Clinical trials: Atrial Fibrillation Catheter Ablation
Hypertension, Resistant to Conventional Therapy, Atrial Fibrillation
Combined Treatment of Resistant Hypertension and Atrial Fibrillation
The purpose of this study is the comparative evaluation of systolic blood pressure (SBP) lowering, atrial fibrillation (AF) recurrence and clinical data in patients with paroxysmal/persistent AF and resistant hypertension…
- Trial name
- NCT01117025
- Testing
- Circumferential PV isolation, Circumferential PVI+renal denervation
- Where
- 2 sites in United States, Russia
- Volunteers
- 26 people
- Sponsor
- Meshalkin Research Institute of Pathology of Circulation
Persistent Atrial Fibrillation
Catheter Versus Thoracoscopic Surgical Ablation Strategy in Persistent Atrial Fibrillation
Atrial fibrillation(AF)is the commonest arrhythmia worldwide and can lead to significant morbidity and mortality, posing an increasing public health burden.
- Trial name
- CASA-AF (NCT01385358)
- Testing
- Thoracoscopically Assisted Surgical Ablation, Catheter Ablation
- Where
- United Kingdom
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Royal Brompton & Harefield NHS Foundation Trust
Atrial Fibrillation, Atrial Tachycardia
Study of Interference Between Oral Anticoagulants and Heparin During Ablation of Atrial Fibrillation (AF) or Left Atrial Tachycardia (GAD) by Catheter.
Catheter ablation of atrial fibrillation (AF) or left atrial tachycardia (GAD) is usually performed in patients treated with vitamin K antagonists (VKAs) or direct oral anticoagulants (DOACs) that are increasingly used.
- Trial name
- FACADO (NCT05802576)
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Atrial Fibrillation Ablation
Efficacy Study for Surgery After Previous Failed Catheter Ablation
Specific Aims: The primary objective of this registry is to determine the percentage of patients who are free from atrial fibrillation (AF) at 6 and 12 months following a surgical ablation procedure when the patient has a history…
- Trial name
- SAVED (NCT01034852)
- Testing
- Totally Thoracoscopic Maze
- Where
- 2 sites in United States
- Volunteers
- 45 people
- Sponsor
- Cardiopulmonary Research Science and Technology Institute
Atrial Fibrillation, Continuous Positive Airway Pressure
Clinical Study on the Effect of CPAP on AF Recurrence After Catheter Ablation in Patients with AF and OSA
Atrial fibrillation (AF) is the most common sustained arrhythmia in clinical practice, significantly increasing the risks of death, stroke, heart failure, cognitive impairment, and dementia, thus severely impacting patients'…
- Conditions
- Atrial Fibrillation, Continuous Positive Airway Pressure, Obstructive Sleep Apnea, Recurrence
- Trial name
- NCT06542263
- Testing
- CPAP
- Where
- China
- Volunteers
- 224 people
- Sponsor
- Second Affiliated Hospital of Soochow University
Atrial Fibrillation
Catheter Contact Force and Electrograms
Until recently, there was no way of telling how firmly the tip of the catheter was in contact with the heart and how this contact was orientated.
- Trial name
- NCT01587404
- Testing
- THERMOCOOL® SMARTTOUCH™ Catheter (including Surround Flow)
- Where
- United Kingdom
- Volunteers
- 55 people
- Sponsor
- Barts & The London NHS Trust
Uncontrolled Hypertension, Atrial Fibrillation
Adjunctive Renal Denervation in the Treatment of Atrial Fibrillation
The objective of the H-FIB trial is to determine the role of renal sympathetic denervation in the prevention of Atrial Fibrillation (AF) recurrence in patients with hypertension for whom a catheter-based AF ablation procedure is…
- Trial name
- H-FIB (NCT01635998)
- Testing
- Boston Scientific Vessix Renal Denervation System
- Where
- 8 sites in United States, Czechia and 1 more
- Volunteers
- 50 people
- Sponsor
- Vivek Reddy
Atrial Fibrillation
Early Detection and Treatment of Esophageal Injury After Catheter Ablation for Atrial Fibrillation
The purpose of this study is to prospectively follow the next 200 patients who undergo catheter ablation of atrial fibrillation for symptoms and signs of esophageal injury.
- Trial name
- NCT00584922
- Testing
- Endoscopy in group I (all patients)
- Where
- United States
- Volunteers
- 175 people
- Sponsor
- University of Oklahoma
Atrial Fibrillation (AF)
Single-Use Spherical Pulsed Ablation Catheter for Paroxysmal Atrial Fibrillation
The goal of this clinical trial is to learn if the cardiac pulsed field ablation system, composed of the cardiac pulsed field ablation device, the single-use spherical pulsed ablation catheter, and the optional cardiac…
- Trial name
- NCT07811934
- Testing
- Investigational Cardiac Pulsed Field Ablation (PFA) System, Conventional Radiofrequency (RF) Catheter Ablation System
- Volunteers
- 284 people
- Sponsor
- Shanghai Shineyo Medical Co., Ltd.
Atrial Fibrillation, Paroxysmal or Persistent
The SAFE Prospective Registry
Secretoneurin (SN) is a neuropeptide from the chromogranin family that influences intracellular calcium handling. SN suppresses calcium leakage from the sarcoplasmic reticulum through the ryanodine receptor.
