Clinical trials: Aetiology
Dyspnea, Hypoxia
Diaphragmatic Paralysis in Arthroscopic Shoulder Surgery
This study aims to assess consequences and causes of hemidiaphragmatic paralysis for ambulatory arthroscopic shoulder surgery in patients with BMI ≥ 30 kg/m².
- Conditions
- Dyspnea, Hypoxia, Analgesia
- Trial name
- NCT03192865
- Testing
- diaphragmatic assessment using ultrasounds.
- Where
- France
- Volunteers
- 82 people
- Sponsor
- Clinique Medipole Garonne
Retinal Disorder
Safety and Efficacy of Zuretinol Acetate in Subjects With Inherited Retinal Disease
To evaluate the efficacy of ZA oral solution in subjects with IRD caused by biallelic recessive RPE65 or LRAT gene mutations and phenotypically diagnosed as Leber's Congenital Amaurosis (LCA) or Retinitis Pigmentosa (RP).
- Trial name
- NCT04311112
- Testing
- ZA Low dose, ZA high dose
- Where
- United States
- Sponsor
- Retinagenix Holdings
COVID, COVID-19
A Study of Combination Therapies to Treat COVID-19 Infection
This study seeks to determine whether dual or quadruple therapy is more effective in treating COVID-19.
- Conditions
- COVID, COVID-19, Corona Virus Infection, Coronavirus Infection
- Trial name
- NCT04459702
- Testing
- hydroxychloroquine, Azithromycin, Ritonavir
- Where
- United States
- Sponsor
- ProgenaBiome
Comorbidities, Critical Care
Method of Measuring Comorbidity to Predict Outcome After Intensive Care
In this study the investigators will validate the impact of comorbidity on readmission to intensive care unit (ICU) and mortality after ICU and which method of measuring comorbidity that is most predictive.
- Trial name
- AA (NCT04109001)
- Volunteers
- 223,495 people
- Sponsor
- Uppsala University
COVID-19, SARS-CoV-2
Nigella Sativa in COVID-19
Natural products with immunomodulation and antiviral activity showed a promising improvement in the outcomes of some viral infectious diseases both in preclinical and primitive clinical studies.
- Trial name
- NCT04401202
- Testing
- Nigella sativa oil
- Where
- Saudi Arabia
- Volunteers
- 183 people
- Sponsor
- King Abdulaziz University
Pleural Effusion
Modified Thoracoscopic Pleural Cryobiopsy in Diagnosis of Exudative Pleural Effusion
Background: Rigid thoracoscopy is the gold standard tool for diagnosing exudative pleural effusion but sometimes it is difficult to obtain sufficient biopsies using the conventional forceps.
- Trial name
- NCT04683419
- Testing
- Modified Thoracoscopic pleural Cryobiopsy
- Where
- Egypt
- Volunteers
- 24 people
- Sponsor
- Alexandria University
Nausea and Vomiting, Chemotherapy-Induced
A Study of the Drug Casopitant for the Prevention of Nausea Caused By Cisplatin-Based Highly Emetogenic Chemotherapy
This is a Phase III trial designed to demonstrate that casopitant when added to dexamethasone and ondansetron is more effective in the prevention of vomiting then dexamethasone and ondansetron alone, in patients who receive a…
- Trial name
- NCT00431236
- Testing
- Oral Casopitant (GW679769), IV Casopitant (GW679769), IV ondansetron hydrochloride
- Where
- 80 sites in Argentina, Belgium and 20 more
- Volunteers
- 810 people
- Sponsor
- GlaxoSmithKline
Neurodegeneration With Brain Iron Accumulation (NBIA)
Testing of NBIA Genes: Analysis of Genetic Heterogeneity and Validation of Mitochondrial Markers for Assessing Causality of Sequence Variants.
Neurodegeneration with brain iron accumulation (NBIA) represent a group of rare neurodevelopmental diseases, genetically as well as phenotypically heterogeneous. The diagnosis is based on brain MRI.
- Trial name
- NBIA MITO (NCT05615571)
- Testing
- Establishment of mitochondrial markers, Sequencing tests
- Where
- France
- Volunteers
- 70 people
- Sponsor
- University Hospital, Bordeaux
External Causes of Morbidity and Mortality, Stillbirth
Linking Facility-based Mortality Audits With Community Engagement in Gilgit-Baltistan, Pakistan
Pakistan is one of the countries in South Asia where neonatal mortality rates remain stagnant. Babies born in Pakistan encounter the highest risk of dying; of every 1,000 babies born, 46 die before the end of their first month…
- Conditions
- External Causes of Morbidity and Mortality, Stillbirth, Neonatal Death
- Trial name
- NCT03904706
- Testing
- Audits only, Audits with community feedback
- Where
- Pakistan
- Volunteers
- 1,871 people, healthy volunteers welcome
- Sponsor
- Aga Khan University
Secondary Raynaud's Phenomenon
Safety and Efficacy Study of Gene Therapy Drug (Neovasculgen) to Treat Secondary Raynaud's Phenomenon
The purpose of this study is to determine whether pl-vegf165 (Neovasculgen) is effective in the treatment of digital ulcers related to secondary Raynaud's phenomenon associated with systemic scleroderma
- Trial name
- NCT02356809
- Testing
- Neovasculgen
- Where
- Russia
- Volunteers
- 30 people
- Sponsor
- Artgen Biotech
Amyotrophic Lateral Sclerosis, ALS
Exposure to Neurotoxins as Risk Factors for Amyotrophic Lateral Sclerosis
This study is a follow-up to an earlier study that examined the relationship of This study will examine whether exposure to neurotoxins, such as lead, mercury, solvents, and pesticides, can contribute to amyotrophic lateral…
- Trial name
- NCT00339976
- Where
- United States
- Sponsor
- National Institute of Environmental Health Sciences (NIEHS)
Coronary Heart Disease, Heart Valve Diseases
Does Coronary Angiography Cause Cognitive Dysfunction?
The purpose of the study is to study if coronary angiography cause cognitive dysfunction.
- Trial name
- NCT01428947
- Testing
- Arterial approach
- Where
- Sweden
- Volunteers
- 80 people
- Sponsor
- Karolinska Institutet
Acute Limb Ischemia, Anticoagulants
Changes in the Etiology of Acute Limb Ischemia in the DOAK Era
This study therefore investigates whether the proportion of embolic acute limb ischemia in patients with atrial fibrillation changed significantly between the pre DOAK era (2006-2010) and the DOAK era (2012-2018) at a university…
- Trial name
- ALI-DOAK (NCT07888985)
- Volunteers
- 400 people
- Sponsor
- University Hospital Augsburg
Multiple Myeloma, Hodgkin Disease
Managing Pain and Symptom Burden Caused by Chemotherapy in People With Myeloma or Lymphoma
The purpose of this study is to find out whether acupuncture treatments can reduce the need for opioid medication when managing pain caused by chemotherapy.
- Conditions
- Multiple Myeloma, Hodgkin Disease, Non-Hodgkin Lymphoma
- Trial name
- NCT04459416
- Testing
- Acupuncture, opioid, Assessments
- Where
- 2 sites in United States
- Volunteers
- 299 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Obesity
The Netherlands Epidemiology of Obesity Study
The Netherlands Epidemiology of Obesity (NEO) study is a population-based cohort study in 6671 men and women aged 45 to 65 years, with an oversampling of individuals with a BMI of 27 kg/m2 or higher.
- Trial name
- NEO (NCT03410316)
- Testing
- No intervention
- Volunteers
- 6,671 people, healthy volunteers welcome
- Sponsor
- Leiden University Medical Center
Alzheimer Disease, Dementia; Alzheimer's Type (Etiology)
Effects of Strength Exercise on Fall Risk in Elderly With Alzheimer's Disease
Interventional study to show the effects of strength exercise on fall risk in elderly with Alzheimer's disease
- Conditions
- Alzheimer Disease, Dementia; Alzheimer's Type (Etiology), Fall Risk, Elderly
- Trial name
- NCT04981587
- Testing
- Strength exercise, Usual treatment
- Where
- 2 sites in Spain
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- University of Jaén
Colon Cancer
Intracorporeal Anastomosis in Laparoscopic Left Colectomy. Cohort Comparative Study
OBJECTIVE: The aim of the study is to demonstrate that the intracorporeal resection and anastomosis in left-sided colon cancer, sigma and upper rectum, is not inferior to extracoprporeal resection and anastomosis, in terms of…
- Trial name
- RIAL-COLECTOMY (NCT04456933)
- Testing
- Extracorporeal left hemicolectomy anastomosis, Intracorporeal left hemicolectomy anastomosis
- Where
- Spain
- Volunteers
- 148 people
- Sponsor
- Corporacion Parc Tauli
Painful Osteoarthritis of the Knee
Radiofrequency Ablation of Genicular Nerves for Advanced Osteoarthrosis of the Knee Joint 1 Year Follow-up.
Pharmacological treatment of pain due to osteoarthritis of the knee often proves to be inadequate and/or cause intolerable side effects.
- Trial name
- NCT02688543
- Testing
- RF treatment, radiofrequency ablation, ultrasound
- Where
- Spain
- Volunteers
- 25 people
- Sponsor
- Hospital General de Jerez de la Frontera
Foramen Ovale Patent
Correlation of Right-left Shunt Detection in Cardioembolism Etiology in Stroke Patient.
The aim of the study is to compare correlation for right to left shunts (mainly patent foramen ovale) detection for three methods-transesophageal echo as a gold standard, transcranial doppler with contrast agent (microbubbles)…
- Trial name
- NCT02351076
- Where
- Czechia
- Volunteers
- 44 people
- Sponsor
- University Hospital Ostrava
Colorectal Neoplasms
Intestinal Microecological Dysregulation Caused by Appendectomy Increases the Risk of Colorectal Cancer
As a good niche for bacterial growth, appendix plays a very important role in maintaining and protecting intestinal symbiotic flora. Appendectomy will lead to intestinal microecological disorders.
- Trial name
- IMDCBAITROCC (NCT05066048)
- Where
- China
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
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