Clinical trials: Coronary Stent Occlusion
Coronary Disease, Coronary Artery Disease
Safety and Efficacy of the ZoMaxx™ Drug-Eluting Stent System in Coronary Arteries
The purpose of this study is to demonstrate the safety and efficacy of the ZoMaxx drug-eluting stent in patients with blockage of native coronary arteries.
- Conditions
- Coronary Disease, Coronary Artery Disease, Coronary Restenosis
- Trial name
- ZoMaxx™ II (NCT00140101)
- Testing
- ZoMaxx™ Drug-Eluting Coronary Stent System, TAXUS™ EXPRESS2™ Paclitaxel Eluting Coronary Stent
- Where
- 92 sites in United States, Australia and 2 more
- Volunteers
- 1,099 people
- Sponsor
- Abbott Medical Devices
Carotid Stenosis
Platelet Inhibition and Transcranial Doppler (TCD)-Detected Microemboli During and After Carotid Artery Stenting (CAS) in Asymptomatic Patients Prior to Cardiac Surgery
As with coronary artery stenting, activation and embolisation of platelets occurs with carotid artery stenting (CAS). Based on promising data on the use of clopidogrel plus aspirin in coronary stenting this dual antiplatelet…
- Trial name
- IMPACT (NCT01146301)
- Testing
- Clopidogrel
- Where
- Netherlands
- Sponsor
- R&D Cardiologie
Coronary Artery Disease, Diabetes Mellitus
PROVIDENCE:Prevention of Restenosis With Oral Rosiglitazone and the Vision Stent in Diabetics With Coronary Lesions
We hypothesize that the combination of the thin-strut MULTI-LINK (i.e. VISION(tm) and/or MINI-VISION(tm)) stent and pharmacologic therapy with the oral PPAR-gamma agonist rosiglitazone will significantly reduce restenosis after…
- Trial name
- NCT00116792
- Testing
- Percutaneous Coronary Intervention (PCI)
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Gold, Herman K., MD
Coronary Artery Disease
GISSOC II: Sirolimus Eluting Stent Versus Bare Metal Stent in Chronic Total Coronary Occlusions
The objective of this study is to compare the Cypher Select-TM Sirolimus Eluting Stent (SES) with the SONIC-TM Bare Metal Stent (BMS) in the treatment of Chronic Total Occlusion lesions (CTO).
- Trial name
- NCT00220558
- Testing
- Coronary placement of bare metal stent vs. drug eluting stent
- Where
- 14 sites in Italy
- Volunteers
- 150 people
- Sponsor
- Società Italiana di Cardiologia Invasiva
Coronary Artery Disease, Atherosclerosis
Rotational Atherectomy Combined With Cutting Balloon to Optimize Stent Expansion in Calcified Lesions
Rotational atherectomy is an established tool to treat blocked arteries in the heart, in which the blockage is due to significant amounts of calcified material.
- Trial name
- ROTA-CUT (NCT04865588)
- Testing
- rotational atherectomy, cutting balloon, plain old balloon
- Where
- 2 sites in United States
- Volunteers
- 60 people
- Sponsor
- Samin Sharma, M.D., F.A.C.C., M.S.C.A.I.
Coronary Artery Disease
The Medtronic RESOLUTE Clinical Trial
To evaluate the clinical safety, efficacy, and pharmacokinetics (PK) of the Endeavor Resolute Zotorolimus Eluting Coronary Stent System for the treatment of single de novo lesions in native coronary arteries with a reference…
- Trial name
- NCT00248079
- Testing
- Coronary Artery Stenting
- Where
- Australia
- Volunteers
- 139 people
- Sponsor
- Medtronic Vascular
Coronary Artery Disease
Late Incomplete Stent Apposition Evaluation II: Comparison Between Polimer-based and No-polimer Stent System. IVUS Based Study
Vascular effects evaluation after non-polimeric and polimeric paclitaxel stent implantation.In particular the investigators will use Taxus )as a polimeric stent)and Axxion (as a non-polimeirc)stent system.
- Trial name
- LISAII (NCT01375855)
- Testing
- Percutaneous transluminal Coronary Angioplasty
- Where
- Spain
- Volunteers
- 320 people
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Coronary Artery Disease
MagicTouch Sirolimus Drug Coated Balloon Catheter for the Treatment of Coronary Lesions
The purpose of this study is to demonstrate the efficacy of MagicTouch DCB in reducing late lumen loss / suppressing neointimal tissue formation as assessed by Quantitative Coronary Angiography / Intravascular Ultrasound…
- Trial name
- MAGIC-TOUCH (NCT02400632)
- Testing
- MAGIC-TOUCH Drug-eluting Balloon
- Where
- 3 sites in Brazil
- Volunteers
- 60 people
- Sponsor
- Scitech Produtos Medicos SA
Coronary Artery Disease
Myocardial Injury After Elective Coronary Stenting
This pilot study aims to identify patients at moderate to high risk for peri-procedural (type 4) myocardial infarction or injury after after undergoing an elective coronary intervention (PCI) as measured by high sensitivity…
- Trial name
- NCT01986621
- Where
- Germany
- Volunteers
- 530 people
- Sponsor
- University Hospital Heidelberg
Coronary Artery Disease
A Study to Examine the Implantation Characteristics of Two Drug-Eluting Stents
Despite recent advances in stent technology and clot reducing drug therapy, acute stent occlusion or thrombosis (ST), still occurs and can be life threatening.
- Trial name
- ORCA-2 (NCT01201369)
- Testing
- Coronary Stent Cypher, Coronary stent Xience
- Where
- United Kingdom
- Volunteers
- 40 people
- Sponsor
- Royal Brompton & Harefield NHS Foundation Trust
Coronary Artery Disease, Myocardial Ischemia
Assessment of Loading With the P2Y12 Inhibitor Ticagrelor or Clopidogrel to Halt Ischemic Events in Patients Undergoing Elective Coronary Stenting
The new P2Y12 inhibitors prasugrel (Efient®-Effient®) and ticagrelor (Brilique®-Brilinta®) have shown promising results in the respective TRITON and PLATO trials making of prasugrel and ticagrelor recommended first line…
- Conditions
- Coronary Artery Disease, Myocardial Ischemia, Myocardial Infarction, Stent Thrombosis
- Trial name
- ALPHEUS (NCT02617290)
- Testing
- Ticagrelor, Clopidogrel
- Where
- France
- Volunteers
- 1,900 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Coronary Arteriosclerosis, Acute Coronary Syndrome
GRAVITAS: Gauging Responsiveness With A VerifyNow Assay-Impact On Thrombosis And Safety
The objective of the GRAVITAS trial is to determine whether tailored anti-platelet therapy using the Accumetrics VerifyNow P2Y12 assay reduces major adverse cardiovascular events after drug-eluting stent implantation.
- Trial name
- GRAVITAS (NCT00645918)
- Testing
- clopidogrel
- Where
- 82 sites in United States, Canada
- Volunteers
- 2,800 people
- Sponsor
- Accumetrics, Inc.
Coronary Artery Disease
The Treatment of Coronary Artery Lesions Using the PRO-Kinetic Energy Cobalt-Chromium, Bare-Metal Stent
The purpose of this study is to the assess the clinical performance of the BIOTRONIK PRO-Kinetic Energy stent in subjects with atherosclerotic disease of native coronary arteries.
- Trial name
- BIOHELIX-II (NCT01811927)
- Testing
- PRO-Kinetic Energy Stent
- Where
- 3 sites in Netherlands, Switzerland
- Volunteers
- 43 people
- Sponsor
- Biotronik AG
Coronary Artery Disease
Evaluation of Effectiveness and Safety of PROMUS Element Stent (IRIS-ELEMENT )
This study is a non-randomized, prospective, open-label registry to compare the efficacy and safety of Promus Element stents versus first-generation drug-eluting stent (DES) in patients with coronary artery disease.
