Clinical trials: Colon or Colorectal Resection
Stage II Colon Cancer, Stage III Colon Cancer
Exploiting Circulating Tumour DNA to Intensify the Postoperative Treatment Resected Colon Cancer Patients
The aims of this study are to evaluate if an intensified adjuvant treatment with FOLFOXIRI could increase the rate of cases with undetectable ct-DNA after chemotherapy and to evaluate if a further adjuvant treatment with…
- Conditions
- Stage II Colon Cancer, Stage III Colon Cancer, HER2-positive Colon Cancer, RAS Wild-type Colon Cancer
- Trial name
- ERASE-CRC (NCT05062889)
- Testing
- 5-Fluorouracil continuous infusion FOLFOXIRI schedule, 5-Fluorouracil bolus FOLFOX schedule, 5-Fluorouracil continuous infusion FOLFOX schedule
- Where
- 28 sites in Italy
- Volunteers
- 477 people
- Sponsor
- Gruppo Oncologico del Nord-Ovest
Colorectal Cancer, Colorectal Neoplasms
Clinical Outcomes After EMR or ESD of Colorectal Neoplasms - A Multicenter Registry
This study aims to establish a multicenter registry platform to capture clinical data from subjects undergoing colorectal EMR and ESD.
- Conditions
- Colorectal Cancer, Colorectal Neoplasms, Colorectal Adenoma
- Trial name
- NCT05653960
- Testing
- EMR or ESD
- Where
- Hong Kong
- Volunteers
- 2,500 people
- Sponsor
- Chinese University of Hong Kong
Colorectal Cancer
Radiation Therapy, Chemotherapy, and Cetuximab Followed by Surgery, Chemotherapy, and Cetuximab in Treating Patients With Locally Advanced or Metastatic Rectal Cancer That Can Be Removed by Surgery
RATIONALE: Radiation therapy uses high-energy x-rays to kill tumor cells. Drugs used in chemotherapy, such as capecitabine, oxaliplatin, fluorouracil, and leucovorin, work in different ways to stop the growth of tumor cells…
- Trial name
- NCT00541112
- Testing
- cetuximab, capecitabine, fluorouracil
- Where
- 10 sites in France
- Volunteers
- 19 people
- Sponsor
- UNICANCER
Colorectal Cancer, Metastatic Cancer
SCH 66336 Before Surgery in Treating Patients With Colorectal Cancer That Has Metastasized to the Liver
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. PURPOSE: Randomized phase I trial to compare the effectiveness of different doses of SCH 66336 before surgery…
- Trial name
- NCT00005030
- Testing
- SCH 66336, conventional surgery
- Sponsor
- M.D. Anderson Cancer Center
Metastatic Colorectal Cancer
Study of Hepatic Arterial Infusion With Intravenous Irinotecan, 5FU and Leucovorin With or Without Panitumumab, in Patients With Wild Type RAS Who Have Resected Hepatic Metastases From Colorectal Cancer
The purpose of this study is to see if Panitumumab plus the other treatments will increase the time of remission. Remission means that there is no sign of the cancer.
- Trial name
- NCT01312857
- Testing
- panitumumab, Randomization to No Panitumumab
- Where
- 8 sites in United States
- Volunteers
- 75 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Colorectal Cancer, Precancerous Condition
Rosuvastatin in Treating Patients With Stage I or Stage II Colon Cancer That Was Removed By Surgery
RATIONALE: Rosuvastatin may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Giving rosuvastatin after surgery may kill any tumor cells that remain after surgery.
- Trial name
- NCT01011478
- Testing
- rosuvastatin
- Where
- 587 sites in United States, Canada
- Volunteers
- 406 people
- Sponsor
- NSABP Foundation Inc
Colorectal Cancer
Safety Study of Totally Laparoscopic Resection With Natural Orifice Specimen Extraction (NOSE) for Rectosigmoid Cancer
The purpose of this study is to compare the safety and efficacy of laparoscopic resection with natural orifice specimen extraction versus conventional laparoscopic surgery for sigmoid colon or rectal cancer.
- Trial name
- NCT02635503
- Testing
- transrectal specimen extraction, Conventional laparoscopic surgery
- Where
- China
- Volunteers
- 366 people
- Sponsor
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences
Colorectal Cancer, Colorectal Anastomosis
Single-Stapled Technique for Colorectal Anastomosis
The goal of this observational multicenter study is to evaluate the safety and feasibility of a single-stapled technique (SST) for colorectal anastomosis and to explore whether this technique is associated with a reduced rate of…
- Conditions
- Colorectal Cancer, Colorectal Anastomosis, Anastomotic Leakage, Diverticular Disease of Left Side of Colon
- Trial name
- SST (NCT07417358)
- Testing
- Single-stapled colorectal anastomosis, Double-stapled colorectal anastomosis
- Where
- 5 sites in Sweden
- Volunteers
- 500 people
- Sponsor
- Umeå University
Colorectal Cancer
Follow-Up Care With or Without CEA Assessments in Patients Who Have Undergone Surgery for Stage II or Stage III Colorectal Cancer
RATIONALE: Diagnostic procedures, such as ultrasound, x-ray, colonoscopy, CT scan, and CEA assessment, may help monitor a patient's response to surgery.
