Clinical trials: Autonomic Nervous System Modulation
Neck Pain
Spinal Pain and Autonomic Responses to Chiropractic Care
This randomized, single-blinded study will investigate the effects of Spinal Manipulative Therapy on Heart Rate Variability and Pain Sensitivity in a population of patients with recurrent and persistent neck pain.
- Trial name
- SPARC (NCT03576846)
- Testing
- Stretching and Spinal manipulative therapy, Stretching
- Where
- 2 sites in Sweden
- Volunteers
- 131 people
- Sponsor
- Karolinska Institutet
Multiple Sclerosis
TMS Combined With Virtual Reality and Multidisciplinary Rehabilitation in Multiple Sclerosis
Multiple sclerosis (MS) is a chronic autoimmune central nervous system disease characterized by inflammation, demyelination, and neurodegeneration, resulting in motor, cognitive, speech-language, psychological, and cardiac…
- Trial name
- TMS (NCT07593807)
- Testing
- Transcranial Magnetic Stimulation, Physiotherapy, Non-immersive serious game training
- Where
- Brazil
- Volunteers
- 30 people
- Sponsor
- University of Sao Paulo
Resistance Training
Autonomic Modulation Recovery After Acute Resistance Exercise
To analyze the autonomic behavior in recovery post-acute resistance exercise performed in different intensities and body segments.
- Trial name
- NCT04569617
- Testing
- Resistance Training - UL endurance protocol, Resistance Training - UL strength protocol, Resistance Training - LL endurance protocol
- Where
- 2 sites in Brazil
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- Universidade Estadual Paulista Júlio de Mesquita Filho
Chronic Disease Obstructive Pulmonary
Rehabilitation Cardiorrespiratory Improvement in Patients With Chronic Disease Obstructive Pulmonary
Chronic obstructive pulmonary disease (COPD) is a condition in which the lung is in chronic state due to an inflammatory response that leads to limitation in lung function of the individual, providing symptoms such as dyspnea…
- Trial name
- NCT02783326
- Testing
- Rehabilitation
- Where
- Brazil
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Universidade Metodista de Piracicaba
Blood Flow Restriction Exercise, Aging
Acute Autonomic Responses During and After BFR Training
The goal of this clinical trial is to compare how the body's nervous system responds to two different types of leg exercise in young and older adults.
- Trial name
- HOLD TIGHT (NCT07722403)
- Testing
- High-Intensity Resistance Training (HIRT), Low-Intensity Resistance Training with Blood Flow Restriction (LIRT-BFR)
- Where
- Portugal
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Egas Moniz - Cooperativa de Ensino Superior, CRL
Autonomic Nervous System Imbalance, Psychological Distress
Stochastic Modulated Vibrations on Autonomic Nervous System of Breast Cancer Patients During Radiotherapy
The aim of this research is to study the influence of stochastic modulated vibrations on the autonomic nervous system of breast cancer patients during radiation therapy
- Conditions
- Autonomic Nervous System Imbalance, Psychological Distress, Cancer-related Pain, Breast Cancer Lymphedema
- Trial name
- NCT04125953
- Testing
- Andullation
- Where
- Belgium
- Volunteers
- 130 people
- Sponsor
- Universitair Ziekenhuis Brussel
Hypertension
Isometric Training on Blood Pressure and on the Autonomic Modulation of Hypertensive Patients
Objective: analyze the effects of isometric handgrip exercise on arterial pressure and on the autonomic cardiac modulation of hypertensive individuals treated in the Unified Health System (UHS).
- Trial name
- NCT03216317
- Testing
- Intervention Group
- Where
- Brazil
- Volunteers
- 65 people
- Sponsor
- Hospital Israelita Albert Einstein
Functional Gastrointestinal Disorders, Vagus Nerve Autonomic Disorder
A Study of Randomized Sham-control Auricular TENS Unit Stimulation in Pediatric Functional Gastrointestinal Disorders
The purpose of this study is to see if using a micro-current through a device called a TENS (Transcutaneous Electrical Nerve Stimulator) unit helps to improve functional gastrointestinal disorder (FGID) symptoms in children by…
- Conditions
- Functional Gastrointestinal Disorders, Vagus Nerve Autonomic Disorder, Irritable Bowel Syndrome, Nausea
- Trial name
- NCT04247100
- Testing
- Transcutaneous Electrical Nerve Stimulation (TENS)
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Gisela Grotewold Chelimsky
Autonomic Nervous System Disease
Resonance Breathing and Postural Resonance: Acute Modulation of Autonomic and Hemodynamic Responses Via Arterial Baroreflex Mechanisms
This study aimed to compare the acute autonomic and hemodynamic effects of two arterial baroreflex resonance interventions-Resonance Breathing (RB) and Postural Resonance (PR)-in healthy young adults.
- Trial name
- Autonomic (NCT07536997)
- Testing
- Resonance Breathing, Postural Resonance
- Where
- China
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Beijing Sport University
Open Heart Surgery
Gaming Technology and Cardiac Rehabilitation
Moderate to vigorous physical activity has been shown to be associated with autonomic regulation of the heart measured with heart rate variability. Cardiac autonomic modulation can be evaluated by heart rate variability.
- Trial name
- NCT05149235
- Testing
- early mobilization group, physio adventure
- Where
- Pakistan
- Volunteers
- 86 people
- Sponsor
- Bahria University
Mechanical Ventilation Weaning
Autonomic Modulation in Patients Undergoing Assisted Mechanical Ventilation: Comparison Between PAV+ and PSV
The aim of the study is to investigate autonomic modulation in terms of heart rate variability (i.e., HRV) in patients undergoing assisted mechanical ventilation in PSV mode, compared to patients assisted in PAV+ mode.
- Trial name
- NCT06590311
- Testing
- Heart Rate Variability
- Where
- Italy
- Volunteers
- 48 people
- Sponsor
- University of Roma La Sapienza
Poor Sleep Quality
Effects of a Programmed Reflexology Therapy on Sleep Quality, Insomnia, Fatigue, and Heart Rate Variability Among Individuals With Poor Sleep Quality
The goal of this clinical trial is to evaluate whether a structured reflexology therapy can improve sleep, reduce insomnia severity, and alleviate fatigue in adults with poor sleep quality, and to understand how it affects…
- Trial name
- NCT07402460
- Testing
- manual reflexology treatment, Feet massage using an electric massager (FEM)
- Where
- Taiwan
- Volunteers
- 32 people
- Sponsor
- National Taipei University of Nursing and Health Sciences
Nerve Growth Factor, Exercise
Cortical Neuroplasticity by Muscle Pain of Pain-induced Plasticity
The purpose of this study is to investigate the sensory-motor cortical excitability response to delayed onset muscle soreness (DOMS) on Extensor Carpi Radialis (ECR) muscle during muscle hyperalgesia provoked by nerve growth…
- Conditions
- Nerve Growth Factor, Exercise, Motor Activity, Abnormality of SSEPs
- Trial name
- NCT03354624
- Testing
- Sterile solutions of recombinant human nerve growth factor (NGF)
- Where
- Denmark
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Aalborg University
Coronary Heart Disease (CHD), Anxiety Disorders
Closed-Loop Neurofeedback Targeting the Left Dorsolateral Prefrontal Cortex for Cardiac Autonomic Modulation in Coronary Artery Disease With Anxiety
The goal of this clinical trial is to test whether closed-loop fNIRS-BCI neurofeedback(NF) targeting the left dorsolateral prefrontal cortex(DLPFC) can reduce cardiac autonomic arousal, indexed by baseline-corrected heart…
- Trial name
- HEART-SET-2 (NCT07244484)
- Testing
- Real-time fNIRS-based neurofeedback
- Where
- China
- Volunteers
- 56 people
- Sponsor
- Shenyang Medical College
Long COVID, Heart Rate Variability (HRV)
Effects os Physiotherapeutic Rehabilitation on Function Autonomic and Inflammatory in Patients With Long Covid
Introduction: Long COVID is characterized by persistent symptoms that persist for weeks or months after the acute phase of infection, with a significant impact on the cardiovascular and autonomic systems.
- Conditions
- Long COVID, Heart Rate Variability (HRV), Cardiac Biomarkers, Inflammatory Biomarkers
- Trial name
- LongCovidRehab (NCT07046208)
- Testing
- physiothreapy protocol
- Volunteers
- 58 people
- Sponsor
- Universidade do Estado do Pará
Diet, Healthy, Systemic Inflammatory Response
Effect of Pectin and Inulin Fibre Supplementation on Glucose and ANS Modulation
The study involves intake of dietary supplements, which are commonly found in the UK diet (not pharmacological agents) to test their effects on inflammation in the body and gut microbiome composition.
- Trial name
- NCT06480799
- Testing
- Fibre intervention
- Where
- United Kingdom
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Elizabeth Simpson
Carotid Artery Diseases
Hemodynamics and Autonomic and Cognitive Performance After Carotid Revascularization Procedures
Carotid revascularization procedures are performed for more than 87% of cases in patients with asymptomatic internal carotid stenosis (ICS), who are assumed to have a life expectancy of at least 5 years.
- Trial name
- BAROX (NCT03493971)
- Testing
- Carotid revascularization performed using CAS, Carotid revascularization performed using CEA
- Where
- Italy
- Volunteers
- 70 people
- Sponsor
- Ospedale San Donato
Chronic Pain Syndrome, Fibromyalgia
Assessing the Impact of Exercise Based Intensive Interdisciplinary Pain Treatment (IIPT) on Endogenous Pain Modulation in Youth With Chronic Pain Syndromes
This work will answer two critical questions: 1) Does intensive interdisciplinary pain treatment (IIPT) involving aerobic exercise help normalize pain processing in youth with chronic pain syndromes and 2) Are aerobic fitness…
- Conditions
- Chronic Pain Syndrome, Fibromyalgia, Chronic Headache Disorder, Functional Abdominal Pain Syndrome
- Trial name
- NCT05491499
- Where
- United States
- Volunteers
- 43 people
- Sponsor
- Boston Children's Hospital
Bipolar Depression
Neurophysiologic Changes in Patients With Bipolar Depression
To examine differences in neurophysiologic parameters between unmedicated patients with bipolar depression and healthy controls To examine within-subject changes in neurophysiologic parameters in patients with bipolar depression…
- Trial name
- NCT01213121
- Testing
- Quetiapine
- Where
- South Korea
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Seoul National University Bundang Hospital
Ischemic Preconditioning, Autonomic Nervous System (ANS) Functioning and Mood State
The Impact of Ischemic Preconditioning on Exercise Performance and Physiological Function
Ischemic Preconditioning has been confirmed to prevent long-term ischemic damage to tissues, among which the improvement of autonomic nerve system function may be one of its mechanisms of action.
- Trial name
- NCT07146399
- Testing
- Ischemic Preconditioning
- Where
- China
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Ziyue Ou