Clinical trials: Damage Muscle, open to volunteers
Muscle Damage
Protein Distribution and Leucine Supplementation Effects on Body Composition and Performance in Tactical Athletes
This randomized controlled trial will examine the effects of within-day protein distribution and leucine supplementation on body composition, physical performance, and biomarkers of muscle damage in tactical athletes during an…
- Trial name
- NCT07438158
- Testing
- L-leucine supplementation, Even Protein Distribution, Skewed Protein Distribution (16-hour Protein-Fasting Window)
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- Tel Aviv University
CP (Cerebral Palsy)
rTMS Treatment of Spasticity in Children With Cerebral Palsy/ Hemiplegia Due to ABI - a RCT
This RCT aims to investigate the effect of repetitive transcranial magnatic stimulation (rTMS) in treating children with hemiplegoc cerebral palsy.
- Trial name
- NCT06128746
- Testing
- Repetitive Transcranial Magnetic Stimulation
- Where
- Hong Kong
- Volunteers
- 20 people
- Sponsor
- The University of Hong Kong
Aseptic Muscle Injury
Effects of Protein and NAC Co-ingestion on Skeletal Muscle Recovery
Previous evidence suggests that though N-acetylcysteine (NAC) supplementation following eccentric exercise-induced muscle damage disrupts the skeletal muscle's repair and remodelling process at 8 days of recovery, it attenuates…
- Trial name
- PRoNAC (NCT06367413)
- Testing
- NAC, NAC + Whey Protein
- Where
- Greece
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Thessaly
Idiopathic Toe Walking, Cerebral Palsy
The Effect of Targeting the Plantaris Muscle-tendon in Surgical Correction of Ankle Equinus in Children
Tight ankle muscles can produce ankle equinus (limited ability to pull the foot upward) and occur often in children, significantly impacting their ability to walk.
- Conditions
- Idiopathic Toe Walking, Cerebral Palsy, Hereditary Spastic Paraparesis, Traumatic Brain Injury
- Trial name
- Plantaris Sx (NCT07090057)
- Testing
- Tendoachilles (TA) lengthening or gastrocnemius (GN) recession, then Plantaris tenotomy, Plantaris tenotomy, then Tendoachilles (TA) lengthening or gastrocnemius (GN) recession
- Where
- Canada
- Volunteers
- 42 people
- Sponsor
- University of Alberta
Healthy
Short-term Effects of Broccoli-derived Glucoraphanin on Recovery From Eccentric Muscle Damage
Eccentric exercise induces muscle damage and delay functional recovery. Broccoli-derived glucoraphanin (a sulforaphane precursor that activates Nrf2 defenses) may aid repair; however, its short-term effects in humans remains…
- Trial name
- NCT07373106
- Testing
- broccoli powder consumption
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Lithuanian Sports University
Cerebral Palsy (CP), Spasticity
Predictors of Motor İmagery Performance in Cerebral Palsy
There are very few studies in the literature examining the effect of age on motor imagery ability in children with cerebral palsy. To our knowledge, no studies have investigated the impact of other related factors.
- Conditions
- Cerebral Palsy (CP), Spasticity, Motor Learning
- Trial name
- NCT07002567
- Testing
- Implicit motor imagery, Explicit motor imagery
- Where
- 3 sites in Turkey (Türkiye)
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Abant Izzet Baysal University
Cerebral Palsy, Muscle Contracture
The Muscle in Cerebral Palsy; Sarcomere Length in Vivo and Microscopic Characterization of Biopsies.
Cerebral palsy (CP) is a motor impairment due to a brain malformation or a brain lesion before the age of two. Spasticity, hypertonus in flexor muscles, dyscoordination and an impaired sensorimotor control are cardinal symptoms.
- Conditions
- Cerebral Palsy, Muscle Contracture, Spasticity, Muscle
- Trial name
- CPMuscleSL (NCT05518565)
- Testing
- No intervention
- Where
- 3 sites in Sweden
- Volunteers
- 150 people
- Sponsor
- Eva Ponten
Exercise Induced Muscle Damage, Cryotherapy
Acute Cryotherapy on Musculoskeletal Function and Biomarkers
In 2020, Dubois and Esculier proposed a paradigm shift in the acute management of musculoskeletal injuries, advocating for the transition from the traditional PRICE protocol- Protect, Rest, Ice, Compression, Elevation-to the more…
- Trial name
- NCT07211412
- Testing
- Cryotherapy, Eccentric exercise-induced muscle damage
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Texas, El Paso
Cerebral Palsy, Musculoskeletal Deformity
Neuromusculoskeletal Modeling of Muscle Spasticity
Cerebral palsy (CP) is a movement and posture disorder caused by an injury to the developing brain, with a prevalence in Sweden of about 2/1000 live births.
- Conditions
- Cerebral Palsy, Musculoskeletal Deformity, Spasticity, Muscle Strength
- Trial name
- NCT05447299
- Where
- Sweden
- Volunteers
- 90 people
- Sponsor
- Region Stockholm
Spastic/Dystonic Quadriplegia, Cerebral Palsy (CP)
Outcomes of Neurosurgical Tone Management
Patients with spastic/dystonic quadriplegia (GMFCS IV/V) are often severely disabled by their tone, and require surgical tone management to improve quality of life, allow for better function, improve comfort, and range of motion.
