Clinical trials: Basic Science
Diabetes, Pharmacist-Patient Relations
Refinement and Testing of Recruitment Methodology for Behavioral Medication Adherence Interventions Using Behavioral Science-based Approaches
The overarching goal of the proposed research is to prepare the clinical pharmacist intervention for sustainable implementation and dissemination.
- Conditions
- Diabetes, Pharmacist-Patient Relations, Medication Adherence
- Trial name
- STIC2IT-2 (NCT06569290)
- Testing
- Primer postcard, Control recruitment letter, Behavioral theory-informed recruitment letter (prospect theory)
- Where
- United States
- Volunteers
- 590 people
- Sponsor
- Brigham and Women's Hospital
Alzheimer's Disease and Related Dementias
Translating Data Science to Palliative Care
This research study is intended to 1) better understand seriously ill adults' and their family care partners' (FCP), particularly for persons living with dementia (PLwD), barriers to accepting community-based palliative care…
- Trial name
- NCT05942040
- Testing
- Tailored Palliative Care Information
- Where
- United States
- Volunteers
- 301 people
- Sponsor
- Rutgers, The State University of New Jersey
Depression, Problematic Alcohol Use
Scaling Up Science-based Mental Health Interventions in Latin America
Conduct systematic, multi-site mental health implementation research in both rural and urban primary care settings with a broad group of stakeholders in the US and Latin America.
- Trial name
- DIADA (NCT03392883)
- Testing
- Laddr
- Where
- 6 sites in Colombia
- Volunteers
- 1,348 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Migraine Headache
TelemEdiciNe-bAsed Cognitive TherapY for Migraines
The goal of this pilot study is to evaluate a bundle of implementation strategies at three Veteran Affairs Medical Centers (VAMCs) to facilitate the referral and adoption of a telehealth based, cognitive behavioral therapy…
- Trial name
- TENACITY (NCT04613362)
- Testing
- TENACITY Telehealth Cognitive Behavioral Therapy for Migraine, Behavioral Usual Care
- Where
- 4 sites in United States
- Volunteers
- 80 people
- Sponsor
- VA Office of Research and Development
Sepsis
Implementation and Effectiveness of Engagement and Collaborative Management to Proactively Advance Sepsis Survivorship
The purpose of this study is to evaluate if implementation of the Sepsis Transition and Recovery (STAR) program within a large healthcare system will improve outcomes for high-risk patients with suspected sepsis, while…
- Trial name
- ENCOMPASS (NCT04495946)
- Testing
- Sepsis Transition and Recovery (STAR) program, Usual care
- Where
- United States
- Volunteers
- 3,894 people
- Sponsor
- Wake Forest University Health Sciences
Airway Disease
Therapeutic Effects of Jing Si Herbal Tea for COPD
Chronic obstructive pulmonary disease (COPD), a leading cause of global mortality, significantly impairs health-related quality of life (HRQL). COPD is characterized by airway inflammation and lung tissue damage.
- Trial name
- NCT06584786
- Testing
- Jing Si herbal tea (JSHT)
- Where
- Taiwan
- Volunteers
- 120 people
- Sponsor
- Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation
HIV (Human Immunodeficiency Virus)
Evaluating an Algorithm-Based Implementation Strategy to Improve HIV Care Outcomes
This study tests a strategy for helping Care Management Agencies prioritize patients with HIV (PWH) for outreach and support. Under the new strategy, care managers are given a list of highest-priority patients who have been…
- Trial name
- NCT07279376
- Testing
- predictive emergency room alerts (pERA), Standard of care
- Where
- United States
- Volunteers
- 2,600 people
- Sponsor
- Hunter College of City University of New York
Breast Cancer, Breast Fibroadenoma
Exploring a Breast Cancer Early Screening Model Based on cfDNA
The goal of this observational study is to use cfDNA multi-omics technology to explore a new breast cancer early detection model to improve the accuracy of early diagnosis in breast cancer patients.
- Conditions
- Breast Cancer, Breast Fibroadenoma, Breast Hypoplasia
- Trial name
- NCT06016790
- Testing
- cfDNA sequencing
- Where
- 8 sites in China
- Volunteers
- 839 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Epilepsy Idiopathic, Clinical Disease and/or Syndrome
Omics-based Precision Medicine of Epilepsy
Epilepsy is a major disease of the nervous system (WHO, 2015), as well as the second most common neural disease. It has been recorded that there have been 65 million epilepsy patients all over the world, more than 10 million in…
- Conditions
- Epilepsy Idiopathic, Clinical Disease and/or Syndrome, Gene Mutation
- Trial name
- NCT03358459
- Testing
- non
- Where
- China
- Volunteers
- 10,000 people
- Sponsor
- Fudan University
Neurodevelopmental Disorders
WHO Mental Health Gap Action Program (mhGAP) for Improving Child Mental and Behavioral Disorder Service Quality in China
The goal of this clinical trial is to learn if the adapted mhGAP intervention guide (mhGAP-IG) can improve quality of child mental and behavioral disorders (CMBDs) services in China.
