Clinical trials: Caffeine
Cognitive Performance
Assessing the Effectiveness of an N-of-1 Platform Using Study of Cognitive Enhancers
The growing consumer-grade molecular and digital wellness market is generating unprecedented volumes of information to support decision-making around individual health.
- Trial name
- NCT04056650
- Testing
- L-theanine, Caffeine supplement, N1 app
- Where
- United States
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
Exercise Response
Caffeine Mouth Rinse on Salivary Immunoglobulin A, Lactoferrin and A-Amylase Levels
The goal of this clinical trial is to investigate the effects of the mouth rinse form of caffeine (400 mg) on salivary lactoferrin, α-amylase and secretory immunoglobulin-a levels after incremental exercise in young amateur…
- Trial name
- NCT06704711
- Testing
- Caffeine 300 MG, Exercise
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Gaziantep
Drug Drug Interaction (DDI)
Drug-Drug Interaction (DDI) Study for TD-9855
This study is designed to assess the effect of fluvoxamine, itraconazole and smoking on the PK disposition of multiple doses TD-9855 in healthy male subjects.
- Trial name
- NCT03432793
- Testing
- TD-9855, Fluvoxamine, Itraconazole
- Where
- United States
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Theravance Biopharma
Sickle Cell Disease
Drug Interaction Study of GBT440 With Caffeine, S-warfarin, Omeprazole, and Midazolam in Healthy Subjects
The purpose of this study to evaluate the effect of concomitant administration of GBT440 on caffeine (a CYP1A2 probe substrate), S warfarin (a CYP2C9 probe substrate), omeprazole (a CYP2C19 probe substrate), and midazolam (a…
- Trial name
- NCT02567682
- Testing
- GBT440
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Global Blood Therapeutics
Fatigue
Evaluate the Effectiveness and Safety of the Alpinia Galanga Formulation, Theacrine Formulation, and Caffeine Formulation on Fatigue, Mental Acuity, and Cognitive Health
The purpose of this study is to assess the effectiveness and safety of the Alpinia galanga formulation, Theacrine formulation, and Caffeine formulation on fatigue, mental acuity, and cognitive health among overall healthy…
- Trial name
- NCT05170113
- Testing
- Alpinia galanga formulation, Theacrine formulation, Caffeine formulation
- Where
- United States
- Volunteers
- 79 people, healthy volunteers welcome
- Sponsor
- Supplement Formulators, Inc.
Mental Fatigue, Cognitive Performance
Phosphatidylserine, Taurine, and Caffeine for Cognitive Fatigue in Professional Football Players
This randomized, double-blind, placebo-controlled, parallel-group trial evaluated neurocognitive fatigue resistance and football-specific decision-making following 28 days of taurine-caffeine supplementation with or without…
- Conditions
- Mental Fatigue, Cognitive Performance, Athletic Performance, Soccer Performance
- Trial name
- TCPS-Foot (NCT07696052)
- Testing
- Taurine Plus Caffeine, Taurine, Caffeine, and Phosphatidylserine
- Where
- 2 sites in Poland
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- Vizja University in Warsaw
Chronic Pain
AZD2066 Cocktail Study
The aims of this study are to examine the effect of repeated doses of AZD2066 and of caffeine, bupropion, tolbutamide, omeprazole, metoprolol and midazolam on the blood concentrations of each other
- Trial name
- NCT00930306
- Testing
- AZD2066, Caffeine, Tolbutamide
- Where
- 2 sites in United Kingdom
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Athletic Performance, Cognitive Fatigue
TCP-600 Supplementation and Performance Response in Professional Football Players
This study will examine whether a 28-day supplementation protocol containing taurine, caffeine, and phosphatidylserine can help professional male football players maintain physical performance, cognitive function…
- Conditions
- Athletic Performance, Cognitive Fatigue, Exercise Recovery, Football-Specific Performance
- Trial name
- TCP600-RESP (NCT07710547)
- Testing
- Taurine, Caffeine, Phosphatidylserine
- Where
- 3 sites in Poland
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- Vizja University in Warsaw
Carbohydrate, Caffeine
Carbohydrate Rinsing and Caffeine Gum on Performance of Romanian Deadlifts Performance
Two experiments were completed to investigate the effects of carbohydrate mouth rinsing and caffeine gum chewing on inertial resistance exercise performance.
- Trial name
- NCT05900349
- Testing
- Carbohydrate mouth rinsing, 200 mg caffeine gum
- Where
- Taiwan
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- National Taiwan Sport University
Ischemia-Reperfusion Injury
Adenosine Receptors Influence Ischemia-Reperfusion Injury
Ischemic preconditioning is defined as the development of tolerance to ischemia-reperfusion injury by a previous short bout of ischemia resulting in a marked reduction in infarct size.
