Clinical trials: Caffeine-Related Disorders
Caffeine, Placebo - Control
Effects of Caffeine Ingestion on Morning Cognitive and Muscle Repeated Sprint Performance in Males
Athletes often compete in the morning when they are biologically weaker; normally in competition heats or quarterfinals to qualify for the finals scheduled in the evening.
- Conditions
- Caffeine, Placebo - Control, No Pill
- Trial name
- NCT07466732
- Testing
- Caffeine, Placabo, No Pill
- Where
- United Kingdom
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Liverpool John Moores University
Enhanced Recovery After Surgery in a Pediatric Population
Dex +/- Caffeine Sedation in a Post-MRI Recovery in a Pediatric Population
Dexmedetomidine (Dex), a selective α2-adrenergic receptor agonist, is the most used sedative for procedural sedation in children and in pediatric Intensive Care Unit (PICU) because it is associated with less respiratory…
- Trial name
- NCT06538584
- Testing
- Caffeine citrate 15mg/kg, 0.9% Sodium Citrate
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Chicago
Obesity, Overweight
A Research Study on How UBT251 Affects Levels of Midazolam, Caffeine and Warfarin in the Blood of Participants With Excess Body Weight
The purpose of this clinical study is to find out if UBT251 is safe and effective to be taken together with medicines, like midazolam, caffeine and warfarin in participants living with overweight or obesity.
- Trial name
- NCT07710768
- Testing
- UBT251, Cocktail (Warfarin/Caffeine/Midazolam)
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Novo Nordisk A/S
Healthy Participants
Estimation of the Effect of Multiple Dose Ritlecitinib (PF-06651600) on the Pharmacokinetics of a Single Dose of Caffeine in Healthy Participants
This will be a Phase 1, 2 period, fixed sequence, multiple-dose, open-label study of the effect of ritlecitinib on caffeine PK in healthy participants.
- Trial name
- NCT04655040
- Testing
- Caffeine, Ritlecitinib
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Pfizer
Healthy
Effects of Repeated Doses of Foliglurax on Drug Metabolizing Enzymes in Healthy Subjects
The purpose of this study is to help determine which types of drugs that may interact with foliglurax
- Trial name
- NCT04275115
- Testing
- Drug Cocktail, Foliglurax, midazolam iv
- Where
- France
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- H. Lundbeck A/S
Cognitive Performance
Effect of Phytochemicals on Aspects of Cognitive Performance
The primary purpose of the research is to test the short-term effects of the consumption of beverages containing phytochemicals and caffeine on several aspects of cognitive performance.
- Trial name
- NCT02167750
- Testing
- Cherry Flavored Beverage
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- PepsiCo Global R&D
Caffeine
Caffeine and Training Intensity Quantification
The goal of this clinical trial is to learn about the effects of caffeine on exercise physiology and the subsequent quantification of athlete training zones in trained cyclists.
- Trial name
- NCT06210984
- Testing
- Low caffeine dose, Moderate caffeine dose
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- St. Mary's University, Twickenham
Cortical Excitability, Brain Stimulation
Neuroplastic Alterations of the Motor Cortex by Caffeine
Caffeine is a psychostimulant drug. It acts as a competitive antagonist at adenosine receptors, which modulate cortical excitability as well.
- Conditions
- Cortical Excitability, Brain Stimulation, Caffeine
- Trial name
- NCT04011670
- Testing
- 200 mg caffeine tablet, Non-active tablet
- Where
- Germany
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University Medical Center Goettingen
Caffeine
Effect of Caffeine on Myocardial Oxygenation
The purpose of this study is to investigate the impact of caffeine on myocardial oxygenation and other cardiovascular magnetic resonance parameters in healthy controls.
- Trial name
- Coffee-O2 (NCT04585854)
- Testing
- Caffeine
- Where
- Switzerland
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Energy Metabolism, Athletic Performance
Caffeine Increases Maximal Fat Oxidation During Exercise in Endurance-trained Men: is There a Diurnal Variation
Maximal fat oxidation during exercise (MFO) and the intensity of exercise that elicits MFO (Fatmax) has been recognized as potential determinants of endurance performance.
