Clinical trials: Articular Cartilage Defect
Defect of Articular Cartilage
HyaloFAST Trial for Repair of Articular Cartilage in the Knee
The purpose of this study is to evaluate the safety and efficacy of Hyalofast® scaffold with bone marrow aspirate concentrate (BMAC) compared to microfracture in the treatment of symptomatic cartilage defects of the knee.
- Trial name
- FastTRACK (NCT02659215)
- Testing
- Hyalofast, Microfracture
- Where
- 48 sites in United States, Austria and 7 more
- Volunteers
- 200 people
- Sponsor
- Anika Therapeutics, Inc.
Osteoarthritis, Hip, Femoroacetabular Impingement
Early Feasibility Study of Cartilage Defect Repair
Any patient aged 14 or older up to 64 years of age with hip disease, resulting in loss of articular cartilage integrity on the femoral head (e.g., femoroacetabular impingement or other structural deformity), has failed…
- Conditions
- Osteoarthritis, Hip, Femoroacetabular Impingement, Osteonecrosis, Legg-Calvé-Perthes Disease
- Trial name
- NCT06823089
- Testing
- ReNew Hip Implant
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Cytex Therapeutics, Inc.
Osteochondral Lesion of Talus, Chondral Defect
AMIC vs. MFx in the Ankle
This clinical investigation is a prospective, double blind, single-centre, randomised controlled trial comparing arthroscopic autologous matrix induced chondrogenesis (AMIC®) to microfracture alone in the treatment of…
- Conditions
- Osteochondral Lesion of Talus, Chondral Defect, Microfracture
- Trial name
- AMARTA (NCT05741983)
- Testing
- Microfracture (MFx), Chondro-Gide®
- Where
- United Kingdom
- Sponsor
- Geistlich Pharma AG
Hip Arthroscopy, Articular Cartilage Defect
AMIC Compared With Microfracture for Focal Articular Cartilage Damage of the Hip
This is a pilot multi-centre RCT of 40 patients (ages 18-55 years, inclusive) undergoing primary hip arthroscopy with a focal articular cartilage defect of the acetabulum to compare the effect of using autologous matrix-induced…
- Conditions
- Hip Arthroscopy, Articular Cartilage Defect, Microfractures
- Trial name
- REPAIR (NCT05402072)
- Testing
- Autologous matrix-induced chondrogenesis (AMIC)
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- McMaster University
Knee Injuries, Cartilage Injury
Biomaterials and Mesenchymal Stem/Stromal Cells in the Treatment of Knee Articular Surface Lesions
The goal of this observational study is to evaluate the combined single-step approach with biomaterials and mesenchymal stem/stromal cells in the treatment of knee articular surface lesions.
- Conditions
- Knee Injuries, Cartilage Injury, Osteochondral Defect
- Trial name
- NCT06078072
- Testing
- Biomaterials augmented with mesenchymal stem/stromal cells
- Where
- Slovenia
- Volunteers
- 90 people
- Sponsor
- University Medical Centre Ljubljana
Acetabular Labrum Tear, Femoro Acetabular Impingement
Use of BMAC With Hip Arthroscopy Treatment of FAI and Labral Tear
Femoro-acetabular impingement is a well known cause of damage to the acetabular labrum and chondrolabral junction. Additionally, it has been proposed that disruption of hip biomechanics resulting from a labral tear causes a…
- Conditions
- Acetabular Labrum Tear, Femoro Acetabular Impingement, Chondral Defect, Bone Marrow Aspirate Concentrate
- Trial name
- NCT03909139
- Testing
- BMAC
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- Massachusetts General Hospital
Acetabular Labrum Tear, Femoro Acetabular Impingement
Effect of PRP, PPP, & BMAC on Functional Outcomes Following Hip Arthroscopy for Acetabular Labral Pathologies
The goal of this clinical trial is to assess the effect of PRP/PPP/BMAC application on functional outcomes after hip arthroscopy to address acetabular labral pathologies. The main questions it aims to answer are: 1.
- Conditions
- Acetabular Labrum Tear, Femoro Acetabular Impingement, Chondral Defect, Bone Marrow Aspirate Concentrate
- Trial name
- PRP; PPP; BMAC (NCT06003101)
- Testing
- Bone marrow aspirate concentrate (BMAC), Control
- Where
- United States
- Volunteers
- 160 people
- Sponsor
- Massachusetts General Hospital
Defect of Articular Cartilage
Mesenchymal Stem Cells in a Clinical Trial to Heal Articular Cartilage Defects
The purpose of this study is to: Compare the treatment efficacy of autologous mesenchymal stem cells (Mesenchymal Stem Cells) versus chondrocytes implanted in a commercial available scaffold in a human clinical trial.
- Trial name
- NCT00885729
- Testing
- stem cells, Chondrocytes, Rehabilitation program
- Where
- Norway
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University Hospital, Akershus
Defect of Articular Cartilage, Osteochondral Lesion of Talus
DeNovo NT Ankle LDC Study
The purpose of this post-market clinical study is to collect long-term outcomes for DeNovo NT Graft treatment of articular cartilage lesions in the ankle in a standard clinical setting.
- Conditions
- Defect of Articular Cartilage, Osteochondral Lesion of Talus, Osteochondritis Dissecans
- Trial name
- NCT01347892
- Testing
- DeNovo NT Natural Tissue Graft
- Where
- 8 sites in United States
- Volunteers
- 205 people
- Sponsor
- Zimmer Orthobiologics, Inc.
