Clinical trials: Defects
Tetralogy of Fallot
Reoxygenation for Cyanotic Pediatric CHD
Evidence is emerging that those patients with cyanotic pathologies may be more vulnerable to end-organ injury during and after surgery than those patients without, because of compromised cardiopulmonary performances or the…
- Trial name
- Reoxygenation (NCT03568357)
- Testing
- Reoxygenation
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Nanjing Medical University
Turner's Syndrome
A Clinical Study to Assess the Efficacy and Safety of DA-3002
A study demonstrates the non-inferiority of DA-3002 when compared with Genotropin®.
- Trial name
- NCT01813630
- Testing
- DA-3002, Genotropin®
- Where
- South Korea
- Volunteers
- 58 people
- Sponsor
- Dong-A ST Co., Ltd.
Turner Syndrome, Primary Ovarian Insufficiency (Poi)
Bleeding Patterns in Sequential and Continuous Progesterone Supplementation in Adolescents With Turner Syndrome
This is a single-site open label non-randomized study comparing effects of sequential versus continuous use of progesterone supplementation amongst Turner Syndrome (TS) patients with primary ovarian insufficiency (POI) prescribed…
- Trial name
- BOOST (NCT06834594)
- Testing
- Micronized progesterone 200 MG, Micronized Progesterone 100 MG
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Children's Mercy Hospital Kansas City
Rare Diseases, Marfan Syndrome
Analysis of Muscular Properties in Patients With MFS and EDS
The goal of this observational study is to learn and assess muscle morphological and electromechanical properties in patients affected with Marfan syndrome (MFS) and Ehlers Danlos syndrome (EDS).
- Conditions
- Rare Diseases, Marfan Syndrome, Ehlers-Danlos Syndrome
- Trial name
- MUSCLE (NCT05720923)
- Testing
- Analysis with Ergometer
- Where
- Italy
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- IRCCS Policlinico S. Donato
Molar-Incisor Hypomineralization (MIH), Masticatory Performance
Evaluation of Occlusal Force and Masticatory Function in Children With Molar-Incisor Hypomineralization
This study aims to evaluate right-left chewing balance and masticatory function in children with Molar-Incisor Hypomineralization (MIH) before and after restorative treatment.
- Conditions
- Molar-Incisor Hypomineralization (MIH), Masticatory Performance, Occlusal Analysis, Chewing Function
- Trial name
- NCT07589179
- Testing
- Glass Hybrid Restorative Treatment
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Marmara University
Intermittent Urethral Catheterization, Spinal Dysraphism
The Effect of Nursing Interventions for Clean Intermittent Catheterization Caregivers and Child
In neurogenic or non-neurogenic bladder disorders, the removal process after the catheter is inserted into the bladder and the urine has been drained is called Clean intermittent catheterization (CIC).
- Conditions
- Intermittent Urethral Catheterization, Spinal Dysraphism, Urinary Tract Infections
- Trial name
- NCT04763382
- Testing
- experimental group: Training of caregivers, Control gruop
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Karadeniz Technical University
Cardiac Defect, Cardiac Anomaly
Post Market Observational Retrospective Study of Glycar Bovine Pericardial Patch (CIP-003)
The overall purpose of this observational Post Market Clinical Follow Up (PMCF) study is to ensure continued acceptability of the benefit risk ratio by assessment of safety and performance, in patients undergoing cardiovascular…
- Conditions
- Cardiac Defect, Cardiac Anomaly, Pericardial Defect
- Trial name
- NCT06088680
- Testing
- Glycar Pericardial Patch
- Where
- South Africa
- Volunteers
- 50 people
- Sponsor
- GLYCAR SA (Pty) Ltd
Patent Ductus Arteriosus
Population Pharmacokinetics and Dosage Individualization of Paracetamol and Ibuprofen in Children With PDA
The investigator's purpose is to study the population pharmacokinetics of paracatamol and ibuprofen in neonates with patent ductus arteriosus (PDA) and assess the feasibility of dosage individualization.
- Trial name
- NCT04397913
- Testing
- Paracetamol, Ibuprofen
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Shandong University
Congenital Heart Disease (CHD), Chest Tube Removal
The Effect of Music and Musical Mobile Interventions on Pain and Physiological Parameters
Chest tube removal in infants undergoing surgery for congenital heart disease is an invasive procedure associated with significant pain and physiological stress responses.
- Trial name
- Music Pain Inf (NCT07564882)
- Testing
- Music Group, Musical Mobile Group
- Where
- Turkey (Türkiye)
- Volunteers
- 54 people
- Sponsor
- Baskent University
Fluorosis, Dental
Nails and Teeth as Biomarkers of Fluoride Exposure
To determine fluoride concentration in fingernails and estimate if there is a correlation between fluoride concentration in fingernails and fluoride concentration in toothpaste used.
- Trial name
- NCT05442320
- Testing
- Biodent Toothpaste (Ilirija d.d., Ljubljana, Slovenia)
- Volunteers
- 342 people
- Sponsor
- University of Ljubljana
Limb Salvage
Reconstruction of Extensive Upper Extremity Long Bone Defects With a Microvascular Fibula Flap
This study assesses the long-term functional outcomes of upper extremity long bone defects treated with the free fibula bone transfer.
- Trial name
- NCT02372838
- Testing
- Microvascular fibula bone transfer
- Volunteers
- 13 people
- Sponsor
- Helsinki University Central Hospital
Patent Ductus Arteriosus
AMPLATZER Duct Occluder II Additional Sizes
The ADO II AS Study is a single arm, prospective, multicenter, nonrandomized clinical investigation to characterize the safety and effectiveness of the ADO II AS device in patients with a patent ductus arteriosus (PDA).
- Trial name
- ADO II AS (NCT03055858)
- Testing
- ADO II AS (PDA closure)
- Where
- 9 sites in United States
- Volunteers
- 200 people
- Sponsor
- Abbott Medical Devices
Congenital Heart Disease (CHD), Mentorship
Optimizing Care Transitions in CHD
Adolescents and young adults (AYA) with congenital heart disease (CHD) face psychosocial stresses as they transition to adult care. Parents of AYA with CHD also experience increased caregiver burden and psychosocial stresses.
- Conditions
- Congenital Heart Disease (CHD), Mentorship, Transition of Care, Peer Support
- Trial name
- NCT07898384
- Testing
- Peer mentorship
- Where
- Canada
- Volunteers
- 110 people
- Sponsor
- The Hospital for Sick Children
Congenital Heart Disease
High-exchange ULTrafiltration to Enhance Recovery After Pediatric Cardiac Surgery
Malformations of the heart are common; 1.35 million infants are born each year with congenital heart disease. Many of these defects carry a considerable threat to the individual's quality of life as well as survival.
- Trial name
- ULTRA (NCT04920643)
- Testing
- Ultrafiltration
- Where
- Canada
- Volunteers
- 104 people
- Sponsor
- IWK Health Centre
22q11.2 Deletion Syndrome
Arithmetic Abilities in Children With 22q11.2DS
The study ARITH22 will investigate the role of visuo-spatial attention on arithmetic abilities of children with 22q11.2 deletion syndrome.
- Trial name
- ARITH22 (NCT04373226)
- Testing
- Magnitude comparison tasks and neuropsychological testing
- Where
- France
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Hôpital le Vinatier
Patency of the Ductus Arteriosus, Acetaminophen
Prophylactic Treatment of the Ductus Arteriosus in Preterm Infants by Acetaminophen
TREOCAPA is a Phase II/III European Multicentre study concerning the prophylactic treatment by Acetaminophen of extremely preterm infant during the first five days after birth.
- Conditions
- Patency of the Ductus Arteriosus, Acetaminophen, Extreme Prematurity
- Trial name
- TREOCAPA (NCT04459117)
- Testing
- Acetaminophen, NACL 0.9%
- Where
- 36 sites in Belgium, Denmark and 10 more
- Volunteers
- 804 people
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Heart Defects, Congenital
Mixed Venous Oxygen Saturation From Central Venous Line, Venous Side of Heart Lung Machine and the Pulmonary Artery
This study was designed to examine if venous saturations from the central venous line and from the venous side of the heart lung machine are interchangeable or not with mixed venous saturation from the pulmonary artery in…
- Trial name
- NCT02498626
- Testing
- venous saturations
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Assiut University
Congenital Heart Disease
Effect of Feeding With Nutrient Dense Formula in Malnourished Infants and Children With Congenital Heart Defects
Infants with congenital heart disease (CHD) are usually born with a normal weight but develop malnutrition over time, and about 20-50% of these children are usually malnourished. Malnutrition in these patients is multifactorial.
- Trial name
- NCT04795076
- Testing
- Infant formula
- Where
- Iran
- Volunteers
- 65 people
- Sponsor
- Shahid Beheshti University
Spinal Cord Injuries, Spina Bifida
Downstream Effects of Personalized 'Top-down' Participation-based Interventions Among Youth With Physical Disabilities
Participation in community-based activities is essential to the health and well-being of youth with physical disabilities; yet, it is extremely restricted.
- Conditions
- Spinal Cord Injuries, Spina Bifida, Musculoskeletal Disorder, Juvenile Arthritis
- Trial name
- NCT05784285
- Testing
- Engagement in a 8-week community-based activity program
- Where
- Canada
- Volunteers
- 150 people
- Sponsor
- McGill University
Ventricular Septal Defect, Pulmonary Hypertension
The Effect of Remote Ischemic Preconditioning on the Ischemic Reperfusion Injury in Infants With Ventricular Septal Defect and Pulmonary Hypertension
Intraoperative myocardial and pulmonary protection is important for better outcome after cardiac surgery. Ischemic preconditioning is one of organ protective strategies against ischemia-reperfusion injury by applying brief…
- Trial name
- NCT01313832
- Testing
- remote ischemic preconditioning (RIPC)
- Where
- South Korea
- Volunteers
- 60 people
- Sponsor
- Seoul National University Hospital
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