- Trial name
- NCT01350791
- Where
- South Korea
- Volunteers
- 3,001 people
- Sponsor
- Seung-Jung Park
Coronary Artery Disease
Comparison of Double-kissing Crush and Double-kissing Culotte Stenting
True bifurcation lesions (TBLs) are not rare clinical conditions and may be associated with adverse cardiovascular outcomes due to their complex anatomy and the variety of interventional therapy.
- Trial name
- NCT04789161
- Testing
- double kissing crush stenting, double kissing culotte stenting
- Where
- Turkey (Türkiye)
- Volunteers
- 200 people
- Sponsor
- Istanbul Mehmet Akif Ersoy Educational and Training Hospital
Myocardial Ischemia, Coronary Artery Stenosis
SPIRIT PRIME Clinical Trial
To evaluate the safety and effectiveness of the XIENCE PRIME and XIENCE PRIME Long Lesion (LL) Everolimus Eluting Coronary Stent System (EECSS) in improving coronary luminal diameter in subjects with symptomatic heart disease due…
- Conditions
- Myocardial Ischemia, Coronary Artery Stenosis, Coronary Disease, Coronary Artery Disease
- Trial name
- SPIRIT PRIME (NCT00916370)
- Testing
- Core size Xience Prime, Xience Prime Long Lesion (LL)
- Where
- 62 sites in United States, Australia
- Volunteers
- 525 people
- Sponsor
- Abbott Medical Devices
Coronary Artery Disease, Coronary Restenosis
DEB Versus 2nd Generation DES in Patients With In-Scaffold Restenosis of Bioresorbable Vascular Scaffold
The aim of the study is to compare angiographic outcomes following revascularization using drug-eluting balloon (DEB) versus 2nd generation drug-eluting stent (DES) in treatment of Bioresorbable Vascular Scaffold Restenosis.
- Trial name
- SMART-BRS-ISR (NCT03074305)
- Testing
- PCI for in-bioresorbable scaffold stenosis
- Where
- South Korea
- Sponsor
- Samsung Medical Center
Coronary Artery Disease
Motivational Interviewing After Coronary Stenting
This study aimed to examine the effect of motivational interviewing on healthy lifestyle behaviors and biochemical parameters in patients who underwent stent implantation after coronary angiography.
- Trial name
- NCT07659951
- Testing
- Motivational Interviewing
- Where
- Turkey (Türkiye)
- Volunteers
- 55 people
- Sponsor
- Biruni University
Coronary Artery Disease
Japan-Drug Eluting Stents Evaluation; a Randomized Trial
To evaluate the procedural, short and long term clinical outcomes of the TAXUS stent compared to Cypher stent in coronary arteries of ≥ 2.5 and ≤ 3.75 mm in the reference vessel diameter with a lesion of ≤ 46 mm (by visual…
- Trial name
- J-DESsERT® (NCT00708669)
- Testing
- TAXUS stent, Cypher stent
- Where
- 122 sites in Japan
- Volunteers
- 3,500 people
- Sponsor
- Associations for Establishment of Evidence in Interventions
Coronary Artery Disease
Intra-patient Study With Polymer Free Drug Eluting Stent Versus Abluminal Biodegradable Polymer Drug Eluting Stent With Early OCT (Optical Coherence Tomography) Follow up
The objective of the study is to evaluate the process of early re-endothelialization of the Coroflex® ISAR Drug-eluting stent compared with the Ultimaster® Drug-eluting stent
- Trial name
- NCT02785237
- Testing
- Coroflex® ISAR Drug-eluting stent, Ultimaster® Drug-eluting stent
- Where
- 3 sites in Spain
- Volunteers
- 70 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute