Clinical trials: Cognitive Aging
Aging
Feasibility and Efficacy of A Remote Tai Chi Program in Older Adults
This project is designed to explore the feasibility and preliminary efficacy of a remote Tai Chi program on older adults' 24-hour movement behaviors (i.e., physical activity, sedentary behavior and sleep patterns).
- Trial name
- NCT06918678
- Testing
- Tai Chi intervention, Usual care condiition
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- The University of Tennessee, Knoxville
Aging, Mild Cognitive Impairment
Application of the Modified Story Memory Technique (mSMT)© to Aging
This study is a double-blind placebo-controlled randomized clinical trial (RCT) to provide Class I evidence in support of or in refute of the efficacy of the modified Story Memory Technique (mSMT) in healthy aging (HA)and in…
- Trial name
- NCT03370224
- Testing
- Memory retraining exercises
- Where
- United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Kessler Foundation
Aging
Cognitive Load of Activity Participation Scale (CLAP): Development and Validation
In this study, we develop and validate the " Cognitive Load of Activity Participation Scale" (CLAPs) to measure the frequency and the perceived levels of cognitive load of the elderly participating in various cognitive activities…
- Trial name
- NCT05749913
- Where
- Taiwan
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Cognitive Impairment, Healthy Participants
Exercise-Modulated Cognitive Hormones
Investigating the influence of a 12-week exercise regimen structured thrice weekly on cognitive capacity, and related hormones like Leptin, Irisin, BDNF hormones, antioxidant status, and inflammatory cytokines, whether these…
- Trial name
- NCT07341568
- Where
- Saudi Arabia
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- King Saud University
Healhty, Aging
Video Game Intervention In Older Adults
The purpose of this clinical trial is to investigate the effects of a rehabilitative game-based intervention on self-efficacy, balance, and visual-motor integration in individuals aged 60 years and older.
- Conditions
- Healhty, Aging, Balance, Self Efficacy
- Trial name
- NCT07433608
- Testing
- Game-Based Virtual Reality Intervention
- Where
- Turkey (Türkiye)
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Biruni University
Mobility Limitation
A Pilot to Evaluate the Feasibility and Efficacy of a Multifaceted Rehabilitation Intervention
The goal of this study is to evaluate the efficacy of multifaceted rehabilitation program in Veterans 65 years and older. This study will also examine the neuromuscular and cognitive attributes that contribute to clinically…
- Trial name
- NCT04446455
- Testing
- InVEST: Increased Velocity Exercise Specific to Task, TAPAT: Tonic and Phasic Alertness Training
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- VA Boston Healthcare System
Central Nervous System Disease, Cerebrovascular Accident
Brain Processing of Language Meanings
This research trial will study discourse processing-that is, how the brain processes the meaning of language. It will examine, for example, how words and sentences are interpreted in cases where more than one meaning is possible.
- Conditions
- Central Nervous System Disease, Cerebrovascular Accident, Craniocerebral Trauma, Head Injury
- Trial name
- NCT00005004
- Where
- United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- National Institutes of Health Clinical Center (CC)
Healthy Aging
Virtual Reality Study - COVID-19 Protocol
The overarching goal of this pilot clinical trial is to use a novel virtual reality (VR)-based intervention that simultaneously engages physical and cognitive activity aimed at improving brain and cognitive outcomes in older…
- Trial name
- NRVR (NCT04678778)
- Testing
- Physical and Cognitive Activity
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- University of Southern California
HIV, Aging
The Targeted Neurocognitive Training (TNT) Study
People with HIV (PWH) often suffer from cognitive impairments known as HIV-Associated Neurocognitive Disorder (HAND). Cognitive impairments in PWH are not fully captured by traditional neurocognitive assessment; thus, we must…
- Conditions
- HIV, Aging, Cognitive Function Abnormal, Cognitive Training
- Trial name
- TNT (NCT05773430)
- Testing
- Targeted Neurocognitive Training
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Transcranial Alternating Current Stimulation, Aging
Effects of Gamma-tACS on Memory and Sleep
The purpose of this clinical trial is to investigate the feasibility and efficacy of non-invasive transcranial alternating current stimulation (tACS) at gamma frequency in enhancing memory recall and modulating sleep network…
- Conditions
- Transcranial Alternating Current Stimulation, Aging, Cognitive Decline, Memory
- Trial name
- NCT05907707
- Testing
- Gamma transcranial alternating current stimulation, Control transcranial alternating current stimulation, EEG headband
- Where
- United States
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Aging, Fall Risk Factors
Use of Virtual Reality for the Assessment of Attentional and Reaction Abilities for Fall Risk Evaluation
Aging is a condition characterized by a general decline in physical and cognitive performance, however its effects on various functions are still controversial.
- Conditions
- Aging, Fall Risk Factors, Sleep
- Trial name
- NCT06940245
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio
Fatigue
Fatigability and Cognitive Demand With Aging
This study will determine the influence of a cognitive task performed during fatiguing contractions.
- Trial name
- NCT05121272
- Testing
- cognitive task
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Oklahoma
Glucose Metabolism Disorders (Including Diabetes Mellitus), Cognitive Decline
Glucose Variability and Cognition in Prediabetes
This study examines the association of variability in glucose values over a 10-day period with cognitive function and AD risk markers among individuals with prediabetes, aged 50 or older.
- Conditions
- Glucose Metabolism Disorders (Including Diabetes Mellitus), Cognitive Decline, PreDiabetes, Aging
- Trial name
- NCT04201600
- Testing
- Continuous Glucose Monitoring System (CGMS)
- Where
- United States
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
Mild Cognitive Impairment
Neural Correlates of Repeated tDCS
Healthy ageing and pathological ageing in the context of a neurodegenerative disease are both associated with changes in brain network integrity.
- Trial name
- NCT02997007
- Testing
- active tDCS
- Where
- Netherlands
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Ageing, Disability
The Beijing Longitudinal Disability Survey in Community Elderly
The goal of this observational study is to establish the prospective cohort of the Beijing Longitudinal Disability Survey in Community Elderly (BLINDSCE) to explore the high-risk factors and preventive interventions for…
- Conditions
- Ageing, Disability, Cognitive Impairment, Frailty
- Trial name
- BLINDSCE (NCT06863727)
- Where
- China
- Volunteers
- 1,962 people, healthy volunteers welcome
- Sponsor
- Xuanwu Hospital, Beijing
Aging, MCI
Enhancing Attention and Wellbeing Using Digital Therapeutics
The goals of the proposed research are to first determine the minimal and/or optimal dose of a digital intervention required for cognitive enhancement, and then to examine the impact of several potential moderators of treatment…
- Conditions
- Aging, MCI, Cognitive Decline
- Trial name
- NCT06397469
- Testing
- MediTrain, Worder
- Where
- United States
- Volunteers
- 4,000 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Amnestic Mild Cognitive Impairment, Aging
Recollection Training in Healthy Older Adults and Older Adults With Amnestic Mild Cognitive Impairment
We have developed a training intervention that successfully improves older adults' memory. We have also shown that older adults whose memory is as good as younger adults' memory (Hi-Old) use an altered pattern of memory-related…
- Trial name
- NCT00643266
- Testing
- Recollection Training, Control
- Where
- Canada
- Volunteers
- 91 people, healthy volunteers welcome
- Sponsor
- Baycrest
Healthy Aging, Cognitive Decline
Cognitively Enriched Walking Program
Dementia currently affects more than 47 million people worldwide, its prevalence is forecasted to triple by 2050, and it has been reported to be one of the most costly disorders in Belgium.
- Conditions
- Healthy Aging, Cognitive Decline, Physical Inactivity
- Trial name
- NCT05500183
- Testing
- Cognitively enriched walking program, walking program
- Where
- 2 sites in Belgium
- Volunteers
- 113 people, healthy volunteers welcome
- Sponsor
- University Ghent
Mild Cognitive Impairment, Aging
Mental Training for Adults With Mild Cognitive Impairment
This study aims to determine the feasibility and acceptability of conducting a larger randomized clinical trial to test whether individuals with MCI can benefit from mental training programs.
- Trial name
- NCT03895346
- Testing
- Mindfulness, Brain Games and Puzzles
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Alzheimer Disease, Healthy Aging
Amyloid Imaging With 11C-PiB in Healthy Aging and Mild Cognitive Impairment
The purpose of this study is to measure the amount of amyloid in the brain. Amyloid is a protein found in the brain of patients with Alzheimer's disease and can be detected using a Positron Emission Tomography (PET) scan.
- Trial name
- NCT04505735
- Testing
- 11C-PiB
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver