Clinical trials: Bronchiectasis
Bronchiectasis
Comparison of Physical Activity Level Between Patients With Bronchiectasis and Healthy Subjects
The purpose of this study is to compare physical activity levels between patients with bronchiectasis and healthy subjects. We hypothesize that patients with bronchiectasis will have lower levels of physical activity, since…
- Trial name
- NCT02550821
- Where
- Turkey (Türkiye)
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
Post-Lung Transplantation Bronchiectasis
Lung Ultrasound Artefact Analysis for Exclusion of Acute Rejection in Lung Transplant Recipients
This study is being done to study a safe and non-invasive way to diagnose lung rejection and infection.
- Trial name
- NCT04582279
- Testing
- Lung ultrasound
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Normal Values of Nasal Nitric Oxide in Healthy Adults
Determination of Normal Values of Nasal Nitric Oxide in Adults
Primary ciliary dyskinesia (PCD) is a rare genetic disorder characterized by impaired airway mucociliary clearance leading to recurrent respiratory infections, bronchiectasis and eventually respiratory insufficiency.
- Trial name
- NCT02133547
- Where
- Switzerland
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire Vaudois
Bronchiectasis Adult, Bronchiectasis With Pseudomonas Aeruginosa Colonization
First in Human Trial of CTX-187 in Healthy Volunteers and Chronically Infected Patients
The primary objective of this trial is to assess the safety and tolerability of single and multiple ascending intravenously (IV) infused doses of CTX-187 when administered to healthy adult male and female participants and…
- Conditions
- Bronchiectasis Adult, Bronchiectasis With Pseudomonas Aeruginosa Colonization, Bacterial Infections
- Trial name
- NCT07708116
- Testing
- CTX-187
- Where
- Netherlands
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- Centauri Therapeutics Limited
Bronchiectasis Adult
Bronchodilators on the Exercise Capacity of Bronchiectasis Patients
The bronchodilators (BD) have been widely used in bronchiectasis (BCE) therapeutic and have been shown to be effective in improving exercise capacity in patients with chronic obstructive pulmonary disease and asthma.
- Trial name
- NCT05183841
- Testing
- Bronchodilator (Ipratropium and Fenoterol)
- Where
- 3 sites in Brazil
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo General Hospital
Healthy Children, Bronchiectasis Adult
The Utility of Lung Clearance Index in Ethnic Groups and in Disease
Introduction: Non-CF, non-PCD bronchiectasis in children is a chronic, suppurative lung disease diagnosed by high resolution computed tomography (HRCT) imaging of the lungs.
- Conditions
- Healthy Children, Bronchiectasis Adult, Lung Clearance Index
- Trial name
- LUCI-ED (NCT05989360)
- Testing
- Lung Clearance Index
- Where
- United Kingdom
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- Birmingham Women's and Children's NHS Foundation Trust
Bronchiectasis, Cystic Fibrosis
Evaluating Bronchodilator Response in Patients With Bronchiectasis
Although patients with bronchiectasis tend to have non reversible obstructive patterns on pulmonary function tests (PFTs), reversible obstruction is not uncommon.
- Conditions
- Bronchiectasis, Cystic Fibrosis, Primary Ciliary Dyskinesia, Primary Immune Deficiency
- Trial name
- NCT05932316
- Testing
- spirometry, Salbutamol
- Where
- Israel
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Rambam Health Care Campus
Asthma, COPD
Acoustic Waveform Respiratory Evaluation
The study will evaluate the feasibility of using smartphone speakers and microphones to evaluate the caliber of the airways, detect airway obstruction, aid in airway disease diagnosis, and identify disease exacerbations.
- Conditions
- Asthma, COPD, Cystic Fibrosis, Ciliary Motility Disorders
- Trial name
- AWARE (NCT06512064)
- Testing
- AWARE
- Where
- 2 sites in United States
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- Indiana University
Bronchiectasis
Pulmonary Rehabilitation in Non-Cystic Fibrosis Bronchiectasis
The purpose of this study is to assess the effect of pulmonary rehabilitation on the transport of secretions, inflammation and respiratory resistance, and its repercussions on the quality of life in patients with bronchiectasis.
- Trial name
- NCT02823587
- Testing
- Pulmonary Rehabilitation, Control
- Where
- Brazil
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Healthy Participants, Non-cystic Fibrosis Bronchiectasis
A Phase 1a/1b Study to Investigate the Safety, Tolerability, Microbiological Response, and Pharmacokinetics of Inhaled Rev-56 in Adult Healthy Volunteers and Adult Non-cystic Fibrosis Bronchiectasis (NCFB) Patients With Chronic P. Aeruginosa
This is a Phase 1a/1b study to test the safety, tolerability, microbiological response, and pharmacokinetics of inhaled Rev-56 compared to placebo in adult healthy participants and non-cystic fibrosis bronchiectasis (NCFB)…
- Trial name
- NCT07709494
- Testing
- Rev-56 for Inhalation
- Where
- United States
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Revagenix, Inc.