- Trial name
- NCT05794464
- Testing
- Catheter ablation and/or electrical cardioversion
- Where
- Czechia
- Volunteers
- 60 people
- Sponsor
- University Hospital Ostrava
Atrial Fibrillation
Usefulness of Markers to Predict Recurrence of Atrial Fibrillation After Radiofrequency Catheter Ablation
Catheter ablation using radiofrequency is a new therapeutic tool to treat atrial fibrillation with a higher success rate than medical therapy (80% versus less than 50% respectively).
- Trial name
- NCT00315068
- Where
- Switzerland
- Volunteers
- 180 people
- Sponsor
- University Hospital, Geneva
Atrial Fibrillation (AF)
Discontinuation of Anticoagulations After Successful Catheter Ablation of Atrial Fibrillation
The DESTINATION Study investigates whether anticoagulation therapy is necessary after successful catheter ablation (CA) for atrial fibrillation (AF).
- Trial name
- DESTINATION (NCT06615596)
- Testing
- discontinue anticoagulation therapy, Anticoagulant drugs, Catheter Ablation
- Where
- 12 sites in United States, China
- Volunteers
- 3,160 people
- Sponsor
- China National Center for Cardiovascular Diseases
Atrial Fibrillation
Non-Invasive Median Nerve Stimulation to Attenuate Atrial Tachyarrhythmias After Catheter Ablation for Atrial Fibrillation
Determine the role of vagal/median nerve stimulation using the CardiaCare RR2 home care wearable neuromodulation system on suppressing atrial arrhythmias and related symptoms in patients who have undergone AF ablation.
- Trial name
- NEUROPULSE (NCT06748157)
- Testing
- CardiaCare RR2
- Where
- United States
- Volunteers
- 51 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Persistent Atrial Fibrillation, Paroxysmal Atrial Fibrillation
A Feasibility Study to Evaluate the Effect of Concomitant Renal Denervation and Cardiac Ablation on AF Recurrence
The purpose of this post market clinical investigation is to complete preliminary evaluation on whether or not concomitant renal denervation with the EnligHTN™ Renal Denervation System and cardiac ablation will result in improved…
- Conditions
- Persistent Atrial Fibrillation, Paroxysmal Atrial Fibrillation, Hypertension
- Trial name
- RDN+AF (NCT01907828)
- Testing
- Renal Artery Ablation, Cardiac Ablation
- Where
- 2 sites in Germany
- Volunteers
- 61 people
- Sponsor
- Abbott Medical Devices
Atrial Fibrillation (AF)
Assessment of Catheter Tissue Contact in PFA
Pulmonary vein isolation remains the cornerstone of invasive treatment for atrial fibrlllation. Despite recent technological advances in the field of pulsed field ablation (PFA) pulmonary vein isolation durability and arrhythmia…
- Trial name
- ASSESS PFA (NCT07721948)
- Testing
- Electrode tissue contact assessment during pulsed field ablation
- Where
- Slovenia
- Volunteers
- 60 people
- Sponsor
- University Medical Centre Ljubljana
Long Standing Persistent Atrial Fibrillation
Remote Monitoring of AF Recurrence Using mHealth Technology
Atrial fibrillation (AF) is the most common arrhythmia worldwide. It carries a significant health burden, conferring on sufferers a reduction in quality of life, risk of significant morbidities such as stroke and heart failure…
- Trial name
- REMOTE-AF (NCT05037136)
- Where
- United Kingdom
- Volunteers
- 35 people
- Sponsor
- Royal Brompton & Harefield NHS Foundation Trust
Atrial Fibrillation
STrategies for Catheter Ablation of peRsistent Atrial Fibrlllation
The objective of this study is to compare the efficacy of three different ablation strategies in patients with persistent AF: 1. PV antral isolation alone (PVAI) 2. PV antral isolation plus ablation of drivers (PVAI+drivers) 3.
- Trial name
- STARAF3 (NCT04428944)
- Testing
- Wide Circumferential Pulmonary Vein Antrum Isolation (PVAI), Pulmonary Vein Antrum Isolation Plus Driver Ablation (PVAI+drivers), Pulmonary Vein Antrum Isolation Plus Box Isolation of Posterior Wall (PVAI+box)
- Where
- 32 sites in United States, Australia and 7 more
- Volunteers
- 617 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Atrial Fibrillation
Comparison of Percutaneous Closure to Manual Compression for Hemostasis
This a prospective randomized trial occurring in patients undergoing routine ablation for atrial fibrillation as standard of care.
- Trial name
- NCT04180540
- Testing
- Percutaneous Closure, Manual Compression
- Where
- 2 sites in United States
- Volunteers
- 109 people
- Sponsor
- Michael S. Lloyd
Persistent Atrial Fibrillation
SmartTouch Catheter for Left Anterior Line - SmarT Line Study
This prospective, randomized study will investigate, if information of the catheter force during ablation of a left anterior line does reduce total RF application time by prevention of ineffective lesions.
- Trial name
- NCT02217657
- Testing
- Thermocool Smart Touch Catheter
- Where
- Germany
- Volunteers
- 75 people
- Sponsor
- LMU Klinikum
Atrial Fibrillation
Catheter Ablation Versus Antiarrythmic Drugs for Atrial Fibrillation in China
The mainstay of treatment for atrial fibrillation remains pharmacological;however,catheter ablation has increasingly been used over the last decades. The relative merits of each strategy have not been extensively studied.
- Trial name
- NCT01341353
- Testing
- catheter ablation, Digaoxin,amiodarone,β receptor antagonist, Calcium Antagonists
- Where
- China
- Volunteers
- 1,800 people
- Sponsor
- Wuhan University