- Trial name
- NCT00184847
- Testing
- acetylcholine, twenty minutes of forearm ischemia, three 5-minute periods of forearm ischemia
- Where
- Netherlands
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Overweight, Obesity
A Study to Test Whether BI 456906 (Survodutide) Influences the Amount of Bupropion, Caffeine and Midazolam in the Blood in People With Overweight or Obesity
This study is open to adults with overweight or obesity who are otherwise healthy. People can join the study if they have a body mass index of 27 to 39.9 kg/m2 and a body weight over 70 kg.
- Trial name
- NCT06564441
- Testing
- Survodutide, Bupropion, Caffeine
- Where
- Belgium
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Boehringer Ingelheim
Cardiovascular Risk
Clinical Trial on the Effects of Caffeine and Taurine From Energy Drinks (EDs) to Parameters of the Cardiovascular System in Humans
The aim of this study is to examine the safety and the effects of EDs at high doses, either alone or in combination with other risk factors such as alcohol intake, physical exercise and sleep deprivation, on cardiovascular…
- Trial name
- NCT01421979
- Testing
- Energy Drink, Taurine, Caffeine
- Where
- Germany
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- University of Hohenheim
Refractive Ametropia, Astigmatism
1-Week Dispensing Evaluation of REVIVE™ Toric Soft Contact Lenses
Experienced soft contact lens wearing subjects were enrolled in this 1-week, post-market, bilateral, repeated measures, dispensing study.
- Trial name
- NCT06053736
- Testing
- REVIVE Toric Soft Contact Lenses
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Bausch & Lomb Incorporated
Anesthesia
A Study to Determine if Caffeine Accelerates Emergence From Anesthesia
At present clinicians have no way to reverse anesthesia. Patients wake when their bodies clear the anesthetic. Most people wake quickly, but some do not.
- Trial name
- NCT02567968
- Testing
- Caffeine
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- University of Chicago
Snoring
The Effect of Caffeine Reduction on Snoring and Quality of Life
Snoring is a problem for many people, often disturbing energy level, quality of sleep, and the relationship with a bed partner. Two observational studies that have indicated a relationship between the consumption of caffeine and…
- Trial name
- NCT00641810
- Testing
- Caffeine reduction
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Vermont
Mental Fatigue
The Effect of a Caffeine Blend on Reaction Time, Mental Performance and Focus in Athletic Males
This is a cross-over design study in which subjects arrived to the lab and were assigned a supplement to ingest. Prior to ingestion subjects completed baseline reaction time testing along with a questionnaire.
- Trial name
- NCT03019523
- Testing
- Caffeine Blend, Sugar Pill
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- University of Mary Hardin-Baylor
Myopia
Evaluation of Short Term Use of Experimental Eye Drops BHVI2, 0.02% Atropine and BHVI2 Plus 0.02% Atropine Eye Drops
To assess the one-month ocular effects of nightly application of experimental BHVI2 and 0.02% atropine eye drops either alone or in combination, in children aged between 6 to 13 years old with myopia and randomized to use of…
- Trial name
- NCT03690414
- Testing
- Experimental BHVI2, Atropine sulfate 0.02% eye drops, Combination eye drops
- Where
- Vietnam
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Hai Yen Eye Care
Caffeine, Balance; Distorted
The Effect of Turkish Coffee on Postural Control and Hand-eye Coordination in Young Adults
Although the effects of different doses of caffeine on balance have been evaluated in various studies, the effects of low doses of caffeine ingested with Turkish coffee on postural control and hand-eye coordination remain…
- Conditions
- Caffeine, Balance; Distorted, Coordination and Balance Disturbances
- Trial name
- NCT06561113
- Testing
- Caffeine intake
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Bezmialem Vakif University
Healthy, Caffeine
Effects of Energy Drinks on Sleep and Cardiovascular Health
The purpose of this study is to learn about the change in quality of sleep, structural organization of sleep, and cardiovascular responses after consuming an energy drink compared to a placebo drink with no caffeine or stimulants.
- Trial name
- NCT05503732
- Testing
- Energy Drink
- Where
- United States
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Headache, Pregnancy Related
Acute Headache Treatment in Pregnancy: Occipital Nerve Block vs PO Acetaminophen With Caffeine
This is an open label randomized controlled trial evaluating response to bupivacaine occipital nerve block compared to Tylenol/Caffeine cocktail in treatment of pregnant patients seeking care of headache.
- Conditions
- Headache, Pregnancy Related, Occipital Nerve Block
- Trial name
- NCT03951649
- Testing
- Occipital Nerve Block
- Where
- United States
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham