Clinical trials: Botulinum Toxin
Breast Cancer, Pain, Postoperative
Botulinum Toxin A (Botox) in Tissue Expander Breast Reconstruction
Each year, the number of breast cancer survivors who choose post-mastectomy breast reconstruction keeps rising. Among women who elect to pursue breast reconstruction, approximately 75% will choose prosthetic breast…
- Conditions
- Breast Cancer, Pain, Postoperative, BRCA1 Mutation, BRCA2 Mutation
- Trial name
- NCT01591746
- Testing
- Botulinum Toxin Type A
- Where
- United States
- Volunteers
- 131 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Spastic Equinovarus Foot, Stroke
Efficacy Study of Selective Tibial Neurotomy in the Treatment of the Spastic Equinovarus Foot Among Adult Hemiplegic Patients
Spastic equinovarus foot (SEF) is a major cause of disability in stroke patients. Treatments may include physical therapy, orthosis, botulinum toxin (BTX) injections and selective neurotomy.
- Trial name
- Neurotomy (NCT00825097)
- Testing
- Selective tibial neurotomy, Botulinum toxin injection
- Where
- Belgium
- Volunteers
- 16 people
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Stroke, Spasticity, Muscle
Efficacy of Extracorporeal Shock Wave Therapy on Spasticity
Introduction: We aimed to compare the efficacy of Botulinum Toxin Type A(BoNT-A) injection and BoNT-A injection in combination with ESWT for post-stroke lower extremity ankle plantar flexor spasticity.
- Trial name
- NCT06225024
- Testing
- ESWT, BoNT A
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Kayseri City Hospital
Parkinson Disease, Parkinsonism
Botulinum Toxin for Treatment of Seborrhic Dermatitis in Parkinsonian Patients
There's high incidence of seborrhic dermatitis among patients suffering from Parkinson's disease. Seborrhic dermatitis is caused by increased exertion of sebaceous glands.
- Conditions
- Parkinson Disease, Parkinsonism, Seborrheic Dermatitis
- Trial name
- NCT00767546
- Testing
- Botulinum toxin
- Volunteers
- 40 people
- Sponsor
- Rabin Medical Center
Idiopathic Cervical Dystonia
Targeting Methods of Botulinum Toxin Injections for Cervical Dystonia
Botulinum toxin injections are the treatment of choice for cervical dystonia. Even if this treatment is successful for most of the patients, partials or completes failures still remained.
- Trial name
- RINOCERAUS (NCT03946046)
- Testing
- Clinical targeting, Ultrasonography targeting
- Where
- France
- Volunteers
- 132 people
- Sponsor
- University Hospital, Lille
Spasmodic Torticollis
PurTox (Botulinum Toxin Type A) for the Treatment of Adult Onset Spasmodic Torticollis/Cervical Dystonia
The safety and efficacy of Mentor Purified Toxin, Botulinum Toxin Type A, Purified Neurotoxin, injected intramuscularly into the neck, is being evaluated as a treatment for painful and non-painful spasmodic torticollis/cervical…
- Trial name
- NCT00549341
- Testing
- Mentor Purified Toxin, Botulinum Toxn Type A, Purified Neurotoxin, Physiologic saline
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Mentor Worldwide, LLC
Stroke, Muscle Spasticity
Study of Responsiveness of Seven Functional Tasks in Patients With Poststroke Upper Limb Spasticity With Botulinum Toxin Type A Treatment
This study evaluates the responsiveness of 7 functional tasks to botulinum toxin Type A treatment in poststroke patients with spasticity of the upper-limb flexors
- Trial name
- NCT00651690
- Testing
- Botulinum Toxin Type A
- Where
- United States
- Volunteers
- 62 people
- Sponsor
- Allergan
Pain Due to Certain Specified Procedures, Neuropathic Pain
Early Administration of Botox® in Neuropathic Pain Due to Thoracoscopy or Thoracotomy
Botulinum toxin type A has been reported to inhibit the release of various pain neurotransmitters (SP, CGRP, glutamate) responsible for neurogenic inflammation, a process that results from the sensitization of C-fiber nociceptors…
- Trial name
- APTODON (NCT01325090)
- Testing
- BOTOX
- Where
- France
- Sponsor
- University Hospital, Limoges
Cervicogenic Headache
Botulinum Toxin Injection in Neck Muscles in Cervicogenic Headache
The purpose of this study is to investigate the effect and side-effects of injections with botulinum toxin in neck muscles in cervicogenic headache compared to injections with sodium water.
- Trial name
- NCT00184197
- Testing
- Botulinum toxin
- Where
- Norway
- Volunteers
- 28 people
- Sponsor
- Norwegian University of Science and Technology
Plantar Fascitis, Botulinum Toxins, Type A
Therapeutic Effect of Botulinum Toxin A for the Treatment of Plantar Fasciitis.
Plantar fasciitis is the most common cause of plantar heel pain and is commonly present in people 40 years of age or older, overweight, sedentary or with intense physical activity.
