Clinical trials: Cerebrovascular Function
Memory Impairment
Cerebrovascular and Cognitive Improvement by Resveratrol (resVida) and Fruitflow-II (CCIRF-II)
The purpose of this study is to determine whether Fruitflow-II, Resveratrol (resVida), alone or in combination, are effective in the treatment of memory problems in adult patients with memory impairment.
- Trial name
- CCIRF-II (NCT01766180)
- Testing
- Fruitflow-II, resVida
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Neurolgy Institute for Brain Health and Fitness
Vascular Diseases, Leukoaraiosis
Concentration of Trimethylamine Oxide (TMAO) in Blood Plasma as a Risk Factor for Vascular Cerebral Damage
The primary aim of the current research project is to answer the question, whether plasma trimethylamine N-oxide (TMAO) level may be used as a marker of ischemic changes in the brain.
- Conditions
- Vascular Diseases, Leukoaraiosis, Ischemia, Cerebral
- Trial name
- NCT03903601
- Testing
- Magnetic Resonance Imaging (MRI), Blood samples collection, Neuropsychological tests
- Where
- Poland
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Gdansk University of Physical Education and Sport
MACE, Cardiac Death
Real-World Cohort Study of Cardiopulmonary Function in Chinese Patients With Cardiovascular Disease: CPET Evaluation and Five-Year Prognostic Follow-Up Based on a Multicenter Structured Data Platform
The goal of this observational study is to observe the characteristics of cardiopulmonary exercise testing (CPET) parameters in patients across different cardiovascular diseases and to evaluate the predictive value of…
- Conditions
- MACE, Cardiac Death, Unplanned Repeat Revascularization, Cardiac Rehospitalization
- Trial name
- China-CPET (NCT07130968)
- Where
- China
- Volunteers
- 200,000 people, healthy volunteers welcome
- Sponsor
- Guangdong Provincial People's Hospital
Dementia, Alzheimer Disease
Effects of Remote-based Resistance Training on Cardiometabolic Risk Factors, Cognitive Function, and Quality of Life in Adults Living With Alzheimer's Disease and/or Related Dementias
The investigators aim to study the effects of a 24-week remote-based resistance exercise training program on cardiovascular disease risk factors, cognitive function, and quality of life in older adults living with mild cognitive…
- Conditions
- Dementia, Alzheimer Disease, Dementia, Vascular, Lewy Body Disease
- Trial name
- NCT05004558
- Testing
- Remote-based Resistance Exercise Training
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Drexel University
Cerebrovascular Circulation
Blood Brain Flow and Exercise
Cerebral vasodilator responses to CO2 will be measured in young healthy adults, healthy sedentary older adults, and healthy exercise trained older adults.
- Trial name
- NCT02653638
- Testing
- Control, Indomethacin
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Subcortical Aphasia, Ischemic Stroke
Language Functional Reorganization in Subcortical Infarction Patients
Post stroke aphasia (PSA) is one of the most frequently happened deficiency of stoke, affecting speaking,comprehension, writing and reading of language.
- Trial name
- NCT03668132
- Testing
- ischemic brain damage
- Where
- China
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Guangzhou General Hospital of Guangzhou Military Command
Stroke, Motor Cortex; Lesion
Imaging Laterality in Chronic Stroke Patients
In healthy individuals, unimanual movement (with either the left or right hand) is associated with activity in a network of predominantly contralateral brain regions, including the primary motor cortex (PMC).
- Trial name
- NCT03584425
- Testing
- Rasch modified version of the Fugl-Meyer Motor assessment, Anatomical image acquisition, Functional MRI task and acquisition
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Cerebral Arterial Diseases
Hemodynamic and Functional Characteristics of the Cerebral Circulation in Obesity
This prospective study is intended to explore differences in the cerebral hemodynamics and vascular functional characteristics between obese and normo-constituted patients; as well as the changes in the hemodynamic and functional…
- Trial name
- HemOB (NCT06067113)
- Testing
- Supraaortic and transcranial duplex
- Where
- Spain
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz
Stroke
Core Stabilization Exercises in Stroke
A stroke due to a cerebrovascular accident (CVA) is a neurological deficit characterized by the rapid settlement of signs and symptoms due to focal or global loss of cerebral function, without any apparent cause other than…
- Trial name
- NCT05549518
- Testing
- Core stabilization + Traditional Physical Therapy, Traditional Physical Therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Biruni University
Healthy Individuals (Controls), Parkinson Disease
Motor Learning in Health and Movement Disorders: Role of Physical Activity and Advanced Devices
The goal of this clinical trial is to investigate motor responses in healthy subjects and patients with movement disorders, brain and spinal cord injury, neuromuscular diseases, or cardiovascular diseases.
- Conditions
- Healthy Individuals (Controls), Parkinson Disease, Multiple Sclerosis, Alzheimer Disease
- Trial name
- Allena-mente (NCT07066137)
- Testing
- CAREN, Control group
- Where
- Italy
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- IRCCS Centro Neurolesi Bonino Pulejo
Age Related Cognitive Decline, Alzheimer's Disease
n-3 PUFA for Vascular Cognitive Aging
Brain scans can help identify changes that appear to increase risk for cognitive decline and dementia. Some of these brain changes are thought to reflect actual damage to the small blood vessels that support normal brain…
- Conditions
- Age Related Cognitive Decline, Alzheimer's Disease, Vascular Dementia, Endothelial Dysfunction
- Trial name
- NCT01953705
- Testing
- Omega 3 PUFA
- Where
- United States
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Stroke
The Relationship Between Motor Cortex Oxygenation and Motor Function Recovery in Stroke Patients
Stroke is the most common cause of motor function impairment. However, the functional impairment is not totally irreversible. Several mechanisms may involved in both the cortical and motor function recovery after onset of stroke…
- Trial name
- NCT01781689
- Testing
- Functional Electric Stimulation, Rehabilitation programs
- Where
- Taiwan
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Kaohsiung Veterans General Hospital.
Stroke
Effects of Intensive Robot-assisted Therapy in Patients With Subacute Stroke
Robot-assisted training (RT) devices developed to date have a significant impact on stroke rehabilitation. Several research groups have developed the robotic devices and examined their efficacy on improving upper limb function…
- Trial name
- RT (NCT01767480)
- Testing
- RT, Conventional rehabilitation (CR)
- Where
- Taiwan
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Traumatic Brain Injury, Post-concussion Syndrome
Measure of Cerebrovascular Dysfunction After TBI With fNIRS
The goal of this project is to determine if it is possible to assess Cerebrovascular Reactivity (CVR) to hypercapnia with functional Near Infrared Spectroscopy (fNIRS).
- Trial name
- NCT01789164
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Uniformed Services University of the Health Sciences
Stroke
HAptic Neurofeedback Design for Stroke
Interventional study with minimal risks and constraints, prospective, monocentric.
- Trial name
- HANDS (NCT04130711)
- Testing
- Visual virtual Conditions, Standard EEG, Neurofeedback Training Stroke Patients
- Where
- France
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Rennes University Hospital
Cerebrovascular Disease
Aerobic Dance Training in Small Vessel Disease
Introduction: Cerebral small vessel disease (SVD) is associated with age-related disabilities including dementia, depression, physical and functional impairment. Chinese are more prone to developing SVD than Caucasians.
- Trial name
- ADTSVD (NCT02730065)
- Testing
- Structured Aerobic Dance Training Group, Stretching plus education
- Where
- 2 sites in Hong Kong
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Stroke, Spasticity, Muscle
Analysis of the Correlation Between Ultrasound Imaging and Functional Parameters in the Medial Gastrocnemius Muscle in Post-stroke Patients With Spasticity in the Lower Limb
The goal of this observational study is to understand the impact of spasticity on muscle changes and functional performance in stroke patients with lower limb spasticity in comparison to non-stroke individuals.
- Trial name
- US-function (NCT06411587)
- Testing
- Ultrasound imaging and functional assessment
- Where
- Spain
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Universidad de Zaragoza
Chronic Stroke
Effect of Somatosensory Motor Intergration Training on Post-stroke Upper Limb Function.
Background: Most patients suffer from post-stroke somatosensory and motor impairments, and 50% to 70% of patients in the chronic stage still have upper extremity impairments that severely limit their functional independence and…
- Trial name
- NCT06057584
- Testing
- somatosensory-motor integration training, pure somatosensory training, pure motor training
- Where
- Taiwan
- Volunteers
- 153 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Nervous System Diseases, Healthy Subjects
Functional Near-infrared Spectroscopy in Unconscious Patients
The study design is a single-center prospective pilot study. Hypothesis: Results of cerebral fNIRS examination in unconscious patients with severe hemorrhagic or ischemic stroke in the ICU are congruent with the results of SSEP…
- Trial name
- fNIRS (NCT04746820)
- Testing
- single-center prospective pilot study
- Where
- Switzerland
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Emanuela Keller
Cadasil, Blood Brain Barrier Defect
MRI Study of Blood-brain Barrier Function in CADASIL
Diffusion prepared pseudo-continuous ASL (DP-pCASL) is a newly proposed MRI method to noninvasively measure the function of blood-brain barrier (BBB).
- Trial name
- NCT05902039
- Testing
- MRI
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Peking University First Hospital