Common Variable Immunodeficiency, Granulomatous Disease
Lymphocyte Immunophenotyping in Common Variable Immunodeficiency
The purpose of this study is to discover if differences in the surface markers of B-cells (antibody producing cells of the immune system) in Common Variable Immune Deficiency (CVID) are related to CVID or its…
- Conditions
- Common Variable Immunodeficiency, Granulomatous Disease, Bronchiectasis, Immunoglobulin Treatment
- Trial name
- NCT01196702
- Where
- United Kingdom
- Volunteers
- 210 people, healthy volunteers welcome
- Sponsor
- Barts & The London NHS Trust
Bronchiectasis
Balance, Cognıtıve Skılls, Hand Functıons and Qualıty of Lıfe Among Patients with Bronchiectasis and Healthy Peers
The aim of this study is to comparatively evaluate the parameters of balance, cognitive skills, hand grip strength, reaction time, quality of life and respiratory functions in elderly and healthy peers individuals.
- Trial name
- NCT06606665
- Testing
- Cognitive skills test, Reaction time test, Quality of life assessment
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Atlas University
Chronic Obstructive Pulmonary Disease, Asthma
Controls for Respiratory Diseases
This is the registry of control participants for patients with various respiratory diseases. We screened healthy volunteers who visited Seoul National Hospital Healthcare System Gangnam Center for routine health check-up, and…
- Conditions
- Chronic Obstructive Pulmonary Disease, Asthma, Idiopathic Pulmonary Fibrosis, Nontuberculous Mycobacterium Infection
- Trial name
- NCT03120481
- Testing
- no intervation
- Where
- South Korea
- Volunteers
- 1,572 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Bronchiectasis
Different Phenotypes of Bronchiectasis
Bronchiectasis is defined as abnormal chronic dilatation of one or more bronchi. Patients have a structural abnormality of the bronchial wall that predisposes them to bacterial infection likely due to impaired mucus clearance.
- Trial name
- NCT03262064
- Testing
- Pulmonary function tests,Bronchiectasis severity index score
- Where
- Egypt
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Assiut University
Bronchiectasis Adult
Combined Effects of Resonant Breathing and Qigong Exercises in Bronchiectasis
Bronchiectasis is a chronic lung disease characterized by permanent dilation of the bronchi, leading to persistent cough, mucus overproduction, dyspnea and frequent respiratory infections.
- Trial name
- NCT07725991
- Testing
- Resonant breathing and Qigong Exercise., Resonant breathing exercise
- Where
- Pakistan
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Riphah International University
Non-cystic Fibrosis Bronchiectasis、Chronic Sinusitis Without Nasal Polyps、Chronic Obstructive Pulmonary Disease
Study on Drug Interactions Affecting the Pharmacokinetics of RSS0343 Tablet
This study is a single-center, single-sequence, self-controlled, open design, aiming to investigate the effects of rifampicin and clarithromycin on the pharmacokinetics of RSS0343 in humans.
- Trial name
- NCT07696091
- Testing
- RSS0343 Tablet; Rifampicin Capsules, RSS0343 Tablet; Clarithromycin Tablets
- Where
- China
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Reistone Biopharma Company Limited
Lung Transplant, Lung Resection
Developing Optimal Parameters for Hyperpolarized Noble Gas and Inert Fluorinated Gas MRI of Lung Disorders
The goal of this research is to optimize the MRI system to obtain ideal lung images using Hyperpolarized (HP) Noble and Inert Fluorinated Gases as contrast agents. Lung coils tuned to the frequencies of these gases will be used.
- Conditions
- Lung Transplant, Lung Resection, Lung Cancer, Asthma
- Trial name
- NCT02748798
- Testing
- HP 3He, HP 129Xe, PFP
- Where
- Canada
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Thunder Bay Regional Health Research Institute
Bronchiectasis Adult
Comparison of Serum SIRT-1 and MMP-9 Levels of Patients With Bronchiectasis and Healthy Controls
The purpose of this a cross-sectinol study is to measure the levels of MMP-9 and SIRT-1 levels in patients with bronchiectasis and healthy controls.
- Trial name
- NCT06589492
- Testing
- Measurement of MMP-9 and SIRT-1 levels in blood serum
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Cumhuriyet University
Temperature Change, Body, Bronchiectasis
Temperature Recording in Lungs of Volunteers With and Without Pulmonary Diseases
The purpose of the project is to estimate the air temperature in the lungs after a change from room temperature (25℃) to an environment with a constant temperature of 88-92℃ in resp.
- Conditions
- Temperature Change, Body, Bronchiectasis, Heat Exposure, Heat
- Trial name
- TEMP-REC-LUNG (NCT05344300)
- Testing
- Temperature-measurement in lungs under sauna bath
- Where
- Denmark
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Chronic Obstructive Pulmonary Disease Trial Network, Denmark
Bronchiectasis Adult, Mediastinal Lymphadenopathy
Lidocaine Administration During Flexible Bronchoscopy and Endobronchial Ultrasound
The purpose of this study is to assess if there is decrease in cough during flexible bronchoscopy and endobronchial ultrasound when different modes of lidocaine administration are used.
- Conditions
- Bronchiectasis Adult, Mediastinal Lymphadenopathy, Pneumonia, Chest--Diseases
- Trial name
- NCT03829618
- Testing
- Topical lidocaine, Nebuliser solution, Nebuliser Suspension
- Where
- United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Milton S. Hershey Medical Center