- Trial name
- NCT03054610
- Testing
- Betamethason Sodium Phosphate, Ropivacaine, Botulinum Toxins, Type A
- Where
- Mexico
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Universidad Autonoma de Nuevo Leon
Bladder Pain Syndrome
Comparative Study Suburothelial and Trigonal Botulinum Toxin A Injection in Treatment of Interstitial Cystitis
There is no consensus of the therapeutic efficacy and safety between suburothelial injection and trigonal injection of botulinum toxin A (BoNT-A) in treatment of interstitial cystitis/bladder pain syndrome (IC/BPS) It is unmet to…
- Trial name
- NCT03076762
- Testing
- intravesical onabotulinumtoxinA injection
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- Buddhist Tzu Chi General Hospital
Chronic Prostatitis With Chronic Pelvic Pain Syndrome, Prostatitis
Botulinum Toxin Type A for the Treatment of Male Chronic Pelvic Pain Syndrome
The aim of this randomized placebo-controlled study is to demonstrate the efficiency and safety of the injection of Botulinum Toxin Type A (200 Units) into the external urethral sphincter for the treatment of chronic…
- Trial name
- BTX-URO-01 (NCT00464373)
- Testing
- Botulinum Toxin Type A
- Where
- Switzerland
- Volunteers
- 11 people
- Sponsor
- Daniel Stephan Engeler
Multiple Sclerosis
Botulinum Toxin in Patients With Spastic Lower Limb Paresis Associated With Multiple Sclerosis
Spastic paraparesis is one of the most disabling functional deficits in the population with multiple sclerosis between 18 and 80 years of age and at any functional level.
- Trial name
- NCT04595045
- Testing
- Botulinum toxin type A infiltrations
- Where
- 2 sites in Spain
- Volunteers
- 84 people
- Sponsor
- Aránzazu Vázquez Doce
Dystonia
Pilot Trial of Botulinum Toxin and Occupational Therapy for Writer's Cramp
Objective: Writer s cramp (WC) is a form of focal hand dystonia (FHD). Focal injections of botulinum toxin (BoNT) are the current best therapy. Past studies showed that some types of rehabilitative therapy can be useful.
- Trial name
- NCT02015039
- Testing
- BoNT Injections, Occupational Therapy
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Keloid Scars
The Effectiveness of Intralesional Botulinum Toxin A and Triamcinolone Acetonide Injections in Keloid Treatment
Keloids are benign fibrous tissue overgrowths that extend beyond the boundaries of the original wound and tend to recur after therapy.
- Trial name
- NCT06814288
- Testing
- Botulinum toxin A, Triamcinolone Acetonide
- Where
- Indonesia
- Volunteers
- 20 people
- Sponsor
- Universitas Padjadjaran
Hereditary Spastic Paraplegia
Effects of Botulinum Toxin Injections in Patients With Hereditary Spastic Paraplegia
Hereditary spastic paraplegias constitute a heterogeneous group of diseases with the common predominant feature of spasticity of the lower limbs.
- Trial name
- SPASTOX (NCT02604186)
- Testing
- Botulinum Toxin Injections
- Where
- Brazil
- Volunteers
- 55 people
- Sponsor
- University of Campinas, Brazil
Diabetic Neuropathies
Botulinum Toxin Type A in Diabetic Peripheral Neuropathy
Background: Diabetes mellitus is commonly complicated by diabetic peripheral neuropathy. Due to common side effects and poor tolerance to medication, poor adherence to medication is common in diabetic peripheral neuropathy.
- Trial name
- NCT05296759
- Testing
- botulinum toxin A, Gabapentin, Duloxetine
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Alexandria University
Brow Lifting
The Impact of Botulinum Toxin on Brow Height and Morphology: A Randomized Controlled Trial
The purpose of this study is to describe three safe and reproducible techniques for brow lifting using botulinum toxin. It will also describe the effect of 2 techniques on the eyebrow shape using quantitative, objective…
- Trial name
- NCT02942303
- Testing
- Dysport, lateral orbicularis injection, Lateral orbicularis + corrugator injection
- Where
- Lebanon
- Volunteers
- 30 people
- Sponsor
- St Joseph University, Beirut, Lebanon
Parkinson's Disease
The Use of Botox in Advanced Parkinson's Patients Experiencing Pain
Most Parkinsonism related pain can be assigned to one or more of five categories: musculoskeletal pain, neuritic or radicular pain, dystonia associated pain, primary or central pain, and akathitic discomfort.
- Trial name
- NCT02472210
- Testing
- Botulinum Toxin
- Volunteers
- 14 people
- Sponsor
- University Health Network, Toronto
Atrial Fibrillation
Botulinum Toxin Injection Into Epicardial Fat Pads to Prevent Atrial Fibrillation in Patients Undergoing Cardiac Surgery
The aim of this prospective randomized double-blind study was to compare the efficacy of botulinum toxin injection in epicardial fat pads for preventing recurrences (in early postoperative period) of atrial tachyarrhythmia in…
- Trial name
- NCT02617069
- Testing
- botulinum toxin injection, 0.9% normal saline injection, Implantable loop recorder
- Where
- Russia
- Volunteers
- 170 people
- Sponsor
- Meshalkin Research Institute of Pathology of Circulation