Clinical trials: Aphasia
Stroke, Aphasia
Choir Singing in Aphasia Rehabilitation
This study evaluates the verbal, cognitive, emotional, and neural efficacy of a choir singing intervention in chronic aphasic patients and their caregivers.
- Trial name
- NCT03501797
- Testing
- Singing-based rehabilitation, Standard care
- Where
- 2 sites in Finland
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Helsinki
Aphasia, Nonfluent Aphasia
Neural Networks and Language Recovery in Aphasia From Stroke: fMRI Studies
The purpose of this research is to utilize functional magnetic resonance imaging (fMRI) to investigate brain reorganization for language behavior in stroke patients with aphasia.
- Conditions
- Aphasia, Nonfluent Aphasia, Stroke
- Trial name
- NCT00467103
- Where
- United States
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Aphasia
Picture Naming in the Context of Image Type and Response Variety in People With and Without Aphasia
The observational study aims to investigate the effect of two factors that influence the ease with which aphasic and healthy participants name visual stimuli.
- Trial name
- NCT05164380
- Testing
- Picture naming tasks
- Where
- 20 sites in Switzerland
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Simone Hemm-Ode
Aging, Aphasia
Exercise Effects on Word Learning
The aging Veteran population will substantially increase over the next 10 years, as the 24.9% of Veterans who are currently between 55-64 years of age join the 38.5% who are already over age 65.
- Trial name
- NCT03370471
- Testing
- Retrieval Practice + Moderate Intensity Exercise, Retrieval Practice + Gentle Stretching, Study Only + Moderate Intensity Exercise
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
FTLD, Progressive Supranuclear Palsy (PSP)
Advancing Research and Treatment for Frontotemporal Lobar Degeneration (ARTFL)
Frontotemporal Lobar Degeneration (FTLD) is the neuropathological term for a collection of rare neurodegenerative diseases that correspond to four main overlapping clinical syndromes: frontotemporal dementia (FTD), primary…
- Conditions
- FTLD, Progressive Supranuclear Palsy (PSP), Frontotemporal Dementia (FTD), Corticobasal Degeneration (CBD)
- Trial name
- ARTFL (NCT02365922)
- Where
- 17 sites in United States, Canada
- Volunteers
- 1,489 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Dysphasia
Use of Local Intraoperative Steroid in MIS TLIF
The purpose of this study is to determine if the frequency and duration of postoperative pain are improved in participants receiving a local steroid injection (methylprednisolone) plus a systemic (intravenous (IV, by vein))…
- Trial name
- NCT03308084
- Testing
- Methylprednisolone, Dexamethasone
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Rush University Medical Center
Aphasia, Primary Progressive, Repetitive Transcranical Magnetic Stimulation
rTMS for the Treatment of Primary Progressive Aphasia: A Randomized Controlled Trial
The primary progressive aphasia (PPA) is a neurodegenerative condition characterized by a gradual, irreversible decline of language function (Mesulam, 2001). There are no known treatments for PPA so far.
- Trial name
- NCT03448133
- Testing
- Magstim rTMS
- Volunteers
- healthy volunteers welcome
- Sponsor
- Peking Union Medical College Hospital
Language Disorders, Aphasia
The Effect of Non-invasive Brian Stimulation on Language Production in Healthy Older Adults
The use of non-invasive brain stimulation techniques like transcranial direct-current stimulation (tDCS) for rehabilitation of language is a growing field that needs further studies to determine how best it can be used to enhance…
- Conditions
- Language Disorders, Aphasia, Stroke
- Trial name
- NCT04260815
- Testing
- Transcranial direct-current stimulation (tDCS)
- Where
- United Kingdom
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- King's College London
Aphasia, Stroke
Adapted Solution Focused Therapy for People With Aphasia (SOFIA Trial)
Around one third of stroke survivors will have aphasia, which means they will have difficulty talking, understanding, reading or writing.
- Trial name
- SOFIA (NCT03245060)
- Testing
- Adapted Solution Focused Brief Therapy
- Where
- United Kingdom
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- City, University of London
Communication Disorder, Healthy
Central Mechanisms in Speech Motor Control Studied With H215O PET
Positron Emission Tomography (PET) is a technique used to investigate the functional activity of the brain. The PET technique allows doctors to study the normal biochemical and metabolic processes of the central nervous system of…
- Conditions
- Communication Disorder, Healthy, Stuttering, Tourette Syndrome
- Trial name
- NCT00001308
- Where
- United States
- Volunteers
- 1,163 people, healthy volunteers welcome
- Sponsor
- National Institute on Deafness and Other Communication Disorders (NIDCD)
Subcortical Aphasia, Ischemic Stroke
Language Functional Reorganization in Subcortical Infarction Patients
Post stroke aphasia (PSA) is one of the most frequently happened deficiency of stoke, affecting speaking,comprehension, writing and reading of language.
