a basic medical history form, and three questionnaires: the IKDC Subjective questionnaire (ages over 18) or the PEDI-IKDC Subjective questionnaire (ages under 18); the KOOS questionnaire; and the Marx Activity Scale (adult) or Pedi-FABS Scale (pediatric). Patients will then continue with their normal course of care as determined by their surgeon and care team.
Mandatory surveys (same as above) will be collected from patients at 2 years, 5 years, 10 years, and 25 years. Patients who cannot return to clinic will have the option to complete the assessments and return in pre-stamped and addressed return envelopes provided by the clinical site the subject is a patient at. Any other follow-up visits between these time intervals will also be options for patients to complete these assessments, however patients will not complete them any closer than intervals 12 weeks apart in order to prevent redundancy.
Additionally, at the initial visit, the surgeon will complete a routine patient history and physical exam, which will be collected. Any surgical procedures or physical therapy a patient undergoes for treatment of his or her OCD lesion will also be documented and collected. At follow-up visits, surgeons will complete their own physical exam follow-up assessment forms, which will be collected.
Study design
- Observational model
- Cohort
- Time perspective
- Prospective
- Number of arms
- 1
| Arm | Type | Receives |
|---|---|---|
| Patients with OCD | – | Other: Other: observational only- no interventionPatients with diagnosis of OCD as confirmed by x-ray or MRI. Surveys collected from patients at 2 years, 5 years, 10 years, and 25 years. |
Who may qualify
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Child, Adult, Older adult
- Study population
- Patients of all ages with osteochondritis dissecans (OCD) or focal articular cartilage defects confirmed via MRI or x-ray.
Key inclusion criteria (1 listed)
- Diagnosis of osteochondritis dissecans or focal articular cartilage defects as confirmed by x-ray or MRI
Key exclusion criteria (1 listed)
- Non-confirmed diagnosis (i.e. patient does not yet have imaging confirmation)
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Other: observational only- no interventionOther: observational only- no intervention | Other | Patients with OCD |
Primary outcome
IKDC questionnaire
Time frame: baseline up to 50 years
The primary outcome endpoint for this study is the patient's score on the IKDC Subjective questionnaire, or PEDI-IKDC Subjective questionnaire for patients under 18 years of age.
PEDI-IKDC questionnaire
Time frame: baseline up to 50 years
The primary outcome endpoint for this study is the patient's score on the IKDC Subjective questionnaire, or PEDI-IKDC Subjective questionnaire for patients under 18 years of age.
4 secondary outcomes
KOOS Knee score
Time frame: baseline up to 50 years
Marx Activity Score questionnaire
Time frame: baseline up to 50 years
Pedi-FABS Score
Time frame: baseline up to 50 years
Radiographic Healing
Time frame: baseline up to 50 years
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 27 May 2026.
- Derived from this study: PubMed 41981903ROCK Group; Nissen CW, Albright JC, Anderson CN, Busch MT, Carey JL, Carlson C, Carsen S, Chambers HG, Crepeau A, Edmonds EW, Ellermann JM, Ellis HB Jr, Erickson JB, Fabricant PD, Godin J, Ganley TJ, Green DW, Grimm NL, Heyworth BE, Hui Hoi Po J, Kocher MS, Koehler R, Krych AJ, Latz KH, Loveland DM, Lyon RM, Meenen NM, Milewski MD, Myer GD, Nelson BJ, Nepple JJ, Nguyen JC, Pace JL, Paterno MV, Pennock AT, Perkins CA, Polousky JD, Riley P, Saluan P, Shea KG, Tompkins MA, Wall EJ, Weiss JM, Willimon SC, Wilson PL, Wright RW, Kostyun RO. The Efficacy of Bracing in Nonoperative Care of Medial Femoral Condyle Osteochondritis Dissecans: A Study From the Research in Osteochondritis Dissecans of the Knee (ROCK) Study Group. Am J Sports Med. 2026 May;54(6):1415-1422. doi: 10.1177/03635465261429407. Epub 2026 Apr 14.
- Individual participant dataSharing planned: Undecided
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Enrolling by invitation
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
James L Carey, MD principal investigator
University of Pennsylvania
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Osteochondritis Dissecans, run by University of Pennsylvania at 1 site in United States.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 1 inclusion and 1 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 27 May 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in United States. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Mounika Ponakala, MS (6093343767, mounika.ponakala@pennmedicine.upenn.edu), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
IKDC questionnaire (time frame: baseline up to 50 years). The study lists 2 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT02771496, which also lists 1 linked publication.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 27 May 2026.