- Trial name
- mhGAP (NCT06702410)
- Testing
- mental health gap action program intervention guide (mhGAP-IG)
- Where
- 9 sites in China
- Volunteers
- 375 people, healthy volunteers welcome
- Sponsor
- Sun Yat-sen University
Health Behavior
Training LHDs to Disseminate Evidence-Based Interventions to Small Worksites
The proposed project will advance implementation science by comparing the effectiveness of different levels of technical support in an important but understudied community-based setting: local health departments.
- Trial name
- NCT03930420
- Testing
- Connect to Wellness
- Where
- United States
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- University of Washington
Physiology Education, Simulation-Based Learning
AI-Assisted Adaptive Simulation in Physiology Education
This randomized controlled trial evaluated whether an AI-assisted, rule-based adaptive screen-based simulation module could improve physiology learning outcomes among undergraduate health science students compared with…
- Conditions
- Physiology Education, Simulation-Based Learning, v, Artificial Intelligence in Education
- Trial name
- PBL (NCT07608315)
- Testing
- AI-Assisted Algorithm-Supported Adaptive Simulation, Conventional Physiology Instruction
- Where
- India
- Volunteers
- 672 people, healthy volunteers welcome
- Sponsor
- Saveetha University
Periodontal Disease
Characterizing Gingival and Periodontal Ligament Fibroblasts Reaction to Infection With the Bacteria Porphyromonas Gingivalis
Porphyromonas gingivalis is one of the major bacteria involved in the formation and progression of chronic periodontitis. Pathogens invading the gingiva face the host's innate immune system at first and later on the acquired…
- Trial name
- NCT01599091
- Testing
- Specimens collection
- Where
- Israel
- Volunteers
- 100 people
- Sponsor
- Hadassah Medical Organization
no Condition, Basic Science
OH Baseline Research Study
The One Health baseline research study is essential to comprehensively understand human, animal, and environmental health interrelation within Zambia's diverse ecosystems.
- Trial name
- OHS (NCT06904521)
- Where
- Zambia
- Volunteers
- 340 people, healthy volunteers welcome
- Sponsor
- Centre for Infectious Disease Research in Zambia
Implementation Science, Type 1 Diabetes in Adolescence
Pilot Implementation Trial of Implementation Toolkits for Diabetes Coaching
The goal of this study is to learn if toolkits of implementation strategies (e.g., provider and staff education, clear plan for how to refer and bill) help pediatric type 1 diabetes medical and psychology providers deliver a…
- Conditions
- Implementation Science, Type 1 Diabetes in Adolescence, Implementation Strategies
- Trial name
- NCT07766811
- Testing
- Base Implementation Toolkit (BIT), BIT-Enhanced, BIT-Sustainment
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Nemours Children's Clinic
Hypertension, Prehypertension
UH3 Phase - Mindfulness-Based Blood Pressure Reduction (MB-BP) : Stage 2a RCT
The primary aim is to identify the impacts of a behavioral intervention called "Mindfulness-Based Blood Pressure Reduction" (MB-BP) vs.
- Trial name
- MB-BP (NCT03859076)
- Testing
- MB-BP, Enhanced Usual Care Control
- Where
- United States
- Volunteers
- 119 people
- Sponsor
- Brown University
Mental Disorder in Adolescence, Behavioral Symptoms
Effects of Web-Based Training on HbA1c, Quality of Life and Depression Levels in Adolescents With Type 1 Diabetes
Objective: This study was conducted to determine the effect of diabetes training on HbA1c, levels of depression and quality of life of Type 1 Diabetes Mellitus adolescents by using the Web-Based Watson Human Care Model.
- Conditions
- Mental Disorder in Adolescence, Behavioral Symptoms, Problem Behavior
- Trial name
- NCT04888780
- Testing
- The web-based Watson's Human Care Theory oriented training
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Gaziantep Islam Science and Technology University
Physiotherapy
Scientific Content Disseminated Via Social Media for Physiotherapists
This study is designed to assess how effective social media is in disseminating scientific knowledge to physiotherapists in Brazil.
- Trial name
- ASTEROID (NCT06605040)
- Testing
- Dissemination via Social Media, Dissemination via Email
- Where
- Brazil
- Volunteers
- 120 people
- Sponsor
- Universidade Federal de Santa Maria
Chronic Disease Prevention
Engaging Partners in Caring Communities
The goal of the EPICC observational study is to learn about capacity to implement evidence-based health promotion programs (EBPs) in congregations that are offered semi-structured technical assistance (TA).
- Trial name
- EPICC (NCT06932549)
- Testing
- Technical assistance is designed to integrate Expert Recommendations for Implementing Change (ERIC) strategies, and Getting To Outcomes-TA.
- Where
- United States
- Volunteers
- 320 people, healthy volunteers welcome
- Sponsor
- Tennessee State University
Back Pain Lower Back Chronic
The Impact of an Instructional Web-based Healthcare App for Relieving Back Pain From Spinal Compression Fractures
With the expected rise of patients with osteoporosis-induced fractures, it has become increasingly urgent to design and use specialized health education materials aimed at easing pain and improving bodily functions
- Trial name
- NCT05386212
- Testing
- web app healthcare instructions for relieving back pain
- Where
- 3 sites in Taiwan
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- National Taipei University of Nursing and Health Sciences