Clinical trials: Advanced Age
Dementia
Group Digital Gaming: Experiences of Older Adults Living With Dementia in an Activity for Cognitive Impairment
The study examines the effects of a group digital gaming intervention on cognitive function, mood, and behaviors in people with early to moderate levels of dementia, using Obie Technology by employing a pretest and posttest…
- Trial name
- PLwD (NCT07541144)
- Testing
- Group-Based Digital Gaming
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- George Mason University
Prodromal Alzheimer's Disease, Mild Cognitive Impairment
The Digital Memory Notebook
Compensatory aids (e.g., alarms, calendars) play an important supporting role when completing everyday tasks (e.g., appointments, medication management), and there is a growing body of scientific work suggesting that compensatory…
- Conditions
- Prodromal Alzheimer's Disease, Mild Cognitive Impairment, Subjective Cognitive Complaints
- Trial name
- DMN (NCT04240665)
- Testing
- Digital Memory Notebook (DMN) Application
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of California, Davis
Dementia, Neurocognitive Disorders
Prefrontal Cortex Dynamics of the Elderly During a Cognitive Stimulation Programme
This research aims to evaluate the effect of cognitive stimulation (CS) on the functioning of the prefrontal cortex (PFC), seeking an analysis of both cerebral hemodynamics in neuroplasticity and aspects related to the initiation…
- Conditions
- Dementia, Neurocognitive Disorders, Cognitive Impairment, Cognitive Dysfunction
- Trial name
- NCT04693611
- Testing
- Individual cognitive stimulation therapy (iCST), Functional near-infrared spectroscopy (fNIRS)
- Where
- Portugal
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- CEDIARA - Assoc. Solidariedade Social de Ribeira de Fráguas
Frail Elderly Syndrome
Screening of the Frailty Degree in the Emergency Department Short Stay Unit
Screen all those> 65 years of age admitted to the Short Stay Unit for frailty, and detect those who are potentially fragile.
- Trial name
- NCT04812834
- Where
- Spain
- Volunteers
- 300 people
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Postoperative Cognitive Dysfunction
Effects of Amantadine on Postoperative Cognitive Dysfunction
Post-operative cognitive dysfunction (POCD) is a fairly well-documented clinical phenomenon. Investigators will determine whether amantadine can reduce the occurrence of POCD in elderly patients with major abdominal surgery.
- Trial name
- NCT03527134
- Testing
- Amantadine
- Where
- China
- Volunteers
- 390 people, healthy volunteers welcome
- Sponsor
- Zhiyi Zuo
Malnutrition
The Dietetic Consultation: an Illuminative Evaluation
This study aims to understand the experience of the dietetic consultation from the perspective of nutritionally vulnerable older patients receiving oral nutrition support and dietitians, as well as other key stakeholders involved…
- Trial name
- NCT03509116
- Testing
- Observations, documents, Interviews, key stakeholders, documents
- Where
- United Kingdom
- Volunteers
- 45 people
- Sponsor
- King's College London
Pre-Hypertension
Respiratory Muscle Training and Intermittent Hypoxia: Additive Health Effects?
The prevalence of pre-hypertension and hypertension in the elderly is very high. Apart from medication, physical exercise training is a potential strategy to reduce blood pressure, however, the ability to perform exercise can be…
- Trial name
- NCT03313284
- Testing
- RMT, RMT + IH, Control
- Where
- Switzerland
- Volunteers
- 14 people
- Sponsor
- Swiss Federal Institute of Technology
Malnutrition
The Nutritional Health for the Elderly Reference Centre Study (NHERC Study)
Elderly are at greater risk of dietary insufficiency due to age-related increases in nutrient requirements concomitant with a reduction in energy requirements, decreases in appetite and energy intake.
