Clinical trials: Defects
Wound Healing, Bone Regeneration
Fucoidan(Seaweed) Based Gel Around Osseous Defects
The current study is a prospective case series study to evaluate the effect of Fucoidan gel around osseous defects to assess the wound healing and bone regeneration
- Trial name
- NCT07793851
- Where
- India
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Krishnadevaraya College of Dental Sciences & Hospital
Atrial Septal Defect, Ventricular Septal Defect
Regional Anesthesia Following Pediatric Cardiac Surgery
The purpose of this study is to evaluate pain control following pediatric cardiac surgery with the use of local anesthesia via an ultrasound guided regional anesthetic technique compared with surgeon delivered wound infiltration.
- Conditions
- Atrial Septal Defect, Ventricular Septal Defect, Pain, Procedural
- Trial name
- NCT05688670
- Testing
- Regional Anesthesia, Wound infiltration, Ropivacaine 0.2% Injectable Solution
- Where
- United States
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Duke University
Molar Incisor Hypomineralization
Minimally Invasive Treatment for Permanent Molars Affected With Molar-incisor Hypomineralization Defects
In this prospective randomized clinical trial, the is aim to compare the clinical and radiographic success of 3 minimally invasive treatment protocols on permanent first molars affected with MIH over 24 months.
- Trial name
- NCT05748067
- Testing
- SDF, HVGIC restoration, SSC
- Where
- Jordan
- Volunteers
- 73 people, healthy volunteers welcome
- Sponsor
- King Abdullah University Hospital
Pentalogy of Cantrell, Mutations in Non-muscle Genes
Genes Mutation Pentalogy of Cantrell
This study will collect blood, urine, and other tissue samples from 50 patients study-wide with Pentalogy of Cantrell and other inherited diseases that involve mutations in non-muscle genes.
- Trial name
- NCT00477932
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Children's Healthcare of Atlanta
Gingival Recession
Inverted T-shape Free Gingival Graft for Treatment of RT2 / RT3 Gingival Recession Defects
The aim of this study is to compare the use of T-inverted shape Free Gingival Graft with Free Gingival Graft for improving the clinical attachment, gain partial root coverage, and improve Keratinized tissue width in recession…
- Trial name
- NCT06615687
- Testing
- Inverted T shape Free Gingival Graft, Free Gingival Graft
- Where
- Egypt
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Cairo University
Molar Incisor Hypomineralization
Resin Infiltration Treatment Versus a Combined Treatment With Microabrasion for the Management of MIH Affected Incisors
The prevalence of molar incisor hypomineralization is relatively high. It has been reported that MIH-affected children experience a wide range of negative impacts because of having visible enamel opacities on their incisors…
- Trial name
- NCT04471571
- Testing
- Resin infiltration and microabrasion for MIH-affected incisors, Resin infiltration for MIH-affected incisors
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Cairo University
Heart Failure, Congenital Heart Defects
Right Ventricular Failure in Congenital Heart Defects
Usually, "heart failure" refers to myocardial insufficiency of the left ventricle. However, in patients with congenital heart defects, often predominantly the right ventricle is affected.
- Trial name
- NCT00266201
- Where
- 9 sites in Germany
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Competence Network for Congenital Heart Defects
Lymphatic Abnormalities, Lymphatic Edema
Lymphatic Function in Patients With a Fontan-Kreutzer Circulation
The lymphatics regulate the interstitial fluid by removing excessive fluid. It represents an extremely important step in the prevention of edema.
- Conditions
- Lymphatic Abnormalities, Lymphatic Edema, Univentricular Heart
- Trial name
- NCT03379805
- Testing
- Near Infrared Fluorescence Imaging, Non-contrast MRI, Strain Gauge Plethysmography
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Hypoplastic Left Heart Syndrome
Near-infrared Spectroscopy (NIRS) Neurodevelopmental Outcomes
We believe that how a baby with Hypoplastic Left Heart Syndrome (HLHS)does after a major open heart operation, measured by things like blood pressure, oxygen saturation, heart rate and others, may have an impact on development.
- Trial name
- NIRS-ND (NCT00464100)
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Medical College of Wisconsin
Enamel Hypomineralization, Dental
The Effectiveness of Biomimetic Materials in Preventing Enamel Demineralization During Fixed Orthodontic Treatment
This study will be done to evaluate the impact of Biosmalto Impact Action Mousse™ on the development and healing of WSLs in individuals receiving orthodontic treatment.
