Clinical trials: Corneal Topography
Keratoconus
Validation of Innovative Scheimpflug Topography Derived RGP Contact Lens Designs In Optometry Network
The goal of this Prospective, single-site, cohort study is to validate rigid gas permeable corneal contact lens (RGP) designs for keratoconus derived from combining the data from corneal topography scans and contact lenses…
- Trial name
- VISION (NCT06312163)
- Testing
- The contact lens to be investigated in this study (Scheimpflug topography derived corneal RGP contact lens design). A CE (UKCA) marked class 2 medical devices.
- Where
- United Kingdom
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Moorfields Eye Hospital NHS Foundation Trust
Corneal Opacity
Comparison of Ultrasonic Pachymetry With Orbscan in Corneal Haze
This study is planned to compare the results of ultrasonic and Orbscan pachymetry in corneal haze not related to surgery. Corneal haze is graded with slit-lamp by a single examiner.
- Trial name
- NCT00439114
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Baskent University
Evaluation of Corneal Stability Post-applanation
Icare Tonometry Effects on Keratometry Readings, Topography Readings, and Corneal Staining
To demonstrate that the Icare tonometer does not alter Keratometry readings, topography, or corneal staining. This would therefore allow intraocular pressure (IOP) testing to be done at any time during an exam, without affecting…
- Trial name
- NCT03275142
- Testing
- Icare tonometer
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Comprehensive EyeCare of Central Ohio
Healthy
A Clinical Evaluation of the Next Generation Diagnostic Instrument (NGDI)
The purpose of this study is to measure the aberrations, corneal surface topography and pachymetry of normal human eyes with the NGDI.
- Trial name
- NCT00347594
- Testing
- Next Generation Diagnostic Instrument (NGDI), Zyoptix Diagnostic Workstation (ZDW)
- Where
- United States
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Bausch & Lomb Incorporated
Keratoconus
Topography Versus Non-Topography-Guided PRK With CXL in Keratoconus
To our knowledge, this study is one of the first to compare the visual results of non-topography-guided and topography-guided photorefractive keratectomy (PRK) applying sequential and simultaneous corneal cross-linking (CXL)…
- Trial name
- keratoconus (NCT03890718)
- Testing
- Photorefractive keratectomy in mile keratoconus
- Where
- Iran
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Shahid Beheshti University
Corneal Topography, Dry Eye Syndromes
Performance Evaluation of the OCUTOP Hand-held Corneal Topographer
The OCUTOP is a new hand-held camera that photographs the front of the eye to map the shape of the cornea and to assess the tear film.
- Conditions
- Corneal Topography, Dry Eye Syndromes, Keratoconus, Healthy Volunteers
- Trial name
- OCUTOP (NCT07895849)
- Testing
- OCUTOP hand-held corneal topographer with OCUGRAPH software, Reference instrument measurement (corneal topography and tear-film assessment)
- Where
- 2 sites in United Kingdom
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of Plymouth
Keratoconus, Keratoconus, Unspecified, Bilateral
Evaluation of Tomographic and Genetic Aspects of Keratoconus Patients Compared to Sounds Corneas
Evaluation of tomographic (Pentacam) parameters and genetic parameters of Visual System Homeobox 1 (VSX1), Superoxide Dismutase (SOD1), Tissue Inhibitors of Metalloproteinases (TIMP3) genes of keratoconus patients diagnosed by…
- Trial name
- NCT03071302
- Testing
- EVALUATION OF VSX1, SOD1, and TIMP3 genes
- Where
- Brazil
- Volunteers
- 210 people, healthy volunteers welcome
- Sponsor
- Sao Jose do Rio Preto Medical School
Healthy
Influence of Artificial Tears on Keratometry and Biometry Measurements With Different Devices
The goal of this clinical trial is to learn about the influence of artificial tears on measurements of healthy eyes with three different devices.
- Trial name
- NCT06358456
- Testing
- Artificial tear, No artificial tears
- Where
- Germany
- Volunteers
- 145 people, healthy volunteers welcome
- Sponsor
- University Clinic Frankfurt
Keratoconus
A Clinical Study of Keratoconus in Asian Patients and Assessment of Different Topographic Patterns of Keratoconus in Asian Patients
A clinical study of keratoconus in Asian Patients and assessment of different topographic patterns of keratoconus in Asian patients
- Trial name
- NCT00347074
- Where
- Singapore
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Singapore National Eye Centre
Corneal Topography
Study of Clinical Performance of Corneal Topography Measurement Using an Optical Biometer
The purpose of this study is to quantify in-vivo repeatability of a new corneal topography measurement mode of an optical biometer, and the clinical performance of measurement in comparison to reference devices.
- Trial name
- NCT01861925
- Where
- Switzerland
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Haag-Streit AG
Myopia, Astigmatism
Compare Anterior Chamber Biometry in Healthy and Post-LASIK Patients
In this study, the investigators employed Visante-OCT (Carl Zeiss, USA), an anterior chamber optical coherence tomography, to monitor the change of anterior chamber dimensions.
- Trial name
- NCT00838734
- Where
- Taiwan
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Far Eastern Memorial Hospital
Refractive Surgery
CONTOURA vs WFO Ablation PRK & LASIK
This is a prospective randomized contralateral double-masked study. Each patient will be randomized as to which eye undergoes wave-front optimized (WFO) vs.
- Trial name
- NCT05037370
- Testing
- Wave-Front Optimized (WFO) ablation vs Topography-guided (TG) ablation
- Where
- United States
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- 59th Medical Wing
Cataract, Keratoconus
Clinical Study - ES 900 - 2020-2
The EYESTAR 900 with software version i9.5.1.0 includes new analysis functionality. Since its clinical performance cannot be assessed based solely on clinical literature as found in the Clinical Evaluation Report, further data…
- Trial name
- NCT04392349
- Testing
- Haag-Streit EYESTAR 900, Tomey CASIA 2, Oculus PENTACAM HR
- Where
- Switzerland
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Haag-Streit AG
Keratoconus, Eye Diseases
Development of a Keratoconus Detection Algorithm by Deep Learning Analysis and Its Validation on Eyestar Images
Monocentric clinical study to develop an imaging analysis algorithm for the Eyestar 900 to identify keratoconus corneas and improve biometry for intraocular lens calculations
- Conditions
- Keratoconus, Eye Diseases, Cataract, Corneal Ectasia
- Trial name
- DKDA (NCT04763785)
- Testing
- Corneal tomography with Eyestar 900, Corneal tomography with Pentacam, Biometry with IOL-Master
- Where
- Switzerland
- Volunteers
- 4,800 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Keratoconus, Stable
Evaluation of Morphology Abnormal Cornea Stability With Corneal Biomechanical
To evaluate the corneal biomechanical properties of stable eyes with abnormal morphology, and introduce a biomechanical stable index to evaluate the stability of the eyes with abnormal morphology at the first diagnosis.
- Trial name
- NCT05748002
- Testing
- Pentacam and Corvis ST
- Where
- China
- Volunteers
- 315 people, healthy volunteers welcome
- Sponsor
- Tianjin Eye Hospital
Keratoconus
Reliability of Topography Measurements in Keratoconus
The purpose of this study is to assess the reliability and repeatability of the parameters obtained using the Galilei dual-scheimpflug corneal topographer for monitoring progression in eyes with keratoconus.
- Trial name
- NCT03511495
- Testing
- Galilei Corneal Topographer
- Where
- United States
- Volunteers
- 86 people, healthy volunteers welcome
- Sponsor
- Milton S. Hershey Medical Center
Pregnancy Related
Comparing Anterior Segment Parameters During Pregnancy and Post-Pregnancy
The aim of this study is to evaluate anterior segment changes during and after pregnancy, and compare them with non pregnant healty women
- Trial name
- NCT05175729
- Testing
- Comprehensive Ophthalmologic Examination
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Akdeniz University
Surgical Procedure, Unspecified
Corneal Cross-linking and Refractive Surface Ablation in Patients With Asymmetric Corneas
The purpose of this study is to evaluate safety and efficacy of corneal cross-linking and photorefractive keratectomy for refractive correction in patients with bilateral asymmetric topography.
- Trial name
- NCT02943967
- Testing
- CXL + PRK group, PRK group
- Where
- Brazil
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Federal University of São Paulo
Cornea, Refraction Error
Corneal Topography and High Order Aberrations in Regular Contraceptive Pills
Effect of regular usage of contraceptive pills on corneal topography and corneal high-order aberrations
- Trial name
- NCT07693673
- Testing
- Hormonal Contraception, Combined Oral Contraceptive (COC)
- Where
- Egypt
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Elshimaa A.Mateen
Cornea
Assessment of Corneal Topography and Densitometry in Rheumatoid Patients
Corneal transparency is a result of its unique ultrastructure with collagen fibrils regularity, integrity of connective tissue, and balanced keratocyte components.
- Trial name
- NCT06759207
- Where
- 2 sites in Egypt
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Sohag University