Clinical trials: Aging and Cognitive Health
Aging, Longevity
Psilocybin Effects on Healthy Aging Biomarkers and Purpose in Life
The LONG-LIFE study is a randomized Phase I, dose-ranging trial designed to evaluate whether psilocybin impacts aging-related biomarkers, cognitive function, and purpose/meaning in life in medically stable older adults.
- Conditions
- Aging, Longevity, Biomarkers of Aging
- Trial name
- LONG-LIFE (NCT07719088)
- Testing
- Psilocybin (Usona Institute)
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Charles Raison
Aging, Alzheimer Disease
Exercise to Improve Brain Health in Older African Americans
The goal of this clinical trial is to test the effects of different types of exercise on brain health and Alzheimer's risk in older African Americans.
- Conditions
- Aging, Alzheimer Disease, Healthy Aging, Cognitive Change
- Trial name
- NCT05597124
- Testing
- Cardio-Dance Fitness, Strength, Flexibility & Balance
- Where
- United States
- Volunteers
- 280 people, healthy volunteers welcome
- Sponsor
- Rutgers, The State University of New Jersey
Cognitive Health, Healthy Aging
Successful Aging and Enrichment (SAGE)
Progress has been made in understanding the impact of different kinds of structured intervention programs in improving cognitive processing and performance in older adults, and in determining whether there is electrophysiological…
- Trial name
- SAGE (NCT05128396)
- Testing
- Cognitive Stimulation, Mindfulness training, Physical Activity
- Where
- United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Healthy Aging, Middle-aged and Older Adults
Peanut Butter and Brain Health
Healthy foods, including peanuts, may improve brain function, which is essential for cognitive and metabolic health, and may contribute to improved food intake regulation.
- Trial name
- NCT07774546
- Testing
- Peanut butter
- Where
- Netherlands
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Penn State University
Aging, Cognitive Decline
Blood Flow Restriction and High-intense Resistance Training in Aging: Interactions Between Neuroplasticity and Muscle
BRAIN-M is a randomized controlled trial designed to examine the effects of a single bout or 12 weeks of blood-flow restriction training or high-intensity resistance training on cognitive function, brain health, muscular…
- Conditions
- Aging, Cognitive Decline, Sarcopenia, Frailty
- Trial name
- BRAIN-M (NCT05744167)
- Testing
- BFRT, MDRT
- Where
- Lithuania
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Lithuanian Sports University
Aging, Cognitive Function 1, Social
Effects of Physical and Cognitive Training in Neuroplasticity, Health and Cognition. Movement Project
The MoveMent project applies non-pharmacological strategies - physical exercise and cognitive training - that have been shown to be effective in promoting active and healthy aging.
- Trial name
- NCT03123900
- Testing
- Physical exercise, Cognitive training, Combined training
- Where
- Spain
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- University of Barcelona
Aging, Mortality
Longevity Metrics AI/ML Development Study
This study builds AI models that score diagnostic screening tests, and that predict screening results, clinical judgment, and life expectancy.
- Conditions
- Aging, Mortality, Cardiovascular Disease Prevention, Metabolic Syndrome
- Trial name
- NCT07808619
- Testing
- AIML scored health screening battery
- Where
- United States
- Volunteers
- 1,000,000 people, healthy volunteers welcome
- Sponsor
- Longevity Metrics, Inc.
Aging, Cognitive Decline
Aging and Cognitive Health Evaluation in Elders (ACHIEVE)
The ACHIEVE study will be a randomized controlled trial nested within the infrastructure of the Atherosclerosis Risk in Communities (ARIC) study.
- Trial name
- ACHIEVE (NCT03243422)
- Testing
- Successful aging health education intervention, Hearing intervention
- Where
- 4 sites in United States
- Volunteers
- 977 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Cognitive Dysfunction, Alzheimer Disease
ALA-enriched Nutrition for Prevention of Cognitive Decline in APOE4 Older Adults
This randomized, double-blind, placebo-controlled pilot trial will evaluate the effects of alpha-linolenic acid (ALA) supplementation on cognitive function, blood-brain barrier integrity, and brain vascular health in older adults…
- Conditions
- Cognitive Dysfunction, Alzheimer Disease, Blood-Brain Barrier, Apolipoprotein E, Deficiency or Defect of
- Trial name
- NCT07392723
- Testing
- Alpha-Linolenic Acid (2.6 g/day)
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Michal Schnaider Beeri, Ph.D.
Adherence, Treatment
Smart Reminders to Promote Home-based Cognitive Training
This study will examine whether among older adults an adaptive and personalized reminder system can better support adherence to home-based cognitive training over typical reminder systems.
