Clinical trials: Bronchoalveolar Lavage
Emphysema
Prostaglandin Inhibition for Emphysema
The Prostaglandin Inhibition for Emphysema (PIE) study will determine if a currently available therapy, ibuprofen 600 mg three times daily, can block PGE production in the lower respiratory tract and if this results in…
- Trial name
- PIE (NCT02006576)
- Testing
- 600 mg ibuprofen three times daily for 48 weeks
- Where
- 5 sites in United States
- Volunteers
- 118 people, healthy volunteers welcome
- Sponsor
- University of Nebraska
Healthy
Validating the Use of Disposable Bronchoscopes for Research Bronchoalveolar Lavage
Validation study to use the disposable bronchoscopes in healthy volunteer research bronchoscopies to ensure adequate sample and cell yield.
- Trial name
- BALval (NCT02515591)
- Testing
- Bronchoalveolar Lavage validation study
- Where
- United Kingdom
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Liverpool University Hospitals NHS Foundation Trust
Immune Checkpoint Inhibitor Associated Pneumonia
Prospective Study on the Efficacy and Safety of Bronchoalveolar Lavage Combined With Pathogen Metagenomic Sequencing Technology in the Diagnosis of Immune Checkpoint Inhibitor Associated Pneumonia
Immune checkpoint inhibitor associated pneumonia (CIP) is a common immune related adverse reaction, accounting for 35% of all deaths.
- Trial name
- NCT06192303
- Testing
- Bronchoalveolar lavage and pathogen metagenomic sequencing
- Where
- China
- Volunteers
- 104 people
- Sponsor
- Nanfang Hospital, Southern Medical University
HRV and RSV Presence in the Lungs of Stable COPD Patients.
Viral Infections in BAL and Bronchial Biopsies of Stable COPD Patients
Background: The presence of low-grade viral infection in the airways of patients with stable chronic obstructive pulmonary disease (COPD) could potentially have implications in the pathogenesis and progression of the disease, but…
- Trial name
- NCT02622009
- Testing
- BRONCHOSCOPIC PROCEDURE
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- University of Athens
Ventilator Associated Pneumonia
Diagnosis of Ventilator- Associated Pneumonia in Children: A Comparative Study of Bronchoscopic and Non-Bronchoscopic Methods
Background and Objectives: There is a need to validate and suggest easy and less costly diagnostic method for diagnosis of ventilator-associated pneumonia in developing country.
- Trial name
- NCT00495963
- Testing
- bronchoaleolar lavage, Bronchoscopy
- Where
- India
- Sponsor
- Sir Ganga Ram Hospital
Acute Hypoxemic Respiratory Failure, Sepsis
EARLY-SARDS: Early AlveolaR Lung biologY Underling Sepsis-Associated ARDS
Sepsis-associated acute respiratory distress syndrome (ARDS) remains a major cause of respiratory failure and mortality in critically ill patients.
- Conditions
- Acute Hypoxemic Respiratory Failure, Sepsis, ARDS (Acute Respiratory Distress Syndrome)
- Trial name
- EARLY-SARDS (NCT07281911)
- Testing
- Serial bronchoalveolar lavage and biological-physiological assessment
- Where
- Spain
- Volunteers
- 145 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Gastroesophageal Reflux Disease
Role of Pepsin Assay in Wheezy Infants
Wheezy infants were tested for gastro-esophageal reflux disease (GERD) using combined multiple channel intraluminal impedance-pH (MII-pH), esophagogastroduodenoscope (EGD), lipid laden macrophage index and BAL pepsin.
- Trial name
- NCT02685436
- Testing
- Omeprazole and domperidone
- Volunteers
- 52 people
- Sponsor
- Mansoura University Children Hospital
INvasive Aspergillosis, Mechanical Ventilation
Diagnostic Study of Biomarkers in BAL of ICU Patients With Lung Infiltrates
The aim of this project is therefore to explore on the clinical significance of analyzing surrogate markers combined with conventional diagnostics in the ICU setting.
- Conditions
- INvasive Aspergillosis, Mechanical Ventilation, Lung Infiltrates, Diagnostics
- Trial name
- NCT01695499
- Where
- Germany
- Volunteers
- 200 people
- Sponsor
- Heidelberg University
Emerging Infectious Diseases, Communicable Diseases
Establishment of a Biobank for the Evaluation of Rapid Diagnostic Solutions
This multicenter prospective registry aims to establish a biobank of residual biological samples and associated clinical data from hospitalized patients.
- Conditions
- Emerging Infectious Diseases, Communicable Diseases, Biological Warfare Agents, Zoonoses
- Trial name
- NCT07411729
- Where
- 10 sites in France
- Volunteers
- 800 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Traumatic Brain Injury, Ventilator Associated Pneumonia
Effect of E-BAL on Severity of VAP Assessed Through CPIS on the Patients of Traumatic Brain Injury in Neurocritical Care, Also Effect on Days of Ventilation and ICU Stay.
Severe traumatic brain injury (STBI) is a leading cause of disability, mortality, and economic burden worldwide. The impact of severe traumatic brain injury (STBI) on the economy of developing countries like Pakistan is…
- Trial name
- NCT04977843
- Testing
- EARLY BRONCHOALVEOLAR LAVAGE
- Where
- Pakistan
- Volunteers
- 60 people
- Sponsor
- Jinnah Hospital
Ventilator Acquired Pneumonia
Direct E-test on Bronchoalveolar Lavage From Patients With Ventilator-acquired Pneumonia
Background: Ventilator-acquired pneumonia (VAP) is the most prevalent nosocomial infection in intensive care units (ICUs). Early microbiological diagnosis and initial administration of appropriate antimicrobial therapy are…
- Trial name
- NCT01042353
- Testing
- E test, standard culture method
- Where
- France
- Volunteers
- 20 people
- Sponsor
- Université Victor Segalen Bordeaux 2
Vaping Related Disorder
Radiology and BAL in Vaping Associated Lung Injury
Radiology and BAL in Vaping associated lung disease
- Trial name
- NCT07499557
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Alexandria University
Alpha1-antitrypsin Deficiency
GLASSIA Safety, Immunogenicity, and Bronchoalveolar Lavage Study
The purpose of the study is 2-fold: (1) to evaluate the safety and potential immunogenicity of GLASSIA following intravenous (IV) administration via in-line filtration; and (2) to assess the effects of GLASSIA augmentation…
- Trial name
- NCT02525861
- Testing
- GLASSIA
- Where
- 18 sites in United States, Canada
- Volunteers
- 34 people
- Sponsor
- Baxalta now part of Shire
HIV, ICL
Tissue Biopsy and Imaging Studies in HIV-Infected Patients
This study will examine tissue from the tonsils, lymph nodes and large bowel of HIV-infected patients to investigate changes in viral load and certain white blood cells during treatment.
- Conditions
- HIV, ICL, Healthy Volunteers
- Trial name
- NCT00001471
- Where
- United States
- Volunteers
- 386 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Lung Neoplasms, Tumor Immune Microenvironment
Association of BAL Fluid T-Cell Immune Activity With Tumor PD-L1 Expression and Its Prognostic Value: A Prospective Observational Study
This prospective observational study aims to evaluate whether immune profiles of T-cell subsets in bronchoalveolar lavage fluid can complement tumor PD-L1 expression, assessed by immunohistochemistry in tumor tissue specimens, in…
- Trial name
- NCT07331701
- Where
- South Korea
- Volunteers
- 60 people
- Sponsor
- Seoul National University Hospital
Pneumonia, Ventilator-Associated
Bilateral Bronchoalveolar Lavage in Ventilator-associated Pneumonia
The purpose of this study is to assess microbiologic concordance rates between right- and left-lung bronchoalveolar lavage cultures from patients with suspected ventilator-associated pneumonia, identify predictors of concordance…
- Trial name
- NCT02542553
- Testing
- Bilateral BAL
- Volunteers
- 79 people
- Sponsor
- Catholic University of the Sacred Heart
Meconium Aspiration
Phase III Randomized Study of Lucinactant in Full Term Newborn Infants With Meconium Aspiration Syndrome
OBJECTIVES: Evaluate the safety and efficacy of lucinactant administered by bronchoalveolar lavage (BAL) in the treatment of meconium aspiration syndrome (MAS) in newborn infants.
- Trial name
- NCT00004500
- Testing
- Lucinactant, Standard Care
- Where
- United States
- Volunteers
- 69 people
- Sponsor
- Windtree Therapeutics
ARDS (Acute Respiratory Distress Syndrome)
Comparative Analysis of Salivary and Bronchoalveolar Lavage IL-6 and TNF-α as Biomarkers in Pediatric Acute Respiratory Distress Syndrome
The aim of this study is to determine the degree of agreement in cytokines level measured through BAL and those measured through salivary glands excretion.
- Trial name
- NCT07380373
- Testing
- Bronchoscopy
- Where
- Egypt
- Volunteers
- 37 people
- Sponsor
- Ain Shams University
Intensive Care
Bedside Measurement of Ventilation With or Without a One-way Valve During Lung Lavage
Surveillance of the lungs for bacteria is routinely undertaken in artificially ventilated patients as these individuals are at high risk of developing pneumonia.
- Trial name
- NCT01143961
- Testing
- CSC100 - Verso airway access adapter CareFusion
- Where
- United Kingdom
- Volunteers
- 50 people
- Sponsor
- Cardiff and Vale University Health Board
Healthy Young Adults, Influenza Vaccines
Characterizing the Human Airway Immune Response to FluMist Vaccination
The goal of this clinical trial is to measure the immune response in the blood, nose, and lungs after participants receive either the FDA-approved inactivated influenza vaccine or the FDA-approved intranasal FluMist vaccine.
- Conditions
- Healthy Young Adults, Influenza Vaccines, Influenza Vaccine Response
- Trial name
- EVax-3 (NCT07177417)
- Testing
- FluMist, inactivated influenza vaccine, bronchoscopy
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine