Clinical trials: Clinical Pain
Postoperative Nausea and Vomiting
The Effect of Electroacustimulation on Postoperative Nausea, Vomiting and Pain in Outpatient Plastic Surgery Patients
Introduction: Current rates of postoperative nausea and vomiting (PONV) experienced by outpatient surgery patients are as high as 20-30%.
- Trial name
- NCT00941005
- Testing
- Electroacustimulation
- Where
- United States
- Volunteers
- 122 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Retreatment, Endodontic Diseases
THE EFFECT OF FILLING MATERIAL AND PLACEMENT TECHNIQUE ON POSTOPERATIVE PAIN IN NON-SURGICAL ENDODONTIC RETREATMENT: A RANDOMIZED CLINICAL TRIAL
Postoperative pain is a common concern following root canal retreatment. The type of root canal filling material and the technique used to place it may influence pain experienced after treatment.
- Trial name
- NCT07908394
- Testing
- BioMTA+, Well-Root PT
- Where
- Turkey (Türkiye)
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- TC Erciyes University
Pain
Assess the Efficacy and Safety in Volunteers of DCF100, TIB200 and SPR300 vs. Placebo and Control(s) in a UV Pain Model
This is a randomised, double blind, cross over clinical study in healthy human volunteers (including pharmacokinetic [PK] sampling and laser Doppler assessment of local blood flow in a subset of up to 6 subjects per cohort of 20)…
- Trial name
- NCT02666846
- Testing
- Ibuprofen, Diclofenac, Methyl-salicylate / Menthol
- Where
- United Kingdom
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Futura Medical Developments Ltd.
Retreatment, Cryotherapy
Effect of Intracanal Cryotherapy on Postoperative Pain
Introduction: Since 1960, cryotherapy, involving the application of cold, has been used in various fields of medicine for pain treatment.
- Trial name
- NCT06764823
- Testing
- Cryotherapy, Control
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Kutahya Health Sciences University
Periapical Diseases, Periapical Periodontitis
Postoperative Pain After Conservative Root Canal Preparation
The goal of this clinical trial is to compare the pain experienced by healthy participants after root canal treatment with small versus large root canal sizes. The main questions it aims to answer are: 1.
- Conditions
- Periapical Diseases, Periapical Periodontitis, Postoperative Pain, Pulp Necroses
- Trial name
- NCT06545773
- Testing
- Root Canal Treatment with ProTaper Next Nickel-Titanium File (PTN), Root Canal Treatment withTruNatomy Nickel-Titanium File (TN)
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Istanbul University
Necrotic Pulp
Effect of Irrigation With Antibiotic-containing Solutions on Postoperative Pain and Intra-canal Bacteria
The aim of this study is to compare the degree of postoperative pain and the antimicrobial effect in terms of bacterial count reduction after using co-amoxiclav-clindamycin solution versus MTAD and sodium hypochlorite irrigating…
- Trial name
- NCT04035070
- Testing
- co-amoxiclav-clindamycin solution, MTAD, 2.5% sodium hypochlorite
- Where
- Egypt
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Cairo University
Post Operative Pain
Effect of Oral Analgesics on Post-op Pain
after 2 visit endodontics treatment, the analgesic efficacy of three different medications will be evaluated.
- Trial name
- NCT07204379
- Testing
- Novafen, Tramadol, Naproxen
- Where
- Pakistan
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Armed Forces Institute of Dentistry, Pakistan
Aging, Pain
RHA® 4 With New Anesthetic - Nasolabial Folds
This is a randomized, controlled, double-blinded, within-subject (split-face), multicenter, prospective study to investigate whether RHA® 4 with New Anesthetic Agent is non-inferior to RHA® 4 (with lidocaine) in terms of…
- Trial name
- NCT04087395
- Testing
- RHA®4 with new anesthetic agent, RHA®4-Lidocaine
- Where
- 3 sites in United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Teoxane SA
Postoperative Pain
Comparative Evaluation of the Efficacy of Intraoral Cryotherapy Versus Intracanal Cryotherapy on Postoperative Pain
The aim of this study is to clinically compare the efficacy of intraoral cryotherapy versus intracanal cryotherapy after single visit root canal therapy in lower molars with irreversible pulpitis and symptomatic apical…
- Trial name
- NCT05041738
- Testing
- Intraoral Cryotherapy, Intracanal Cryotherapy
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Cairo University
Local Anaesthetic Drug Adverse Reaction
Computer - Controlled Intraligamentary Local Anaesthesia In Extraction of Primary Molars
Background: Exodontia poses a psychological threat for children, increasing the need for profound local anesthesia to assure painless extraction and maintain child cooperation on the dental chair.
- Trial name
- NCT04739735
- Testing
- Dental Local Anaesthesia
- Where
- Egypt
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Alexandria University
Pain
Laser Acupuncture for Pain Prevention in Neonates
Pain prevention and/or therapy in neonates is still a challenge. It is widely accepted that early pain experience can have a tremendous impact on the pain memory.
- Trial name
- NCT00528125
- Testing
- active laser acupuncture
- Where
- Germany
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University Children Hospital Homburg
Open Wound of Palate Without Complication, Pain, Postoperative
The Effect of Ozone Therapy on Pain Perception After Free Gingival Graft Surgery in Patients With Mucogingival Defects
Gaseous ozone (O3-triatomic oxygen) is the third-strongest oxidizing agent worldwide. It influences the cellular and the humoral immune system, by stimulating the proliferation of immunocompetent cells and the synthesis of…
- Conditions
- Open Wound of Palate Without Complication, Pain, Postoperative, Free Gingival Grafts, Mucogingival Defects
- Trial name
- NCT05291715
- Testing
- Ozone generator device (Ozone DTA-APOZAa-enterprize CO9-Taiwan, R.0.C)
- Where
- Egypt
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Omaima Mossad Mahmoud AL-Sherbini
Myofascial Pain Syndrome, Pain
Treatment of Myofascial Pain Syndrome With Lidocaine Injection and Physical Therapy.
Background: Myofascial pain syndrome (MPS) of the shoulder girdle and cervical region is a common musculoskeletal problem that is often chronic or recurrent.
- Conditions
- Myofascial Pain Syndrome, Pain, Myofascial Trigger Point Pain, Musculoskeletal Pain
- Trial name
- NCT01250184
- Testing
- Physical therapy, Lidocaine injection, Lidocaine injection + physical therapy
- Where
- 2 sites in Colombia
- Volunteers
- 127 people, healthy volunteers welcome
- Sponsor
- Grupo Rehabilitacion en Salud
Postoperative Pain
Effect of Manual Glide Path Establishment on Endodontic Postoperative Pain
All patients will be treated in a single session approach regardless of the group. All molars will be anesthetized either through infiltration in case of maxillary molars or inferior alveolar nerve block in case of mandibular…
- Trial name
- NCT05206214
- Testing
- Manual glide path, Mechanical glide path
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Cairo University
Patellofemoral Pain
Limited Ankle Dorsiflexion and Effect on Single Limb Squats in Individuals With Patellofemoral Pain
The purpose of this graduate student research study is to investigate the relationship between limited ankle dorsiflexion and the potential effects on a single limb squat task in the Patellofemoral/Knee Pain population.
- Trial name
- NCT05285007
- Testing
- Mobilization with Movement, No mobilization with movement and education
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Loma Linda University
Temporomandibular Disorders
Efficacy of Red and Infrared Lasers in Treatment of Temporomandibular Disorders
The study hypothesis was that the red (600nm) and infrared (800nm) laser therapy have the same efficacy in relieving pain and improving the quality of life of TMD patients
- Trial name
- TMD (NCT01659840)
- Testing
- Red laser, Infrared laser
- Where
- Brazil
- Volunteers
- 116 people, healthy volunteers welcome
- Sponsor
- Federal University of São Paulo
Low Back Pain
A Trial on the Effect on Low Back Pain Related Disability of Different Health Education Programs for Retired Persons
The primary purpose of this study is to compare, in retired persons living in the Balearic Islands, the effectiveness on low back pain related disability of three educational programs.
- Trial name
- NCT00441038
- Testing
- The Back Guide, The Back Book, Cardiovascular and general health
- Where
- Spain
- Volunteers
- healthy volunteers welcome
- Sponsor
- Kovacs Foundation
Acute Pain
Trial Comparing Morphine to Hydromorphone in Elderly Patients With Severe Pain
The purpose of this research study is to determine which opiate pain medication (morphine or hydromorphone (Dilaudid)) is more effective in the treatment of acute pain in patients presenting to the emergency department.
- Trial name
- NCT00305058
- Testing
- Morphine, Hydromorphone
- Where
- United States
- Volunteers
- 194 people, healthy volunteers welcome
- Sponsor
- Montefiore Medical Center
Pain, Acute Pain
A Clinical Study in Healthy Adults Who Sometimes Take Drugs for Pleasure to Investigate the Safety and Tolerability of GRT0151Y and to Find Out Which Single Dose of the Compound is Maximally Tolerated
The purpose of this study is to determine the maximum dose of GRT0151Y that is tolerable and to explore the safety profile of the drug. For each Treatment Period (Visits 2-5), dosing will be separated by at least one week.
- Conditions
- Pain, Acute Pain, Chronic Pain
- Trial name
- NCT03765658
- Testing
- GRT0151Y dose escalation
- Where
- Canada
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Grünenthal GmbH
Propofol, Addictive Behaviors
Propofol-related Euphoria in Pain-free Gastrointestinal Endoscopy Patients
To define the prevalence, duration and severity of propofol-associated euphoria in patients undergoing painless gastrointestinal endoscopy and to explore the independent influencing factors by means of a single-center…
- Trial name
- NCT06602297
- Where
- China
- Volunteers
- 986 people, healthy volunteers welcome
- Sponsor
- Northern Jiangsu People's Hospital
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