- Trial name
- NCT04320446
- Testing
- Test in the morning, Test in the afternoon
- Where
- Spain
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Universidad de Granada
Autonomic Nervous System Imbalance
Caffeine and the Autonomic Nervous System
Caffeine consumption has been linked to dysfunction of the autonomic nervous system. In this study the investigators analyze the effects of caffeine containing drinks (including energy drinks and coffee) on ECG based parameters…
- Trial name
- NCT04886869
- Testing
- caffeine
- Where
- Germany
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- LMU Klinikum
Dehydration, Dehydration Related to Exercise
The Impact of a Caffeinated Sports Drink on Performance
Caffeine is known to enhance physical and mental performance, but few beverages combine caffeine with electrolytes and carbohydrates to enhance exercise performance.
- Trial name
- NRG (NCT06721793)
- Testing
- carbohydrate electrolyte drink, no-sugar electrolyte drink, Caffeinated Carbohydrate and electrolyte drink
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Arizona State University
Coffee, Anthocyanins
Short-term Effects of Caffeine and a Multi-ingredient Pre-workout on Exercise Performance
The investigators are conducting a study to see how a commercial pre-workout supplement, coffee, and water affect how well people perform. The study is conducted across four visits.
- Conditions
- Coffee, Anthocyanins, Exercise Performance
- Trial name
- NCT07024940
- Testing
- Ethiopian Coffee, Supplement
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- St. Louis University
Caffeine
5 vs 10-Minute Chewing of Caffeinated Gum: Plasma Caffeine Pharmacokinetics
The goal of this study is to understand how chewing duration affects how quickly caffeine from caffeinated chewing gum appears in the blood and how long higher caffeine levels are maintained.
- Trial name
- NCT07386899
- Testing
- Caffeine 300 MG
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Ege University
Muscle Hypotrophy, Exercise Performance
Resistance Training Adaptations and Caffeine Intake
This parallel-group, randomized, double-blind, placebo-controlled trial investigates the effects of three different caffeine supplementation strategies on resistance training-induced adaptations in 120 caffeine-naive, inactive…
- Conditions
- Muscle Hypotrophy, Exercise Performance, Muscle Strength, Adaptation
- Trial name
- NCT07410195
- Testing
- Caffeine (Constant Daily Dose), Caffeine (Escalating Dose), Caffeine (Training Days Only)
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Istanbul University - Cerrahpasa
High Myopia, Choroid
Effect of Caffeine on Ocular Circulation in High Myopes
To investigate the effect of caffeine on ocular circulation by using Optical Coherence Tomography and Optical Coherence Tomography Angiography.
- Trial name
- NCT03294967
- Testing
- Caffeine, Vitamin E
- Where
- Hong Kong
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- The Hong Kong Polytechnic University
Healthy
The Effect of Coffee on Energy Expenditure and Caffeine Metabolism
Obesity is a risk factor for chronic diseases, and improving energy expenditure is a way to prevent and treat obesity. The purpose of this project is to explore the relationship between the effect of coffee on energy expenditure…
- Trial name
- NCT06712511
- Testing
- Caffeine content
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Shenzhen Institutes of Advanced Technology ,Chinese Academy of Sciences
Caffeine, Exercise Performance
Energy Drink Effects on Performance, Mood, and Cardiovascular Outcomes
Energy drinks are widely promoted to increase energy, enhance mental alertness, and improve physical performance. ccording to the National Center for Complementary and Integrative Health (NCCIH) at NIH [1], next to multivitamins…
- Conditions
- Caffeine, Exercise Performance, Energy Drink, Cardiovascular Safety
- Trial name
- NCT05559372
- Where
- United States
- Volunteers
- 109 people, healthy volunteers welcome
- Sponsor
- Nathaniel Jenkins
Healthy Adult Male
Effects of Caffeine on Agility in Amateur Soccer Players
This randomized, double-blind, placebo-controlled crossover clinical trial aims to investigate the acute effects of caffeine supplementation on motor and perceptual-cognitive components of agility performance in male amateur…
- Trial name
- NCT07844122
- Testing
- Caffeine 300 MG
- Where
- Slovakia
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Comenius University
Healthy Adult Male
Acute Effects of Caffeine on Repeated Sprint Performance and Energy Distribution
The goal of this study is to learn if low-dose caffeinated coffee improves repeated sprint performance and affects energy system contributions in combat sports athletes.
- Trial name
- NCT07596511
- Testing
- Cycling Repeated Sprint Test (6 × 10 s), Breath-by-Breath VO₂ Monitoring - COSMED K5, Capillary Blood Lactate Sampling (non-invasive)
- Where
- Turkey (Türkiye)
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Trabzon University