Clinical trials: Cognitive Aging
Breast Cancer Survivors
A Study of Changes in Thinking Related to Aging and Cancer in Breast Cancer Survivors (TRAC)
The purpose of this study is to look at how differences in cognitive (mental) function develop over time in breast cancer survivors compared to volunteers without a history of cancer (healthy volunteers).
- Trial name
- TRAC (NCT06334354)
- Testing
- Assessments, Assessment (Survivors Only), APOE and DNA Isolation
- Where
- 7 sites in United States
- Volunteers
- 420 people, healthy volunteers welcome
- Sponsor
- Memorial Sloan Kettering Cancer Center
Aging, Cognitive Decline
Aging and Cognitive Health Evaluation in Elders (ACHIEVE)
The ACHIEVE study will be a randomized controlled trial nested within the infrastructure of the Atherosclerosis Risk in Communities (ARIC) study.
- Trial name
- ACHIEVE (NCT03243422)
- Testing
- Successful aging health education intervention, Hearing intervention
- Where
- 4 sites in United States
- Volunteers
- 977 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Cognitive Aging, Adverse Childhood Experiences
Physical Exercise for Augmenting Cognitive Health (PEACH)
PEACH is a pilot project which is being conducted to determine the feasibility and acceptability of a 12-week home-based exercise intervention among Black and African American adults.
- Trial name
- PEACH (NCT04922710)
- Testing
- Home-based aerobic exercise
- Where
- 2 sites in United States, Jamaica
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Motoric Cognitive Risk Syndrome
ENGAGE for Brain Health
Age-related cognitive decline has a profound impact on the daily functioning of older adults, their families and healthcare systems.
- Trial name
- ENGAGE-B (NCT03750682)
- Testing
- Physical Activity (PA) Intervention, Healthy Aging Education (HE) Intervention
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Tufts University
Mild Cognitive Impairment, Healthy Aging
Non-invasive, Wearable Multi-parameter System for the Early Prediction of Cognitive Decline and Dementia in Older Adults
This project develops an innovative screening system and prediction model to detect preclinical symptoms of cognitive impairment and predict the potential development of mild cognitive impairments and dementia in older adults.
- Trial name
- NCT04262674
- Testing
- Cognitive-motor training
- Where
- Switzerland
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- Empa, Swiss Federal Laboratories for Materials Science and Technology
Depressive Symptom, Cognitive Functions
Cognicise Training for Seniors for Healthy Aging
The goal of this clinical trial is to assess the impact of two 8-week motor-cognitive exercise programs - Cognicise and yoga - on psychological, respiratory, cardiovascular, postural, and biochemical health in elderly women.
- Conditions
- Depressive Symptom, Cognitive Functions, Quality of Life, Physical Fitness
- Trial name
- NCT07098533
- Testing
- Cognicise Training, Yoga Training
- Where
- Poland
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Poznan University of Physical Education
Alzheimer Disease (AD), Cardio Vascular Disease
Arlington Longitudinal Optimal Healthy Aging Study (ALOHA)
The Arlington Longitudinal Optimal Healthy Aging (ALOHA) Study is a community-based research project led by the Marymount University Center for Optimal Aging (MCOA).
- Conditions
- Alzheimer Disease (AD), Cardio Vascular Disease, Mild Cognitive Impairment (MCI), Frailty Syndrome
- Trial name
- ALOHA (NCT07180147)
- Where
- United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Marymount University
Physical Functional Impairment, Cognitive Impairment
Community Recreation to Enhance Function in Aging
This aim of this study is to examine the therapeutic impacts of a group-based recreational program that delivers guided visual artmaking and dual-task exergaming, to older adults.
- Trial name
- NCT07104435
- Testing
- Artmaking and exergaming
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- State University of New York at Buffalo
Aging
The Impact of Piano Training on Cognitive Performance and Psychosocial Well-Being in Older Adults
This project evaluates the effects of piano training and computerized cognitive training on cognitive performance in healthy older adults compared to controls.
- Trial name
- NCT02564601
- Testing
- Piano Training, Computer Cognitive Training
- Where
- United States
- Volunteers
- 93 people, healthy volunteers welcome
- Sponsor
- University of South Florida
Alzheimer's Disease
Neuroplasticity Enhancement From Cognitive Training Reinforced by Psilocybin
Background: Normal aging, as well as dementias such as Alzheimer s disease, can cause changes in the brain that affect memory, attention, and thinking.
- Trial name
- NCT07721467
- Testing
- Psilocybin, Cognitive Training
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- National Institute on Aging (NIA)
Aging
Pilot Intervention With Near Infrared Stimulation
The current study will test whether age-related cognitive and mood changes in older adults and those will be affected by near infrared (NIR) stimulation.
- Trial name
- NCT03551392
- Testing
- Medx Console System, Vielight 810 intranasal stand alone unit
- Where
- 2 sites in United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Florida
Presbycusis
Hearing and Cognition in Aging Adults
This cohort study is expected to provide valuable insights into the complex interplay between auditory and cognitive functions and how they change over time.
- Trial name
- ACAV (NCT06183450)
- Testing
- auditory level, cognitive level, quality of life level
- Where
- France
- Volunteers
- 262 people, healthy volunteers welcome
- Sponsor
- University Hospital, Toulouse
Aging, Cognitive Decline
Social and Cognitive Online Training: the SCOT Project
Social isolation and reduced involvement in cognitive activities are associated with repercussions on cognitive well-being and health status in elderly adults.
- Trial name
- SCOT (NCT05023187)
- Testing
- SCOT, CON
- Where
- Italy
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Università degli Studi di Trento
Alzheimer Disease
PET Changes in Alzheimer's Disease (AD)
The purpose of this study is to identify the earliest predictors of memory and brain deterioration in pre-clinical Alzheimer's disease using positron emission tomography (PET) to monitor brain glucose metabolism.
- Trial name
- NCT00094913
- Where
- United States
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- National Institute on Aging (NIA)
Care Transition
Comparing Two Acute Care Transition Programs for Older Adults and Their Family Caregivers
This study investigates better ways to help people after they leave the hospital and how to involve their families in this process.
- Trial name
- NCT07661355
- Testing
- Patient-Centered Program, Family Caregiver Enhanced Program
- Where
- 4 sites in United States
- Volunteers
- 2,560 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Type 2 Diabetes Mellitus, Telomere Shortening
Efficacy of Pythagorean Self-Awareness for Aging Biomarkers Improvement, in T2D Patients and Healthy Individuals.
The present study explored the effects of the implementation of the Pythagorean Self Awareness Intervention (PSAI) on the dynamics of stress-related aging factors of immune cells in healthy volunteers and a cohort patients with…
- Trial name
- NCT04763525
- Testing
- Pythagorean Self-Awareness Intervention(PSAI)
- Where
- Greece
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- National and Kapodistrian University of Athens
Mild Cognitive Impairment
Digital Tools to Support Healthcare Decision Making
The goal for this project is to support the cognitive components of older adults' health-management activities through development of digital assistant technology tools tailored to three exemplar healthcare management task…
- Trial name
- CREATE P3 (NCT07485725)
- Testing
- Project 3, Phase 2: Clinical Trial
- Where
- 3 sites in United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
Cognitive Decline, Mild
Cognition, Flavonoids, Exercise, Gut Microbiome
This NIH project will examine the effects of routine flavonoid-rich blueberry intake (12-weeks), combined with or in the absence of regular moderate exercise, on cognitive function in a clinical population of older participants…
- Trial name
- NCT06495190
- Testing
- Blueberry, Walking, Stretching
- Where
- United States
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Appalachian State University
Cognitive Decline, Mild Cognitive Impairment
The Effects of Chicken Extract and a Peptide Supplement for the Prevention of Cognitive Decline in Non-demented Elderly Adults
This trial investigates the effect of a chicken extract supplement and a peptide supplement on cognitive function and potential mechanisms of action of cognitive decline during ageing, among non-demented elderly adults using a…
- Conditions
- Cognitive Decline, Mild Cognitive Impairment, Aging
- Trial name
- NCT04555655
- Testing
- Chicken extract supplement, Peptide Supplement
- Where
- 3 sites in Taiwan
- Volunteers
- 276 people, healthy volunteers welcome
- Sponsor
- Brand's Suntory Asia
Cognitive Wellness, Healthy Aging
MEVA Cognitive Wellness Platform Study for Adults
The goal of this observational study is to evaluate the reliability, usability, and feasibility of the MEVA Cognitive Wellness Platform in community-dwelling adults aged 55 to 75.
- Conditions
- Cognitive Wellness, Healthy Aging, Age-Related Cognitive Change, Aging
- Trial name
- MEVA (NCT07595250)
- Testing
- MEVA Cognitive Wellness Platform
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Mentage LLC