Clinical trials: Caffeine
Cardiovascular Risk
Clinical Trial on the Effects of Caffeine and Taurine From Energy Drinks (EDs) to Parameters of the Cardiovascular System in Humans
The aim of this study is to examine the safety and the effects of EDs at high doses, either alone or in combination with other risk factors such as alcohol intake, physical exercise and sleep deprivation, on cardiovascular…
- Trial name
- NCT01421979
- Testing
- Energy Drink, Taurine, Caffeine
- Where
- Germany
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- University of Hohenheim
Mental Energy, Physical Performance
Dose Effect of a Plant Extract on Fatigue
Test the short-term effects of the acute consumption of two separate beverages containing different concentrations of polyphenols, a beverage containing 75 mg of caffeine and a flavored placebo beverage on mental energy and…
- Trial name
- NCT03870126
- Testing
- Flavored beverage
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- PepsiCo Global R&D
ADHD, Attention Difficulties
A Clinical Trial to Assess the Efficacy of a Plant-based Energy Shot on Focus and ADHD-like Symptoms
This is a virtual, single-arm clinical trial that will last 28 days. Participants will drink 1 bottle of Proper Wild energy shot daily and complete questionnaires at baseline, day 1, day 14, and day 28.
- Conditions
- ADHD, Attention Difficulties, Mood, Anxiety
- Trial name
- NCT05857956
- Testing
- Proper Wild energy shot
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Proper Wild, Inc.
Vertigo, Diseases, Vestibular
Effect of Caffeine Intake in Vestibular Function
Objective: Assess the effect of caffeine in the following vestibular function tests: Cervical Vestibular Evoked Potential (cVEMP), Ocular Vestibular Evoked Potential(oVEMP) and Caloric Test.
- Conditions
- Vertigo, Diseases, Vestibular, Caffeine
- Trial name
- NCT02825199
- Testing
- Caffeine, Non caffeine
- Where
- Brazil
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Instituto Brasiliense de Otorrinolaringologia
Healthy
Pre-workout Supplement Versus Caffeine on Energy Expenditure.
The primary purpose of this study was to examine the acute effects of a multi-ingredient pre-workout supplement versus an ergogenic dose of caffeine (6 mg/kg) on energy expenditure during low-intensity exercise.
- Trial name
- NCT04539054
- Testing
- ENGN Shred, Nutricost caffeine powder, Crystal Light
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Northern Illinois University
Athletic Performance, Postural Stability
Effects of Caffeine and Nicotine Gum on Balance Performance in Athletes
This randomized, single-blind, placebo-controlled, four-condition crossover study evaluates the acute effects of caffeine gum (~3 mg/kg) and nicotine gum (4 mg) on balance performance in healthy, trained adults.
- Conditions
- Athletic Performance, Postural Stability, Healhty
- Trial name
- NCT07254832
- Testing
- Caffeine Gum 3mg/kg, Nicotine Gum (4 mg)
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Gülbin Rudarlı
Exercise Response
Caffeine Mouth Rinse on Salivary Immunoglobulin A, Lactoferrin and A-Amylase Levels
The goal of this clinical trial is to investigate the effects of the mouth rinse form of caffeine (400 mg) on salivary lactoferrin, α-amylase and secretory immunoglobulin-a levels after incremental exercise in young amateur…
- Trial name
- NCT06704711
- Testing
- Caffeine 300 MG, Exercise
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Gaziantep
Cortical Excitability, Brain Stimulation
Cortical Excitability Changes on the Sensorimotor Cortex Induced by Caffeine Consumption: A TMS Study
Caffeine is a widely used psychostimulant drug and acts as a competitive antagonist at adenosine receptors. Its effect is on neurons and glial cells of all brain areas.
- Trial name
- NCT03720665
- Testing
- Caffeine_TMS
- Where
- Germany
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University Medical Center Goettingen
Healthy
Variation in the Impact of Coffee on the Metabolic Rate
The purpose of this study is to explore variation in the impact of coffee on metabolic rate. The investigators plan to recruit healthy participants, half male and half female.
- Trial name
- NCT06432504
- Testing
- Caffeine content
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Shenzhen Institutes of Advanced Technology ,Chinese Academy of Sciences
Healthy
CYP1A2 and ADORA2A Genotypes and Endurance Performance.
The aim of this randomized, double-blind, placebo-controlled experiment will be to assess the potential effect of the selected gene polymorphism (CYP1A2, ADORA2A) on performance after caffeine ingestion.
- Trial name
- NCT06547307
- Testing
- Caffeine 2 mg, Caffeine 4 mg, Caffeine 0 mg
- Where
- Czechia
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Masaryk University
Exercise Performance of Fit Athletes, Exercise Performance
Effect of the Combination of Nitrate and Caffeine on Critical Power In Trained Male Cyclists
This study is investigating the independent and combined effects of acute dietary nitrate and caffeine supplementation on performance during a 3-minute all-out cycling test in trained male cyclists.
- Conditions
- Exercise Performance of Fit Athletes, Exercise Performance, Cycling Performance
- Trial name
- BEET (NCT07501806)
- Testing
- Dietary Nitrate, Caffeine
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Lindenwood University
Exercise Performance, Physical Performance
Effects of Different Caffeine Forms on Aerobic and Anaerobic Exercise Performance
This study investigated the effects of different caffeine delivery forms on aerobic and anaerobic exercise performance in healthy adults.
- Trial name
- NCT07497685
- Testing
- Comparative Acute Effects of Caffeine Delivery Forms (Capsule, Chewing Gum, Mouth Rinse) on Aerobic Capacity and Wingate Anaerobic Performance Outcomes in Recreational Male Athletes: A Randomized Coun
- Where
- Turkey (Türkiye)
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- University of Gaziantep
Anesthesia
A Study to Determine if Caffeine Accelerates Emergence From Propofol Anesthesia
At present clinicians have no way to reverse anesthesia. Patients wake when their bodies clear the anesthetic. Most people wake quickly, but some do not.
- Trial name
- NCT03360903
- Testing
- Caffeine
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- University of Chicago
Healthy
Pharmacokinetic and Safety Study of Cenicriviroc and HMG-CoA Reductase Inhibitors, Caffeine and Digoxin
This is a Phase 1, Open-Label, 3-Period, Single-sequence, Drug-drug Interaction Study in Healthy Subjects to Assess the Effect of Cenicriviroc on the Pharmacokinetics (PK) of HMG-CoA Reductase Inhibitors [Rosuvastatin (ROS)…
- Trial name
- NCT02685462
- Testing
- Rosuvastatin, Atorvastatin, Simvastatin
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Tobira Therapeutics, Inc.
Drug Reactions
Effects of Repeated Doses of Lu AF35700 on Drug Metabolizing Enzymes
This study will help determine which types of drugs that may interact with Lu AF35700
- Trial name
- NCT03195946
- Testing
- Lu AF35700, Midazolam, Cocktail of CYP450 substrates
- Where
- United Kingdom
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- H. Lundbeck A/S
Cognitive Performance, Gaming Performance
Citicoline Dose on Energy Drink Efficacy
The purpose of this study is to determine how the doses of cognitive-enhancing ingredients such as citicoline and caffeine effect the efficacy of acute energy drink consumption for improving cognitive performance (primary…
- Conditions
- Cognitive Performance, Gaming Performance, Blood Pressure, Heart Rate
- Trial name
- NCT06890962
- Testing
- Energy drink consumption
- Where
- United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Nathaniel Jenkins
Neurologic Symptoms
Fasciculations in Healthy Adults After Consumption of Caffeine: an Ultrasound Study
Fasciculations are clinically defined as spontaneous intermittent contractions of a portion of muscles. Depending on associated symptoms they may be a sign of lower motor neuron disorder.
- Trial name
- NCT05977920
- Testing
- Caffeine
- Where
- Switzerland
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Zurich Regional Health Center
Body Composition Measurement
Acute Effects of Caffeinated and Decaffeinated Coffee on Bioelectrical Impedance Analysis
This study investigates how caffeinated coffee, decaffeinated coffee, and water affect body composition, as measured by BIA. Participants were divided into three groups, consuming their respective beverages, with measurements…
- Trial name
- NCT06754748
- Testing
- Caffeinated coffee, Decaffeinated coffee, Water
- Where
- Turkey (Türkiye)
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Marmara University
Cognitive Function, Mood
The Effects of Caffeine and L-theanine Both Alone and in Combination on Cerebral Blood Flow, Cognition and Mood
Although the beneficial effects of caffeine on cognition and mood have been reported in a number of studies, relatively few studies have looked at the effects of caffeine in combination with other phytonutrients despite the fact…
- Trial name
- NCT00981955
- Testing
- Caffeine and L-theanine
- Where
- United Kingdom
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Northumbria University
Ischemia Reperfusion Injury
Does Caffeine Reduce Rosuvastatin-Induced Protection Against Ischemia-Reperfusion Injury?
Does caffeine reduce rosuvastatin induced protection against ischemia reperfusion injury?
- Trial name
- NCT00457652
- Testing
- Rosuvastatin
- Where
- Netherlands
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center