- Trial name
- SURVEILLANCE (NCT00995202)
- Testing
- Standard Monitoring CEA, Intensive Monitoring CEA, Standard Monitoring Imagery
- Where
- 117 sites in Belgium, France and 1 more
- Volunteers
- 1,997 people
- Sponsor
- Federation Francophone de Cancerologie Digestive
Lung Non-Small Cell Carcinoma, Metastatic Colorectal Carcinoma
Microwave Ablation or Wedge Resection for the Treatment of Lung, Sarcoma and Colorectal Lesions, ALLUME Study
This study compares the outcomes and safety of two standard treatment options called microwave ablation and surgical wedge resection in patients with non-small cell lung cancer, sarcoma and colorectal cancer that has spread to…
- Conditions
- Lung Non-Small Cell Carcinoma, Metastatic Colorectal Carcinoma, Metastatic Sarcoma, Stage I Lung Cancer AJCC v8
- Trial name
- NCT04430725
- Testing
- Computed Tomography with Contrast, Microwave Ablation, Questionnaire Administration
- Where
- United States
- Volunteers
- 74 people
- Sponsor
- M.D. Anderson Cancer Center
Colon and/or Rectal Resection With Anastomosis for Cancer
Management of Patients With High C-reactive Protein After Scheduled Resection of Colorectal Cancer
Anastomotic fistula is the most feared complication after surgical resection of colorectal cancer (CCR). It occurs in 6 to 15% of patients.
- Trial name
- GESPACE (NCT03097276)
- Testing
- blood sample, CT scan
- Where
- France
- Volunteers
- 105 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
Colorectal Cancer
Simo Decoction and Acupuncture on POI in Colorectal Cancer
Colorectal cancer resection is one of the most common types of abdominal surgery. Though most patients undergoing colorectal resection show recovery of bowel movements within a week, some have prolonged intestinal paralysis or…
- Trial name
- SMD/POI (NCT02813278)
- Testing
- simo decoction, gum chewing
- Where
- China
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Guangxi Medical University
Colon Cancer
Colonic Resection or Stoma, or Self-expandable Metallic Stent for obstruCtive Left cOlon Cancer
CROSCO-1 study is a national, multi-center, prospective observational study presenting patients to the emergency departments of the participating centers with obstructive left colon cancer (in the absence of metastases and…
- Trial name
- CROSCO-1 (NCT05801211)
- Testing
- primary tumor resection
- Volunteers
- 434 people
- Sponsor
- Azienda Sanitaria di Firenze
Colon Cancer
Acute Colon Resection Versus Bridge to Colon Surgery With Stent or Stoma
P) patients with acute obstructive colon cancer I) resection or bridge to surgery with stent or stoma C) emergency procedure O ) morbidity and mortality within 30 days, 90 day mortality and 3 \& 5 years overall survival
- Trial name
- ACBC (NCT04450758)
- Testing
- Bridge to Surgery (stent or stoma)
- Where
- Sweden
- Volunteers
- 1,000 people
- Sponsor
- Skane University Hospital
Hepatic Metastases, Colorectal Cancer
Resection of Colorectal Liver Metastases With or Without Routine Hilar Lymphadenectomy
It is uncertain, whether hilar lymphadenectomy should be performed routinely in patients undergoing resection of colorectal liver metastases.
- Trial name
- RELY (NCT01073358)
- Testing
- Routine hilar lymphadenectomy
- Where
- Germany
- Volunteers
- 166 people
- Sponsor
- Heidelberg University
Esophageal Cancer, Colorectal (Colon or Rectal) Cancer
Quantitative Fluorescence Angiography With ICG for Perfusion Assessment During Surgery
The accurate assessment of intraoperative tissue perfusion is essential in any branch of surgery. Anastomotic leakage (AL) is one of the most feared complications following gastrointestinal surgery, with potentially threatening…
- Trial name
- SPY Q-ICG PAS (NCT05489757)
- Testing
- SPY Portable Handheld Imaging (SPY-PHI) System with SPY-QP Software
- Where
- Italy
- Volunteers
- 196 people
- Sponsor
- IRCCS San Raffaele
Colorectal Cancer
Tegafur-Uracil or Observation in Treating Patients With Stage II Colorectal Cancer That Has Been Completely Removed By Surgery
RATIONALE: Drugs used in chemotherapy, such as tegafur-uracil, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Trial name
- NCT00392899
- Testing
- UFT adjuvant chemotherapy
- Where
- 272 sites in Japan
- Volunteers
- 2,025 people
- Sponsor
- Translational Research Center for Medical Innovation, Kobe, Hyogo, Japan
Metastatic Colorectal Cancer
Study Comparing Pathological Responses Observed on Colorectal Cancer Metastases Resected After Preoperative Bevacizumab With FOLFOX or FOLFIRI.
The study is designed to analyze the pathological tumor response on resected colorectal cancer metastases after preoperative treatment with bevacizumab combined with FOLFOX or FOLFIRI regimen in a prospective cohort and to…
- Trial name
- BEV-ONCO2012 (NCT01858649)
- Testing
- Metastases resection, Bevacizumab, 5 FU
- Where
- 11 sites in Belgium
- Volunteers
- 60 people
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Colorectal Cancer
Curcumin in Preventing Colorectal Cancer in Patients Undergoing Colorectal Endoscopy or Colorectal Surgery
RATIONALE: Chemoprevention is the use of certain drugs to keep cancer from forming. The use of curcumin may prevent or treat colorectal cancer.
- Trial name
- NCT00973869
- Testing
- curcumin, high performance liquid chromatography, laboratory biomarker analysis
- Where
- 2 sites in United Kingdom
- Volunteers
- 30 people
- Sponsor
- University of Leicester
Colorectal Cancer
Surgery With or Without Chemotherapy and Radiation Therapy in TreatingPatients With Stage I Rectal Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Radiation therapy uses high-energy x-rays to damage tumor cells.
- Trial name
- NCT00023751
- Testing
- fluorouracil, leucovorin calcium, conventional surgery
- Where
- 180 sites in United States, Canada and 1 more
- Volunteers
- 320 people
- Sponsor
- Alliance for Clinical Trials in Oncology