Clinical trials: Coronary Patient
Non ST Segment Elevation Acute Coronary Syndrome
Study of Effects of Ticagrelor on Microparticles and Micro-RNA in NSTE-ACS
The aim of the study is to learn more about the pathophysiology of acute coronary syndrome (ACS) and to evaluate the mechanisms responsible of the action and benefits of ticagrelor.
- Trial name
- TIGER-M (NCT02071966)
- Testing
- Ticagrelor, Clopidogrel
- Where
- Italy
- Volunteers
- 55 people
- Sponsor
- Catholic University of the Sacred Heart
Quality of Life, Pacemaker Ddd Permanent
Clinical Benefit of Rigourous AV Delay Optimization in Patients With a Dual Chamber Pacemaker
Though AV optimization has become a cornerstone in optimization of patients with a cardiac resynchronization therapy (CRT) device, surprisingly the use of AV optimization in patients with a dual chamber (bicameral (BIC))…
- Conditions
- Quality of Life, Pacemaker Ddd Permanent, Atrial Dysfunction
- Trial name
- CBRAVO (NCT01998256)
- Testing
- AV optimization
- Where
- Belgium
- Volunteers
- 28 people
- Sponsor
- Jessa Hospital
Shock, Fluid Overload
Evaluating Fluid Responsiveness in ICU Patients Using VTI and Trendelenburg Positioning
Fluid administration is a commonly performed in the ICU for critically ill patients. However, it can lead to complications such as fluid overload, pulmonary edema, and increased mortality in some patients.
- Conditions
- Shock, Fluid Overload, Cardiac Output, Low
- Trial name
- TREND-US (NCT06418022)
- Testing
- Trendelenburg positioning VTI
- Where
- United States
- Sponsor
- Northwell Health
Primary Amyloidosis of Light Chain Type
High Cut-off Hemodialysis in Patients With Advanced Cardiac AL Amyloidosis and End Stage Renal Disease
The aim of the study is to assess survival of patients with advanced cardiac AL amyloidosis treated with high cut-off hemodialysis (HCO-HD) combined with chemotherapy.
- Trial name
- DIACAL (NCT01531751)
- Testing
- High Cut-off Hemodialysis, Chemotherapy
- Where
- Italy
- Sponsor
- Fondazione IRCCS Policlinico San Matteo di Pavia
Severe Aortic Stenosis
A Prospective, Multicenter, Single-arm Study to Evaluate a Transcatheter Aortic Valve System Safety and Efficacy for the Treatment of Patients With Severe Aortic Stenosis
Trial Title: Prospective, multicenter, single-arm target value clinical trial to evaluate the safety and efficacy of a transcatheter aortic valve system in the treatment of patients with severe aortic stenosis Test device…
- Trial name
- NCT06136429
- Testing
- Transcatheter aortic valve replacement
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Pan Xiangbin
Coronary Artery Disease, Valvular Heart Disease
Hemodynamic Effect of Topical Anesthesia During Induction in Patients Undergoing Cardiac Surgery
Patients scheduled for cardiac surgery are fragile. Hemodynamic fluctuation might be associated with adverse outcomes. Therefore, it is essential to keep hemodynamics stable during and after the induction period.
- Conditions
- Coronary Artery Disease, Valvular Heart Disease, Arrythmia
- Trial name
- NCT05323786
- Testing
- The combined topical anesthesia induction group, The routine induction group
- Where
- China
- Volunteers
- 96 people
- Sponsor
- Qianfoshan Hospital
Heart Failure With Reduced Ejection Fraction HFrEF
Effect of Carvedilol Rapid Up-Titration in Patients With Heart Failure With Reduced Ejection Fraction
Guidelines-directed medical therapy has improved dramatically outcomes in heart failure with reduced ejection fraction (HFrEF) patients.
- Trial name
- NCT05179070
- Testing
- Carvedilol
- Where
- Indonesia
- Volunteers
- 26 people
- Sponsor
- Universitas Sebelas Maret
Patients Undergoing Coronary Artery Bypass Graft (CABG) Surgery Requiring Extracorporeal Circulation
Role of Mitochondrial Dysfunction in the Occurrence of Acute Kidney Injury (AKI) in Postoperative Cardiac Surgery
Cardiac Surgery and Acute Kidney Failure (AKI) post Surgery: AKI is a frequent complication in the immediate aftermath of cardiac surgery with an incidence varying from 5 to 40%.
- Trial name
- MIT-CEC (NCT04125069)
- Testing
- Coronary Artery Bypass Graft (CABG)
- Where
- France
- Volunteers
- 27 people
- Sponsor
- University Hospital Center of Martinique
Acute Kidney Injury
Treatment Costs of Kidney Injury in Patients Having Heart Surgery in the UK
Single-centre retrospective analysis of prospectively collected data with propensity matched scoring groups (AKI v/s non-AKI). Data collection from databases (or their equivalent): PATS Dendrite, Electronic Medical Records…
- Trial name
- Cost-AKI (NCT07719569)
- Testing
- No Intervention: Observational Cohort
- Where
- United Kingdom
- Volunteers
- 4,600 people
- Sponsor
- The Royal Wolverhampton Hospitals NHS Trust
Acute Coronary Syndrome, Heart Failure With Reduced Ejection Fraction
Effect of Vericiguat on Acute Coronary Syndrome( ACS）Patients With Ejection Fraction <45%
Investigators evaluate whether differences exsit in acute coronary syndrome（ACS） patients with ejection <45% between participants who take vericiguat regularly and those who donot.
- Trial name
- NCT06321094
- Where
- China
- Volunteers
- 149 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Atherosclerotic Cardiovascular Disease
ODYSSEY Outcomes: Evaluation of Cardiovascular Outcomes After an Acute Coronary Syndrome During Treatment With Alirocumab
Primary Objective: To compare the effect of alirocumab with placebo on the occurrence of cardiovascular (CV) events (composite endpoint of coronary heart disease (CHD) death, non-fatal myocardial infarction (MI), fatal and…
- Trial name
- NCT01663402
- Testing
- Alirocumab, LMT
- Where
- 1,388 sites in United States, Argentina and 55 more
- Volunteers
- 18,924 people
- Sponsor
- Sanofi
Adherence, Patient, Atrial Fibrillation
ASsessment of Adherence TO Medication in AtRIAl Fibrillation - an eMonitoring Drug Dispensing Device Study
The ASTORIA study is a prospective cohort single-armed multicenter observational study that aims to assess adherence to rivaroxaban using a high technological electronical pillbox connected to a phone application in a group of…
- Trial name
- ASTORIA (NCT04815161)
- Testing
- Adherence
- Volunteers
- 200 people
- Sponsor
- Oslo University Hospital
Myocardial Infarction, Chronic Periodontitis
The Effect of Periodontal Therapy in Chronic Periodontitis Patients With and Without Acute Myocardial Infarction
The aim of this study was to evaluate the effects of periodontal treatment on gingival crevicular fluid (GCF) levels of Neopterin(N) and vascular cell adhesion molecule (VCAM-1) in chronic periodontitis(CP) patients with acute…
- Trial name
- NCT03005886
- Testing
- Periodontal examination, GCF sampling, phase I therapy
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Gazi University
Coronary Artery Disease
Omega-3 Supplementation on Serum Fetuin-A Levels
Background and aims: One of the investigated possible modulators of serum fetuin-A, associated with the risk of developing coronary artery disease (CAD), is omega-3 fatty acids (FAs).
- Trial name
- NCT05661994
- Testing
- Omega-3 fatty acid supplementation
- Where
- Turkey (Türkiye)
- Volunteers
- 34 people
- Sponsor
- Amasya University
Uncontrolled Hypertension
A Study of Modified Release RTN-001 In Patients With Uncontrolled Hypertension
The purpose of this clinical trial is to measure the safety and efficacy of RTN-001 in adult participants with uncontrolled hypertension versus placebo.
- Trial name
- NCT07142356
- Testing
- RTN-001
- Where
- 34 sites in United States
- Volunteers
- 280 people
- Sponsor
- Retension Pharmaceuticals. Inc.
Heart Failure, ESKD
Study of Diastolic Dysfunction in ESKD in Hemodialysis Patient
To Asses the prevalence , pattern , and severity of diastolic dysfunction in patients ESKD undergoing regular dialysis and to investigate its correlation with clinical parameters dialysis-related factors and echocardiographic…
- Conditions
- Heart Failure, ESKD, Hemodialysis Patients
- Trial name
- NCT07180888
- Testing
- Echocardiography, Echocardiographic assessment of diastolic dysfunction
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Sohag University
Myocardial Infarction
Fractional Flow Reserve (FFR) Stability in Non-Culprit Vessels at ST Elevation Myocardial Infarction(STEMI)
It has been shown that if it can be accomplished within a 90 minute "door to balloon" time, opening an artery in an acute heart attack situation (ST elevation myocardial infarction or STEMI) is best treated with balloon…
- Trial name
- NCT01065103
- Testing
- FFR (Fractional Flow Reserve)
- Where
- 2 sites in Canada
- Volunteers
- 48 people
- Sponsor
- Cardiology Research UBC
Advanced Care Planning
Advance Care Planning (ACP) in Elderly Cardiac Surgery Patients
This is a prospective epidemiological pilot study to evaluate the feasibility of recruiting and retaining patients in a large multicenter study that will audit Advanced Care Planning (ACP) practices and satisfaction with End Of…
- Trial name
- DIMAN (NCT02680327)
- Where
- Canada
- Volunteers
- 35 people
- Sponsor
- Montreal Heart Institute
Iron Overload, Cardiomyopathy
Intensive Combined Chelation Therapy for Iron-Induced Cardiac Disease in Patients With Thalassemia Major
Myocardial iron overload is the leading cause of death in patients with beta-thalassemia major (TM). Therapy with deferoxamine (DFO) combined with deferiprone (DFP) reduces myocardial iron and improves cardiac function.
- Trial name
- DFODFPTM (NCT00800761)
- Testing
- Deferoxamine and Deferiprone, Deferoxamine
- Where
- Italy
- Sponsor
- Ospedale Microcitemico
Atrial Fibrillation, Pulmonary Embolism
Development of a Questionnaire to Assess Patient Knowledge About Non-vitamin K Anticoagulants (NOAC)
Pharmacists are in the best position to counsel and educate patients on anticoagulant agents such as NOACs. This should enable patients to play a more active role in their treatment and ultimately enhance adherence behaviour.
- Conditions
- Atrial Fibrillation, Pulmonary Embolism, Deep Vein Thrombosis
- Trial name
- NCT03124654
- Testing
- Education
- Where
- Switzerland
- Volunteers
- 60 people
- Sponsor
- University Hospital, Basel, Switzerland
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