Clinical trials: Neuromuscular Function
Multiple Sclerosis, Peripheral Neuropathy
Effects of Meditation on Multiple Sclerosis and Peripheral Neuropathy
This study will evaluate the effects of mindfulness and concentration meditation on pain, fatigue, and physical functioning in patients with either multiple sclerosis or peripheral neuropathy.
- Trial name
- NCT00981643
- Testing
- Meditation instruction and practice
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- The Cleveland Clinic
Duchenne Muscular Dystrophy
Relationship Between PFTs and Pdi in DMD
A cross-sectional study to explore the relationship between clinically assessed pulmonary function test (PFT) measures and transdiaphragmatic (Pdi) measures in Duchenne muscular dystrophy (DMD) as well as to explore the…
- Trial name
- NCT03335384
- Testing
- Esophageal Balloon, Gastric Balloon, Nasal Pressure Transducer
- Sponsor
- University of Minnesota
Neurofibromatosis Type 1, Muscle Weakness
Whole-body Vibration in Children With Neurofibromatosis Type 1
It is known that children with NF1 can have weak muscles and suffer from tiredness. It is also known that in similar conditions affecting children's muscles, standing on a vibration device for a few minutes each day can…
- Trial name
- NCT03888248
- Testing
- Whole-body vibration, Muscle strengthening exercises
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- Manchester University NHS Foundation Trust
Neuromuscular Diseases
Validation of Completion of Items 18, 19 and 22 of the Motor Function Measure (MFM) on a Digital Tablet
Motor Function Measure (MFM) is a validated tool assessing the motor function of neuromuscular patients constituted of 32 items.
- Trial name
- MFM-tablet (NCT03465358)
- Testing
- Items completion
- Where
- 5 sites in France
- Volunteers
- 100 people
- Sponsor
- Hospices Civils de Lyon
Duchenne Muscular Dystrophy, Natural History
phenotypeS in Non Ambulant Duchenne Muscular Dystrophy
The aims of the study are to prospectively collect information on several aspects of function in non-ambulant DMD patients by using a structured battery of tests including motor, respiratory and cardiac function
- Conditions
- Duchenne Muscular Dystrophy, Natural History, Motor Function; Retardation
- Trial name
- GUP21003 (NCT06366815)
- Testing
- Different Phenotypes of non ambulant patients with Duchenne Muscular Dystrophy
- Where
- 2 sites in Italy
- Volunteers
- 250 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Mitochondrial Myopathies
NiaMIT Continuation With Early-stage Mitochondrial Myopathy Patients
The most frequent form of adult-onset mitochondrial disorders is mitochondrial myopathy, often manifesting with progressive external ophthalmoplegia (PEO), progressive muscle weakness and exercise intolerance.
- Trial name
- NCT04538521
- Testing
- Niacin
- Where
- Finland
- Volunteers
- 3 people
- Sponsor
- University of Helsinki
Cerebral Palsy
The Effect of Treadmill Back Walking Training on Balance and Function in Cerebral Palsy
The aim of this study was to investigate the effect of treadmill back walking training on balance and function in cerebral palsy.
- Trial name
- CP (NCT04136678)
- Testing
- walking training
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people
- Sponsor
- Istanbul Medipol University Hospital
Muscle Spasticity, Gait Disorders, Neurologic
Ultrasonographic Assessment of Muscle Morphology, Function, and Clinical Findings in Spastic Cerebral Palsy
This study focuses on children with spastic cerebral palsy and aims to examine how muscle morphology and tissue characteristics, as assessed by ultrasound, may relate to functional motor abilities.
- Conditions
- Muscle Spasticity, Gait Disorders, Neurologic, Cerebral Palsy, Spastic
- Trial name
- US-sCP (NCT07118228)
- Where
- Turkey (Türkiye)
- Volunteers
- 36 people
- Sponsor
- Kocaeli University
Cerebral Palsy, Spastic Diplegia
Effects of Proprioceptive Neuromuscular Facilitation and Task-Oriented Training on Upper Extremity Function in Children With Spastic Diplegic Cerebral Palsy
Children with spastic diplegic cerebral palsy often experience upper extremity impairments, including reduced coordination, muscle control, and functional hand use, which limit independence in daily activities.
- Trial name
- PNF-TOT-CP (NCT07694804)
- Testing
- Proprioceptive Neuromuscular Facilitation (PNF), Task-Oriented Training (TOT), Combined Proprioceptive Neuromuscular Facilitation and Task-Oriented Training
- Where
- Pakistan
- Volunteers
- 63 people
- Sponsor
- Ibadat International University, Islamabad
Erb's Palsy
Neuromuscular Electrical Stimulation With and Without Constraint Induced Movement Therapy in Erb's Palsy
Erb's Duchenne paralysis constitutes the single commonest form of brachial plexus injury, brachial plexus injury (BPI) is unfortunately a rather common injury in newborn children.
- Trial name
- NCT05723042
- Testing
- EMS with CIMT, EMS
- Where
- Pakistan
- Volunteers
- 22 people
- Sponsor
- Riphah International University
Youth Volleyball, Sports Performance
Comparative Effects of High-Intensity Interval and Functional Training on Performance Outcomes in Adolescent Female Volleyball Players
Background Volleyball requires repeated explosive actions, agility, and technical precision, demanding contributions from both aerobic and anaerobic energy systems.
