Clinical trials: Atheromatosis
Peripheral Arterial Disease(PAD), Chronic Limb Threatening Ischemia
Intravascular Ultrasound for Peripheral Artery Disease Revascularization
The purpose of this study is to determine if IVUS use, as compared to angiography alone, prevent major adverse limb events (MALE) or binary restenosis (a greater than 50% re-narrowing of the treated artery) in adult patients who…
- Conditions
- Peripheral Arterial Disease(PAD), Chronic Limb Threatening Ischemia, Intravascular Ultrasound, Major Adverse Limb Events
- Trial name
- CLARITY (NCT06979284)
- Testing
- IVUS-guided strategy
- Where
- 5 sites in Canada
- Volunteers
- 772 people
- Sponsor
- Hamilton Health Sciences Corporation
Acute Coronary Syndrome Without ST Elevation on Electrocardiogram, Acute Coronary Syndromes (ACS)
Occurrence of Severe Cardiac Rhythm and Conduction Disturbances in Emergency Department Patients With Non-ST Elevation Acute Coronary Syndrome
Cardiovascular diseases are the leading cause of death worldwide. Among them, coronary artery disease-especially in its acute form, known as acute coronary syndrome (ACS)-is the most frequent cause of cardiovascular death.
- Conditions
- Acute Coronary Syndrome Without ST Elevation on Electrocardiogram, Acute Coronary Syndromes (ACS), Myocardial Infarction, Unstable Angina Pectoris, Sudden Cardiac Death, Stroke, Peripheral Artery Disease
- Trial name
- SurvSCA (NCT07112547)
- Where
- 10 sites in France
- Volunteers
- 500 people
- Sponsor
- University Hospital, Strasbourg, France
Peripheral Artery Disease
Clinical Trial for Evaluation of Vermillion's Blood Test to Predict the Probability of Peripheral Artery Disease
Purpose This study is to verify and validate PAD1 as a qualitative serum test which will combine the results of multiple assays into a single numeric result, to be determined by evaluation of the study data.
- Trial name
- PAD-001 (NCT01336426)
- Where
- 10 sites in United States
- Volunteers
- 1,033 people
- Sponsor
- Vermillion, Inc.
Peripheral Arterial Disease
The Inperia Advance Post-Market Retrospective Study
The Inperia Advance Carbostent™ is a CE-marked infra-popliteal stent for treatment of infra-popliteal artery stenosis. The aim of this post-market retrospective study protocl P32203 is to collect clinical data of patients treated…
- Trial name
- NCT05622084
- Testing
- Inperia Advance
- Where
- France
- Volunteers
- 32 people
- Sponsor
- CID S.p.A.
Cardiovascular Disease, Atherosclerosis
Cardiovascular Molecular Calcification Assessed by 18F-NaF PET CT
The purpose of the CAMONA study is to demonstrate the feasibility of cardiovascular molecular calcification (CMC) assessment by means of 18F-sodium-fluoride (18F-NaF) positron emission tomography (PET) computed tomography (CT) in…
- Conditions
- Cardiovascular Disease, Atherosclerosis, Angina Pectoris
- Trial name
- CAMONA (NCT01724749)
- Where
- 2 sites in Denmark
- Volunteers
- 144 people, healthy volunteers welcome
- Sponsor
- Odense University Hospital
Atherosclerosis, Endothelial Function
Evaluation of The Effects of Nebivolol in Comparison to Atenolol on Wall Shear Stress and Rupture Prone Coronary Plaques
Nebivolol is a novel blood pressure lowering drug with an additional effect on the inner lining of blood vessels to release a compound called nitric oxide that can relax blood vessels.
- Trial name
- NCT01230892
- Testing
- Nebivolol, Atenolol
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- Emory University
Peripheral Arterial Disease
Drug Eluting Stents In The Critically Ischemic Lower Leg 2
The objective of this clinical evaluation is to evaluate the immediate and long term (up to 12 months) outcome of the XIENCE PRIME Everolimus Eluting Coronary Stent System (Abbott Vascular) in a controlled prospective…
- Trial name
- DESTINY 2 (NCT01442636)
- Testing
- stent
- Where
- 6 sites in Australia, Belgium and 1 more
- Volunteers
- 60 people
- Sponsor
- Flanders Medical Research Program
Peripheral Artery Disease
Static Muscular Stretching for Treatment of PAD
Patients with peripheral arterial disease (PAD) often have walking impairment due to insufficient oxygen supply to skeletal muscle.
- Trial name
- NCT04222751
- Testing
- Ankle Splint
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Florida State University
Systemic Lupus Erythematosus, Insulin Resistance
Insulin Resistance and Atherosclerosis in Women With Lupus
This study will test the effects of insulin resistance on atherosclerosis (hardening of the arteries) in women who have systemic lupus erythematosus, more commonly known as lupus.
- Conditions
- Systemic Lupus Erythematosus, Insulin Resistance, Atherosclerosis
- Trial name
- NCT00544102
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Coronary Heart Disease
The Effect of Simvastatin Combined With Ezetimibe in Patients With Stable Angina and Diabetes
In this study, simvastatin combined with Ezeimebum was used to enhance lipid reduction, and IVUS was used to evaluate the volume and composition of coronary plaque before and after treatment.
