Clinical trials: Defects
Defect of Articular Cartilage
Mesenchymal Stem Cells in a Clinical Trial to Heal Articular Cartilage Defects
The purpose of this study is to: Compare the treatment efficacy of autologous mesenchymal stem cells (Mesenchymal Stem Cells) versus chondrocytes implanted in a commercial available scaffold in a human clinical trial.
- Trial name
- NCT00885729
- Testing
- stem cells, Chondrocytes, Rehabilitation program
- Where
- Norway
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University Hospital, Akershus
Dental Caries Secondary to Acquired Defects of Tooth Structure
10-years Clinical Trial of Sealed of Margin Failures
Assess the effectiveness of sealing localized marginal defects of amalgam restorations that were initially scheduled for replacement of restorations.
- Trial name
- Sealant (NCT02075801)
- Testing
- Sealing of amalgam margin defects
- Where
- Chile
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of Chile
Long QT Syndrome, Abnormalities, Drug-Induced
Novel Approaches for Minimizing Drug-Induced QT Interval Lengthening
This research will determine if: 1) Oral progesterone attenuates drug-induced QT interval, J-Tpeak and Tpeak-Tend lengthening in postmenopausal women 50 years of age or older, and 2) Transdermal testosterone attenuates…
- Trial name
- NCT04675788
- Testing
- Progesterone, Ibutilide, Testosterone
- Where
- 3 sites in United States
- Volunteers
- 73 people, healthy volunteers welcome
- Sponsor
- Indiana University
Molar-Incisor Hypomineralisation
Silver Diamine Fluoride in Molar-Incisor Hypomineralisation
The objective of this study is to assess the efficacy of silver diamine fluoride application in molars affected by molar-incisor hypomineralization.
- Trial name
- NCT06165042
- Testing
- glass hybrid restorative system, Fluoride varnish + Glass hybrid restorative system
- Where
- Turkey (Türkiye)
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Marmara University
Congenital Heart Disease
Executive Functions in Adults With Congenital Heart Disease
Research in children with congenital heart disease (CHD) requiring cardiopulmonary bypass surgery in the neonatal period or during early childhood has shown that the survival rate for this population has dramatically increased…
- Trial name
- NCT04041557
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University Children's Hospital, Zurich
Heart Defects, Congenital, Tetralogy of Fallot
Physical Capacity and Activity in Children With Congenital Heart Disease
Congenital malformations correspond to defects in organ morphogenesis identifiable at birth or intrauterine life, affecting 2-3% of births.
- Trial name
- NCT03275844
- Testing
- Physical activity assessment
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Rodrigo Torres
Diabetes, Congenital Heart Disease
The Roles of Trust and Respect in Patient Reactions to Race-based and Personalized Medicine Vignettes: An Experimental Study
Background: Genetic research has implications for drug development and marketing. Race-based medicine may be able to provide specific treatment for populations with increased disease-specific morbidity and mortality.
- Conditions
- Diabetes, Congenital Heart Disease, Hypertension
- Trial name
- NCT00911833
- Where
- United States
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- National Human Genome Research Institute (NHGRI)
Bone Loss, Alveolar
Evaluation of Bone Gain Using Customized 3D Zirconia Barrier Versus Titanium Mesh
Evaluation of clinical and radiographical amount of bone gained using customized 3D printed zirconia barrier compared to titanium mesh in combined ridge defect at the esthetic zone.
- Trial name
- NCT06559605
- Testing
- zirconia barrier, titanium mesh
- Where
- Egypt
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Cairo University
Aortic Geometry, Vascular Remodeling
Impact of Aortic Geometry on Vascular Remodeling After Stent Implantation in Coarctation of the Aorta
This study aims to assess: 1. Aortic geometrical changes and their relationship to hypertension and cardiovascular events. 2. Aortic geometrical differences between healthy individuals and patients with repaired coarctation of…
- Conditions
- Aortic Geometry, Vascular Remodeling, Coarctation of Aorta, Blood Pressure
- Trial name
- NCT07131111
- Testing
- CT aortography, CMR
- Where
- Egypt
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Assiut University
Periodontal Bone Loss, Periodontal Pocket
Treatment of Intraosseous Periodontal Defects With Hyaluronic Acid
The aim of the present investigation will be evaluate the healing of periodontal intraosseous defects following Minimally Invasive Non Surgical Debridement (MINSD) and application of a hyaluronic acid-based gel, compared to MINSD…
- Trial name
- NCT05188898
- Testing
- MINSD and Hyaluronic acid, MINSD
- Where
- Italy
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Federico II University
Mucogingival Defects
Resveratrol-Based Gel Application in a Palatal Wound Following Free Gingival Graft Surgery
Aim of the study to compare the effect of Resveratrol- Based gel versus 0.2% Hyaluronic acid gel applied to the palatal donor site and acrylic resin stent only in post-operative pain reduction after free gingival graft harvesting.
- Trial name
- NCT06521333
- Testing
- Resveratrol-Based gel, Hyaluronic acid gel 0.2%, Stent
- Where
- Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Cairo University
Chiari Malformations
Dynamic MRI and Quantitative MR CSF Flow Studies in Craniovertebral Junction Anomalies
The purpose of this study is to decide which position of the neck affects cerebral spinal fluid (CSF) flow between the spinal cord and the brain.
- Trial name
- NCT00795080
- Testing
- Dynamic cervical MRI scans
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Peri-Implantitis
Regenerative Outcomes for Peri-implant Bony Defects Using Amnion-chorion Barrier vs. Collagen Membrane
The purpose of this study is to compare the clinical and radiographic outcomes of two different barrier membranes-amnion-chorion membranes (ACM) and conventional collagen membranes-used in guided bone regeneration (GBR)…
- Trial name
- NCT07032259
- Testing
- BioXclude Amnion Chorion Membrane, Collagen Membrane
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Loma Linda University
Root Coverage, Tunneling Technique
Root Coverage With Connective Tissue Graft Associated With VISTA Versus Tunnel Technique
Several techniques were proposed in the literature to solve the problems associated with gingival recession. Root coverage was mainly indicated for esthetic concern, however, it might also be indicated for treatment of root…
- Conditions
- Root Coverage, Tunneling Technique, VISTA Technique, Sub Epithelial Connective Tissue Graft
- Trial name
- NCT03690635
- Testing
- VISTA (vestibular incision subperiosteal tunnel acess)
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Cairo University
Molar Incisor Hypomineralisation, Enamel Hypomineralization
Comparison of Two Minimally Invasive Approaches for Masking Molar-Incisor Hypomineralization Opacities
This clinical study aimed to compare the effectiveness of two minimally invasive approaches for masking molar-incisor hypomineralization (MIH) opacities and to evaluate esthetic perceptions of children and their parents.
- Conditions
- Molar Incisor Hypomineralisation, Enamel Hypomineralization, Tooth Discoloration
- Trial name
- NCT07494682
- Testing
- Resin infiltration, Etch Bleach Seal Technique
- Where
- Turkey (Türkiye)
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Pamukkale University
Periodontal Attachment Loss, Periodontal Bone Loss
Platelet-Rich Fibrin and Anorganic Bovine Bone vs Collagen Membrane and Anorganic Bovine Bone in Intrabony Defects
The primary outcome of periodontal reconstructive therapy is to regenerate all tissues of the periodontium including a functional periodontal ligament, alveolar bone and cementum.
- Conditions
- Periodontal Attachment Loss, Periodontal Bone Loss, Periodontal Diseases
- Trial name
- NCT03715374
- Testing
- Periodontal Surgery with PRF+ABB, Periodontal Surgery with Collagen Membrane +ABB
- Where
- Italy
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- G. d'Annunzio University
Gestational Diabetes Mellitus, Type 2 Diabetes Mellitus
Combined Liraglutide and Metformin Therapy in Women With Previous Gestational Diabetes Mellitus (GDM)
A diagnosis of gestational diabetes mellitus (GDM)has significant implications for the future health of the mother. GDM is often the culmination of years of unrecognized and unmodified diabetes risk factors that lead to overt and…
- Conditions
- Gestational Diabetes Mellitus, Type 2 Diabetes Mellitus, Metabolic Syndrome, Impaired Glucose Tolerance
- Trial name
- NCT01234649
- Testing
- Metformin XR plus liraglutide
- Where
- United States
- Volunteers
- 153 people, healthy volunteers welcome
- Sponsor
- Woman's
Periodontitis
Autologous Micrografts From the Palatal Mucosa for Periodontal Regeneration
Some research studies have demonstrated that autologous micrografts made out of different oral tissues may enhance tissue regeneration.
- Trial name
- NCT06105125
- Testing
- Rigenera + bone substitute, Bone substitute alone
- Where
- Italy
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- University of Turin, Italy
Bone Loss in Jaw
Evaluation of Melatonin and Metformin Loaded Nanoparticles in the Treatment of Periodontal Intra-bony Defects
The goal of this clinical trial is to assess the effectiveness of local delivery of melatonin and metformin loaded nanoparticle gel as adjunct to scaling and root planning (SRP) in the treatment of periodontal intra bony defect.
- Trial name
- NCT05906563
- Testing
- Melatonin gel, Metformin and melatonin gel, scaling and root planning
- Where
- Egypt
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Amira ragab
Congenital Heart Disease, Aortic Root Dilatation
Predictors of Aortic Root Dilatation in Tetralogy of Fallot Patients
To predict vulnerable patients for aortic root dilatation in TOF patients using CT as a reliable imaging modality, thus aiding early intervention, and identifying those who will require strict follow-up.
- Conditions
- Congenital Heart Disease, Aortic Root Dilatation, Tetralogy of Fallot
- Trial name
- NCT06081855
- Testing
- CT
- Volunteers
- 77 people, healthy volunteers welcome
- Sponsor
- Assiut University