- Trial name
- NCT05940701
- Testing
- Curasept Biosmalto Mousse and toothpaste, Colgate toothpaste
- Where
- Iraq
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- University of Baghdad
Periodontal Regeneration, Clinical and Radiographic Results, Modified Minimal Invasive Surgery
Evaluation of Healing of Intra-bony Defects in Modified Minimal Invasive Surgical Technique
This study is aiming to compare the clinical and radiographic outcomes after complete versus incomplete removal of granulation tissue during modified minimally invasive surgical technique for management of periodontal intrabony…
- Trial name
- NCT03562039
- Testing
- M-MIST
- Where
- 2 sites in Egypt
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Cairo University
Pain Management, Mucogingival Defects
Use of a Custom-Made Acrylic Palatal Stent to Minimize Donor Site Morbidity After Suture-Free Epithelialized Gingival Graft Harvesting: A Randomized Clinical Trial
Epithelialized gingival graft (EGG) harvesting from the palate is associated with postoperative morbidity, including pain and bleeding, due to healing by secondary intention.
- Conditions
- Pain Management, Mucogingival Defects, Healing
- Trial name
- NCT07501754
- Testing
- Custom-Made Acrylic Palatal Stent, No Palatal stent
- Where
- Italy
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- University of Turin, Italy
Dental Caries, Dental Fluorosis
Anticaries Potential and Fluorosis Risk From Different Fluoride Toothpastes
Fluoride toothpaste has been associated not only with declining dental caries prevalence but also with an increase in dental fluorosis.
- Trial name
- NCT01589991
- Testing
- Toothpaste
- Where
- Brazil
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Campinas, Brazil
Periodontal Defects After Third Molar Extraction, Periodontal Disease
Comparison of Autologous Tooth and Bovine Xenograft in Periodontal Healing After Mandibular Third Molar Extraction
This study investigates the healing of periodontal defects on the distal surface of the second lower molars after the surgical extraction of impacted third molars.
- Trial name
- NCT07824518
- Testing
- Autologous Tooth Graft
- Where
- Spain
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Universidad Complutense de Madrid
Scar
Comparison of Scar Results and Time for Closures of Scalp Defects Via Pulley Sutures or Layered Repairs
Surgical defects on the scalp require closure via various techniques of suture placement. A traditional technique requires both dermal (deep) and epidermal (superficial) placement of sutures to close the defect; this is referred…
- Trial name
- NCT02744950
- Testing
- Pulley stitches, Intermediate Repair
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Henry Ford Health System
Fontan Procedure, Hypoplastic Left Heart Syndrome
Impact of Vitamin C on Endothelial Function and Exercise Capacity in Fontan-Palliated Patients
In this study, investigators will evaluate the effect of vitamin C on endothelial function, exercise tolerance and quality of life in patients with a single ventricle who have been palliated to Fontan physiology.
- Conditions
- Fontan Procedure, Hypoplastic Left Heart Syndrome, Tricuspid Atresia
- Trial name
- NCT00974025
- Testing
- Vitamin C
- Where
- United States
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Chronic Periodontitis
Clinical, Anti-Inflammatory And Anti-Infective Properties Of Amniotic Membranes Used For Guided Tissue Regeneration
The objective of this study is to evaluate the anti-inflammatory and anti-infective properties of amniotic membrane (AM) when used for guided tissue regeneration (GTR) in periodontal bone defects.
- Trial name
- NCT02033226
- Testing
- Amniotic Membrane, Control group (Hydroxyapatite only)
- Where
- India
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- SVS Institute of Dental Sciences
Coagulation Defects, Other and Unspecified
High-Shear Microfluidic Thrombosis Assay
The purpose of this study is to characterize a new test to assess the rate and time it takes to form a blood clot in people who either do or do not take aspirin.
- Trial name
- NCT02422810
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Emory University
Congenital Heart Disease, Metabolism Disorder
Metabolic Remodeling in Fontan Patients
Assessment of metabolic alterations in adult Fontan patients with a dominant left ventricle with the help of serum examinations (Metabolomics).
- Trial name
- NCT03886935
- Testing
- Metabolomics
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Medical University Innsbruck
Coagulopathy, Congenital Heart Disease
FFP Usage in Pediatric CV Surgery
When small children undergo heart surgery with the heart-lung machine, in the past, blood products to help the blood clot such as Fresh Frozen Plasma (FFP) was routinely used in children under 10kg.
- Trial name
- NCT05819788
- Where
- Canada
- Volunteers
- 431 people, healthy volunteers welcome
- Sponsor
- University of Alberta