Clinical trials: Achalasia Cardia
Esophageal Achalasia
Quality of Life After POEM for Achalasia
Achalasia is an esophageal motility disorder, characterized by insufficient lower esophageal sphincter relaxation and loss of esophageal peristalsis.
- Trial name
- NCT05010889
- Testing
- Peroral endoscopic myotomy (POEM)
- Where
- China
- Volunteers
- 200 people
- Sponsor
- First Affiliated Hospital, Sun Yat-Sen University
Achalasia, Alacrima
Genetic Evaluation of AAAS Gene in Early-Onset Achalasia and Alacrima Patients
The AAAS gene has been known to cause achalasia, alacrima, adrenal abnormalities and a progressive neurological syndrome. A considerable proportion of achalasia patients have been known to show alacrima (decreased secretion of…
- Trial name
- AAAS (NCT00856921)
- Volunteers
- 19 people
- Sponsor
- Asan Medical Center
Esophageal Achalasia
Clinical Impact of Peroral Endoscopic Myotomy for Esophageal Achalasia
Achalasia is a rare esophageal motility disorder, which is characterized clinically by symptoms of dysphagia, regurgitation, weight loss and chest pain.
- Trial name
- NCT01649843
- Testing
- POEM
- Where
- China
- Volunteers
- 450 people
- Sponsor
- Shanghai Zhongshan Hospital
Achalasia, Epidermoid Carcinoma
Epidermoid Cancer Development in Esophageal Achalasia
Esophageal achalasia is a precancerous condition for epidermoid carcinoma; incidence and risk factors for cancer development are not defined.
- Trial name
- NCT03546998
- Testing
- Clinical instrumental examinations
- Where
- Italy
- Volunteers
- 681 people
- Sponsor
- Sandro Mattioli
Achalasia Cardia, GERD-HRQL Scale
Compare the Quality of Life of Patients With Achalasia Cardia (AC) After Laparoscopic and Open Esophagocardiomyotomy.
Study design. A randomized, prospective design study with retrospective data addition was conducted at two medical institutions between December 2017 and July 2025.
- Conditions
- Achalasia Cardia, GERD-HRQL Scale, Eckardt Scale
- Trial name
- GERD-HRQL (NCT07177222)
- Testing
- laparoscopic esophagocardiomyotomy, open surgery
- Where
- Kyrgyzstan
- Volunteers
- 38 people
- Sponsor
- Osh State University
Achalasia Cardia, Esophageal Cancer (EsC)
INCIDENCE, PREVALENCE AND OVERALL RISK OF ESOPHAGEAL CANCER IN ACHALASIA: A PROPENSITY-MATCHED POPULATION-BASED STUDY FROM A LARGE MULTICENTER DATABASE
Esophageal Achalasia has been investigated as a potential risk factor for esophageal cancer (EC). Longstanding disease, repeated treatment, age and male sex seem the most relevant risk factors, but no clear effect size estimation…
- Trial name
- RECAP (NCT07022886)
- Testing
- achalasia treatments
- Where
- Italy
- Volunteers
- 47,000 people, healthy volunteers welcome
- Sponsor
- IRCCS San Raffaele
Symptoms and Signs, Quality of Life
Quality of Life After Surgery for End-stage Achalasia
Therapy for end-stage achalasia is under debate: comparative data on the long-term functional results of myotomy and oesophagectomy are lacking.
- Trial name
- NCT04152902
- Testing
- Objective outcome, Quality of life
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- University of Bologna
Achalasia Cardia
Comparison of Balloon Dilatation and Per Oral Endoscopic Myotomy in Children With Achalasia Cardia
To compare the efficacy of balloon dilatation (BD) and per oral endoscopic myotomy (POEM) in improving the symptoms of children with achalasia in short and long term Presently most guidelines such as American Society for…
- Trial name
- NCT07167355
- Testing
- POEM, BALLOON DILATATION
- Volunteers
- 70 people
- Sponsor
- Asian Institute of Gastroenterology, India
Dysphagia, Esophageal Stricture
Impact of Body Positioning on EndoFLIP Measurements: A Comparative Study of Supine and Left Lateral Decubitus Positions
This is a prospective, single-center, crossover study comparing EndoFLIP measurements obtained in two patient positions, supine and left lateral decubitus, in pediatric and young adult patients.
- Conditions
- Dysphagia, Esophageal Stricture, Epidermolysis Bullosa (EB), Achalasia
- Trial name
- NCT07780981
- Testing
- EndoFlip
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Johns Hopkins University
Achalasia Cardia, Tumor
Artificial Intelligence-Guided Detection of Blood Vessels to Enhance Safety in Third-Space Endoscopic Procedures
This prospective study aims to evaluate the performance of a novel Artificial Intelligence (AI) clinical decision support tool during third space endoscopic procedures, such as Endoscopic Submucosal Dissection (ESD) and Peroral…
- Trial name
- NCT07399652
- Testing
- AI generated segmentation mask for sub-mucosal blood vessels
- Where
- India
- Volunteers
- 40 people
- Sponsor
- Asian Institute of Gastroenterology, India
Achalasia, Gastric Outlet Obstruction
Endoscopic Surgery for Gastrointestinal Disorders: A Multicenter Registry Study
Currently, there is limited multi-center data on endoscopic surgery outcomes in western populations. Evaluation of these measurement would help the investigators compare them to conventional treatment modalities within current…
- Conditions
- Achalasia, Gastric Outlet Obstruction, Gastroparesis, GERD
- Trial name
- NCT05041608
- Testing
- Endoscopic Surgery
- Where
- United States
- Volunteers
- 5,000 people
- Sponsor
- Advanced Endoscopy Research, Robert Wood Johnson Medical School Rutgers University
Esophageal Achalasia
Assessment of Different Modified POEM for Achalasia
The aims of this study is to compare the efficacy and safety of conventional myotomy (circular myotomy) and modified myotomy (full-thickness myotomy) in the treatment of achalasia patients.
- Trial name
- NCT04578769
- Testing
- conventional myotomy, full-thickness myotomy
- Where
- China
- Volunteers
- 69 people
- Sponsor
- Peking Union Medical College Hospital
Rare Disorders, Undiagnosed Disorders
Rare Disease Patient Registry & Natural History Study - Coordination of Rare Diseases at Sanford
The Coordination of Rare Diseases at Sanford (CoRDS) is an international patient registry that serves as a centralized resource for rare disease research.
- Conditions
- Rare Disorders, Undiagnosed Disorders, Disorders of Unknown Prevalence, Cornelia De Lange Syndrome
- Trial name
- CoRDS (NCT01793168)
- Where
- United States
- Volunteers
- 20,000 people
- Sponsor
- Sanford Health
Esophageal Achalasia
Short Versus Long Submucosal Tunneling in Per-oral Endoscopic Myotomy (POEM) for Type II Achalasia.
this study is prospective , randomized and interventional ,will be performed on 50 patients to compare the clinical utility , safety profile and postoperative recovery metrics between short and long per-oral endoscopic myotomy …
- Trial name
- NCT07686471
- Testing
- per-oral endoscopic myotomy
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Assiut University
Esophageal Motility Disorders
The Clinical Manifestation and Prognosis of Pediatric Esophageal Motility Disorders
Background: Abnormal esophageal peristalsis mostly occurs in adults, but some patients have onset in childhood. Most of the symptoms of esophageal motility disorders in children are not as clear as those described by adult…
- Trial name
- NCT06629025
- Testing
- High-resolution impedance manometry
- Where
- Taiwan
- Volunteers
- 10 people
- Sponsor
- National Taiwan University Hospital