Clinical trials: Botulinum Toxin
Keloid
Examining the Therapeutic Potential of Botulinum Toxin Type A in the Treatment of Keloids
Keloids are a common form of hypertrophic scars that by definition last beyond 6 months and grow beyond the site of initial injury.
- Trial name
- NCT05330078
- Testing
- Botulinum toxin type A, Vehicle
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Sun-induced Wrinkles
Safety and Efficacy of the Full Face Applications of Variable Doses of a Commercial Botulinum Toxin Type a (Dysport®)
This is an open-label and phase IV study of full face injections of variable doses of botulinum toxin type A (BT-A). As it is an open-label and not blind study, both investigator and subjects will know the injection local and…
- Trial name
- NCT01032954
- Testing
- Botulinum toxin
- Where
- Brazil
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Hexsel Dermatology Clinic
Scar, Hypertrophic Scar
Randomized Controlled Trial Examining the Efficacy of Botulinum Toxin in Biopsy Scar Minimization
The proposed study seeks to evaluate the scar reduction capacity of BTA on excision/biopsy wounds compared to the control (normal saline) in a double-blinded randomized control trial.
- Trial name
- NCT05478551
- Testing
- Botulinum Toxin, Normal saline
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Henry Ford Health System
Lateral Canthal Lines, Crow's Feet
Safety and Efficacy Study of RT001 to Treat Moderate to Severe Lateral Canthal Lines
The purpose of this study is to evaluate the efficacy and safety of a single administration of RT001 compared to placebo gel for the treatment of moderate to severe lateral canthal lines.
- Conditions
- Lateral Canthal Lines, Crow's Feet, Facial Wrinkles
- Trial name
- NCT00968825
- Testing
- Botulinum Toxin Type A
- Where
- United States
- Volunteers
- 73 people, healthy volunteers welcome
- Sponsor
- Revance Therapeutics, Inc.
Healthy
Study to Evaluate Safety and PK of a Single IM Dose of G03-52-01 vs Placebo in Adult Subjects
A Phase 1, randomized, double-blind, placebo-controlled dose escalation trial of four dose cohorts of 10 subjects (1: 10mg, 2: 25mg, 3: 50mg, 4: 100mg).
- Trial name
- NCT04171115
- Testing
- G03-52-01
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Alachua Government Services, Inc.
Stroke Patient
Variability of the Unique Fiber Potentials of a Spastic Muscle Treated With Botulinum Toxin
The main objective is to study the variability and evolution of single-fiber jitter and fiber density (FD) electrophysiological parameters in a spastic muscle during botulinum toxin type A (BTA) treatment in hemiplegic patients…
- Trial name
- JITTOX (NCT04002843)
- Testing
- paraclinical evaluation of single fibre
- Where
- France
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
RECOMBINANT BOTULINUM VACCINE A/B
Study to Evaluate the Safety, Tolerability and Immunogenicity of Recombinant Botulinum Vaccine A/B in Healthy Adults
The purpose of this trial is to evaluate the safety and tolerability of a two-dose regimen (Day 0 and Day 28) of recombinant Botulinum Vaccine (rBV) A/B in healthy volunteers when given intramuscularly at three ascending dosage…
- Trial name
- NCT00098098
- Testing
- rBV A/B
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- DynPort Vaccine Company LLC, A GDIT Company
Forehead Rhytid Complex, Glabellar Rhytid Complex
Treatment of Forehead/Glabellar Rhytide Complex With Botulinum Toxin A Injection
This cross-over design study will evaluate the onset of action, efficacy, and duration of botulinum toxin A treatment on forehead/glabellar rhytid complexes with and without subsequent muscle contraction.
- Trial name
- NCT01688076
- Testing
- Botulinum Toxin A
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Dislocation of Temporomandibular Joint TMJ, Subluxation of Temporomandibular Joint
Assessment of Botulinum Toxin Injection for Treatment of Temporomandibular Joint Dislocation
Assessment of the effect of Botulinum toxin injection on the frequency of luxation and TMJ Pain in patients with TMJ dislocation either chronic recurrent dislocation or subluxation
- Trial name
- NCT05863286
- Testing
- Botulinum toxin type A
- Where
- Egypt
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Cairo University
Adjuvant Zinc May Increase the Efficacy of Botulinum Toxin, Zinc Supplementation for Botulinum Toxin Treatment of the Forehead
Efficacy of Zinc Supplementation on Botox Treated Forehead Rhytids
The current literature suggests that zinc supplementation may increase the duration of botulinum toxin; however, each study had their limitations.