- Trial name
- NHERC (NCT03240952)
- Where
- 4 sites in Singapore
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Abbott Nutrition
Ischemic Stroke, Embolic Stroke of Undetermined Source
SENIOR: Stroke Prevention in the Elderly by Patent Foramen Ovale closuRe vs Anticoagulation
Patent foramen ovale (PFO) is an important mechanism of embolic stroke of undetermined source (ESUS). Current guidelines recommend PFO closure for high-risk PFO in patients younger than 60 years, and a recent retrospective cohort…
- Conditions
- Ischemic Stroke, Embolic Stroke of Undetermined Source, Patent Foramen Ovale (PFO), Elderly
- Trial name
- SENIOR (NCT07479147)
- Testing
- PFO closure, Medication
- Where
- 3 sites in Taiwan
- Volunteers
- 400 people
- Sponsor
- Taichung Veterans General Hospital
Aging
Health TAPESTRY Ontario
The Health Teams Advancing Patient Experience: Strengthening Quality (Health TAPESTRY) is a community-based program led by primary care teams, that creates connections between trained community volunteers, interprofessional…
- Trial name
- NCT03397836
- Testing
- Health TAPESTRY Intervention, Usual Care
- Where
- Canada
- Volunteers
- 599 people, healthy volunteers welcome
- Sponsor
- McMaster University
Physical Frailty, Physical Disability
Multidomain Intervention to Prevent Disability in Elders
Prevention of physical disability represents a major priority for the public health system. Physical disability is the final result of a complex cascade of negative events occurring at different levels (i.e., environmental…
- Conditions
- Physical Frailty, Physical Disability, Mobility Disability
- Trial name
- MINDED (NCT02082171)
- Testing
- Multidomain intervention
- Where
- France
- Volunteers
- 210 people
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Standard Therapy, Non-standard Therapy
SD vs. NSD Therapy in Elderly AML
It is known that treatment outcome could be positively associated with treatment intensity. However, tolerance of chemotherapy decreases in the elder, some patients could not tolerate standard (SD) therapy and even died of side…
- Trial name
- NCT03733834
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Femur Fracture
Compartment Psoas Block Efficacy and Safety
A randomized controlled trial to assess the efficacy and safety of the prolonged compartment psoas block for analgesia and anesthesia for femur surgery in the elderly
- Trial name
- NCT04648332
- Testing
- Bupivacaine Hydrochloride
- Where
- Ukraine
- Volunteers
- 90 people
- Sponsor
- Bogomolets National Medical University
Neoplasms, Chemotherapy-induced Nausea and Vomiting
Serious Gaming for Chemotherapy-induced Nausea and Vomiting
The purpose of this study is to examine the effectiveness of a technology-based intervention for managing nausea and vomiting in older adults with cancer.
- Trial name
- NCT05838638
- Testing
- eSSET-CINV
- Where
- 2 sites in United States
- Volunteers
- 610 people
- Sponsor
- University of Central Florida
Sarcopenia, Muscular Atrophy
Exercise and Nutrition Interventions in Age-related Sarcopenia
This project will investigate the synergistic effects of Aerobic and Resistance type Exercise, in combination with Protein Supplementation, on; Body Composition, Musculoskeletal Functioning, Nutritional Status and Quality of Life…
- Trial name
- NCT02912130
- Testing
- Protein Supplementation, Aerobic Exercise, Resistance Exercise
- Where
- United Kingdom
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Liverpool Hope University
Covid19
Elderly Patients and COVID-19 Infection: a Cohort of Fifty Patients Over Ninety Years of Age
SARS-CoV2 or CoVid19 disease is a newly described pathology linked to a subtype of the coronavirus family identified in China in December 2019.
- Trial name
- NCT04499300
- Testing
- Data collection from medical files
- Where
- Belgium
- Volunteers
- 50 people
- Sponsor
- Murielle Surquin
Age-related Cognitive Decline
Acute Effects of THC in Older Adult
The primary objective of this study is to determine if increasing age confers greater vulnerability to the acute A) cognitive (e.g., memory, attention, psychomotor function), B) subjective (e.g., anxiogenic and rewarding…
- Trial name
- THC-Aging (NCT06948136)
- Testing
- Delta-9-THC Low Dose, Delta-9-THC Medium Dose
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Yale University
Age Problem, Abdominal Cancer
Dosage of Epidural Morphine in Elderly Patients
This a clinical trial that evaluates the efficacy and safety of three different doses of morphine, namely 1.5 mg, 3 mg and 4.5 mg, via the epidural route regarding reducing pain in elderly patients after a cancer surgery in the…
- Trial name
- NCT04316871
- Testing
- 1.5 mg of Morphine Sulfate, Normal saline, 3 mg of Morphine Sulfate
- Where
- Egypt
- Volunteers
- 96 people
- Sponsor
- Assiut University
Age Associated Immune Deficiency, Elderly Infection
Immunophenotype of Risk in Older Patients Admitted for Pneumonia
The objective is to evaluate if the immune risk phenotype (IRP) in patients who have been admitted for pneumonia predisposes to worse long-term outcomes.
- Conditions
- Age Associated Immune Deficiency, Elderly Infection, Pneumonia, Nutrition Disorders in Old Age
- Trial name
- NCT04062799
- Testing
- no intervention
- Where
- Spain
- Volunteers
- 174 people
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Post Operative Cognitive Dysfunction
Ketamine and Postoperative Cognitive Dysfunction
Over 30 million patients require a major surgery annually in the US alone and more than half of them are performed in patients over 60 years of age.
- Trial name
- POCK (NCT02892916)
- Testing
- Ketamine
- Where
- France
- Volunteers
- 307 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris