Clinical trials: Cognitive Disorders
Cognitive Decline
Cognitive Training and Social Interaction Effects on Cognitive Performance of Older Adults
Aging is associated with a decline in almost all aspects of cognitive functions, particularly memory. Recent research suggests that combining cognitive training with ongoing social interaction may aid in improving cognitive…
- Trial name
- NCT05016336
- Testing
- Social interaction combined with cognitive training based on mnemonic strategies., Social interaction group
- Where
- Israel
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Bar-Ilan University, Israel
Dementia
Human-LLM Conversations as a Digital Signature of Cognitive Performance in Adults
Subtle changes in language are among the early signs of cognitive decline in Alzheimer's disease and related conditions. Researchers are therefore studying whether language can help identify cognitive changes earlier and at…
- Trial name
- HLC-CogMark (NCT07890207)
- Testing
- No Intervention: Observational Cohort
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Technion, Israel Institute of Technology
Obesity
The Effect of Brain Stimulation (tDCS) in Food Cravings Control in Overweight/Obese Women
This study is a randomized clinical trial to test the effect of a type of non-invasive brain stimulation on the response to a behavioral intervention designed to enhance cognitive control over food cravings in obese and…
- Trial name
- NCT04420767
- Testing
- tDCS, Go-No GO task
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Sexually Transmitted Infection (STI) Prevention, Unintended Pregnancy Prevention
Preventing Health Damaging Behaviors in Male and Female Army Recruits
Health damaging (risk) behaviors of young military personnel are reflections of health problems facing all young people in the U.S.
- Conditions
- Sexually Transmitted Infection (STI) Prevention, Unintended Pregnancy Prevention, Sexual Risk Reduction, Alcohol and Other Substance Use Prevention
- Trial name
- NCT01234103
- Testing
- Preventing Helath Damaging Health Behaviors in Male and Female Army Recruits
- Where
- United States
- Volunteers
- 933 people, healthy volunteers welcome
- Sponsor
- United States Department of Defense
Psychological Distress, Quality of Life
The Effectiveness of Culturally Adapted Cognitive Behavioral Intervention Among COVID-19 Survivors
The effectiveness study for Culturally-Adapted Cognitive Behavioral Intervention (CA-CBI) will be conducted with individuals infected with and recovered from Coronavirus disease (COVID-19) to measure if this intervention is…
- Conditions
- Psychological Distress, Quality of Life, Depressive Symptoms, Anxiety
- Trial name
- NCT04949061
- Testing
- Culturally Adapted Cognitive Behavioral Intervention (CA-CBI), Enhanced Treatment as Usual (ETA-U)
- Where
- Turkey (Türkiye)
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Koç University
Primary Insomnia
Comparison of Efficacy of Behavioral Approaches for Treatment of Insomnia
This study compares the efficacy of four different types (Cognitive Behavior Therapy for Insomnia (CBT-I); Focus of Attention (FOA); Combined CBT-I and FOA; and Sleep Hygiene (control group) for the treatment of insomnia.
- Trial name
- CEBATI (NCT03461666)
- Testing
- Cognitive Behavior Therapy-Insomnia, Focus of Attention, Combined-CBT-I and FOA Group
- Where
- 2 sites in United States
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Pacific Institute of Medical Sciences
Aging, Physical Activity
Exercise Periodization and Older Adults
The present study aimed at investigating the effects of two different resistance training protocols - nonperiodized (NP) and daily undulating periodization (DUP) - on hemodynamic, morphofunctional and cognitive parameters of…
- Conditions
- Aging, Physical Activity, Sarcopenia, Cognitive Decline
- Trial name
- NCT03443375
- Testing
- Physical exercise
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- University of Campinas, Brazil
Cognitive Dysfunction
GABA-glutamate Interactions and Psychosis
This study investigates the interactions between NMDA (N-Methyl-D-aspartic acid) antagonism and GABA (gamma-aminobutyric acid) system as it relates to cognitive function assessed by ERPs (event-related potentials) in healthy…
- Trial name
- NCT00611572
- Testing
- iomazenil
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Yale University
Schizophrenia, Exercise
Comparison of the Effects of Aerobic Exercise and Computerized Cognitive Stimulation in Patients With Schizophrenia - A Randomized Controlled Trial
Schizophrenia is a chronic mental disorder characterized by the occurrence of both positive symptoms, such as hallucinations and delusions, and negative symptoms, such as apathy and withdrawal, repetition of cognitive skills and…
- Conditions
- Schizophrenia, Exercise, Computerized Cognitive Stimulation
- Trial name
- NCT06572657
- Testing
- cognitive stimulation, physical exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Dr. Lutfi Kirdar Kartal Training and Research Hospital
Frailty Syndrome, Sarcopenia
Design and Validation of FEXO: A Playful Exercise Program for Institutionalized Frail Older Adults
This multicenter randomized controlled trial aims to evaluate the effectiveness of a playful multicomponent exercise intervention (FEXO - Fun Exercise for Older Adults) on intrinsic capacity, frailty, and functional health in…
- Trial name
- FEXO-FRAIL (NCT07133581)
- Testing
- FEXO (Fun Exercise for Older Adults)
- Where
- Spain
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Cardenal Herrera University
Aging, Cognitive Decline
Aging and Cognitive Health Evaluation in Elders (ACHIEVE)
The ACHIEVE study will be a randomized controlled trial nested within the infrastructure of the Atherosclerosis Risk in Communities (ARIC) study.
- Trial name
- ACHIEVE (NCT03243422)
- Testing
- Successful aging health education intervention, Hearing intervention
- Where
- 4 sites in United States
- Volunteers
- 977 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Parkinson Disease, Progressive Supranuclear Palsy
Oxford Study of Quantification in Parkinsonism
The OxQUIP (Oxford QUantification In Parkinsonism) study is recruiting patients with Parkinson's Disease and Progressive Supranuclear Palsy.
- Trial name
- OxQUIP (NCT04139551)
- Where
- United Kingdom
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Cerebral Small Vessel Disease
Neural Correlates (EEG and fMRI) of Gait in Small Vessel Disease
What is the purpose of this study? This observational study is being done to understand how cerebral small vessel disease (SVD) affects walking and balance.
- Trial name
- doesn't exist (NCT07372937)
- Testing
- No Intervention: Observational
- Where
- Egypt
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Mild Cognitive Impairment
Consumption of Potatoes, Avocados and Chickpeas and Cognitive Function in Older Adults
Cognitive impairment is also a major risk factor for development of dementia later in life. Findings from the investigators studies suggest that the carotenoids, lutein and zeaxanthin may be important in cognitive function in the…
- Trial name
- NCT01620567
- Testing
- avocado, potato or chickpea
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Tufts University
Schizophrenia
Cerebral Reorganization in Schizophrenia
The purpose of this study is to reveal the specific effects of computer-aided cognitive training on cerebral reorganization in schizophrenia
- Trial name
- NCT01781000
- Testing
- Brain Fitness & Brain Training- Posit Science, Facial Affect Training- FAT, Treatment as usual
- Where
- Germany
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Konstanz
Cognitive Impairment
Preoperative Cognitive Screening of Elderly Surgical Patients
The objectives of this pilot study are: 1. to determine whether a short cognitive test battery administered in the preadmission test center can be used to cognitively stratify elderly patients presenting for elective surgical…
- Trial name
- NCT01826825
- Testing
- Cognitive Screen, Mini-Cog
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Mild Traumatic Brain Injury
A Community Support Network Intervention in SOAR Project Intimate Partner Violence-Related Traumatic Brain Injury
Intimate Partner Violence (IPV) comprises physical, sexual and emotional abuse and controlling behaviors imposed by an intimate partner.
- Trial name
- SOAR-CSNI (NCT04890925)
- Testing
- Community Support Network (CSN) intervention, Usual care
- Where
- Canada
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Atherosclerosis
ELITE: Early Versus Late Intervention Trial With Estradiol
The purpose of this study is to examine the effects of oral 17B-estradiol (estrogen) on the progression of early (subclinical) atherosclerosis and cognitive decline in healthy postmenopausal women.
- Trial name
- NCT00114517
- Testing
- 17B-estradiol
- Where
- United States
- Volunteers
- 643 people, healthy volunteers welcome
- Sponsor
- University of Southern California
Cognitive Decline, Nutrition, Healthy
Long-term Effects of Blueberry Supplementation on Brain Health in Older Adults
This study will test whether consuming blueberry powder 20g/d for 24 weeks can improve memory and other cognitive function and alter serum biomarkers of brain injury among older adults.
- Conditions
- Cognitive Decline, Nutrition, Healthy, Brain Injuries
- Trial name
- NCT05764824
- Testing
- Blueberry powder, Controlled and matched powder
- Where
- United States
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Social Anxiety, Sexual Risk
Sexual Confidence: CBT for Social Anxiety Disorder With HIV Risk Reduction Counselling for HIV-negative gbMSM
Given the continued high human immunodeficiency virus (HIV) prevalence rates among gay, bisexual, and other men who have sex with men (MSM) in North American cities, there is a critical need for HIV prevention interventions for…
- Conditions
- Social Anxiety, Sexual Risk, HIV
- Trial name
- SC-RCT (NCT04381559)
- Testing
- Cognitive Behavioural Therapy, Applied Relaxation
- Where
- Canada
- Volunteers
- 176 people, healthy volunteers welcome
- Sponsor
- Toronto Metropolitan University
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