Clinical trials: Age Related Cognitive Decline
Alzheimer Disease, Dementia
TAS Test: Online Motor-cognitive Tests for Early Detection of Alzheimer's Disease
Global dementia prevalence is rising. Alzheimer's disease (AD), the most common cause, has devastating effects on people's quality of life.
- Conditions
- Alzheimer Disease, Dementia, Age-related Cognitive Decline
- Trial name
- TASTest (NCT05194787)
- Testing
- Cognitive test scores, clinical diagnosis and blood biomarkers
- Where
- Australia
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- University of Tasmania
Apathy, Bipolar Disorder
Apathy-related Neurobehavioral Markers of Cognitive Decline in Old-age Bipolar Disorders: Proof-of-concept
The goal of this clinical trial is to identify reliable markers of apathy in elderly subjects with bipolar disorder, age between 70 and 85 years, in order to accurately identify subjects at high risk of progressing to dementia by…
- Trial name
- ANACONDA (NCT06914284)
- Testing
- Actigraphy and MRI
- Where
- France
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Hospital Center Guillaume Régnier
Age-related Memory Disorders, Mood Disorders
Omega-3 and Blueberry Supplementation in Age-Related Cognitive Decline
The aim of this study is to determine the efficacy of 6 months' dietary supplementation with omega-3 fatty acids and whole freeze dried blueberry powder in improving cognition in older adults.
- Trial name
- NCT01746303
- Testing
- Omega-3 fatty acid, Blueberry powder
- Where
- United States
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- University of Cincinnati
Age-related Cognitive Decline
Acute Effects of THC in Older Adult
The primary objective of this study is to determine if increasing age confers greater vulnerability to the acute A) cognitive (e.g., memory, attention, psychomotor function), B) subjective (e.g., anxiogenic and rewarding…
- Trial name
- THC-Aging (NCT06948136)
- Testing
- Delta-9-THC Low Dose, Delta-9-THC Medium Dose
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Yale University
Cognitive Decline, Mild
Cognition, Flavonoids, Exercise, Gut Microbiome
This NIH project will examine the effects of routine flavonoid-rich blueberry intake (12-weeks), combined with or in the absence of regular moderate exercise, on cognitive function in a clinical population of older participants…
- Trial name
- NCT06495190
- Testing
- Blueberry, Walking, Stretching
- Where
- United States
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Appalachian State University
Complications of Prematurity
Prematurity Related Risks of Cognitive Impairment at School Age
The main purpose of this study is to better evaluate prematurely born children cognitive development at school age, with regards to birth conditions but also to social situation, intra family relationships, and modalities of…
- Trial name
- NEORIS (NCT02054507)
- Testing
- Cognitive evaluation (Wechsler IV tests)
- Where
- 2 sites in France
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Jean Michel Hascoet
Age-related Hearing Loss
Prediction of Age-Related Hearing Loss Based on Comprehensive Risk Factors
This study aims to develop a predictive model for age-related hearing loss (ARHL) based on multi-source risk factors and artificial intelligence techniques.
- Trial name
- NCT07612618
- Testing
- Not applicable- observational study
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Chinese PLA General Hospital
Age Related Cognitive Decline, Alzheimer's Disease
n-3 PUFA for Vascular Cognitive Aging
Brain scans can help identify changes that appear to increase risk for cognitive decline and dementia. Some of these brain changes are thought to reflect actual damage to the small blood vessels that support normal brain…
- Conditions
- Age Related Cognitive Decline, Alzheimer's Disease, Vascular Dementia, Endothelial Dysfunction
- Trial name
- NCT01953705
- Testing
- Omega 3 PUFA
- Where
- United States
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Cognitive Decline
Study of Postoperative Cognitive Decline in Aged Patients
postoperative cognitive decline is a common and deleterious complication in aged patients.The link between inflammation and postoperative cognitive decline has also been reported.However,the link between SOD1，SOD2，Osteopontin，…
- Trial name
- NCT03765840
- Where
- China
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Jia-feng Wang
Aging, Cognitive Change
Cardiorespiratory Fitness, Apolipoprotein E Genotype, and Cognitive Functions: A Prospective Study
The current research project aims to investigate the interaction of cardiorespiratory fitness (CRF) and the ApoE genotype with neurocognitive functions.
- Trial name
- NCT05652140
- Testing
- Data collections
- Where
- Taiwan
- Volunteers
- 159 people, healthy volunteers welcome
- Sponsor
- National Taiwan Normal University
Dementia of the Alzheimer Type, Age-related Cognitive Decline
Dosage and Efficacy of Probucol-induced apoE to Negate Cognitive Deterioration
DEPEND is an open-label but dosage-masked trial of the retired cholesterol-lowering drug probucol as an agent to increase availability of apolipoprotein E (apoE) in the cerebrospinal fluid (CSF) of cognitively intact older…
- Conditions
- Dementia of the Alzheimer Type, Age-related Cognitive Decline, Mild Cognitive Impairment Due to Alzheimer Disease
- Trial name
- DEPEND (NCT02707458)
- Testing
- Probucol
- Where
- Canada
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Douglas Mental Health University Institute
Cognitive Decline, Healthy
The Effects of Attentional Filter Training on Working Memory
The investigators are interested in how attentional filter training/ distractor inhibition training could influence cognitive functions like working memory, executive control, problem solving, decision making and attentional…
- Conditions
- Cognitive Decline, Healthy, Age-related Cognitive Decline
- Trial name
- DIIN (NCT03228446)
- Testing
- filter training, memory training, no training (control)
- Where
- Germany
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- German Center for Neurodegenerative Diseases (DZNE)
Frailty, Age-Related Macular Degeneration
Visual Frailty in Ageing
The goal of this observational study is to define visual frailty and refine monitoring for an ageing population. It involves piloting a visual frailty assessment tool in a cohort of patients aged 60 and above with a known…
- Conditions
- Frailty, Age-Related Macular Degeneration, Functional Status, Mental Health
- Trial name
- VFiA (NCT06604104)
- Where
- 2 sites in United Kingdom
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
Aging, Age-related Cognitive Decline
Acute Raspberry Intake on Metabolic Control and Cognitive Function
The purpose of this project is to determine whether restoring the post-prandial metabolic/inflammatory balance via supplementation with raspberries results in improved cognitive performance, and if these enhancements are mediated…
- Conditions
- Aging, Age-related Cognitive Decline, Obesity
- Trial name
- NCT03743792
- Testing
- Active breakfast, Control breakfast
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- USDA Human Nutrition Research Center on Aging
Age-Related Loss of Skeletal Muscle Mass, Aging
Agility Training for Older Adults to Improve Fall Risk Factors
In this randomized controlled trial the effect of 4 months of multi-component (strength, balance, cognition, endurance) exercise training intervention on measures of neuromuscular performance, cognition, and endurance as well as…
- Conditions
- Age-Related Loss of Skeletal Muscle Mass, Aging, Sarcopenia, Cognitive Decline
- Trial name
- AgilE (NCT05727254)
- Testing
- Agility training, Exercise recommendations, Exercise diary
- Where
- Switzerland
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Oliver Faude
Alzheimer's Disease, Mild Cognitive Impairment
Effectiveness of a Brain-Computer Interface Based System for Cognitive Enhancement in the Normal Elderly
The primary objective is to examine the efficacy of 8-weeks of a locally developed brain-computer interface based system (BrainpalTM)intervention for improving attention and memory in normal elderly.
- Conditions
- Alzheimer's Disease, Mild Cognitive Impairment, Age-Related Cognitive Decline, Dementia
- Trial name
- 3ECog (NCT01661894)
- Testing
- BrainPalTM
- Where
- Singapore
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- Duke-NUS Graduate Medical School
Age Related Macular Degeneration, Mild Cognitive Impairment (MCI)
Association Between Age-related Macular Degeneration and Cognitive Impairment Based on Exosome Proteomics
Aim: Preliminary serum exosomal proteomics of patients with dry age-related macular degeneration (AMD) and mild cognitive impairment (MCI) were analyzed using proteomics technology.
- Conditions
- Age Related Macular Degeneration, Mild Cognitive Impairment (MCI), Alzheimer's Disease (AD)
- Trial name
- NCT06883461
- Where
- China
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Shanghai 10th People's Hospital
Atherosclerosis, Vascular Disease
The Effect of Folic Acid on Atherosclerosis, Cognitive Performance and Hearing
The purpose of this study is to determine if folic acid supplementation can slow down atherosclerotic progression, age-related cognitive decline and age-related hearing loss.
- Conditions
- Atherosclerosis, Vascular Disease, Cognitive Decline, Hearing Loss
- Trial name
- NCT00110604
- Testing
- folic acid (0.8 mg)
- Where
- Netherlands
- Volunteers
- 835 people, healthy volunteers welcome
- Sponsor
- Wageningen University
Cognition, Mood
Prevention of the Age-Related Cognitive Impairment by Exercise and Mental Activity - Berlin Bleibt Fit
The trial will evaluate the effects of frequent exercise and increased mental activity on the age-related impairment of cognitive function in elderly women.
- Trial name
- BBF (NCT00629174)
- Testing
- Exercise, Mental activity
- Where
- 2 sites in Germany
- Volunteers
- 252 people, healthy volunteers welcome
- Sponsor
- Charite University, Berlin, Germany
Impaired Cognition, Geriatric Disorder
The Efficacy of Using Volunteers to Implement a Cognitive Stimulation Program in Two Long-Term Care Homes
Many volunteers visiting seniors make socially-based "friendly visits". This study investigated the efficacy of volunteers making visits focused on stimulating cognition.
- Conditions
- Impaired Cognition, Geriatric Disorder, Learning Disorders, Age-Related Memory Disorders
- Trial name
- VolCogStim (NCT01818778)
- Testing
- Cognitive stimulation program, Standard Friendly Visit
- Where
- Canada
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Queen's University