- Conditions
- Youth Volleyball, Sports Performance, Neuromuscular Function, Aerobic Capacity
- Trial name
- NCT07181031
- Testing
- High-Intensity Interval Training (HIIT), High-Intensity Functional Training (HIFT)
- Where
- Turkey (Türkiye)
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Duvenciler Anadolu Lİsesi
Spastic Cerebral Palsy, Physical Therapy Modalities
Effectiveness of Whole-Body Vibration
Cerebral Palsy is the most common cause of severe physical disability in childhood and may present difficulties and limitations that will have an impact on their independence and integration in all social areas.
- Conditions
- Spastic Cerebral Palsy, Physical Therapy Modalities, Vibration; Exposure, Lower Extremity Weakness, Spastic
- Trial name
- WBVibration (NCT06330311)
- Testing
- Physiotherapy
- Where
- Spain
- Volunteers
- 30 people
- Sponsor
- Universidad Complutense de Madrid
Burns, Pediatric Burns
Resistance, Plyometric, and Combined Exercise Training in Children With Severe Burns
Children who experience severe burns may continue to have reduced muscle strength, power, balance, and physical function after their wounds have healed.
- Conditions
- Burns, Pediatric Burns, Burn Injury
- Trial name
- NCT07843355
- Testing
- Traditional Resistance Training, Plyometric Training, Combined Resistance and Plyometric Training
- Where
- Egypt
- Volunteers
- 78 people
- Sponsor
- Qassim University
Cerebral Palsy (CP)
Constraint-induced Movement Therapy Combined With Functional Electrical Stimulation in Children With Cerebral Palsy
This randomized controlled trial aims to compare the effectiveness of Constraint-Induced Movement Therapy (CIMT) combined with Functional Electrical Stimulation (FES) versus CIMT alone in improving upper limb function, reducing…
- Trial name
- CIMT-FES-CP (NCT07587476)
- Testing
- Constraint-Induced Movement Therapy Combined with Functional Electrical Stimulation, Constraint-Induced Movement Therapy
- Where
- Pakistan
- Volunteers
- 46 people
- Sponsor
- Montiha Azeem
Polyneuropathy, Charcot Marie Tooth Disease (CMT)
Effects of Resistance Exercises in Hereditary Sensory-Motor Neuropathy (Charcot-Marie-Tooth Disease)
The goal of this clinical trial is to compare the effects of an 8-week resistance exercise training program on skeletal muscle quality, functional capacity, and quality of life in young individuals aged 15 to 29 years, with and…
- Trial name
- PNP (NCT07152197)
- Testing
- Progressive Resistance Exercise Training
- Where
- 2 sites in Chile
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Universidad de La Frontera
Guillain-Barre Syndrome
Effects of Proprioceptive Neuromuscular Training on Sensory and Motor Function in Guillain Barre Syndrome
This study aims to determine the effects of Proprioceptive Neuromuscular Training on Sensory versus Motor Function in patients presenting with Guillain Barre Syndrome.
- Trial name
- NCT05491096
- Testing
- Proprioceptive Neuromuscular Training, Conventional Physical Therapy
- Where
- Pakistan
- Volunteers
- 26 people
- Sponsor
- Riphah International University
Rare Disorders, Undiagnosed Disorders
Rare Disease Patient Registry & Natural History Study - Coordination of Rare Diseases at Sanford
The Coordination of Rare Diseases at Sanford (CoRDS) is an international patient registry that serves as a centralized resource for rare disease research.
- Conditions
- Rare Disorders, Undiagnosed Disorders, Disorders of Unknown Prevalence, Cornelia De Lange Syndrome
- Trial name
- CoRDS (NCT01793168)
- Where
- United States
- Volunteers
- 20,000 people
- Sponsor
- Sanford Health
Cauda Equina Syndrome, Functional Neurological Disorder
BLB Study Back or Leg Pain and Bladder Symptoms Study
The research focuses on Cauda Equina Syndrome (CES) which describes damage to the nerves in the lower back which supply bladder, bowels, sexual function and the legs usually from slipped discs in the spine.
- Trial name
- BLB (NCT03325374)
- Testing
- Questionnaires and examination
- Where
- United Kingdom
- Volunteers
- 100 people
- Sponsor
- University of Edinburgh
Duchenne Muscular Dystrophy
Observational Study of Patients With Duchenne Muscular Dystrophy Theoretically Treatable With Exon 53 Skipping
PreU7-53 is a natural history study. The objective is to monitor the clinical and radiological course of upper limb muscle impairment in patients with Duchenne Muscular Dystrophy (DMD), potentially treatable with AAV-mediated…
- Trial name
- pre U7-53 (NCT01385917)
- Where
- 2 sites in France, United Kingdom
- Volunteers
- 45 people
- Sponsor
- Genethon
Chronic Pain Syndrome, Fibromyalgia
Assessing the Impact of Exercise Based Intensive Interdisciplinary Pain Treatment (IIPT) on Endogenous Pain Modulation in Youth With Chronic Pain Syndromes
This work will answer two critical questions: 1) Does intensive interdisciplinary pain treatment (IIPT) involving aerobic exercise help normalize pain processing in youth with chronic pain syndromes and 2) Are aerobic fitness…
- Conditions
- Chronic Pain Syndrome, Fibromyalgia, Chronic Headache Disorder, Functional Abdominal Pain Syndrome
- Trial name
- NCT05491499
- Where
- United States
- Volunteers
- 43 people
- Sponsor
- Boston Children's Hospital