- Trial name
- NCT07817745
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Boston Children's Hospital
Athletic Performance, Muscle Fatigue
Whole-Body Photobiomodulation Use in Professional Soccer Players During a State Championship
This study aims to investigate the effects of whole-body photobiomodulation on professional soccer players during a state championship.
- Conditions
- Athletic Performance, Muscle Fatigue, Muscle Strength, Sports
- Trial name
- WBPBM-PSC (NCT07224646)
- Testing
- Whole-Body Photobiomodulation (PBM) (Active PBM)
- Where
- Brazil
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Universidade Federal de Sao Carlos
Cerebral Palsy
Strength Training Combined With Blood Flow Restriction and Cerebral Palsy
load resistance exercises are performed while partially restricting venous blood flow to the exercising limb using a pneumatic cuff.
- Trial name
- NCT07748052
- Testing
- strength training combined with blood flow restriction and designed physical therapy program, a specially designed physical therapy program
- Volunteers
- 26 people
- Sponsor
- Cairo University
Muscle Spasticity, Gait Disorders, Neurologic
Ultrasonographic Assessment of Muscle Morphology, Function, and Clinical Findings in Spastic Cerebral Palsy
This study focuses on children with spastic cerebral palsy and aims to examine how muscle morphology and tissue characteristics, as assessed by ultrasound, may relate to functional motor abilities.
- Conditions
- Muscle Spasticity, Gait Disorders, Neurologic, Cerebral Palsy, Spastic
- Trial name
- US-sCP (NCT07118228)
- Where
- Turkey (Türkiye)
- Volunteers
- 36 people
- Sponsor
- Kocaeli University
Cerebral Palsy (CP), Drooling
Effectiveness of Neuromuscular Electrical Stimulation Added to Oral Motor Therapy in Cerebral Palsy
This randomized, controlled, single-blind trial aims to investigate the effectiveness of neuromuscular electrical stimulation (NMES) combined with oral motor therapy in reducing drooling severity among children with cerebral…
- Trial name
- NOMES-CP (NCT07069257)
- Testing
- Oral Motor Therapy, Neuromuscular Electrical Stimulation (NMES)
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Aslinur Keles Ercisli, MD, PhD
Neuromuscular Disorders, Neurodevelopmental Disorders
Safety, Usability, and Effectiveness of a Gait Exoskeleton for Children and Adolescents With Neurodevelopmental Disorders.
Neurodevelopmental disorders often result in abnormal development of the Central Nervous System (CNS), frequently causing motor dysfunctions such as the inability to stand and walk.
- Trial name
- NCT07159360
- Testing
- CLINICAL EXPLORER
- Where
- 2 sites in Mexico, Spain
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- MarsiBionics
Cerebral Palsy, Myelomeningocele
Ready, Set, Go! A Physical Fitness Intervention for Children With Mobility Challenges
Barriers to keeping and maintaining fitness as a young person with a disability exist across many domains of access to community locations such as fitness centers, so looking outside of these establishments may be necessary to…
- Conditions
- Cerebral Palsy, Myelomeningocele, Arthrogryposis, Motor Skills Disorders
- Trial name
- NCT04789746
- Testing
- adapted Chicago Run running program
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Northwestern University
Spastic Cerebral Palsy
Feasibility Nutritional Supplements for Muscle Growth in CP
The purpose of this study is to investigate the feasibility of a 10-week plan with a nutritional supplement (leucine) and to perform pilot analyses on the effect of leucine on macroscopic muscle morphology in children with…
- Trial name
- Nut-CP (NCT06044168)
- Testing
- Dietary Supplement: Leucine
- Where
- Belgium
- Volunteers
- 5 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Spastic Cerebral Palsy
3D-Microscopic Muscle Architecture in Cerebral Palsy
The focus of this study is to understand and define the mechanisms of the altered muscle development and growth on a microscopic level within a long-term perspective in children with cerebral palsy and to relate these findings to…
- Trial name
- 3D-MMAP (NCT06584851)
- Where
- Belgium
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Spastic Cerebral Palsy (sCP)
Virtual Reality Combined With Bobath Therapy for Spastic Cerebral Palsy
Spastic cerebral palsy is a common neurodevelopmental disorder characterized by increased muscle tone, impaired balance, and limitations in motor function, particularly in the lower limbs.
- Trial name
- VR-BOBATH-CP (NCT07392398)
- Testing
- Virtual Reality Combined With Bobath Therapy, Conventional Bobath Therapy
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Tongren Hongxin Kangxin Traditional Chinese Medicine Hospital, Guizhou Province
Cerebral Palsy, Spasticity
Lateral Cord Stimulation as a New Treatment for Refractory Spastic Cerebral Palsy
The aim of our work is to investigate whether electrical Lateral Cord Stimulation (LCS) causes an inhibitory and modulatory action by indirect cerebellar activation, so releasing spasticity and the spastic syndrome in selected…
- Trial name
- Andreani1 (NCT02199015)
- Testing
- Lateral spinal cord surgical implant of electrodes
- Where
- 2 sites in Argentina, Germany
- Volunteers
- 40 people
- Sponsor
- Juan Carlos M. Andreani MD