Cartilage Injury, Defect of Articular Cartilage
BioPoly RS Knee Registry Study for Cartilage Defect Replacement
Information will be collected on the pre-op and post-op clinical status of patients with focal cartilage defects of the femoral condyles treated with the BioPoly RS Partial Resurfacing Knee Implant, a permanent orthopaedic…
- Conditions
- Cartilage Injury, Defect of Articular Cartilage, Cartilage Damage
- Trial name
- NCT01473199
- Testing
- BioPoly RS Partial Resurfacing Knee Implant
- Where
- 5 sites in United Kingdom
- Volunteers
- 38 people
- Sponsor
- BioPoly LLC
Chondral Defect, Osteochondral Defect
EB-OC for the Treatment of Focal Chondral/Osteochondral Defects in the Knee
EB-OC is a tissue engineered osteochondral tissue graft comprising of a living tissue engineered cartilage layer attaching to a bone scaffold.
- Trial name
- NCT06895889
- Testing
- EB-OC Graft Implantation, Abrasion chondroplasty
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Epibone, Inc.
Degenerative Lesion of Articular Cartilage of Knee
Observational Study on the Treatment of Knee Osteochondral Lesions of Grade III-IV
The purpose of the study is to evaluate prospectively the outcome of treatment interventions of knee osteochondral lesions Outerbridge grade III and IV.
- Trial name
- LOGIC (NCT01554878)
- Testing
- knee surgery
- Where
- 4 sites in Italy
- Volunteers
- 20 people
- Sponsor
- Ettore Sansavini Health Science Foundation
Articular Cartilage Defect
Autologous Costal Osteochondral Transplantation for Talar Osteochondral Lesions
The goal of this clinical trial is to evaluate the effectiveness and safety of autologous costal osteochondral transplantation in the treatment of Hepple Stage V talar osteochondral lesions, compared with autologous…
- Trial name
- NCT05942430
- Testing
- Autologous costal osteochondral transplantation, Autologous iliac osteoperiosteal transplantation
- Where
- China
- Volunteers
- 50 people
- Sponsor
- The Third Affiliated Hospital of Southern Medical University
Articular Cartilage Defect, Chondral Defect
Introduction of ACI for Cartilage Repair
This study was aimed to evaluate effectiveness and safety of autologous chondrocyte suspension for treatment of knee articular cartilage defects.
- Conditions
- Articular Cartilage Defect, Chondral Defect, Osteochondritis
- Trial name
- NCT04296487
- Testing
- autologous chondrocytes
- Where
- Switzerland
- Volunteers
- 218 people
- Sponsor
- Centre Hospitalier Universitaire Vaudois
Knee Chondral or Osteochondral Defect
Comparison of Autologous Chondrocyte Implantation Versus Mosaicoplasty: a Randomized Trial
Numerous surgical techniques have been developped for the treatment of chondral and osteochondral defects of the knee. Among those techniques autologous chondrocyte transplantation (ACT) was promising but have potential…
- Trial name
- Cartipatch (NCT00560664)
- Testing
- Autologous chondrocytes transplantation, Mosaicoplasty
- Where
- 12 sites in France
- Volunteers
- 58 people
- Sponsor
- University Hospital, Brest
Chondral Defect
The Biomechanical Outcomes of Autologous Chondrocyte Implantation
Injury to the knee can damage the lining of the knee's bones, called cartilage. Cartilage injuries cause pain and limit movement, making activities like walking, playing sports, and working difficult.
- Trial name
- NCT06921889
- Testing
- Autologous Chondrocyte Implantation (ACI)
- Where
- 7 sites in United Kingdom
- Volunteers
- 47 people
- Sponsor
- University of Manchester
Chondral Defect, Articular Cartilage Defect
A Study of MACI in Patients Aged 17 to 65 Years With Symptomatic Chondral or Osteochondral Defects of the Ankle
The objective of this study is to demonstrate the superiority of MACI (autologous cultured chondrocytes on porcine collagen membrane) versus Bone Marrow Stimulation in the treatment of patients aged 17 to 65 years with…
- Trial name
- MASCOT (NCT06915233)
- Testing
- autologous cultured chondrocytes on porcine collagen membrane, Bone Marrow Stimulation
- Where
- 9 sites in United States
- Volunteers
- 309 people
- Sponsor
- Vericel Corporation
Defect of Articular Cartilage
Protected Versus Early Weight Bearing Post Microfracture Surgery
To test using a randomised control trial, whether conservative rehabilitation and protected weight bearing versus early weight bearing and accelerated rehabilitation affects patient outcomes post microfracture surgery of the knee.
- Trial name
- NCT02542566
- Testing
- Physiotherapy rehabilitation
- Where
- United Kingdom
- Volunteers
- 6 people
- Sponsor
- Robert Jones and Agnes Hunt Orthopaedic and District NHS Trust
Articular Cartilage Disorder, Degeneration; Articular Cartilage
Neocartilage Implant to Treat Cartilage Lesions of the Knee
ISTO Technologies, Inc. is proposing a clinical study with 225 subjects, to establish the safety and efficacy of the Neocartilage Implant for the treatment of ICRS Grade 3 and 4 articular cartilage lesions of the knee compared to…
- Conditions
- Articular Cartilage Disorder, Degeneration; Articular Cartilage, Chronic Cartilage Injury, Acute Cartilage Injury
- Trial name
- NCT01400607
- Testing
- Neocartilage Implant/DeNovo® ET (Engineered Tissue Graft), Microfracture
- Where
- 9 sites in United States
- Volunteers
- 14 people
- Sponsor
- ISTO Technologies, Inc.
Cartilage Disease
Non-interventional Study With NOVOCART® Inject in the Reconstruction of the Knee Cartilage Defects
Retrospective non-interventional study to evaluate safety and efficacy of NOVOCART® Inject in patients with full-thickness cartilage defects in the knee joint.
- Trial name
- RENOVO (NCT02941120)
- Where
- 7 sites in Germany
- Volunteers
- 245 people
- Sponsor
- Tetec AG