Clinical trials: Cardiac Resynchronization
Left Bundle Branch Area Pacing
Cardiac ResynchronizatiOn and arrhythmiaS Sensing Via the LEFT Bundle.
Evaluation of ventricular arrhythmias sensing via a left bundle branch area pacing lead.
- Trial name
- CROSS LEFT (NCT05102227)
- Testing
- Left bundle branch area pacing
- Where
- France
- Volunteers
- 10 people
- Sponsor
- University Hospital, Tours
Ischemic Mitral Regurgitation
Effect of Ranolazine on Valvular Disease in Patients With Pacemakers
The purpose of this study is to find out whether mitral regurgitation (or a leaky heart valve) caused by ischemic heart disease (decreased blood flow to heart muscle) will improve after administration of ranolazine.
- Trial name
- REIN-MR (NCT01979965)
- Testing
- Ranolazine (Active drug)
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University Cardiology
Sudden Cardiac Death
'Effect of CRT on Defibrillation Threshold Estimates' Study
The purpose of this prospective study is to evaluate the effect of cardiac resynchronization therapy (CRT) on the defibrillation threshold (DFT) estimates in cardiac resynchronization therapy defibrillators (CRT-D) patients.
- Trial name
- NCT00626093
- Testing
- Cardiac Resynchronization Therapy - Defibrillator (CRT-D)
- Where
- 2 sites in United States
- Volunteers
- 77 people
- Sponsor
- Abbott Medical Devices
Heart Failure
Real Time 3-Dimensional Echocardiography for Left Ventricular Lead Site Selection to Reduce Cardiac Resynchronization Therapy Non-Responder Rates
The purpose of this study is to demonstrate that cardiac resynchronization therapy (CRT) responder rate can be improved by 3-dimensional (3D) echo-guided left ventricular (LV) lead placement compared to traditional LV lead…
- Trial name
- ENVISION (NCT01278030)
- Testing
- 3D echo-guided LV lead placement
- Where
- United States
- Volunteers
- 78 people
- Sponsor
- Abbott Medical Devices
Heart Failure, Implantable Cardioverter Defibrillator (ICD)
Upper Extremity Function in Patients With Reduced Ejection Fraction Heart Failure and Cardiac Implantable Electronic Devices
The aim of this study is to evaluate in detail the factors that determine upper extremity function, determine its effect on prognosis, hospital admission, hospitalization, and mortality, and examine the results according to the…
- Conditions
- Heart Failure, Implantable Cardioverter Defibrillator (ICD), Cardiac Resynchronisation Therapy (CRT), Reduced Ejection Fraction Heart Failure
- Trial name
- NCT07253909
- Testing
- Not applicable- observational study
- Where
- Turkey (Türkiye)
- Volunteers
- 72 people
- Sponsor
- Hacettepe University
Systolic Heart Failure, Heart Failure With Reduced Ejection Fraction
Evaluation of Left Bundle Branch Area Pacing As A Rescue Strategy for Cardiac Resynchronization Therapy Non-Response
This study aims to investigate whether the investigators can improve heart function in patients with heart failure who have undergone cardiac resynchronization therapy, but have not had an improvement in their heart function at…
- Conditions
- Systolic Heart Failure, Heart Failure With Reduced Ejection Fraction, CRT Non-Response, Left Bundle Branch Area Pacing
- Trial name
- NCT05884411
- Testing
- Left bundle branch area pacing, Cardiac MRI
- Where
- United States
- Sponsor
- VA Office of Research and Development
Congestive Heart Failure
BOAT: Beta Blocker Uptitration With OptiVol After Cardiac Resynchronization Therapy (CRT)
Many heart failure patients are unable to reach target beta blocker doses. This study will address whether cardiac resynchronization therapy (CRT) will enable uptitration of beta-blockers to target doses and whether it will…
- Trial name
- NCT00433043
- Testing
- Beta blocker (carvedilol or metoprolol succinate), CRT (cardiac resynchronization therapy)
- Where
- 3 sites in United States
- Volunteers
- 2 people
- Sponsor
- St. Luke's-Roosevelt Hospital Center
Heart Failure, Congestive
HEAL-HF: A Cardiac Resynchronization Therapy (CRT) Outcomes Study
The literature shows that approximately 40% of individuals who receive a cardiac resynchronization therapy (CRT) device for symptomatic congestive heart failure (CHF) do not have a clinical benefit from the device.
- Trial name
- NCT00370526
- Testing
- Acute hemodynamic assessment using PV Loops (CD Leycom, The Netherlands) during LV lead placement
- Where
- 5 sites in United States, Canada and 1 more
- Volunteers
- 100 people
- Sponsor
- Stereotaxis
Heart Failure
Cardiac Resynchronization Therapy (CRT) and Left Ventricular Assist Devices (LVAD) Therapy
Cardiac resynchronization therapy (CRT) or biventricular pacing is a useful treatment for heart failure and those suffering from arrhythmias.
- Trial name
- NCT02083419
- Testing
- LVAD CRT
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- University of Florida
Heart Failure
Quadripolar Pacing Post Approval Study
The purpose of this post-approval study is to evaluate the acute and chronic performance of a Quadripolar CRT-D device system in a patient population indicated for cardiac resynchronization therapy (CRT).
- Trial name
- Quad PAS (NCT01555619)
- Testing
- CRT-D System
- Where
- 71 sites in United States
- Volunteers
- 1,971 people
- Sponsor
- Abbott Medical Devices
Atrioventricular Block, Conduction System Pacing
Impact of Atrioventricular Delay Optimization on Ventricular Function in Conduction System Pacing
Conduction system pacing has emerged as a physiological pacing strategy that preserves ventricular electrical activation and minimizes pacing-induced dyssynchrony.
- Trial name
- OPTI-CSP (NCT07624552)
- Testing
- Echocardiography-Guided Atrioventricular Delay Optimization
- Where
- Turkey (Türkiye)
- Volunteers
- 39 people
- Sponsor
- Bursa Yuksek Ihtisas Training and Research Hospital
Heart Failure
Cardiac Resynchronization Therapy Modular Registry
The purpose of the study is to collect some parameters (clinical, electrical, radiographic, echocardiographic and ECG) able to predict response to cardiac resynchronization therapy.
- Trial name
- CRT-MORE (NCT01573091)
- Testing
- Cardiac Resynchronization Therapy
- Where
- 12 sites in Italy
- Volunteers
- 500 people
- Sponsor
- Giuseppe Ricciardi
Left Ventricular Ejection Fraction, Heart Failure (HF)
REsynchronization Comparison In LBBB and Normal or Mildly Reduced VENTricular Function With CRT (REINVENT-CRT)
Primary Objective - To determine if implantation of a permanent CRT pacing device (with LB-CRT, or conventional BiV-CRT with a coronary sinus LV lead) can improve electromechanical function, HF symptoms, and natriuretic peptide…
- Conditions
- Left Ventricular Ejection Fraction, Heart Failure (HF), Left Bundle-Branch Block
- Trial name
- REINVENT (NCT05652218)
- Testing
- LB-CRT, BIV-CRT
- Where
- 2 sites in United States
- Volunteers
- 21 people
- Sponsor
- Inova Health Care Services
Heart Failure, Cardiomyopathy
Correlating QLV Interval to Left Ventricular (LV) Lead Position in Patients Receiving Cardiac Resynchronization Therapy.
This is a prospective clinical trial to determine the optimal QLV interval during implantation to achieve the best possible response from cardiac resynchronization therapy for heart failure patients.
- Conditions
- Heart Failure, Cardiomyopathy, Cardiac Arrhythmia
- Trial name
- QLV (NCT02166762)
- Testing
- QLV interval measurement
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of California, San Diego
Heart Failure
Acute Optimization of Cardiac Resynchronization Therapy (CRT)Using Echocardiography and SonR
The purpose of this study is to correlate the three lead placement (wires that go to the heart) possibilities and the responses from the patient's heart.
- Trial name
- SonR Access (NCT01293526)
- Testing
- Control, Experimental, Experimental 2
- Where
- United States
- Sponsor
- Piedmont Healthcare
Heart Failure, Arrhythmias, Cardiac
Monitoring of Fluid Status in Heart Failure Patients by Intrathoracic Impedance Measurement (HomeCARE II)
The new BIOTRONIK implantable cardioverter defibrillator (ICD) family Lumax 540 is capable of measuring the intrathoracic impedance on a daily basis and transmission of impedance trend data via the Home Monitoring technology.
- Trial name
- HomeCARE II (NCT00711360)
- Testing
- Intrathoracic impedance measurement
- Where
- 28 sites in Germany, Spain and 1 more
- Volunteers
- 303 people
- Sponsor
- Biotronik SE & Co. KG
Cardiovascular Disease
Medtronic Shock-Less Study on Physician Utilization of Shock Reduction Programming
The purpose of this clinical trial is to determine whether periodic therapy programming reports illustrating physician usage of shock reduction programming can increase utilization of recommended programming guidelines for…
- Trial name
- NCT00856349
- Testing
- Therapy Programming Report (TPR)
- Where
- 104 sites in United States, Argentina and 10 more
- Volunteers
- 4,384 people
- Sponsor
- Medtronic Cardiac Rhythm and Heart Failure
Atrial Fibrillation (AF)
Bachmann's Bundle Versus Right Atrial Appendage Pacing
Participants will be randomly assigned to one of two clinical treatment Arms, both of which are standard care procedures performed in the right atrium (RA): Arm A: Pacing from the Bachmann's Bundle (BB) in the right atrium (upper…
- Trial name
- BACH-RAP (NCT07874763)
- Testing
- Bachmann's Bundle Pacing, Right Atrial Appendage Pacing
- Where
- United States
- Volunteers
- 334 people
- Sponsor
- Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute)
Heart Failure
Study to Evaluate the Superior Efficacy of Cardiac Resynchronization (SyncAVTM) Using the SyncAVTM Algorithm
Heart Failure (HF) is a cardiovascular disease secondary to a structural and / or functional alteration of the heart that prevents its correct function.
- Trial name
- CRUSTY (NCT03961399)
- Testing
- Abbott Medical® CRT device with SyncAVTM stimulation function, Abbott Medical® CRT device with biventricular stimulation (BiV)
- Where
- 15 sites in Spain
- Volunteers
- 56 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Arterial Stiffness
Response To Cardiac Resynchronization Therapy In Heart Failure: Role Of Arterial Stiffness
To determine if arterial stiffness as measured by non-invasive pulse wave velocity can predict the response to resynchronization therapy in heart failure.
- Trial name
- NCT00970476
- Volunteers
- healthy volunteers welcome
- Sponsor
- Creighton University