- Trial name
- NCT05016856
- Testing
- Adherence Promotion With Person-centered Technology (APPT) System, Standard Reminder System (Active Control)
- Where
- United States
- Volunteers
- 199 people, healthy volunteers welcome
- Sponsor
- Florida State University
Autophagy, Healthy Aging
Effects of Miricell Supplementation on Biomarkers of Healthy Aging and Autophagy
The goal of this clinical trial is to learn if a dietary supplement called Miricell works to improve cellular health and signs of healthy aging in adults. It will also learn about the safety of Miricell.
- Trial name
- NCT07675200
- Testing
- Spermidine
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Nutraland USA, Inc.
Aging
Feasibility and Efficacy of A Remote Tai Chi Program in Older Adults
This project is designed to explore the feasibility and preliminary efficacy of a remote Tai Chi program on older adults' 24-hour movement behaviors (i.e., physical activity, sedentary behavior and sleep patterns).
- Trial name
- NCT06918678
- Testing
- Tai Chi intervention, Usual care condiition
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- The University of Tennessee, Knoxville
Patient Compliance
Cognitive Regulation Training and Exercise
The purpose of this study is to compare CORTEX (Cognitive Regulation Training and Exercise), a multi-faceted, general and exercise-specific cognitive training program plus a 4-month exercise program, to an attention-control…
- Trial name
- CORTEX (NCT01837004)
- Testing
- CORTEX
- Where
- United States
- Volunteers
- 133 people, healthy volunteers welcome
- Sponsor
- University of Illinois at Urbana-Champaign
Mild Cognitive Impairment (MCI), Healthy Aging
cMIND AI Web Tool Usability Study (Hong Kong)
This study is testing a new web-based tool that uses artificial intelligence (AI) to help older adults in Hong Kong check how healthy their Cantonese-style meals are for brain health.
- Conditions
- Mild Cognitive Impairment (MCI), Healthy Aging, Nutrition
- Trial name
- NCT07735013
- Testing
- Web-Based AI Dietary Assessment System
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Hong Kong Metropolitan University
Alzheimer's Disease, Plaque, Amyloid
Cognitive Health in Ageing Register: Investigational, Observational and Trial Studies in Dementia Research: Prospective Readiness Cohort Study
The purpose of this study is to prospectively investigate the longitudinal change of the components of the Preclinical Alzheimer Cognitive Composite (PACC) and the components (index scores) of the Repeatable Battery for the…
- Trial name
- CHARIOT:PRO (NCT02114372)
- Where
- 2 sites in United Kingdom
- Volunteers
- 1,136 people, healthy volunteers welcome
- Sponsor
- Janssen Research & Development, LLC
Aging, Chronic Disease
Active Ageing and Health
Background: 36% of the Italian population will have more than 65 years in 2050. The European Union has indicated among its priorities to increase research on active aging.
- Conditions
- Aging, Chronic Disease, Cognitive Decline, Quality of Life
- Trial name
- NCT03858114
- Testing
- Mild-to-moderate physical activity, Cultural group program
- Where
- 3 sites in Italy
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- University of Cagliari
Aging
The Impact of Piano Training on Cognitive Performance and Psychosocial Well-Being in Older Adults
This project evaluates the effects of piano training and computerized cognitive training on cognitive performance in healthy older adults compared to controls.
- Trial name
- NCT02564601
- Testing
- Piano Training, Computer Cognitive Training
- Where
- United States
- Volunteers
- 93 people, healthy volunteers welcome
- Sponsor
- University of South Florida
Mild Cognitive Impairment (MCI), Dementia
Exploring the Impact of Dementia Prevention Programs Using Robots as Intervention Tools on Community Elderly
The purpose of this study is to intervene in the cognitive functions of the community elderly through the "Robot Dementia Prevention Course" training.
- Conditions
- Mild Cognitive Impairment (MCI), Dementia, Cognitive Decline, Psychological Well-being
- Trial name
- NCT06984458
- Testing
- Robot Dementia Prevention Course
- Where
- Taiwan
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- National Taiwan Normal University
Patient Compliance
Cognitive Regulation Training and Exercise Trial
The purpose of this double-blinded, randomized controlled study is to compare CORTEX (Cognitive Regulation Training and Exercise), a multi-faceted, center- and home-delivered- general and exercise-specific-active and traditional…
- Trial name
- CORTEX-II (NCT03124667)
- Testing
- Games, Videos
- Where
- United States
- Volunteers
- 233 people, healthy volunteers welcome
- Sponsor
- University of Illinois at Urbana-Champaign
Memory Impairment, Age-related Cognitive Decline
Development of an Innovative Health Ingredient From Marine By-products for the Healthy Aging
This interventional, randomised, placebo-controlled and double-blind study aims to evaluate the effect of a dietary supplementation with a blue fish hydrolysate derived from marine by-products, containing peptides and n-3…
- Trial name
- BRAINBOOSTER (NCT04910399)
- Testing
- Blue fish hydrolysate
- Where
- 2 sites in France
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- Abyss Ingredients