- Trial name
- NCT03668132
- Testing
- ischemic brain damage
- Where
- China
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Guangzhou General Hospital of Guangzhou Military Command
Aphasia
The Usage of High-resolution Magnetic Resonance Imaging in Patients With Post-stroke Aphasia for Predicting the Outcome
Combined analysis of functional and structural language network changes may be a good model for predicting language outcome.
- Trial name
- NCT03475745
- Where
- China
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital of Zhejiang University
Aphasia Primary Progressive
Characterisation of Primary Progressives Aphasias
Primary progressive aphasias (PPA) represent a challenging group of degenerative language diseases that has led to growing interest in the scientific and medical community.
- Trial name
- CAPP (NCT02297035)
- Testing
- Behavioural testing, Brain imaging, Genetic screening
- Where
- France
- Volunteers
- 155 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
To Healthy Volunteer, Virtual Lesions for Aphasia
Effects of Navigated Repetitive Transcranial Magnetic Stimulation According to Post-stroke Aphasia Types
Repetitive transcranial magnetic stimulation induced virtual lesions for aphasia.
- Trial name
- NCT01877161
- Testing
- Repetitive magnetic stimulation to superior temporal gyrus, Repetitive magnetic stimulation to middle temporal gyrus
- Where
- South Korea
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Seoul National University Bundang Hospital
Aphasia, Language
Phonological Treatment Paired With Intensive Speech Therapy Promotes Reading Recovery in Chronic Aphasia
Participants will receive either intensive phonology or semantic feature analysis treatment for 16 weeks to improve naming, reading, and writing in individuals with chronic post-stroke aphasia.
- Trial name
- NCT02799017
- Testing
- Intensive Phonology Treatment, Intensive SFA Treatment
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Austin Speech Labs
Aphasia, Language
tDCS as an Adjuvant to Intensive Speech Therapy for Chronic Post Stroke Aphasia
The purpose of this study is to determine if transcranial direct current stimulation (tDCS) in conjunction with intensive speech therapy will improve sentence production and word retrieval in individuals with chronic post stroke…
- Trial name
- NCT02801864
- Testing
- Real tDCS, Intensive Speech Therapy
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Austin Speech Labs
Aphasia
Intensive Interdisciplinary Treatment Program for Individuals With Stroke-Induced Aphasia
An intensive, interdisciplinary treatment program was administered during the summer as part of regular clinic services in the Aphasia Resource Center (ARC) at Sargent College.
- Trial name
- NCT03096015
- Testing
- Intensive Comprehensive Aphasia Program
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Boston University Charles River Campus
Dyslexia, Dysphasia
Developmental Language Difficulties: Behavioural and Electrophysiological Studies
This study will help to better characterize oral and written language disorders and determine if these disorders are continuous or not.
- Trial name
- LANGAGE (NCT02872870)
- Testing
- auditory lexical decision task, electroencephalogram
- Where
- 3 sites in Belgium, France
- Volunteers
- 196 people, healthy volunteers welcome
- Sponsor
- Lille Catholic University
Apraxia of Speech, Aphasia
Auditory Masking Effects on Speech Fluency in Aphasia and Apraxia of Speech
Impaired speech production is a major obstacle to full participation in life roles by stroke survivors with aphasia and apraxia of speech.
- Conditions
- Apraxia of Speech, Aphasia, Cerebrovascular Accident
- Trial name
- NCT02094014
- Testing
- Normal Auditory Feedback, Masked Auditory Feedback, Altered Auditory Feedback
- Where
- United States
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Aphasia
Effect of Verb Network Strengthening Treatment (VNeST) on Lexical Retrieval in Aphasia
The purpose of this study is to evaluate the effect of Verb Network Strengthening Treatment (VNeST) on the ability to produce sentences and connected speech in persons with aphasia.
- Trial name
- VNeST (NCT01300624)
- Testing
- Verb Network Strengthening Treatment
- Where
- United States
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- US Department of Veterans Affairs