Clinical trials: Carotid Disease
Rare Disorders, Undiagnosed Disorders
Rare Disease Patient Registry & Natural History Study - Coordination of Rare Diseases at Sanford
The Coordination of Rare Diseases at Sanford (CoRDS) is an international patient registry that serves as a centralized resource for rare disease research.
- Conditions
- Rare Disorders, Undiagnosed Disorders, Disorders of Unknown Prevalence, Cornelia De Lange Syndrome
- Trial name
- CoRDS (NCT01793168)
- Where
- United States
- Volunteers
- 20,000 people
- Sponsor
- Sanford Health
Hypertension, Coronary Artery Disease
Cardiovascular Epidemiology in Russian Federation
The study addresses epidemiology of cardiovascular risk factors and major cardiovascular diseases in Russian Federation (urban and rural population). 12 regions of 1600 participants in each will be included.
- Conditions
- Hypertension, Coronary Artery Disease, Diabetes, Heart Failure
- Trial name
- ESSE-RF (NCT02449460)
- Where
- 2 sites in Russia
- Volunteers
- 18,000 people, healthy volunteers welcome
- Sponsor
- Federal State Budgetary Institution, V. A. Almazov Federal North-West Medical Research Centre, of the Ministry of Health
Stroke Not Otherwise Specified, Control Condition
Vessel Angles and Diameters in Stroke Disease
Retrospective analysis of internal carotid artery morphology on CT angiography images of patients with acute ischemic stroke.
- Trial name
- NCT06756724
- Where
- Turkey (Türkiye)
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- Tokat Gaziosmanpasa University
Rheumatoid Arthritis (RA), Psoriatic Arthritis (PsA)
Carotid Ultrasound-Based Strategy for Primary Prevention of Cardiovascular Events in Inflammatory Rheumatic Disease (PREVENER)
PREVENER is a randomized, open-label, multicenter, phase IV clinical trial designed to evaluate the efficacy and safety of a carotid ultrasound-based strategy for the primary prevention of cardiovascular events in patients with…
- Conditions
- Rheumatoid Arthritis (RA), Psoriatic Arthritis (PsA), Axial Spondy, Systemic Lupus Erythematosus (SLE)
- Trial name
- PREVENER (NCT07611747)
- Testing
- Carotid Ultrasound, High-intensity lipid-lowering therapy, Standard care according to ESC 2021 guidelines
- Where
- 17 sites in Spain
- Volunteers
- 1,944 people
- Sponsor
- Instituto de Investigación Marqués de Valdecilla
Hypotensive Syncope
Stop Vasodepressor Drugs in Reflex Syncope
Investigate clinical effects (reduction of number of syncope and associate symptoms) of suspension of vasoactive drugs in patients affected by vasodepressor reflex syncope.
- Trial name
- STOP-VD (NCT02137278)
- Testing
- Vasoactive drug therapies, Stop/reduce vasoactive drugs
- Where
- Italy
- Volunteers
- 58 people
- Sponsor
- Gruppo Italiano Multidisciplinare per lo Studio della Sincope
Symptomatic Carotid Stenosis, Hypercholesterolemia
The Multicenter Atorvastatin Plaque Stabilization (MAPS) Study
The impact on cardiovascular events achieved by statin therapy seems to be mostly attributable to the cholesterol-lowering effect with a highly debated contribution of the lipid-independent pleiotropic effects.
- Conditions
- Symptomatic Carotid Stenosis, Hypercholesterolemia, Indication for Carotid Endarterectomy
- Trial name
- MAPS (NCT01053065)
- Testing
- Atorvastatin - Cholestyramine - Sitosterol
- Where
- 3 sites in Italy
- Volunteers
- 60 people
- Sponsor
- University of Padova
Arthritis, Rheumatoid, Arthritis, Psoriatic
Impact of Nurse-led Programme With Carotid Ultrasound on Addressing Cardiovascular Risk in Patients With Arthritis
Elevated CVD risk is a significant public health problem that contributes greatly to the increased morbidity and shortened lifespan of individuals with RA and PsA.
- Trial name
- NCT03625089
- Testing
- Atorvastatin
- Where
- Hong Kong
- Sponsor
- Chinese University of Hong Kong
Ischemic Cerebrovascular Disease, Artificial Intelligence
Research on Early Prediction Model of Ischemic Cerebrovascular Disease Based on Artificial Intelligence Technology.
Establish an artificial intelligence clinical decision support system for patients with carotid/vertebral artery cerebrovascular stenosis, early identification of patients who may have cerebral infarction.
- Conditions
- Ischemic Cerebrovascular Disease, Artificial Intelligence, Prediction Model
- Trial name
- NCT06978348
- Where
- China
- Volunteers
- 244,296 people
- Sponsor
- Shanghai Jiao Tong University School of Medicine
Carotid Artery Stenosis
A Prospective, Multicenter, Single Arm Registry of ENROUTE NPS in Conjunction With Carotid WALLSTENT in Chinese Population
The study is a prospective, non-randomized, single-arm, multi-center registry to confirm the safe delivery of the Carotid WALLSTENT Endoprosthesis when used with the ENROUTE® Transcarotid Neuroprotection System in the Chinese…
- Trial name
- ASCENT-C (NCT07458243)
- Testing
- transcarotid artery revascularization
- Volunteers
- 60 people
- Sponsor
- Boston Scientific Corporation
Aging, Arterial Stiffness
Inorganic Nitrate Supplementation on Cerebrovascular Aging and Arterial Stiffness Study
This study investigates the effect of dietary inorganic nitrate supplementation on 1) large elastic artery stiffness and hemodynamics and 2) cerebrovascular function in middle-aged and older adults.
- Conditions
- Aging, Arterial Stiffness, Endothelial Dysfunction, Hypertension
- Trial name
- INCA (NCT03617302)
- Testing
- Experimental: Nitrate-containing
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Gary L. Pierce, PhD
Carotid Atherosclerosis
Potential Impact of Neuroimmune and Autophagic Alterations on the Progression and Severity of Human Atherosclerotic Process
The hypothesis of this study is that neural regulations of the atherosclerotic plaque, identified in the murine model of atherosclerosis, could also exist in human pathology.
- Trial name
- NCT03922698
- Testing
- No interventions
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- Neuromed IRCCS
Atherosclerosis
Predictor of Advanced Sub-Clinical Atherosclerosis (PASA) Study
The study will evaluate the clinical utilization of skin Cholesterol (SC) for cardiovascular risk assessment in asymptomatic individuals at low, intermediate and high risk based on Framingham global risk estimates.
- Trial name
- NCT00258999
- Testing
- Skin Cholesterol Testing
- Where
- United States
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Moyamoya Disease
RNF213 Variants and Collateral Vessels in Moyamoya Disease
The purpose of this study is to detect the association between RNF213 variants and collateral vessels in patients with moyamoya disease.
- Trial name
- NCT04906564
- Testing
- Identification of genetic variants
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Beijing Tiantan Hospital
Asymptomatic Carotid Artery Stenosis
Efficacy and Safety Study of Endovascular Treatment of Asymptomatic Carotid Artery Stenosis
This study is a multicenter, prospective, open-label, endpoint-blinded, randomized controlled trial designed to evaluate the safety and efficacy of endovascular stenting combined with optimal medical therapy versus optimal…
- Trial name
- NCT06899399
- Testing
- Endovascular treatment, Best medical treatment
- Where
- China
- Volunteers
- 982 people
- Sponsor
- Beijing Tiantan Hospital
Carotid Artery Diseases, Regional Anesthesia
Stress Reduction Using Video Googles on Patients Undergoing Vascular Surgery
One treatment option of internal carotid artery stenosis is open surgical endarterectomy. The operation is frequently carried out under regional plexus anesthesia, allowing the patient to remain awake during the procedure.
- Conditions
- Carotid Artery Diseases, Regional Anesthesia, Distress, Procedural
- Trial name
- MEP-VASC (NCT06704230)
- Testing
- video googles
- Where
- Germany
- Volunteers
- 100 people
- Sponsor
- University Hospital Augsburg
Coronary Artery Disease
Carotid Atherosclerosis: MEtformin for Insulin ResistAnce Study
Hypothesis: Treatment with metformin in overweight non-diabetic individuals with coronary heart disease and on standard cardiovascular risk reducing agents including statins will have a beneficial impact on carotid artery…
- Trial name
- CAMERA (NCT00723307)
- Testing
- Metformin
- Where
- United Kingdom
- Volunteers
- 173 people
- Sponsor
- Professor Naveed Sattar
Carotid Stenosis, Constriction, Pathologic
GORE Flow Reversal System and GORE Embolic Filter Extension Study
The objective of this study is to provide an ongoing evaluation of clinical outcomes associated with the GORE Flow Reversal System and the GORE Embolic Filter when used for embolic protection during carotid artery stenting.
- Conditions
- Carotid Stenosis, Constriction, Pathologic, Carotid Artery Diseases, Cerebrovascular Disorders
- Trial name
- FREEDOM (NCT01343667)
- Testing
- Gore Flow Reversal System, Gore Embolic Filter
- Where
- 39 sites in United States
- Volunteers
- 1,397 people
- Sponsor
- W.L.Gore & Associates
Coronary Artery Bypass
Stroke and Carotid-Cerebral Vascular Disease After CABG
Review the data of patients who underwent coronary artery bypass grafting (CABG) at the Department of Cardiovascular Surgery in Ruijin hospital from March 2020 to May 2022, including medical history, head and neck CTA, head CT…
- Trial name
- SCCAB (NCT05036044)
- Where
- China
- Volunteers
- 1,002 people
- Sponsor
- Ruijin Hospital
Atherosclerosis Cardiovascular Disease
Isometric Resistance Exercise on Accelerated Atherosclerosis in Hypertension
Background: Hypertension (HT) is the most common condition worldwide, predisposing to atherosclerotic disease. However, most HT patients have suboptimal BP control despite anti-HT medications.
- Trial name
- IRE-HT (NCT07665034)
- Testing
- Squatting Exercise, Stretching (Yoga) Exercise
- Where
- Hong Kong
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Atherosclerosis
Influenza A VIRus and Destabilization of Atherosclerotic Carotid Plaques
Atherosclerosis is the main cause of cardiovascular diseases and is characterized by the accumulation of lipids and inflammatory cells such as macrophages and lymphocytes within the vessel wall of large and medium-sized arteries…
- Trial name
- VIRAL (NCT06217471)
- Testing
- Carotid Endoarterectomy
- Where
- Italy
- Volunteers
- 160 people
- Sponsor
- IRCCS Policlinico S. Donato
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