- Trial name
- NCT03771053
- Testing
- Ezetimibe with simvastatin, Simvastatin
- Where
- China
- Volunteers
- 240 people
- Sponsor
- Chinese PLA General Hospital
Heart Diseases, Cardiovascular Diseases
Genetics of Coronary Artery Disease in Alaskan Natives (GOCADAN)
To document cardiovascular disease and cardiovascular disease risk factors among 1,200 Native Alaskans who are members of approximately 40 families.
- Conditions
- Heart Diseases, Cardiovascular Diseases, Atherosclerosis, Hypertension
- Trial name
- NCT00006192
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Cardiovascular Disease, Cerebrovascular Disease
The Evening Versus Morning Polypill Utilization Study
Background and rationale: In clinical practice, antihypertensives are generally prescribed for use in the morning, whereas some statins are recommended for use in the evening.
- Conditions
- Cardiovascular Disease, Cerebrovascular Disease, Peripheral Arterial Disease
- Trial name
- TEMPUS (NCT01506505)
- Testing
- Cardiovascular Agents
- Where
- Netherlands
- Volunteers
- 78 people
- Sponsor
- UMC Utrecht
Atherosclerotic Cardiovascular Disease, Cardiovascular Diseases
Immunomodulatory Effects of PCSK9 Inhibition
Cardiovascular disease (CVD) represents the leading cause of death worldwide. While medications, such as statins, significantly reduce atherosclerotic CVD (ASCVD) risk by lowering low density lipoprotein levels, they may also…
- Conditions
- Atherosclerotic Cardiovascular Disease, Cardiovascular Diseases, Atherosclerosis, Arterial Inflammation
- Trial name
- INSPIRAR (NCT05720156)
- Testing
- 99mTc-tilmanocept SPECT/CT scanning
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Peripheral Artery Disease
Effects of Pulse Varieties on Blood Vessel Function in Peripheral Artery Disease
Consumption of a diet containing pulse crops provides flavonoid compounds that will improve vascular function and glycemic control in individuals with Peripheral Artery Disease.
- Trial name
- PULV-2011 (NCT01382056)
- Testing
- control foods, Mixed bean (higher amount), Mixed beans (lower amount)
- Where
- Canada
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- University of Manitoba
Peripheral Arterial Disease
Multi-Center Registry for Peripheral Arterial Disease Interventions and Outcomes
XLPAD is an observational study designed to evaluate the effectiveness and use of stent and non-stent based therapies among PAD patients.
- Trial name
- XLPAD (NCT01904851)
- Where
- 24 sites in United States
- Volunteers
- 14,000 people
- Sponsor
- Baylor Research Institute
Peripheral Arterial Disease, Peripheral Artery Disease
Implementation of Telemedicine for Patient With Lower Extremity Wounds
The objective of this study is to determine if patients with lower extremity wounds in rural communities who undergo specialty referral through telemedicine have expedited care compared to patients who are treated through…
- Conditions
- Peripheral Arterial Disease, Peripheral Artery Disease, Peripheral Vascular Diseases, Diabetic Foot
- Trial name
- NCT04440839
- Testing
- Telemedicine specialty consultation
- Where
- United States
- Volunteers
- 116 people
- Sponsor
- University of California, Davis
Epicardial Fat, Visceral Fat
Epicardial Fat, Visceral Fat and Coronary Atherosclerosis
Background: Visceral fat is increasingly associated with metabolic syndrome and with fatty liver, a condition carrying a high risk of cardiovascular disease.
- Conditions
- Epicardial Fat, Visceral Fat, Atherosclerosis
- Trial name
- NCT01344694
- Testing
- patient with liver fat, pts. with excess of visceral fat, control
- Where
- Israel
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Ziv Hospital
Atherosclerosis, Ischemic Stroke
A Phase I Study to Evaluate Safety and Pharmacokinetics of Escalating Single Doses and Multiple Doses of SP-8356
This is a 2-part, single-centre, randomised study in healthy males. Part 1 is a double-blind, randomised, placebo-controlled, single ascending dose (SAD) study in healthy males.
- Trial name
- NCT05574166
- Testing
- SP-8356
- Where
- United Kingdom
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Shin Poong Pharmaceutical Co. Ltd.
Critical Limb Ischemia
Best Endovascular vs. Best Surgical Therapy in Patients With Critical Limb Ischemia
This study will compare the effectiveness of best available surgical treatment with best available endovascular treatment in adults with critical limb ischemia (CLI) who are eligible for both treatment options.
- Trial name
- BEST-CLI (NCT02060630)
- Testing
- Open surgical revascularization, Endovascular revascularization
- Where
- 161 sites in United States, Canada and 3 more
- Volunteers
- 1,843 people
- Sponsor
- Carelon Research
Atherosclerosis, Cardiovascular Diseases
The Role of Stem Cells on Immune Cells in the Development of Cardiovascular Diseases
An observational pilot proof-of-principle study. 15 patients with significant coronary artery disease and 15 matched controls. To investigate whether long-term activation of the innate immune system, named 'trained innate…
- Trial name
- ATHEROSTEM (NCT03172507)
- Where
- 2 sites in Netherlands
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
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