- Conditions
- Adjuvant Zinc May Increase the Efficacy of Botulinum Toxin, Zinc Supplementation for Botulinum Toxin Treatment of the Forehead, Glabellar Frown Lines, Botulinum Toxin, Cosmetic
- Trial name
- NCT05894109
- Testing
- zinc citrate 50 mg
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of New Mexico
Botulinum Toxin, Rejuvenation, Neck, Therapy
Botulinum Toxin for Neck Rejuvenation
The purpose of this study is to describe a safe and consistent technique for neck rejuvenation using botulinum toxin. This study will also evaluate the efficiency of the intervention and determine the patients that would benefit…
- Trial name
- NCT02864511
- Testing
- Nefertiti lift
- Where
- Lebanon
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- St Joseph University, Beirut, Lebanon
Glabellar Frown Lines
Efficacy and Safety Study of MT10107 in the Treatment of Glabella Line
This study design is a parallel, active drug controlled, double blind, randomized, multi-centered, phase III clinical trial to compare the efficacy and safety of MT10107 versus BOTOX® in treatment of glabella line.
- Trial name
- NCT03908008
- Testing
- Botox (Botulinum toxin type A), MT10107 (Botulinum toxin type A)
- Volunteers
- 136 people, healthy volunteers welcome
- Sponsor
- Medy-Tox
Cervical Dystonia
Static Graviceptive Functions in Patients With Cervical Dystonia (CD)
The purpose of this experimental pilot study is to test the effect of normalization of the head position on the sense of balance at patients with cervical dystonia under routine botulinum toxin treatment.
- Trial name
- NCT01180270
- Where
- Austria
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Kirsten Elwischger
Male Pattern Baldness
Treatment of Male Pattern Baldness With Botulinum Toxin
This proof of concept study seeks to demonstrate that Botulinum toxin injections are a safe and effective method for treating this form of hair loss.
- Trial name
- NCT00965640
- Testing
- Botulinum Toxin - A injections
- Where
- Canada
- Volunteers
- healthy volunteers welcome
- Sponsor
- The Crown Institute
Spasmodic Dysphonia
Zinc Supplementation Prior to Botox Injections for Spasmodic Dysphonia
One initial study has shown that Botulinum Toxin (BT) in combination with zinc supplementation may increase the duration of effects BT treatment. This initial study was in the context of facial aesthetics.
- Trial name
- NCT05892770
- Testing
- Zinc gluconate supplement, Botulinum toxin type A
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of Florida
Healthy Volunteers
Botulism Antitoxin Effects on Paralysis Induced by Botulinum Neurotoxins in the EDB Muscle
The primary purpose of this study is: 1. To evaluate the model determined by the ability of botulism antitoxin (bivalent, Aventis) to neutralize Botulinum toxin in the Extensor Digitorum Brevis model of muscle paralysis in Stage…
- Trial name
- NCT00636519
- Testing
- Botulism Antitoxin Bivalent (Equine) Types A and B, Botulism Antitoxin Heptavalent (Equine) Types A-G
- Where
- 2 sites in United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Emergent BioSolutions
Cosmetic Treatment Wish
Quality of Life After Cosmetic Treatments
Prospective cohort study, investigating the pre-post treatment effect of cosmetic injectable and surgical treatments on quality of life (primary outcome measure: FACE-Q Psychological, secondary outcome measure: FACE-Q Social)…
- Trial name
- NCT07687030
- Volunteers
- 1,080 people, healthy volunteers welcome
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Healthy
Safety and Efficacy of NT 201, Free of Complexing Proteins, in the Treatment of Glabellar Frown Lines
NT 201 is a Botulinum toxin type A preparation free of complexing proteins. Injected into the muscle, NT 201 causes a reversible local relaxation of the injected muscle.
- Trial name
- NCT00694148
- Testing
- NT 201
- Where
- Germany
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- Merz Pharmaceuticals GmbH
Glabellar Frown Lines
The Safety and Efficacy Study of PROTOXIN in Subjects With Moderate to Severe Glabellar Lines
This study will be conducted in Phase I/II clinical trials. In Phase I, subjects with moderate to severe glabellar lines are enrolled and those who are judged to be eligible for this study will be injected with the "PROTOXIN" at…
- Trial name
- NCT04996810
- Testing
- PROTOXIN, Botox®
- Where
- 2 sites in South Korea
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Protox Inc.
Hyperhidrosis
Hyperhydrosis Treatment Using Botulinum Toxin
The purpose of this study is to describe two safe and reproducible techniques for the treatment of hyperhidrosis using botulinum toxin.
- Trial name
- NCT03816046
- Testing
- botulinum toxin A
- Where
- Lebanon
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- St Joseph University, Beirut, Lebanon